{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:14:01Z","timestamp":1791976441508,"version":"4.4.0"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>This retrospective study evaluates the impact of implementing a standardized scheduled metamizole dosing protocol within a multimodal analgesia approach after cardiac surgery. The results showed that scheduled metamizole administration was associated with lower opioid consumption, while maintaining adequate pain control and safety. Pain scores measured by the Numeric Rating Scale improved from 1.12 pre-protocol to 0.89 post-protocol (p &amp;lt; 0.0001). Mean opioid consumption decreased from 119.51\u00a0mg morphine equivalents to 95.91\u00a0mg (p &amp;lt; 0.0001). No cases of clinically relevant agranulocytosis or persistent neutropenia were observed. Renal function, assessed by changes in serum creatinine, showed no significant differences between groups, suggesting renal safety. Despite improved analgesia and reduced opioid use, hospital length of stay increased slightly, potentially due to confounding factors. Our findings support scheduled metamizole as a safe and effective opioid-sparing agent in postoperative cardiac surgery pain management. Further prospective randomized trials are warranted to confirm these results and establish optimal protocols.<\/jats:p>","DOI":"10.3389\/fphar.2026.1767338","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T06:54:59Z","timestamp":1771397699000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["The effect of scheduled metamizole on opioid consumption after cardiac surgery"],"prefix":"10.3389","volume":"17","author":[{"given":"Chen","family":"Seidenberg","sequence":"first","affiliation":[{"name":"Herzliya Medical Center","place":["Herzliya, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adina","family":"Grunberger","sequence":"additional","affiliation":[{"name":"Herzliya Medical Center","place":["Herzliya, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Mishali","sequence":"additional","affiliation":[{"name":"Herzliya Medical Center","place":["Herzliya, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avi","family":"Hefets","sequence":"additional","affiliation":[{"name":"Herzliya Medical Center","place":["Herzliya, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Singer","sequence":"additional","affiliation":[{"name":"Herzliya Medical Center","place":["Herzliya, Israel"]},{"name":"The research laboratory on Computerized Decision Making, Dina Recanati School of Medicine, Reichman University","place":["Herzliya, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Setton","sequence":"additional","affiliation":[{"name":"Herzliya Medical Center","place":["Herzliya, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Slevin Kish","sequence":"additional","affiliation":[{"name":"Herzliya Medical Center","place":["Herzliya, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1186\/s12871-021-01382-4","article-title":"Feasibility and postoperative opioid sparing effect of an opioid-free anaesthesia in adult cardiac surgery: a retrospective study","volume":"21","author":"Aguerreche","year":"2021","journal-title":"BMC Anesthesiol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"20f13699","DOI":"10.4088\/JCP.20f13699","article-title":"Metamizole and agranulocytosis: what are the risks?","volume":"81","author":"Andrade","year":"2020","journal-title":"J. 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