{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T22:39:33Z","timestamp":1773268773758,"version":"3.50.1"},"reference-count":165,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>\n                    <jats:italic>Kadsura<\/jats:italic>\n                    Kaempf. ex Juss., belonging to the Schisandraceae family, is a key ethnomedicinal resource in traditional Asian medicine, valued for both dietary and therapeutic roles. Traditionally used to boost blood circulation, relieve pain, and dispel wind-cold-damp pathogens, its metabolites have been validated by modern pharmacology to exhibit potent anti-rheumatoid arthritis, hepatoprotective, antioxidant, and anti-inflammatory properties, supporting clinical applications for rheumatic and hepatic conditions. Literature was retrieved from major databases (Google Scholar, Web of Science, PubMed, ScienceDirect, Baidu Scholar, CNKI, etc.), monographs, and dissertations using \u201c\n                    <jats:italic>Kadsura<\/jats:italic>\n                    \u201d as the core keyword. Species identities were verified via Plants of the World Online (\n                    <jats:ext-link>http:\/\/www.plantsoftheworldonline.org<\/jats:ext-link>\n                    ), and data on ethnobotany, pharmacology, and molecular pharmacognosy were rigorously screened and synthesized. Our analysis reveals that while\n                    <jats:italic>Kadsura<\/jats:italic>\n                    species share core medicinal attributes, the scientific basis for their species-specific traditional therapeutic effects remains unclear. Furthermore, the mechanisms of some pharmacological activities are not fully elucidated, systematic safety evaluations are insufficient, and molecular pharmacognosy research is limited to preliminary transcriptomic and metabolomic screening and expression profiling. Meanwhile, systematic reviews on these aspects remain lacking. To address this gap, this review summarizes the ethnobotany, pharmacology, and molecular pharmacognosy of the genus to date, laying a theoretical foundation for further development and utilization (\n                    <jats:italic>Kadsura ananosma<\/jats:italic>\n                    Kerr, a synonym of\n                    <jats:italic>Kadsura coccinea<\/jats:italic>\n                    (Lem.) A.C.Sm.;\n                    <jats:italic>Kadsura polysperma<\/jats:italic>\n                    Y.C.Yang and\n                    <jats:italic>Kadsura interior<\/jats:italic>\n                    A.C.Sm., a synonym of\n                    <jats:italic>Kadsura heteroclita<\/jats:italic>\n                    (Roxb.) Craib).\n                  <\/jats:p>","DOI":"10.3389\/fphar.2026.1768643","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T06:51:09Z","timestamp":1773211869000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A review on the genus Kadsura: ethnobotany, pharmacology, and molecular pharmacognosy"],"prefix":"10.3389","volume":"17","author":[{"given":"Niaojiao","family":"Xu","sequence":"first","affiliation":[{"name":"College of Pharmacy, Dali University","place":["Dali, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianjing","family":"Li","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Dali University","place":["Dali, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Southern Medicine Utilization, Yunnan Branch of Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College","place":["Jinghong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Qu","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Southern Medicine Utilization, Yunnan Branch of Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College","place":["Jinghong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haitao","family":"Li","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Southern Medicine Utilization, Yunnan Branch of Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College","place":["Jinghong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunqiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Southern Medicine Utilization, Yunnan Branch of Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College","place":["Jinghong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meifang","family":"Song","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Southern Medicine Utilization, Yunnan Branch of Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College","place":["Jinghong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baozhong","family":"Duan","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Dali University","place":["Dali, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhonglian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Yunnan Key Laboratory of Southern Medicine Utilization, Yunnan Branch of Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College","place":["Jinghong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,11]]},"reference":[{"key":"B1","first-page":"7","article-title":"Research progress on chemical metabolites and activities of Kadsura coccinea","author":"Ai","year":"2005","journal-title":"Chem. 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