{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T06:04:26Z","timestamp":1789538666850,"version":"build-2803163510"},"reference-count":187,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>Mitochondria act as a central integrative hub for oxidative phosphorylation, calcium homeostasis and metabolic signaling, reflecting their evolutionary origin from an \u03b1-proteobacterial endosymbiont. Although nearly 90% of their ancestral genes have been transferred to the nuclear genome, their role extends far beyond energy production. Emerging evidence positions mitochondria as active modulators of stress responses, which we term the \u201cMito-Mood Hypothesis.\u201d This framework proposes that mitochondrial dynamics actively regulate gene expression and signaling, thereby shaping vulnerability to mood disorders such as depression, dysthymia, and seasonal affective disorder. Consistent with this view, patients with major depressive disorders show altered expression of nuclear-encoded mitochondrial genes, linking bioenergetics directly to psychiatric risk. We further discuss how oxidative phosphorylation (OXPHOS) modulates neurotransmitter cycles and how mitohormesis\u2014adaptive responses to mild mitochondrial stress\u2014can enhance resilience and cognition. Beyond psychiatry, mitochondrial vulnerability manifests in clinical settings: patients with mitochondrial diseases face elevated anesthetic risk, where agents such as propofol or volatile anesthetics may precipitate life-threatening metabolic crises. Collectively, these insights underscore mitochondria as central regulators of human health and highlight novel therapeutic opportunities bridging mood disorders and perioperative medicine.<\/jats:p>","DOI":"10.3389\/fphar.2026.1723748","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T07:29:53Z","timestamp":1772090993000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Current perspectives on circadian regulation of mitochondrial dynamics in mood disorders and perioperative stress"],"prefix":"10.3389","volume":"17","author":[{"given":"Florencia","family":"Verbal","sequence":"first","affiliation":[{"name":"Mitochondrial Interactions in Neurological Disorders, Department of Physiology, Faculty of Biological Sciences, University of Concepci\u00f3n","place":["Concepci\u00f3n, Chile"]},{"name":"Laboratory for the Screening of Neuroactive Compounds, Department of Physiology, Faculty of Biological Sciences, University of Concepci\u00f3n","place":["Concepci\u00f3n, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Rubilar","sequence":"additional","affiliation":[{"name":"Mitochondrial Interactions in Neurological Disorders, Department of Physiology, Faculty of Biological Sciences, University of Concepci\u00f3n","place":["Concepci\u00f3n, Chile"]},{"name":"Laboratory for the Screening of Neuroactive Compounds, Department of Physiology, Faculty of Biological Sciences, University of Concepci\u00f3n","place":["Concepci\u00f3n, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana M","family":"Marileo","sequence":"additional","affiliation":[{"name":"Laboratory of Neuropharmacology, Department of Physiology, Faculty of Biological Sciences, University of Concepci\u00f3n","place":["Concepci\u00f3n, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humberto","family":"Fierro","sequence":"additional","affiliation":[{"name":"Center for Advanced Research in Biomedicine, University of Concepci\u00f3n","place":["Concepci\u00f3n, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar Guillermo","family":"Ramirez-Molina","sequence":"additional","affiliation":[{"name":"Laboratory for the Screening of Neuroactive Compounds, Department of Physiology, Faculty of Biological Sciences, University of Concepci\u00f3n","place":["Concepci\u00f3n, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Araceli","family":"Pinto-Leon","sequence":"additional","affiliation":[{"name":"Laboratory for the Screening of Neuroactive Compounds, Department of Physiology, Faculty of Biological Sciences, University of Concepci\u00f3n","place":["Concepci\u00f3n, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo E","family":"Yev\u00e9nes","sequence":"additional","affiliation":[{"name":"Laboratory of Neuropharmacology, Department of Physiology, Faculty of Biological Sciences, University of Concepci\u00f3n","place":["Concepci\u00f3n, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Fuentealba","sequence":"additional","affiliation":[{"name":"Laboratory for the Screening of Neuroactive Compounds, Department of Physiology, Faculty of Biological Sciences, University of Concepci\u00f3n","place":["Concepci\u00f3n, Chile"]},{"name":"Center for Advanced Research in Biomedicine, University of Concepci\u00f3n","place":["Concepci\u00f3n, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Panes-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Mitochondrial Interactions in Neurological Disorders, Department of Physiology, Faculty of Biological Sciences, University of Concepci\u00f3n","place":["Concepci\u00f3n, Chile"]},{"name":"Laboratory for the Screening of Neuroactive Compounds, Department of Physiology, Faculty of Biological Sciences, University of Concepci\u00f3n","place":["Concepci\u00f3n, Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.pbb.2012.12.027","article-title":"Coenzyme Q10 displays antidepressant-like activity with reduction of hippocampal oxidative\/nitrosative DNA damage in chronically stressed rats","volume":"104","author":"Aboul-Fotouh","year":"2013","journal-title":"Pharmacol. Biochem. Behav."},{"key":"B2","doi-asserted-by":"publisher","first-page":"e174501792307240","DOI":"10.2174\/17450179-v19-230823-2023-4","article-title":"Dexmedetomidine in the treatment of depression: an up-to-date narrative review","volume":"19","author":"AL-Mahrouqi","year":"2023","journal-title":"Clin. Pract. Epidemiol. Ment. Health"},{"key":"B3","doi-asserted-by":"publisher","first-page":"e88669","DOI":"10.7759\/cureus.88669","article-title":"Anesthetic management of a pediatric patient with mitochondrial depletion syndrome and hypertrophic cardiomyopathy undergoing scoliosis correction: a case report","volume":"17","author":"Alkuwaiti","year":"2025","journal-title":"Cureus"},{"key":"B4","doi-asserted-by":"publisher","first-page":"386","DOI":"10.3389\/fnins.2018.00386","article-title":"Mitochondria and mood: mitochondrial dysfunction as a key player in the manifestation of depression","volume":"12","author":"Allen","year":"2018","journal-title":"Front. Neurosci."},{"key":"B5","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.mito.2020.11.010","article-title":"Severe life stress, mitochondrial dysfunction, and depressive behavior: a pathophysiological and therapeutic perspective","volume":"56","author":"Allen","year":"2021","journal-title":"Mitochondrion"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.033860","article-title":"Pramipexole prevents ischemic cell death via mitochondrial pathways in ischemic stroke","volume":"12","author":"Andrabi","year":"2019","journal-title":"Dis. Model. Mech."},{"key":"B7","doi-asserted-by":"publisher","first-page":"112614","DOI":"10.1016\/j.jphotobiol.2022.112614","article-title":"Mitochondria and light: An overview of the pathways triggered in skin and retina with incident infrared radiation","volume":"238","author":"Arranz-Para\u00edso","year":"2023","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1097\/00004647-200110000-00001","article-title":"An energy budget for signaling in the grey matter of the brain","volume":"21","author":"Attwell","year":"2001","journal-title":"J. Cereb. Blood Flow. Metab."