{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:24:13Z","timestamp":1790871853133,"version":"4.1.0"},"reference-count":50,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004480","name":"Natural Science Foundation of Shanxi Province","doi-asserted-by":"publisher","award":["No. 202303021211175"],"award-info":[{"award-number":["No. 202303021211175"]}],"id":[{"id":"10.13039\/501100004480","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Mild cognitive impairment (MCI) is an intermediate condition between normal aging and dementia. Drug intervention is an important way to prevent MCI from developing into dementia. GuiLingJi (GLJ) is a traditional Chinese medicine formulae and it has the effect of enhancing memory. In view of the absence of special effective drugs for MCI, GLJ warrants investigation as a potential therapeutic agent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study uses a rat model of MCI, induced by D-galactose injections and a semi-high-fat diet, to explore the therapeutic efficacy of GLJ in MCI and elucidate the potential underlying pharmacological mechanisms by behavioral experiments and biochemical indexes, combined with serum and hippocampal metabolomics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>GLJ treatment mitigated D-galactose combined with semi-high-fat diet induced impairments, including abnormal blood lipids, oxidative stress, inflammation, cholinergic dysfunction, apoptosis, and reduced brain-derived neurotrophic factors, along with hippocampal damage. LC-MS metabolomics indicated that these effects involved unsaturated fatty acid and amino acid metabolism. By normalizing linoleic acid and \u03b1-linolenic acid levels and activating GPR120, GLJ inhibited the NF-\u03baB\/TNF-\u03b1 pathway.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      These findings demonstrate that GLJ alleviates MCI symptoms, at least in part, by modulating fatty acid metabolism and suppressing neuroinflammation\n                      <jats:italic>via<\/jats:italic>\n                      the GPR120\/NF-\u03baB pathway. This study supports GLJ as a promising proprietary TCM formulation for MCI treatment.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphar.2026.1729885","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T06:51:25Z","timestamp":1773211885000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["GuiLingJi ameliorates mild cognitive impairment by targeting unsaturated fatty acid metabolism to inhibit GPR120\/NF-\u03baB mediated neuroinflammation"],"prefix":"10.3389","volume":"17","author":[{"given":"Jingchao","family":"Shi","sequence":"first","affiliation":[{"name":"School of Traditional Chinese Materia Medica and Food Engineering, Shanxi University of Chinese Medicine","place":["Jinzhong, China"]},{"name":"Taihang Institute of Materia Medica, Shanxi University of Chinese Medicine","place":["Jinzhong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingfan","family":"Ni","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Materia Medica and Food Engineering, Shanxi University of Chinese Medicine","place":["Jinzhong, China"]},{"name":"Taihang Institute of Materia Medica, Shanxi University of Chinese Medicine","place":["Jinzhong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ShuTing","family":"Yu","sequence":"additional","affiliation":[{"name":"Taihang Institute of Materia Medica, Shanxi University of Chinese Medicine","place":["Jinzhong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxia","family":"Gao","sequence":"additional","affiliation":[{"name":"Modern Research Center for Traditional Chinese Medicine, Shanxi University","place":["Taiyuan, Shanxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Qin","sequence":"additional","affiliation":[{"name":"Taihang Institute of Materia Medica, Shanxi University of Chinese Medicine","place":["Jinzhong, China"]},{"name":"Modern Research Center for Traditional Chinese Medicine, Shanxi University","place":["Taiyuan, Shanxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"105198","DOI":"10.1016\/j.nbd.2020.105198","article-title":"Deficient astrocyte metabolism impairs glutamine synthesis and neurotransmitter homeostasis in a mouse model of Alzheimer's disease","volume":"148","author":"Andersen","year":"","journal-title":"Neurobiol. 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