{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T14:06:51Z","timestamp":1775570811470,"version":"3.50.1"},"reference-count":18,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chlorpheniramine maleate is a commonly used antiallergic drug; excessive ingestion can cause adverse effects such as hallucinations, tachycardia, central nervous system depression, and organ dysfunction. However, rhabdomyolysis induced by this drug is rarely reported. This study presents a case of rhabdomyolysis secondary to chlorpheniramine maleate poisoning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Report<\/jats:title>\n                    <jats:p>A 14-year-old female student developed palpitations after oral ingestion of 100 tablets of chlorpheniramine maleate (4\u00a0mg per tablet). Six hours post-ingestion, laboratory tests showed elevated concentrations of myoglobin (&amp;gt;1,200\u00a0ng\/mL) and creatine kinase (1529.7\u00a0U\/L). Nine hours post-ingestion, the myoglobin concentration gradually decreased to 889\u00a0ng\/mL, while the creatine kinase concentration continued to rise to 7,315\u00a0U\/L. One day after ingestion, the myoglobin concentration further decreased, whereas the creatine kinase concentration peaked at 11,219\u00a0U\/L. Indicators including troponin, creatine kinase-MB mass, serum creatinine, and serum uric acid remained within the normal range. Following treatment with gastrointestinal decontamination, diuresis, and maintenance of electrolyte balance, the patient\u2019s condition improved and she was discharged.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Chlorpheniramine maleate poisoning can cause hallucinations, hypertension, tachycardia, organ dysfunction, and central nervous system depression. Additionally, it may be a potential etiological factor for rhabdomyolysis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphar.2026.1770052","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T06:43:14Z","timestamp":1771483394000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Rhabdomyolysis secondary to chlorpheniramine maleate toxicity: a case report"],"prefix":"10.3389","volume":"17","author":[{"given":"Anyang","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Emergency, Mianyang Central Hospital","place":["Mianyang, Sichuan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Emergency, Mianyang Central Hospital","place":["Mianyang, Sichuan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1007\/s11739-007-0060-8","article-title":"Rhabdomyolysis","volume":"2","author":"Bagley","year":"2007","journal-title":"Intern Emerg. 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