},{"key":"B9","doi-asserted-by":"publisher","first-page":"2464","DOI":"10.1038\/s41598-023-29607-8","article-title":"Meta-analysis of NAD(P)(H) quantification results exhibits variability across mammalian tissues","volume":"13","author":"Azouaoui","year":"2023","journal-title":"Sci. Rep."},{"key":"B10","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1111\/j.1399-6576.2006.00988.x","article-title":"Volatile anaesthetics depolarize neural mitochondria by inhibiton of the electron transport chain","volume":"50","author":"Bains","year":"2006","journal-title":"Acta Anaesthesiol. Scand."},{"key":"B11","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.biopsych.2008.03.004","article-title":"N-acetyl cysteine as a glutathione precursor for schizophrenia--a double-blind, randomized, placebo-controlled trial","volume":"64","author":"Berk","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"B12","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1002\/wps.21266","article-title":"Past, present and future of research on brain energy metabolism in bipolar disorder","volume":"24","author":"Berk","year":"2025","journal-title":"World Psychiatry"},{"key":"B13","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.clnu.2004.12.005","article-title":"Potential role of ubiquinone (coenzyme Q10) in pediatric cardiomyopathy","volume":"24","author":"Bhagavan","year":"2005","journal-title":"Clin. Nutr."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1681\/ASN.2012121216","article-title":"The mitochondrial-targeted compound SS-31 re-energizes ischemic mitochondria by interacting with cardiolipin","volume":"24","author":"Birk","year":"2013","journal-title":"J. Am. Soc. Nephrol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1046\/j.1460-9592.2003.01001.x","article-title":"Anaesthesia for an adolescent with mitochondrial encephalomyopathy-lactic acidosis-stroke-like episodes syndrome","volume":"13","author":"Bolton","year":"2003","journal-title":"Paediatr. Anaesth."},{"key":"B16","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/j.devcel.2017.02.020","article-title":"The putative Drp1 inhibitor mdivi-1 is a reversible mitochondrial complex I inhibitor that modulates reactive oxygen species","volume":"40","author":"Bordt","year":"2017","journal-title":"Dev. Cell"},{"key":"B17","doi-asserted-by":"publisher","first-page":"i47","DOI":"10.1093\/bja\/aet073","article-title":"Mitochondrial protectant pramipexole prevents sex-specific long-term cognitive impairment from early anaesthesia exposure in rats","volume":"110","author":"Boscolo","year":"2013","journal-title":"Br. J. Anaesth."},{"key":"B18","first-page":"148","article-title":"Anesthetic management of the patient with mitochondrial disease: a review of current best evidence","volume":"90","author":"Brody","year":"2022","journal-title":"Aana J."},{"key":"B19","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1146\/annurev-neuro-060909-153200","article-title":"General anesthesia and altered states of arousal: a systems neuroscience analysis","volume":"34","author":"Brown","year":"2011","journal-title":"Annu. Rev. Neurosci."},{"key":"B20","doi-asserted-by":"publisher","first-page":"453","DOI":"10.62641\/aep.v52i4.1622","article-title":"Mental health and suicidal behaviour in Chilean youth during the Covid-19 pandemic","volume":"52","author":"Bustos Villarroel","year":"2024","journal-title":"Actas Esp. Psiquiatr."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1656","DOI":"10.3390\/antiox12091656","article-title":"Lactate: a Theranostic biomarker for metabolic psychiatry?","volume":"12","author":"Caddye","year":"2023","journal-title":"Antioxidants (Basel)"},{"key":"B22","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.ejphar.2012.10.017","article-title":"Anti-depressant-like effect of vitexin in BALB\/c mice and evidence for the involvement of monoaminergic mechanisms","volume":"699","author":"Can","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.cmet.2015.05.023","article-title":"NAD(+) metabolism and the control of energy homeostasis: a balancing act between mitochondria and the nucleus","volume":"22","author":"Cant\u00f3","year":"2015","journal-title":"Cell Metab."},{"key":"B24","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.yhbeh.2012.02.020","article-title":"Melatonin and mitochondrial dysfunction in the central nervous system","volume":"63","author":"Cardinali","year":"2013","journal-title":"Horm. Behav."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1114231","DOI":"10.3389\/fphys.2023.1114231","article-title":"Mitochondria: it is all about energy","volume":"14","author":"Casanova","year":"2023","journal-title":"Front. Physiol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1097\/00000542-199708000-00030","article-title":"Perioperative white matter degeneration and death in a patient with a defect in mitochondrial oxidative phosphorylation","volume":"87","author":"Casta","year":"1997","journal-title":"Anesthesiology"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1089\/neu.2016.4624","article-title":"Phenelzine protects brain mitochondrial function in vitro and in vivo following traumatic brain injury by scavenging the reactive carbonyls 4-Hydroxynonenal and acrolein leading to cortical histological neuroprotection","volume":"34","author":"Cebak","year":"2017","journal-title":"J. Neurotrauma"},{"key":"B28","doi-asserted-by":"publisher","first-page":"106078","DOI":"10.1016\/j.psyneuen.2023.106078","article-title":"A comparative meta-analysis of peripheral 8-hydroxy-2'-deoxyguanosine (8-OHdG) or 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dG) levels across mood episodes in bipolar disorder","volume":"151","author":"\u00c7eli","year":"2023","journal-title":"Psychoneuroendocrinology"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1338544","DOI":"10.3389\/fphys.2024.1338544","article-title":"Integrating mitoepigenetics into research in mood disorders: a state-of-the-art review","volume":"15","author":"Ceylan","year":"2024","journal-title":"Front. Physiol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"101026","DOI":"10.1016\/j.lanwpc.2024.101026","article-title":"Projecting the 10-year costs of care and mortality burden of depression until 2032: a markov modelling study developed from real-world data","volume":"45","author":"Chan","year":"2024","journal-title":"Lancet Reg. Health West Pac"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1016\/j.cell.2013.05.027","article-title":"SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging","volume":"153","author":"Chang","year":"2013","journal-title":"Cell"},{"key":"B32","doi-asserted-by":"publisher","first-page":"5607","DOI":"10.3892\/mmr.2016.5948","article-title":"Neuroprotective effects of vitexin against isoflurane-induced neurotoxicity by targeting the TRPV1 and NR2B signaling pathways","volume":"14","author":"Chen","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"B33","doi-asserted-by":"publisher","first-page":"116656","DOI":"10.1016\/j.biopha.2024.116656","article-title":"Mitochondrial dynamics dysfunction: unraveling the hidden link to depression","volume":"175","author":"Chen","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"B34","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1186\/s12888-023-04581-7","article-title":"Prevalence and economic burden of depression and anxiety symptoms among Singaporean adults: results from a 2022 web panel","volume":"23","author":"Chodavadia","year":"2023","journal-title":"BMC Psychiatry"},{"key":"B35","doi-asserted-by":"publisher","first-page":"166920","DOI":"10.1016\/j.bbadis.2023.166920","article-title":"A mitochondrial nexus in major depressive disorder: integration with the psycho-immune-neuroendocrine network","volume":"1870","author":"Ciubuc-Batcu","year":"2024","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11092488","article-title":"Mitochondria and brain disease: a comprehensive review of pathological mechanisms and therapeutic opportunities","volume":"11","author":"Clemente-Su\u00e1rez","year":"2023","journal-title":"Biomedicines"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1111\/j.1471-4159.2007.05097.x","article-title":"Therapeutic effects of coenzyme Q10 (CoQ10) and reduced CoQ10 in the MPTP model of parkinsonism","volume":"104","author":"Cleren","year":"2008","journal-title":"J. Neurochem."