{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T06:14:23Z","timestamp":1776147263632,"version":"3.50.1"},"reference-count":51,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>APMCG-1 is a glycopeptide derived from the mountain-cultivated ginseng C. A. Mey (APMCG-1), and recent studies have demonstrated its neuroprotective effects. Concurrently, ferroptosis plays an indispensable role in the pathogenesis of ischemic stroke. Investigate the neuroprotective effects of APMCG-1 in mitigating cortical brain injury and neurological dysfunction by suppressing oxidative stress, ferroptosis, and inflammation via the Nrf2 pathway.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Rats underwent middle cerebral artery occlusion (MCAO) model. APMCG-1 (20\u00a0mg\/kg and 40\u00a0mg\/kg, gavage, 14\u00a0days). CoCl\n                      <jats:sub>2<\/jats:sub>\n                      and glucose-free Dulbecco\u2019s Modified Eagle Medium induce hypoxia-glucose deprivation\/reperfusion (OGD\/R) in a PC12-BV2 co-culture model. APMCG-1 (12.5, 25, and 50\u00a0\u03bcg\/mL, 24\u00a0h). The study investigated how APMCG-1 modulates oxidative stress, ferroptosis, and inflammation in rat cortical and neuronal cells via the Nrf2 pathway.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>APMCG-1 inhibited oxidative stress, ferroptosis, and inflammation, protecting against cortical injury and neurological dysfunction in MCAO rats, as well as safeguarding cells under OGD\/R conditions. These effects were abolished upon Nrf2 inhibition by ML385, indicating that APMCG-1\u2019s neuroprotective actions might depend on Nrf2 signaling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>APMCG-1 could mitigate cerebral ischemia-reperfusion injury by inhibiting ferroptosis through the Nrf2 pathway, exerting antioxidant effects, and suppressing inflammation, thereby establishing a foundation for potential therapeutic strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphar.2026.1768692","type":"journal-article","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T05:39:53Z","timestamp":1776145193000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["APMCG-1: a mountain-cultivated ginseng-derived glycopeptide alleviates cerebral ischemic injury by resisting oxidative stress, ferroptosis and inflammation via the Nrf2 signaling pathway"],"prefix":"10.3389","volume":"17","author":[{"given":"Yuci","family":"Wu","sequence":"first","affiliation":[{"name":"Rehabilitation Medicine Academy, Changchun University of Chinese Medicine","place":["Changchun, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meiting","family":"Wang","sequence":"additional","affiliation":[{"name":"Rehabilitation Medicine Academy, Changchun University of Chinese Medicine","place":["Changchun, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingyue","family":"He","sequence":"additional","affiliation":[{"name":"Rehabilitation Medicine Academy, Changchun University of Chinese Medicine","place":["Changchun, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chong","family":"Yang","sequence":"additional","affiliation":[{"name":"Rehabilitation Medicine Academy, Changchun University of Chinese Medicine","place":["Changchun, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xindan","family":"Ai","sequence":"additional","affiliation":[{"name":"Jilin Ginseng Academy, Changchun University of Chinese Medicine","place":["Changchun, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingxiao","family":"Li","sequence":"additional","affiliation":[{"name":"Integrated Chinese and Western Medicine, Changchun University of Chinese Medicine","place":["Changchun, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Yang","sequence":"additional","affiliation":[{"name":"Rehabilitation Medicine Academy, Changchun University of Chinese Medicine","place":["Changchun, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaijin","family":"Mu","sequence":"additional","affiliation":[{"name":"Rehabilitation Medicine Academy, Changchun University of Chinese Medicine","place":["Changchun, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yulin","family":"Dai","sequence":"additional","affiliation":[{"name":"Jilin Ginseng Academy, Changchun University of Chinese Medicine","place":["Changchun, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Liu","sequence":"additional","affiliation":[{"name":"Rehabilitation Medicine Academy, Changchun University of Chinese Medicine","place":["Changchun, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"101207","DOI":"10.1016\/j.plipres.2022.101207","article-title":"Compartmentalized regulation of lipid signaling in oxidative stress and inflammation: plasmalogens, oxidized lipids and ferroptosis as new paradigms of bioactive lipid research","volume":"89","author":"Astudillo","year":"2023","journal-title":"Prog. 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