{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T06:49:21Z","timestamp":1776840561374,"version":"3.51.2"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Currently, postoperative nonsteroidal anti-inflammatory drugs-associated kidney damage in hypertensive patients remains undetermined. This study aimed to examine renal safety of short-term post-surgery use of flurbiprofen axetil (FA) in well-controlled hypertensive patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were collected from January 2020 to March 2021\u00a0at four major hospitals on patients who had undergone total knee replacement surgery (TKA). Patients were divided into well-controlled hypertensive and normotensive groups, and received short-term intravenous FA postoperatively. The primary outcomes were trajectory changes of postoperative renal injury biomarkers. Second outcomes included acute kidney injury (AKI), pain intensity and other complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 120 patients were enrolled. Post-surgery FA significantly reduced pain in both groups. The results of repeated measures analysis of variance (ANOVA) demonstrated that the main effects of group, time and the group-by-time interaction on blood urea nitrogen (BUN), serum creatine (SCr) and Cystatin C (Cys C) levels were not statistically significant on postoperative day 2 and 5 (POD2 and POD5) (all P &amp;gt; 0.05). Urine N-acetyl-beta-glucosaminidase (NAG) levels were significantly higher on POD2 and POD5 in both groups [preoperative: (6.66 \u00b1 4.87) U\/L, POD2: (10.07 \u00b1 6.88) U\/L, POD5: (10.25 \u00b1 7.68) U\/L in normotensive group; preoperative: (7.39 \u00b1 4.07) U\/L, POD2: (12.34 \u00b1 7.1) U\/L, POD5: (15.57 \u00b1 12.34) U\/L in well-controlled hypertensive group; all P &amp;lt; 0.001] compared with baseline. However, only the well-controlled hypertensive group showed a continued increase in NAG levels on POD5 (P = 0.039). AKI occurred in 7.0% (4\/57) and 3.2% (2\/63) of well-controlled hypertensive and normotensive patients (P = 0.335), and all the AKI patients were at stage 1. After adjusting for confounding factors, hypertension had no impact on AKI (OR = 0.733, 95%CI: 0.074\u20137.222, P = 0.790). No significant differences in other complications were observed between the groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The current FA regimen after surgery is effective, and it does not increase AKI incidence in well-controlled hypertensive TKA patients, thought posing a risk of tubular damage.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphar.2026.1773939","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T05:50:58Z","timestamp":1776837058000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Renal safety of postoperative short-term use of flurbiprofen axetil in well-controlled hypertensive patients: a prospective multicenter cohort study"],"prefix":"10.3389","volume":"17","author":[{"given":"Liang","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Peking University People\u2019s Hospital","place":["Beijing, China"]},{"name":"Department of Anesthesiology, Peking University People\u2019s Hospital Shijiazhuang Campus\/Shijiazhuang People\u2019s Hospital","place":["Shijiazhang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhui","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Peking University People\u2019s Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoran","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Peking University People\u2019s Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanhong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, 1st Medical Center of Chinese PLA General Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yubo","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital of Guangxi Medical University","place":["Nanning, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxia","family":"An","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital of Zhejiang University School of Medicine","place":["Hangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weidong","family":"Mi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, 1st Medical Center of Chinese PLA General Hospital","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Peking University People\u2019s Hospital","place":["Beijing, China"]},{"name":"Department of Anesthesiology, Peking University People\u2019s Hospital Shijiazhuang Campus\/Shijiazhuang People\u2019s Hospital","place":["Shijiazhang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"C482","DOI":"10.1152\/ajpcell.1994.267.2.C482","article-title":"Mechanical stretch\/relaxation of cultured rat mesangial cells induces protooncogenes and cyclooxygenase","volume":"267","author":"Akai","year":"1994","journal-title":"Am. 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