},{"key":"B38","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.jep.2012.07.005","article-title":"Life or death: neuroprotective and anticancer effects of quercetin","volume":"143","author":"Dajas","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.3390\/life10110296","article-title":"Analysis of human mutations in the supernumerary subunits of complex I","volume":"10","author":"Dang","year":"2020","journal-title":"Life (Basel)"},{"key":"B40","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.neubiorev.2015.04.015","article-title":"Clinical trials of N-acetylcysteine in psychiatry and neurology: a systematic review","volume":"55","author":"Deepmala","year":"2015","journal-title":"Neurosci. Biobehav Rev."},{"key":"B41","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1007\/s44254-024-00078-y","article-title":"Advances in the use of dexmedetomidine for postoperative cognitive dysfunction","volume":"2","author":"Deng","year":"2024","journal-title":"Anesthesiol. Perioper. Sci."},{"key":"B42","doi-asserted-by":"publisher","first-page":"3701","DOI":"10.1523\/JNEUROSCI.4160-14.2015","article-title":"Monitoring of vacuolar-type H+ ATPase-mediated proton influx into synaptic vesicles","volume":"35","author":"Egashira","year":"2015","journal-title":"J. Neurosci."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1560","DOI":"10.1017\/S0033291717003336","article-title":"Socio-economic variations in the mental health treatment gap for people with anxiety, mood, and substance use disorders: results from the WHO world mental health (WMH) surveys","volume":"48","author":"Evans-Lacko","year":"2018","journal-title":"Psychol. Med."},{"key":"B44","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1097\/DBP.0b013e3181ef42c1","article-title":"Neurodevelopmental manifestations of mitochondrial disease","volume":"31","author":"Falk","year":"2010","journal-title":"J. Dev. Behav. Pediatr."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1621070","DOI":"10.3389\/fnmol.2025.1621070","article-title":"Calcium signaling in postsynaptic mitochondria: mechanisms, dynamics, and role in ATP production","volume":"18","author":"Feofilaktova","year":"2025","journal-title":"Front. Mol. Neurosci."},{"key":"B46","doi-asserted-by":"publisher","first-page":"e457","DOI":"10.4088\/JCP.15r09984","article-title":"N-Acetylcysteine in depressive symptoms and functionality: a systematic review and meta-analysis","volume":"77","author":"Fernandes","year":"2016","journal-title":"J. Clin. Psychiatry"},{"key":"B47","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1177\/0883073816661458","article-title":"Propofol is mitochondrion-toxic and may unmask a mitochondrial disorder","volume":"31","author":"Finsterer","year":"2016","journal-title":"J. Child. Neurol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1093\/bja\/aen014","article-title":"Mitochondrial disorders and general anaesthesia: a case series and review","volume":"100","author":"Footitt","year":"2008","journal-title":"Br. J. Anaesth."},{"key":"B49","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1097\/JCP.0000000000000326","article-title":"Antidepressant effects of open label treatment with coenzyme Q10 in geriatric bipolar depression","volume":"35","author":"Forester","year":"2015","journal-title":"J. Clin. Psychopharmacol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"11364","DOI":"10.1073\/pnas.0802076105","article-title":"Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress","volume":"105","author":"Gautier","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B51","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1080\/08998280.2001.11927725","article-title":"Dexmedetomidine: a novel sedative-analgesic agent","volume":"14","author":"Gertler","year":"2001","journal-title":"Proc. Bayl Univ. Med. Cent."},{"key":"B52","doi-asserted-by":"publisher","first-page":"546801","DOI":"10.3389\/fpsyt.2021.546801","article-title":"The role of mitochondria in mood disorders: from physiology to pathophysiology and to treatment","volume":"12","author":"Gim\u00e9nez-Palomo","year":"2021","journal-title":"Front. Psychiatry"},{"key":"B53","doi-asserted-by":"publisher","first-page":"16080","DOI":"10.1038\/nrdp.2016.80","article-title":"Mitochondrial diseases","volume":"2","author":"Gorman","year":"2016","journal-title":"Nat. Rev. Dis. Prim."},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21113743","article-title":"Urinary 8-OHdG as a biomarker for oxidative stress: a systematic literature review and meta-analysis","volume":"21","author":"Graille","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B55","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1097\/CCM.0000000000006289","article-title":"Anaerobic lactate production is associated with decreased microcirculatory blood flow and decreased mitochondrial respiration following cardiovascular surgery with cardiopulmonary bypass","volume":"52","author":"Greenwood","year":"2024","journal-title":"Crit. Care Med."},{"key":"B56","doi-asserted-by":"publisher","first-page":"e2059","DOI":"10.1002\/mgg3.2059","article-title":"Kearns-sayre syndrome case. Novel 5,9 kb mtDNA deletion","volume":"11","author":"Grigalionien\u0117","year":"2023","journal-title":"Mol. Genet. Genomic Med."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1446","DOI":"10.1038\/cdd.2012.18","article-title":"Inhibition of Drp1 provides neuroprotection in vitro and in vivo","volume":"19","author":"Grohm","year":"2012","journal-title":"Cell Death and Differ."},{"key":"B58","doi-asserted-by":"publisher","first-page":"640","DOI":"10.3390\/neurolint13040062","article-title":"Anesthetic considerations for patients on psychotropic drug therapies","volume":"13","author":"Harbell","year":"2021","journal-title":"Neurol. Int."},{"key":"B59","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.biocel.2014.01.020","article-title":"Coenzyme Q10 as a therapy for mitochondrial disease","volume":"49","author":"Hargreaves","year":"2014","journal-title":"Int. J. Biochem. and Cell Biol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1007\/s11064-018-2588-6","article-title":"A ketogenic diet improves mitochondrial biogenesis and bioenergetics via the PGC1\u03b1-SIRT3-UCP2 axis","volume":"44","author":"Hasan-Olive","year":"2019","journal-title":"Neurochem. Res."