{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T06:03:06Z","timestamp":1784872986155,"version":"3.55.0"},"reference-count":82,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>The expression of certain genes and proteins in brain tumors, particularly gliomas, presents potential therapeutic targets and biomarkers. One of such genes encodes the protein PINK1 (PTEN-induced Kinase 1), which has been primarily studied due to its mutations being linked to Parkinson\u2019s disease (PD). Additionally, epidemiological studies have observed a reduced risk of developing certain types of cancer in patients with neurodegenerative diseases and vice versa. The GPR55 receptor (G protein-coupled receptor 55) exhibits pro-oncogenic properties, and its expression correlates with tumor aggressiveness and the activation of the MAPK\/ERK signaling pathway. This review would aim to provide an overview of the current understanding of the relationship between PINK1 and GPR55 proteins in glioma pathophysiology and explore the potential use of plant extracts as a therapeutic alternative to regulate their expression.<\/jats:p>","DOI":"10.3389\/fphar.2026.1760169","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T05:36:54Z","timestamp":1784871414000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["GPR55 and PINK1 as emerging therapeutic targets in Glioma: insights into their modulation by phytochemicals and plant extracts"],"prefix":"10.3389","volume":"17","author":[{"given":"Andres David","family":"Turizo Smith","sequence":"first","affiliation":[{"name":"Departamento de Patolog\u00eda, Facultad de Medicina, Universidad Nacional de Colombia","place":["Bogot\u00e1, Colombia"]},{"name":"Grupo de investigaci\u00f3n INFARMA-HUS, Hospital Universitario de la Samaritana","place":["Bogot\u00e1, Colombia"]},{"name":"Grupo de Investigaci\u00f3n en Fitoqu\u00edmica y Farmacognosia de la Universidad Nacional de Colombia, Departamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia","place":["Bogot\u00e1, Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Carlos","family":"Martinez Perez","sequence":"additional","affiliation":[{"name":"Departamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia","place":["Bogot\u00e1, Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Camilo","family":"Marin Loaiza","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n en Fitoqu\u00edmica y Farmacognosia de la Universidad Nacional de Colombia, Departamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia","place":["Bogot\u00e1, Colombia"]},{"name":"Departamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia","place":["Bogot\u00e1, Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Arboleda","sequence":"additional","affiliation":[{"name":"Departamento de Patolog\u00eda, Facultad de Medicina, Universidad Nacional de Colombia","place":["Bogot\u00e1, Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"4708","DOI":"10.1158\/0008-5472.can-15-3079","article-title":"PINK1 is a negative regulator of growth and the warburg effect in glioblastoma","volume":"76","author":"Agnihotri","year":"2016","journal-title":"Cancer Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"e0200101","DOI":"10.1371\/journal.pone.0200101","article-title":"Anticancer potential, molecular mechanisms and toxicity of Euterpe oleracea extract (a\u00e7a\u00ed): a systematic review","volume":"13","author":"Alessandra-Perini","year":"2018","journal-title":"PloS One"},{"key":"B3","doi-asserted-by":"publisher","first-page":"45","DOI":"10.18632\/oncotarget.26534","article-title":"Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells","volume":"10","author":"Alharris","year":"2019","journal-title":"Oncotarget"},{"key":"B4","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1016\/j.tips.2018.02.011","article-title":"Lysophosphatidylinositols, from cell membrane constituents to GPR55 ligands","volume":"39","author":"Alhouayek","year":"2018","journal-title":"Trends Pharmacol. 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