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The \u03b1lpha-7 nicotinic acetylcholine receptor (\u03b17nAChR) is a central mediator of the cholinergic anti-inflammatory pathway and has emerged as a promising therapeutic target in various conditions, such as sepsis, arthritis, metabolic dysfunction, and atherosclerosis. This review aims to examine the emerging therapeutic potential of \u03b17nAChR in HF and HFpEF pathology, focusing on its protective role in modulating the complex interplay between systemic and cardiovascular inflammation, renin-angiotensin-aldosterone system activation, neurocardiac signaling and metabolic dysfunction.<\/jats:p>","DOI":"10.3389\/fphar.2026.1756039","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T06:50:43Z","timestamp":1773903043000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Alpha-7 nicotinic acetylcholine receptor: targeting the interplay between inflammation, renin-angiotensin aldosterone system, and nervous system for the novel treatment of heart failure"],"prefix":"10.3389","volume":"17","author":[{"given":"Jordan","family":"Swiderski","sequence":"first","affiliation":[{"name":"Institute for Health and Sport (IHES), Victoria University","place":["Melbourne, VIC, Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura Kate","family":"Gadanec","sequence":"additional","affiliation":[{"name":"Institute for Health and Sport (IHES), Victoria University","place":["Melbourne, VIC, Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Hearth","sequence":"additional","affiliation":[{"name":"School of Health Sciences, The University of Notre Dame Australia","place":["Sydney, NSW, Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin Darcy","family":"Rowlands","sequence":"additional","affiliation":[{"name":"School of Health Sciences, The University of Notre Dame Australia","place":["Sydney, NSW, Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew James","family":"Murphy","sequence":"additional","affiliation":[{"name":"Division of Immunometabolism, Baker Heart and Diabetes institute","place":["Melbourne, VIC, Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasso","family":"Apostolopoulos","sequence":"additional","affiliation":[{"name":"School of Health and Biomedical Science, RMIT University","place":["Melbourne, VIC, Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Zulli","sequence":"additional","affiliation":[{"name":"Institute for Health and Sport (IHES), Victoria University","place":["Melbourne, VIC, Australia"]},{"name":"School of Health Sciences, The University of Notre Dame Australia","place":["Sydney, NSW, Australia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"328","DOI":"10.3389\/fendo.2018.00328","article-title":"Impact of intestinal peptides on the enteric nervous system: novel approaches to control glucose metabolism and food intake","volume":"9","author":"Abot","year":"2018","journal-title":"Front. 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