},{"key":"B61","doi-asserted-by":"publisher","first-page":"102848","DOI":"10.1016\/j.redox.2023.102848","article-title":"Protective effects of luteolin against amyloid beta-induced oxidative stress and mitochondrial impairments through peroxisome proliferator-activated receptor \u03b3-dependent mechanism in Alzheimer's disease","volume":"66","author":"He","year":"2023","journal-title":"Redox Biol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/7854_2021_300","article-title":"Neuroinflammation and mitochondrial dysfunction link social stress to depression","volume":"54","author":"Hollis","year":"2022","journal-title":"Curr. Top. Behav. Neurosci."},{"key":"B63","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1038\/jcbfm.2012.35","article-title":"Updated energy budgets for neural computation in the neocortex and cerebellum","volume":"32","author":"Howarth","year":"2012","journal-title":"J. Cereb. Blood Flow. Metab."},{"key":"B64","doi-asserted-by":"publisher","first-page":"2326409817707770","DOI":"10.1177\/2326409817707770","article-title":"Mitochondrial disease and anesthesia","volume":"5","author":"Hsieh","year":"2017","journal-title":"J. Inborn Errors Metabolism Screen."},{"key":"B65","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1213\/ANE.0000000000005430","article-title":"Anesthetic hypersensitivity in a case-controlled series of patients with mitochondrial disease","volume":"133","author":"Hsieh","year":"2021","journal-title":"Anesth. Analg."},{"key":"B66","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/j.cmet.2015.08.006","article-title":"Hepatic Bmal1 regulates rhythmic mitochondrial dynamics and promotes metabolic fitness","volume":"22","author":"Jacobi","year":"2015","journal-title":"Cell Metab."},{"key":"B67","doi-asserted-by":"publisher","first-page":"e14576","DOI":"10.1111\/cns.14576","article-title":"Mitochondria in depression: the dysfunction of mitochondrial energy metabolism and quality control systems","volume":"30","author":"Jiang","year":"2024","journal-title":"CNS Neurosci. Ther."},{"key":"B68","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.cmet.2017.06.002","article-title":"CRY1\/2 selectively repress PPAR\u03b4 and limit exercise capacity","volume":"26","author":"Jordan","year":"2017","journal-title":"Cell Metab."},{"key":"B69","doi-asserted-by":"publisher","first-page":"383","DOI":"10.3390\/biom15030383","article-title":"The association among bipolar disorder, mitochondrial dysfunction, and reactive oxygen species","volume":"15","author":"Kageyama","year":"2025","journal-title":"Biomolecules"},{"key":"B70","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/mp.2015.156","article-title":"Depression-like episodes in mice harboring mtDNA deletions in paraventricular thalamus","volume":"21","author":"Kasahara","year":"2016","journal-title":"Mol. Psychiatry"},{"key":"B71","doi-asserted-by":"publisher","first-page":"695","DOI":"10.3390\/biom13040695","article-title":"Connecting dots between mitochondrial dysfunction and depression","volume":"13","author":"Khan","year":"2023","journal-title":"Biomolecules"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25133060","article-title":"Flavonoids and mitochondria: activation of cytoprotective pathways?","volume":"25","author":"Kicinska","year":"2020","journal-title":"Molecules"},{"key":"B73","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1093\/schbul\/sbw129","article-title":"Redox dysregulation in schizophrenia revealed by in vivo NAD+\/NADH measurement","volume":"43","author":"Kim","year":"2017","journal-title":"Schizophr. Bull."},{"key":"B74","doi-asserted-by":"publisher","first-page":"5450","DOI":"10.7150\/ijbs.97723","article-title":"N-Acetylcysteine alleviates depressive-like behaviors in adolescent EAAC1(-\/-) mice and early life stress model rats","volume":"20","author":"Kim","year":"2024","journal-title":"Int. J. Biol. Sci."},{"key":"B75","doi-asserted-by":"publisher","first-page":"967","DOI":"10.33549\/physiolres.934529","article-title":"Current progress in the therapeutic options for mitochondrial disorders","volume":"69","author":"Ko\u0148a\u0159\u00edkov\u00e1","year":"2020","journal-title":"Physiol. Res."},{"key":"B76","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1056\/NEJMra1012478","article-title":"Monogenic mitochondrial disorders","volume":"366","author":"Koopman","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"B77","article-title":"Top Ten Facts you need to Know About the anesthetic management of Patients with mitochondrial disease","volume":"64","author":"Kurnutala","year":"2023","journal-title":"Journal of the Mississippi State Medical Association,"},{"key":"B78","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.ibneur.2023.04.002","article-title":"Mitochondria dysfunction and bipolar disorder: from pathology to therapy","volume":"14","author":"Lam","year":"2023","journal-title":"IBRO Neurosci. Rep."},{"key":"B79","doi-asserted-by":"publisher","first-page":"1950","DOI":"10.3390\/antiox10121950","article-title":"Clinical diagnosis and treatment of leigh syndrome based on SURF1: genotype and phenotype","volume":"10","author":"Lee","year":"2021","journal-title":"Antioxidants (Basel)"},{"key":"B80","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1007\/s12264-008-0304-2","article-title":"Depressive-like behavior in mice recently recovered from motor disorders after 3-nitropropionic acid intoxication","volume":"24","author":"Li","year":"2008","journal-title":"Neurosci. Bull."},{"key":"B81","doi-asserted-by":"publisher","first-page":"167","DOI":"10.3390\/nu8030167","article-title":"Quercetin, inflammation and immunity","volume":"8","author":"Li","year":"2016","journal-title":"Nutrients"},{"key":"B82","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1007\/s12264-023-01072-3","article-title":"Targeting NAD metabolism for the therapy of age-related neurodegenerative diseases","volume":"40","author":"Li","year":"","journal-title":"Neurosci. Bull."},{"key":"B83","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1016\/j.jad.2024.04.073","article-title":"Pramipexole improves depression-like behavior in diabetes mellitus with depression rats by inhibiting NLRP3 inflammasome-mediated neuroinflammation and preventing impaired neuroplasticity","volume":"356","author":"Li","year":"","journal-title":"J. Affect. Disord."},{"key":"B84","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1186\/s12888-024-05606-5","article-title":"Circadian rhythms of melatonin and its relationship with anhedonia in patients with mood disorders: a cross-sectional study","volume":"24","author":"Li","year":"","journal-title":"BMC Psychiatry"},{"key":"B85","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.3390\/ijms26051895","article-title":"Changes in mitochondrial transcriptional rhythms and depression-like behavior in the hippocampus of IL-33-Overexpressing mice","volume":"26","author":"Li","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"B86","doi-asserted-by":"publisher","first-page":"4785089","DOI":"10.1155\/2018\/4785089","article-title":"A brief review on the neuroprotective mechanisms of vitexin","volume":"2018","author":"Lima","year":"2018","journal-title":"Biomed. Res. Int."},{"key":"B87","doi-asserted-by":"publisher","first-page":"109910","DOI":"10.1016\/j.intimp.2023.109910","article-title":"Dexmedetomidine alleviates oxidative stress and mitochondrial dysfunction in diabetic peripheral neuropathy via the microRNA-34a\/SIRT2\/S1PR1 axis","volume":"117","author":"Lin","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.3390\/healthcare12171721","article-title":"Estimation of the global disease burden of depression and anxiety between 1990 and 2044: an analysis of the global burden of disease study 2019","volume":"12","author":"Liu","year":"2024","journal-title":"Healthc. (Basel)"},{"key":"B89","doi-asserted-by":"publisher","first-page":"613","DOI":"10.3390\/antiox14050613","article-title":"The ferroptosis\u2013mitochondrial axis in depression: unraveling the feedforward loop of oxidative stress, metabolic homeostasis dysregulation, and neuroinflammation","volume":"14","author":"Liu","year":"2025","journal-title":"Antioxidants"},{"key":"B90","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1590\/1984-0462\/;2018;36;4;00003","article-title":"Leigh syndrome: a case report with a mitochondrial dna mutation","volume":"36","author":"Lopes","year":"2018","journal-title":"Rev. Paul. Pediatr."