{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T12:20:06Z","timestamp":1777638006501,"version":"3.51.4"},"reference-count":21,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The international consensus on vasopressors for managing hypotension emphasizes maintaining maternal systolic blood pressure (SBP) during cesarean delivery greater than 90% of the baseline and not below 80%. This study was to determine the ED90 values of prophylactic norepinephrine and phenylephrine infusions under higher blood pressure management target of maintaining maternal SBP at greater than 90% of the baseline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Sixty patients aged 18\u201345\u00a0years, who were scheduled to undergo cesarean delivery under spinal anesthesia, were randomly assigned to the norepinephrine group and the phenylephrine group. The first patients in each group were administered prophylactic infusion rates of 0.05 and 0.5\u00a0\u03bcg\/kg\/min, respectively. Effectiveness was determined based on whether the current vasopressor infusion dose could achieve the predefined target for maternal SBP management at greater than 90% of the baseline prior to fetal delivery. Subsequently, the vasopressor infusion rate was adjusted incrementally or decrementally by 0.01 and 0.1\u00a0\u03bcg\/kg\/min as needed. Additionally, maternal adverse events and neonatal outcomes were systematically recorded and analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Through isotonic regression analysis, the ED90 values for prophylactic norepinephrine and phenylephrine infusions under a higher blood pressure management target were estimated to be 0.140\u00a0\u03bcg\/kg\/min (95% CI: 0.133\u20130.147) and 1.280\u00a0\u03bcg\/kg\/min (95% CI: 1.180\u20131.380), respectively. There was no statistically significant difference in the incidence of adverse events or neonatal outcomes between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>When the target was established to maintain the blood pressure of patients at greater than 90% of the baseline prior to delivery in patients undergoing cesarean delivery, the prophylactic infusion rates for norepinephrine and phenylephrine were determined to be 0.140 and 1.280\u00a0\u03bcg\/kg\/min, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link>Clinicaltrials.gov<\/jats:ext-link>\n                      , NCT06158048.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphar.2026.1781654","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T06:09:56Z","timestamp":1777442996000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Determining the ED90 of prophylactic phenylephrine and norepinephrine infusions for higher blood pressure target maintenance during cesarean delivery: a randomized sequential allocation trial"],"prefix":"10.3389","volume":"17","author":[{"given":"Yongqiang","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, General Hospital of Ningxia Medical University","place":["Yinchuan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, General Hospital of Ningxia Medical University","place":["Yinchuan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yueji","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, General Hospital of Ningxia Medical University","place":["Yinchuan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Xi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, General Hospital of Ningxia Medical University","place":["Yinchuan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, General Hospital of Ningxia Medical University","place":["Yinchuan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1213\/ANE.0b013e3181e1db21","article-title":"A double-blind, placebo-controlled trial of four fixed rate infusion regimens of phenylephrine for hemodynamic support during spinal anesthesia for cesarean delivery","volume":"111","author":"Allen","year":"2010","journal-title":"Anesth. 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