{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T04:45:52Z","timestamp":1776746752450,"version":"3.51.2"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Rhodomyrtus tomentosa<\/jats:italic>\n                      (Ait.) Hassk. (Myrtaceae) has been traditionally used in Southeast Asia to treat inflammation, fever, and respiratory ailments. However, its bioactive components and molecular mechanisms remain unclear. To design novel dihydrofuro [2,3-b]benzofuran derivatives inspired by\n                      <jats:italic>R. tomentosa<\/jats:italic>\n                      constituents and to evaluate their anti-inflammatory activity and mechanism in a lipopolysaccharide (LPS)-induced acute lung injury (ALI) model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A series of rhodomentosone-like compounds were screened in LPS-stimulated RAW264.7 macrophages for\n                      <jats:italic>IL-1<\/jats:italic>\n                      \u03b2 and\n                      <jats:italic>TNF-<\/jats:italic>\n                      \u03b1 expression. The most active molecule, QFM-3m, was tested in LPS-induced murine ALI through histopathology, cytokine assays, and vascular permeability analysis. Mechanistic studies were conducted using transcriptomic and protein analyses of primary macrophages.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      QFM-3m significantly inhibited LPS-induced\n                      <jats:italic>IL-1a<\/jats:italic>\n                      ,\n                      <jats:italic>IL-1<\/jats:italic>\n                      \u03b2\n                      <jats:italic>, IL-6<\/jats:italic>\n                      and\n                      <jats:italic>TNF-<\/jats:italic>\n                      \u03b1 expression\n                      <jats:italic>in vitro<\/jats:italic>\n                      and attenuated lung inflammation, cytokine production, and vascular leakage\n                      <jats:italic>in vivo<\/jats:italic>\n                      . Transcriptomic, western blot and molecular docking analysis revealed that QFM-3m selectively suppressed ERK, JNK, and p38 phosphorylation, while NF-\u03baB activation remained unaffected.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      QFM-3m, a novel dihydrofurobenzofuran derivative derived from\n                      <jats:italic>R. tomentosa<\/jats:italic>\n                      , exerts potent anti-inflammatory and lung-protective effects through selective inhibition of the MAPK pathway. These findings highlight the therapeutic potential of\n                      <jats:italic>R. tomentosa<\/jats:italic>\n                      -inspired scaffolds for inflammatory lung diseases.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphar.2026.1763318","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T04:22:09Z","timestamp":1776745329000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A dihydrofuro[2,3-b] benzofuran derivative alleviates lipopolysaccharide induced acute lung injury via suppressing MAPK signaling"],"prefix":"10.3389","volume":"17","author":[{"given":"Yuxi","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Respirology, Hangzhou Lin\u2019an Traditional Chinese Medicine Hospital, Affiliated Hospital, Hangzhou City University","place":["Hangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeping","family":"Shan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Hangzhou City University School of Medicine","place":["Hangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shenyan","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Hangzhou City University School of Medicine","place":["Hangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Hangzhou City University School of Medicine","place":["Hangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aijing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Hangzhou City University School of Medicine","place":["Hangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guimei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Respirology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine","place":["Hangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Respirology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine","place":["Hangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuqing","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Respirology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine","place":["Hangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengyun","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Respirology, Hangzhou Lin\u2019an Traditional Chinese Medicine Hospital, Affiliated Hospital, Hangzhou City University","place":["Hangzhou, China"]},{"name":"Department of Pharmacology, Hangzhou City University School of Medicine","place":["Hangzhou, China"]},{"name":"Key laboratory of Quantum Materials Control of Zhejiang Provience, School of Information and Electrical Engineering, Hangzhou City University","place":["Hangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"109130","DOI":"10.1016\/j.intimp.2022.109130","article-title":"Interleukin-6 cytokine: an overview of the immune regulation, immune dysregulation, and therapeutic approach","volume":"111","author":"Aliyu","year":"2022","journal-title":"Int. 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