},{"key":"B91","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/s11920-023-01423-x","article-title":"Suicide in global mental health","volume":"25","author":"Lovero","year":"2023","journal-title":"Curr. Psychiatry Rep."},{"key":"B92","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1007\/s00127-023-02534-9","article-title":"Association between depressive symptoms and all-cause mortality in Chilean adult population: prospective results from two national health surveys","volume":"59","author":"Luna","year":"2024","journal-title":"Soc. Psychiatry Psychiatr. Epidemiol."},{"key":"B93","doi-asserted-by":"publisher","first-page":"3117","DOI":"10.3892\/etm.2018.5758","article-title":"Protective effect of vitexin reduces sevoflurane-induced neuronal apoptosis through HIF-1\u03b1, VEGF and p38 MAPK signaling pathway in vitro and in newborn rats","volume":"15","author":"Lyu","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"B94","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1017\/S1461145710001203","article-title":"Neural mechanisms of antidepressant efficacy of the dopamine receptor agonist pramipexole in treatment of bipolar depression","volume":"14","author":"Mah","year":"2011","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"B95","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1007\/s00415-013-7225-3","article-title":"The m.3243A>G mitochondrial DNA mutation and related phenotypes. A matter of gender?","volume":"261","author":"Mancuso","year":"2014","journal-title":"J. Neurol."},{"key":"B96","doi-asserted-by":"publisher","first-page":"e70756","DOI":"10.7759\/cureus.70756","article-title":"Balancing anesthesia in a child with mitochondrial disease: a case report","volume":"16","author":"Manickam","year":"2024","journal-title":"Cureus"},{"key":"B97","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1007\/s10571-021-01078-3","article-title":"Overview of the neuroprotective effects of the MAO-inhibiting antidepressant phenelzine","volume":"42","author":"Matveychuk","year":"2022","journal-title":"Cell Mol. Neurobiol."},{"key":"B98","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1097\/JCP.0000000000000938","article-title":"Evaluating the effect of coenzyme Q10 augmentation on treatment of bipolar depression: a double-blind controlled clinical trial","volume":"38","author":"Mehrpooya","year":"2018","journal-title":"J. Clin. Psychopharmacol."},{"key":"B99","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1038\/s41398-021-01464-x","article-title":"Melatonin\u2019s neuroprotective role in mitochondria and its potential as a biomarker in aging, cognition and psychiatric disorders","volume":"11","author":"Melhuish Beaupre","year":"2021","journal-title":"Transl. Psychiatry"},{"key":"B100","doi-asserted-by":"publisher","first-page":"424","DOI":"10.3390\/metabo11070424","article-title":"Altered Ca(2+) handling and oxidative stress underlie mitochondrial damage and skeletal muscle dysfunction in aging and disease","volume":"11","author":"Michelucci","year":"2021","journal-title":"Metabolites"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2025.13443","article-title":"Mitochondrial DNA copy number alterations: Key players in the complexity of glioblastoma (Review)","volume":"31","author":"Mohamed Yusoff","year":"2025","journal-title":"Mol. Med. Rep."},{"key":"B102","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1016\/s1734-1140(12)70905-2","article-title":"Characterization of motor, depressive-like and neurochemical alterations induced by a short-term rotenone administration","volume":"64","author":"Morais","year":"2012","journal-title":"Pharmacol. Rep."},{"key":"B103","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1097\/00000542-200205000-00036","article-title":"Mitochondrial defects and anesthetic sensitivity","volume":"96","author":"Morgan","year":"2002","journal-title":"Anesthesiology"},{"key":"B104","doi-asserted-by":"publisher","first-page":"E1673","DOI":"10.1073\/pnas.1519650113","article-title":"Circadian control of oscillations in mitochondrial rate-limiting enzymes and nutrient utilization by PERIOD proteins","volume":"113","author":"Neufeld-Cohen","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B105","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.tem.2013.09.002","article-title":"Ketone bodies as signaling metabolites","volume":"25","author":"Newman","year":"2014","journal-title":"Trends Endocrinol. Metab."},{"key":"B106","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.neuroscience.2025.01.061","article-title":"Therapeutic modulation of mitochondrial dynamics by agmatine in neurodegenerative disorders","volume":"569","author":"Nibrad","year":"2025","journal-title":"Neuroscience"},{"key":"B107","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1093\/clinchem\/43.7.1209","article-title":"Plasma malondialdehyde as biomarker for oxidative stress: reference interval and effects of life-style factors","volume":"43","author":"Nielsen","year":"1997","journal-title":"Clin. Chem."},{"key":"B108","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1001\/jama.2023.18588","article-title":"Diagnosis and treatment of bipolar disorder: a review","volume":"330","author":"Nierenberg","year":"2023","journal-title":"Jama"},{"key":"B109","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1111\/pan.12158","article-title":"Anesthetic considerations in patients with mitochondrial defects","volume":"23","author":"Niezgoda","year":"2013","journal-title":"Paediatr. Anaesth."},{"key":"B110","doi-asserted-by":"publisher","first-page":"6","DOI":"10.3390\/clinbioenerg1010006","article-title":"Mitochondria, oxidative stress, and psychiatric disorders: an integrative perspective on brain bioenergetics","volume":"1","author":"Nunes","year":"2025","journal-title":"Clin. Bioenerg."},{"key":"B111","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/s40501-024-00322-z","article-title":"The ketogenic diet as a treatment for mood disorders","volume":"11","author":"Ozan","year":"2024","journal-title":"Curr. Treat. Options Psychiatry"},{"key":"B112","doi-asserted-by":"publisher","first-page":"114877","DOI":"10.1016\/j.intimp.2025.114877","article-title":"Vitexin mitigates AIM2 inflammasome-mediated mitochondrial dysfunction and neuroinflammation in chronic constriction injury induced neuropathy model","volume":"158","author":"Pal","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"B113","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.pnpbp.2012.10.017","article-title":"Antioxidants as potential therapeutics for neuropsychiatric disorders","volume":"46","author":"Pandya","year":"2013","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"B114","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1038\/gim.2014.177","article-title":"Diagnosis and management of mitochondrial disease: a consensus statement from the mitochondrial medicine society","volume":"17","author":"Parikh","year":"2015","journal-title":"Genet. Med."