{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T13:48:09Z","timestamp":1774878489562,"version":"3.50.1"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sertraline, a selective serotonin reuptake inhibitor is commonly prescribed for adolescent patients with depression, either as monotherapy or in combination with other treatments. Therapeutic doses typically range from 50 to 300\u00a0mg\/day, whereas overdose cases generally exceed 450\u00a0mg, as observed in this study. This study aimed to characterise the pharmacokinetic profiles of sertraline in acute overdose settings and evaluate the impact of gastric lavage on drug clearance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This observational case retrospective study analysed the clinical manifestations, severity, treatment interventions, and outcomes of sertraline overdose cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The dataset comprised 16 cases of sertraline overdose. Gastric lavage was administered between 0.67\u00a0h and 12\u00a0h post-ingestion, with blood sampling commencing after lavage completion. The median ingested dose was 925\u00a0mg (range: 450\u20131,400\u00a0mg). Apparent elimination half-lives, estimated from two-point concentration measurements obtained 1\u201322\u00a0h and 27\u2013146\u00a0h post-ingestion, ranged from 13.27 to 52.78\u00a0h (median: 24.12\u00a0h). These estimates represent post-decontamination kinetics and may not reflect true elimination half-lives due to unknown peak concentration timing. No life-threatening toxicity or severe organ dysfunction was observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study characterized post-gastric lavage sertraline concentrations in 16 adolescent intentional overdose cases. Apparent half-life estimates overlapped with therapeutic ranges, but methodological constraints, including unknown Tmax and two-point sampling, preclude definitive conclusions regarding overdose pharmacokinetics. Gastric lavage appeared well-tolerated and may reduce drug exposure, though its impact on clinical outcomes requires further study. These preliminary observations require validation in prospective studies with serial sampling.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphar.2026.1781140","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T12:55:17Z","timestamp":1774875317000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Pharmacokinetics of acute sertraline overdose: an observational retrospective study"],"prefix":"10.3389","volume":"17","author":[{"given":"Renzhu","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy, The Central Hospital of Xiangtan (The Affiliated Hospital of Hunan University)","place":["Xiangtan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qichang","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, The Central Hospital of Xiangtan (The Affiliated Hospital of Hunan University)","place":["Xiangtan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, The Central Hospital of Xiangtan (The Affiliated Hospital of Hunan University)","place":["Xiangtan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wencan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, The Central Hospital of Xiangtan (The Affiliated Hospital of Hunan University)","place":["Xiangtan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keqian","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, The Central Hospital of Xiangtan (The Affiliated Hospital of Hunan University)","place":["Xiangtan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haibo","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, The Central Hospital of Xiangtan (The Affiliated Hospital of Hunan University)","place":["Xiangtan, China"]},{"name":"School of Biomedical Sciences, Hunan University","place":["Changsha, Hunan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, The Central Hospital of Xiangtan (The Affiliated Hospital of Hunan University)","place":["Xiangtan, China"]},{"name":"School of Biomedical Sciences, Hunan University","place":["Changsha, Hunan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1080\/14756360701809977","article-title":"Comparative study of the inhibitory effect of antidepressants on cholinesterase activity in Bungarus sindanus (Krait) venom, human serum and rat striatum","volume":"23","author":"Ahmed","year":"2008","journal-title":"J. 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