{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T17:34:15Z","timestamp":1790444055230,"version":"4.1.0"},"reference-count":59,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>\n                    <jats:italic>Echinococcosis<\/jats:italic>\n                    : is a zoonotic parasitic disease caused by infection with the larvae of\n                    <jats:italic>Echinococcus<\/jats:italic>\n                    tapeworms. At present, the standardized treatment regimen for this disease consists of radical lesion resection combined with albendazole. For patients who are inoperable or experience postoperative recurrence, the treatment with anti-echinococcosis drugs is particularly crucial. To date, albendazole remains the primary drug clinically used for anti-echinococcosis treatment. However, it has inherent drawbacks such as low bioavailability, poor solubility, long treatment course, and multiple adverse reactions, which reduce the medication adherence of patients with echinococcosis and compromise the clinical therapeutic efficacy. In recent years, with the in-depth development of research in molecular biology, pharmacology, and natural medicines, significant progress has also been made in the field of anti-echinococcosis drugs. This article systematically reviews the research progress in the development of new anti-echinococcosis drugs from four aspects: structural modification and new formulations of benzimidazole drugs, targeted drug therapy, combined medication strategies, and exploration of natural medicines and active components of traditional Chinese medicines.\n                  <\/jats:p>","DOI":"10.3389\/fphar.2026.1743435","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T06:42:15Z","timestamp":1769496135000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Progress on new drug treatments for hepatic echinococcosis"],"prefix":"10.3389","volume":"17","author":[{"given":"Yunzhang","family":"Li","sequence":"first","affiliation":[{"name":"Clinical Medical College of Qinghai University","place":["Xining, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nana","family":"Xie","sequence":"additional","affiliation":[{"name":"Clinical Medical College of Qinghai University","place":["Xining, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinping","family":"Chai","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine-Cardiovascular, Qinghai Provincial People\u2019s Hospital","place":["Xining, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qindong","family":"Jing","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Qinghai Provincial People\u2019s Hospital","place":["Xining, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linxun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Qinghai Provincial People\u2019s Hospital","place":["Xining, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jide","family":"A","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Qinghai Provincial People\u2019s Hospital","place":["Xining, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongshuai","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Qinghai Provincial People\u2019s Hospital","place":["Xining, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"127","DOI":"10.18502\/ijpa.v14i1.726","article-title":"Evaluation of the protoscolicidal effects of albendazole and albendazole loaded solid lipid nanoparticles","volume":"14","author":"Aminpour","year":"2019","journal-title":"Iran. 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