},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2017.107","article-title":"Patient care standards for primary mitochondrial disease: a consensus statement from the mitochondrial medicine society","volume":"19","author":"Parikh","year":"2017","journal-title":"Genet. Med."},{"key":"B116","doi-asserted-by":"publisher","first-page":"3529","DOI":"10.1007\/s11357-023-00861-y","article-title":"The mitochondrially targeted peptide elamipretide (SS-31) improves ADP sensitivity in aged mitochondria by increasing uptake through the adenine nucleotide translocator (ANT)","volume":"45","author":"Pharaoh","year":"2023","journal-title":"Geroscience"},{"key":"B117","doi-asserted-by":"publisher","first-page":"1952","DOI":"10.3390\/nu14091952","article-title":"The therapeutic role of ketogenic diet in neurological disorders","volume":"14","author":"Pietrzak","year":"2022","journal-title":"Nutrients"},{"key":"B118","doi-asserted-by":"publisher","first-page":"2197","DOI":"10.1007\/s00210-021-02161-8","article-title":"Coenzyme Q10 a mitochondrial restorer for various brain disorders","volume":"394","author":"Pradhan","year":"2021","journal-title":"Naunyn Schmiedeb. Arch. Pharmacol."},{"key":"B119","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1001\/jama.2022.0799","article-title":"Effect of sublingual dexmedetomidine vs placebo on acute agitation associated with bipolar disorder: a randomized clinical trial","volume":"327","author":"Preskorn","year":"2022","journal-title":"Jama"},{"key":"B120","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1242\/jcs.114439","article-title":"A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity","volume":"126","author":"Qi","year":"2013","journal-title":"J. Cell Sci."},{"key":"B121","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.2147\/PPA.S406046","article-title":"Implementing the hospice shared care model to support a patient with advanced Colon cancer: a case report","volume":"17","author":"Qiao","year":"2023","journal-title":"Patient Prefer Adherence"},{"key":"B122","doi-asserted-by":"publisher","first-page":"152456","DOI":"10.1016\/j.comppsych.2024.152456","article-title":"Diagnosis of peripartum depression disorder: a state-of-the-art approach from the COST action Riseup-PPD","volume":"130","author":"Rado\u0161","year":"2024","journal-title":"Compr. Psychiatry"},{"key":"B123","doi-asserted-by":"publisher","first-page":"1881","DOI":"10.1113\/JP284370","article-title":"Circadian regulation of glutamate release pathways shapes synaptic throughput in the brainstem nucleus of the solitary tract (NTS)","volume":"601","author":"Ragozzino","year":"2023","journal-title":"J. Physiol."},{"key":"B124","doi-asserted-by":"publisher","first-page":"e0145500","DOI":"10.1371\/journal.pone.0145500","article-title":"A clinical, neuropathological and genetic study of homozygous A467T POLG-related mitochondrial disease","volume":"11","author":"Rajakulendran","year":"2016","journal-title":"PLOS ONE"},{"key":"B125","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1111\/jpi.12360","article-title":"Melatonin as an antioxidant: under promises but over delivers","volume":"61","author":"Reiter","year":"2016","journal-title":"J. Pineal Res."},{"key":"B126","doi-asserted-by":"publisher","first-page":"3863","DOI":"10.1007\/s00018-017-2609-7","article-title":"Melatonin as a mitochondria-targeted antioxidant: one of evolution's best ideas","volume":"74","author":"Reiter","year":"2017","journal-title":"Cell Mol. Life Sci."},{"key":"B127","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/j.neuint.2008.09.012","article-title":"Inhibition of mitochondrial respiratory chain in brain of rats subjected to an experimental model of depression","volume":"53","author":"Rezin","year":"2008","journal-title":"Neurochem. Int."},{"key":"B128","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1161\/HYPERTENSIONAHA.117.10787","article-title":"Chronic supplementation with a mitochondrial antioxidant (MitoQ) improves vascular function in healthy older adults","volume":"71","author":"Rossman","year":"2018","journal-title":"Hypertension"},{"key":"B129","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.1176\/ajp.2006.163.11.1905","article-title":"Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report","volume":"163","author":"Rush","year":"2006","journal-title":"Am. J. Psychiatry"},{"key":"B130","doi-asserted-by":"publisher","first-page":"3314","DOI":"10.3390\/nu14163314","article-title":"Luteolin-7-O-Glucuronide improves depression-like and stress coping behaviors in sleep deprivation stress model by activation of the BDNF signaling","volume":"14","author":"Ryu","year":"2022","journal-title":"Nutrients"},{"key":"B131","doi-asserted-by":"publisher","first-page":"118056","DOI":"10.1016\/j.biopha.2025.118056","article-title":"Contemporary insights into elamipretide's mitochondrial mechanism of action and therapeutic effects","volume":"187","author":"Sabbah","year":"2025","journal-title":"Biomed. Pharmacother."},{"key":"B132","doi-asserted-by":"publisher","first-page":"e47198","DOI":"10.7759\/cureus.47198","article-title":"Anesthetic management of a patient with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes syndrome during extensive spinal surgery with both motor evoked potentials and somatosensory evoked potentials: a case report","volume":"15","author":"Salehpoor","year":"2023","journal-title":"Cureus"},{"key":"B133","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.mito.2020.12.002","article-title":"Mitochondrial dysfunction as a critical event in the pathophysiology of bipolar disorder","volume":"57","author":"Scaini","year":"2021","journal-title":"Mitochondrion"},{"key":"B134","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1038\/s41380-021-01312-w","article-title":"Dysregulation of mitochondrial dynamics, mitophagy and apoptosis in major depressive disorder: does inflammation play a role?","volume":"27","author":"Scaini","year":"2022","journal-title":"Mol. Psychiatry"},{"key":"B135","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1177\/0004867419857808","article-title":"Changed cortical risk gene expression in major depression and shared changes in cortical gene expression between major depression and bipolar disorders","volume":"53","author":"Scarr","year":"2019","journal-title":"Aust. N. Z. J. Psychiatry"},{"key":"B136","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/j.cmet.2018.01.011","article-title":"Circadian control of DRP1 activity regulates mitochondrial dynamics and bioenergetics","volume":"27","author":"Schmitt","year":"2018","journal-title":"Cell Metab."},{"key":"B137","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1038\/nrg3275","article-title":"Human mitochondrial DNA: roles of inherited and somatic mutations","volume":"13","author":"Schon","year":"2012","journal-title":"Nat. Rev. Genet."},{"key":"B138","doi-asserted-by":"publisher","first-page":"e473","DOI":"10.1002\/ams2.473","article-title":"Propofol infusion syndrome complicated with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes: a case report","volume":"7","author":"Shimizu","year":"2020","journal-title":"Acute Med. Surg."},{"key":"B139","doi-asserted-by":"publisher","first-page":"114083","DOI":"10.1016\/j.bbr.2022.114083","article-title":"Effects of melatonin supplementation on BDNF concentrations and depression: a systematic review and meta-analysis of randomized controlled trials","volume":"436","author":"Shokri-Mashhadi","year":"2023","journal-title":"Behav. Brain Res."