{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T12:40:41Z","timestamp":1776429641737,"version":"3.51.2"},"reference-count":53,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018806","name":"Department of Science and Technology of Hubei Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018806","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>\n                    Colchicine, a classical microtubule-targeting agent (MTA), exhibits remarkable anti-tumor potential, but its clinical translation is severely restricted by a narrow therapeutic window, systemic off-target toxicity, and complex pharmacokinetic vulnerabilities. Driven by the objective of \u201ctoxicity reduction and efficacy enhancement,\u201d this review comprehensively summarizes colchicine\u2019s multidimensional translational research. First, precise chemical modifications of its tricyclic scaffold and multi-site synergistic strategies are analyzed, exploring structure-activity relationship (SAR) mechanisms in enhancing target affinity and reversing multidrug resistance (MDR). Second, precision delivery systems\u2014including prodrug-anchored liposomes, stimuli-responsive smart nanocarriers, inorganic mesoporous platforms, and photodynamic co-delivery\u2014are evaluated, demonstrating their capacity to overcome biophysical barriers, reshape spatiotemporal distribution, and mediate immune synergy. Furthermore, the risks of drug-drug interactions (DDIs) and pharmacodynamic synergy arising from colchicine\u2019s cytochrome P450 3A4 (CYP3A4)\/P-glycoprotein (P-gp) dual-substrate nature in complex oncology regimens are dissected. To address this, a clinical management framework integrating ultrasensitive trace sensing and macroscopic pharmacovigilance is proposed. Finally, current translational gaps are critically confronted, notably the over-reliance on the enhanced permeability and retention (EPR) effect and the\n                    <jats:italic>in vitro<\/jats:italic>\n                    -\n                    <jats:italic>in vivo<\/jats:italic>\n                    druggability disconnect. Breakthrough paradigms like targeted protein degradation (TPD, e.g., PROTACs) and dynamic responsive carriers are subsequently proposed to guide the future precision clinical innovation of colchicine therapeutics.\n                  <\/jats:p>","DOI":"10.3389\/fphar.2026.1779469","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T11:43:47Z","timestamp":1776426227000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The therapeutic potential of colchicine in oncology studies: from structural modification and targeted delivery to clinical management"],"prefix":"10.3389","volume":"17","author":[{"given":"Pengyu","family":"Jin","sequence":"first","affiliation":[{"name":"The First College of Clinical Medical Sciences, China Three Gorges University","place":["Yichang, Hubei, China"]},{"name":"Institute of Organ Fibrosis and Targeted Drug Delivery, China Three Gorges University","place":["Yichang, Hubei, China"]},{"name":"Yichang Central People\u2019s Hospital","place":["Yichang, Hubei, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyuan","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Organ Fibrosis and Targeted Drug Delivery, China Three Gorges University","place":["Yichang, Hubei, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiping","family":"Yao","sequence":"additional","affiliation":[{"name":"Yichang Central People\u2019s Hospital","place":["Yichang, Hubei, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiran","family":"Ni","sequence":"additional","affiliation":[{"name":"The First College of Clinical Medical Sciences, China Three Gorges University","place":["Yichang, Hubei, China"]},{"name":"Institute of Organ Fibrosis and Targeted Drug Delivery, China Three Gorges University","place":["Yichang, Hubei, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziang","family":"Yuan","sequence":"additional","affiliation":[{"name":"The First College of Clinical Medical Sciences, China Three Gorges University","place":["Yichang, Hubei, China"]},{"name":"Institute of Organ Fibrosis and Targeted Drug Delivery, China Three Gorges University","place":["Yichang, Hubei, China"]},{"name":"Yichang Central People\u2019s Hospital","place":["Yichang, Hubei, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aidi","family":"Che","sequence":"additional","affiliation":[{"name":"The First College of Clinical Medical Sciences, China Three Gorges University","place":["Yichang, Hubei, China"]},{"name":"Institute of Organ Fibrosis and Targeted Drug Delivery, China Three Gorges University","place":["Yichang, Hubei, China"]},{"name":"Yichang Central People\u2019s Hospital","place":["Yichang, Hubei, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijuan","family":"Tian","sequence":"additional","affiliation":[{"name":"The First College of Clinical Medical Sciences, China Three Gorges University","place":["Yichang, Hubei, China"]},{"name":"Institute of Organ Fibrosis and Targeted Drug Delivery, China Three Gorges University","place":["Yichang, Hubei, China"]},{"name":"Yichang Central People\u2019s Hospital","place":["Yichang, Hubei, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junming","family":"Li","sequence":"additional","affiliation":[{"name":"The First College of Clinical Medical Sciences, China Three Gorges University","place":["Yichang, Hubei, China"]},{"name":"Yichang Central People\u2019s Hospital","place":["Yichang, Hubei, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"144","DOI":"10.3390\/cancers12010144","article-title":"Targeted nano-drug delivery of colchicine against colon cancer cells by means of mesoporous silica nanoparticles","volume":"12","author":"AbouAitah","year":"2020","journal-title":"Cancers (Basel)"},{"key":"B2","doi-asserted-by":"publisher","first-page":"100382","DOI":"10.1016\/j.ijpx.2025.100382","article-title":"Development of a potential nano-based delivery system combining colchicine-loaded lipid nanocapsules and biot-nfl-peptide to target glioblastoma","volume":"10","author":"Alnemeh-Al Ali","year":"2025","journal-title":"Int. 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