{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T05:48:23Z","timestamp":1782366503487,"version":"3.54.5"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:sec>\n                    <jats:title>Study Objective<\/jats:title>\n                    <jats:p>To investigate the hemodynamic effects of rescue bolus administration of norepinephrine (NE) and phenylephrine (PE) in the treatment of hypotensive events in preeclamptic women with severe features following spinal anesthesia during cesarean section.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 40 preeclamptic women with severe features (\n                      <jats:italic>n<\/jats:italic>\n                      = 20 per group) experienced hypotensive events (defined as SBP below 80% of baseline value) following spinal anesthesia were randomly receive 6\u00a0\u00b5g NE or 75\u00a0\u00b5g\u00a0PE as a rescue measure. The primary outcomes were the maximal changes and the percentage of these changes in hemodynamic indicators, including systolic blood pressure (SBP), heart rate (HR), cardiac output (CO), and systemic vascular resistance (SVR) within a 3-min period following the administration of NE or PE. Additionally, the occurrence of maternal bradycardia, reactive hypertension, analysis of umbilical artery blood gas, and assessment of neonatal Apgar score were recorded.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the NE group, there was a lower magnitude of maximal changes (85.40 \u00b1 17.76 vs. 71.10 \u00b1 11.88 beats\/min,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.005; 7.78 \u00b1 1.98 vs. 6.11 \u00b1 1.44\u00a0L\/min,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.004) after vasopressor administration, accompanied by lower respective percentages of change (\u221215.54% \u00b1 11.49% vs. \u221223.41% \u00b1 10.03%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.026; \u22121.75% \u00b1 6.50% vs. \u221216.56% \u00b1 10.21%,\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt; 0.001) for HR and CO, as well as a decreased incidence of bradycardia (5.0% vs. 30.0%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.030) compared to the PE group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Either 6\u00a0\u00b5g NE or 75\u00a0\u00b5g\u00a0PE can effectively rescue and exhibit comparable efficacy in managing hypotensive events following spinal anesthesia in preeclamptic women with severe features. However, NE demonstrates superior capability in maintaining CO and HR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphar.2026.1783419","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T05:30:38Z","timestamp":1782365438000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The hemodynamic effects of bolus norepinephrine and phenylephrine in the treatment of hypotensive events in preeclamptic women with severe features following spinal anesthesia during cesarean section: a randomized controlled trial"],"prefix":"10.3389","volume":"17","author":[{"given":"Lili","family":"Zou","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, General Hospital of Ningxia Medical University","place":["Yinchuan, Ningxia, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongping","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Peking University First Hospital Ningxia Women and Children\u2019s Hospital (Ningxia Hui Autonomous Region Maternal and Child Health Hospital)","place":["Yinchuan, Ningxia, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqiang","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, General Hospital of Ningxia Medical University","place":["Yinchuan, Ningxia, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Xi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, General Hospital of Ningxia Medical University","place":["Yinchuan, Ningxia, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, General Hospital of Ningxia Medical University","place":["Yinchuan, Ningxia, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"key":"B2","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1007\/s00540-014-1941-4","article-title":"The effect of preeclampsia on the skin to subarachnoid distance in spinal anesthesia","volume":"29","author":"Basaran","year":"2015","journal-title":"J. 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