},{"key":"B140","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1038\/jcbfm.2012.211","article-title":"Phenelzine mitochondrial functional preservation and neuroprotection after traumatic brain injury related to scavenging of the lipid peroxidation-derived aldehyde 4-hydroxy-2-nonenal","volume":"33","author":"Singh","year":"2013","journal-title":"J. Cereb. Blood Flow. Metab."},{"key":"B141","first-page":"106","article-title":"Mitochondria-targeted antioxidants as therapies","volume":"11","author":"Smith","year":"2011","journal-title":"Discov. Med."},{"key":"B142","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1002\/mds.23148","article-title":"A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in parkinson's disease","volume":"25","author":"Snow","year":"2010","journal-title":"Mov. Disord."},{"key":"B143","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1080\/1354750X.2021.2023219","article-title":"Dexmedetomidine modulates mitochondrial dynamics to protect against endotoxin-induced lung injury via the protein kinase C-\u0251\/haem oxygenase-1 signalling pathway","volume":"27","author":"Song","year":"2022","journal-title":"Biomarkers"},{"key":"B144","doi-asserted-by":"publisher","first-page":"115652","DOI":"10.1016\/j.biopha.2023.115652","article-title":"Mitochondrial dysfunction: a fatal blow in depression","volume":"167","author":"Song","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"B145","doi-asserted-by":"publisher","first-page":"101715","DOI":"10.1016\/j.xcrm.2024.101715","article-title":"Acutely blocking excessive mitochondrial fission prevents chronic neurodegeneration after traumatic brain injury","volume":"5","author":"Sridharan","year":"2024","journal-title":"Cell Rep. Med."},{"key":"B146","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/j.tem.2012.06.005","article-title":"The dynamic regulation of NAD metabolism in mitochondria","volume":"23","author":"Stein","year":"2012","journal-title":"Trends Endocrinol. Metab."},{"key":"B147","doi-asserted-by":"publisher","first-page":"a011395","DOI":"10.1101\/cshperspect.a011395","article-title":"Clinical and molecular features of POLG-related mitochondrial disease","volume":"5","author":"Stumpf","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B148","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.1016\/S0140-6736(16)30580-3","article-title":"Dexmedetomidine for prevention of delirium in elderly patients after non-cardiac surgery: a randomised, double-blind, placebo-controlled trial","volume":"388","author":"Su","year":"2016","journal-title":"Lancet"},{"key":"B149","doi-asserted-by":"publisher","first-page":"e60575","DOI":"10.7759\/cureus.60575","article-title":"A comprehensive review on the role of melatonin's anesthetic applications in pediatric care","volume":"16","author":"Subhadarshini","year":"2024","journal-title":"Cureus"},{"key":"B150","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1038\/clpt.2014.174","article-title":"Serendipity and the discovery of novel compounds that restore mitochondrial plasticity","volume":"96","author":"Szeto","year":"2014","journal-title":"Clin. Pharmacol. Ther."},{"key":"B151","doi-asserted-by":"publisher","first-page":"2607","DOI":"10.3390\/cells11162607","article-title":"Mitochondrial impairment: a common motif in neuropsychiatric presentation? The link to the tryptophan-kynurenine metabolic system","volume":"11","author":"Tanaka","year":"2022","journal-title":"Cells"},{"key":"B152","doi-asserted-by":"publisher","first-page":"173962","DOI":"10.1016\/j.ejphar.2021.173962","article-title":"Dexpramipexole attenuates myocardial ischemia\/reperfusion injury through upregulation of mitophagy","volume":"899","author":"Tang","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"B153","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1192\/bjp.bp.116.188078","article-title":"Undertreatment of people with major depressive disorder in 21 countries","volume":"210","author":"Thornicroft","year":"2017","journal-title":"Br. J. Psychiatry"},{"key":"B154","doi-asserted-by":"publisher","first-page":"198","DOI":"10.3390\/antiox8070198","article-title":"Melatonin prevents oxidative stress-induced mitochondrial dysfunction and apoptosis in high glucose-treated schwann cells via upregulation of Bcl2, NF-\u03baB, mTOR, wnt signalling pathways","volume":"8","author":"Tiong","year":"2019","journal-title":"Antioxidants"},{"key":"B155","doi-asserted-by":"publisher","first-page":"104149","DOI":"10.1016\/j.ajp.2024.104149","article-title":"The effect of bright light therapy on major depressive disorder: a systematic review and meta-analysis of randomised controlled trials","volume":"99","author":"Tong","year":"2024","journal-title":"Asian J. Psychiatry"},{"key":"B156","doi-asserted-by":"publisher","first-page":"1070827","DOI":"10.3389\/fpubh.2023.1070827","article-title":"Sex difference in the associations among risk factors with depression in a large Taiwanese population study","volume":"11","author":"Tseng","year":"2023","journal-title":"Front. Public Health"},{"key":"B157","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1186\/s12967-025-06604-1","article-title":"Chronic mild stress disrupts mitophagy and mitochondrial status in rat frontal cortex","volume":"23","author":"Ulecia-Mor\u00f3n","year":"2025","journal-title":"J. Transl. Med."},{"key":"B158","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1016\/j.redox.2017.03.024","article-title":"Classifying oxidative stress by F(2)-isoprostane levels across human diseases: a meta-analysis","volume":"12","author":"Van't Erve","year":"2017","journal-title":"Redox Biol."},{"key":"B159","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1111\/j.1399-6576.2011.02628.x","article-title":"Inborn oxidative phosphorylation defect as risk factor for propofol infusion syndrome","volume":"56","author":"Vanlander","year":"2012","journal-title":"Acta Anaesthesiol. Scand."},{"key":"B160","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1146\/annurev.genet.39.110304.095751","article-title":"A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine","volume":"39","author":"Wallace","year":"2005","journal-title":"Annu. Rev. Genet."},{"key":"B161","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1080\/15622975.2016.1197423","article-title":"Transcriptional profiling of mitochondria associated genes in prefrontal cortex of subjects with major depressive disorder","volume":"18","author":"Wang","year":"2017","journal-title":"World J. Biol. Psychiatry"},{"key":"B162","doi-asserted-by":"publisher","first-page":"11738","DOI":"10.18632\/aging.202868","article-title":"Administration of quercetin improves mitochondria quality control and protects the neurons in 6-OHDA-lesioned parkinson's disease models","volume":"13","author":"Wang","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"B163","doi-asserted-by":"publisher","first-page":"113724","DOI":"10.1016\/j.bbr.2021.113724","article-title":"Antidepressant actions of melatonin and melatonin receptor agonist: focus on pathophysiology and treatment","volume":"420","author":"Wang","year":"2022","journal-title":"Behav. Brain Res."},{"key":"B164","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1007\/s11626-025-01059-6","article-title":"Dexmedetomidine preserves neuronal function by promoting mitochondrial biogenesis through the AMPK\/PGC-1\u03b1 pathway","volume":"61","author":"Wang","year":"2025","journal-title":"Vitro Cell Dev. Biol. Anim."},{"key":"B165","doi-asserted-by":"publisher","first-page":"120087","DOI":"10.1016\/j.jad.2025.120087","article-title":"Efficacy and tolerability of pramipexole versus antidepressants for Parkinson's disease with depression: a meta-analysis of randomized controlled trials","volume":"392","author":"Wei","year":"2026","journal-title":"J. Affect. Disord."},{"key":"B166","doi-asserted-by":"publisher","first-page":"6256399","DOI":"10.1155\/2021\/6256399","article-title":"PER2 regulates reactive oxygen species production in the circadian susceptibility to ischemia\/reperfusion injury in the heart","volume":"2021","author":"Weng","year":"2021","journal-title":"Oxid. Med. Cell Longev."},{"key":"B167","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1186\/s13054-023-04745-7","article-title":"Modulation of mitochondrial function with near-infrared light reduces brain injury in a translational model of cardiac arrest","volume":"27","author":"Wider","year":"2023","journal-title":"Crit. Care"},{"key":"B168","doi-asserted-by":"publisher","first-page":"305","DOI":"10.3390\/ijms23010305","article-title":"Associations between Melatonin, neuroinflammation, and brain alterations in depression","volume":"23","author":"Won","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B169","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cccn.2003.09.010","article-title":"Urinary 8-OHdG: a marker of oxidative stress to DNA and a risk factor for cancer, atherosclerosis and diabetics","volume":"339","author":"Wu","year":"2004","journal-title":"Clin. Chim. Acta"},{"key":"B170","doi-asserted-by":"publisher","first-page":"e0138256","DOI":"10.1371\/journal.pone.0138256","article-title":"A mitochondrion-targeted antioxidant ameliorates isoflurane-induced cognitive deficits in aging mice","volume":"10","author":"Wu","year":"2015","journal-title":"PLoS One"},{"key":"B171","doi-asserted-by":"publisher","first-page":"119","DOI":"10.3389\/fncel.2017.00119","article-title":"Elamipretide (SS-31) ameliorates isoflurane-induced long-term impairments of mitochondrial morphogenesis and cognition in developing rats","volume":"11","author":"Wu","year":"2017","journal-title":"Front. Cell Neurosci."},{"key":"B172","doi-asserted-by":"publisher","first-page":"9633212","DOI":"10.1155\/da\/9633212","article-title":"Magnetic resonance spectroscopy insights into late\u2010life depression: advances in brain metabolic profiling","volume":"2025","author":"Wu","year":"2025","journal-title":"Depress. Anxiety"},{"key":"B173","doi-asserted-by":"publisher","first-page":"2435","DOI":"10.4103\/0366-6999.216395","article-title":"Reference intervals of mitochondrial DNA copy number in peripheral blood for Chinese minors and adults","volume":"130","author":"Xia","year":"2017","journal-title":"Chin. Med. J. Engl."},{"key":"B174","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1093\/bja\/aex071","article-title":"Coenzyme Q10 reduces sevoflurane-induced cognitive deficiency in young mice","volume":"119","author":"Xu","year":"2017","journal-title":"Br. J. Anaesth."},{"key":"B175","doi-asserted-by":"publisher","first-page":"109849","DOI":"10.1016\/j.biopha.2020.109849","article-title":"Vitexin attenuates myocardial ischemia\/reperfusion injury in rats by regulating mitochondrial dysfunction induced by mitochondrial dynamics imbalance","volume":"124","author":"Xue","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"B176","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1002\/ana.26918","article-title":"Mitochondrial dysfunction of peripheral platelets as a predictive biomarker for postoperative delirium in elderly patients","volume":"96","author":"Yang","year":"2024","journal-title":"Ann. Neurol."},{"key":"B177","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1016\/j.nbd.2005.08.011","article-title":"Melatonin reduces the severity of anesthesia-induced apoptotic neurodegeneration in the developing rat brain","volume":"21","author":"Yon","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"B178","doi-asserted-by":"publisher","first-page":"e2318611","DOI":"10.1001\/jamanetworkopen.2023.18611","article-title":"Effect of dexmedetomidine on posttraumatic stress disorder in patients undergoing emergency trauma surgery: a randomized clinical trial","volume":"6","author":"Yu","year":"2023","journal-title":"JAMA Netw. Open"},{"key":"B179","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.neuroscience.2023.01.031","article-title":"Luteoloside prevents sevoflurane-induced cognitive dysfunction in aged rats via maintaining mitochondrial function and dynamics in hippocampal neurons","volume":"516","author":"Zhang","year":"2023","journal-title":"Neuroscience"},{"key":"B180","doi-asserted-by":"publisher","first-page":"e3508","DOI":"10.1002\/brb3.3508","article-title":"Mitochondrial antioxidant elamipretide improves learning and memory impairment induced by chronic sleep deprivation in mice","volume":"14","author":"Zhang","year":"","journal-title":"Brain Behav."},{"key":"B181","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1186\/s12974-024-03285-3","article-title":"Unraveling the role and mechanism of mitochondria in postoperative cognitive dysfunction: a narrative review","volume":"21","author":"Zhang","year":"","journal-title":"J. Neuroinflammation"},{"key":"B182","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/s40779-023-00495-3","article-title":"Targeting NR1D1 in organ injury: challenges and prospects","volume":"10","author":"Zhang-Sun","year":"2023","journal-title":"Mil. Med. Res."},{"key":"B183","doi-asserted-by":"publisher","first-page":"34682","DOI":"10.1074\/jbc.M402999200","article-title":"Cell-permeable peptide antioxidants targeted to inner mitochondrial membrane inhibit mitochondrial swelling, oxidative cell death, and reperfusion injury","volume":"279","author":"Zhao","year":"2004","journal-title":"J. Biol. Chem."},{"key":"B184","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1186\/s12974-019-1627-9","article-title":"Elamipretide (SS-31) improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice","volume":"16","author":"Zhao","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"B185","doi-asserted-by":"publisher","first-page":"e2353252","DOI":"10.1001\/jamanetworkopen.2023.53252","article-title":"Effect of dexmedetomidine on postpartum depression in women with prenatal depression: a randomized clinical trial","volume":"7","author":"Zhou","year":"2024","journal-title":"JAMA Netw. Open"},{"key":"B186","doi-asserted-by":"publisher","first-page":"101097","DOI":"10.1016\/j.jpha.2024.101097","article-title":"Luteolin and its antidepressant properties: from mechanism of action to potential therapeutic application","volume":"15","author":"Zhou","year":"2025","journal-title":"J. Pharm. Anal."},{"key":"B187","doi-asserted-by":"publisher","first-page":"251","DOI":"10.3389\/fncel.2020.00251","article-title":"Elamipretide attenuates pyroptosis and perioperative neurocognitive disorders in aged mice","volume":"14","author":"Zuo","year":"2020","journal-title":"Front. Cell Neurosci."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2026.1723748\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T07:29:56Z","timestamp":1772090996000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2026.1723748\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,26]]},"references-count":187,"alternative-id":["10.3389\/fphar.2026.1723748"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2026.1723748","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,26]]},"article-number":"1723748"}}