{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T04:51:37Z","timestamp":1782449497554,"version":"3.54.5"},"reference-count":278,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>\n                    The advancement of Traditional Chinese Medicine (TCM) requires model systems capable of dissecting its multi-component, multi-target pharmacology in a rapid and systematic manner. This review presents the zebrafish as a versatile\n                    <jats:italic>in vivo<\/jats:italic>\n                    pharmacological platform for modern TCM research, not merely a screening tool. We synthesize its recent applications across cardiovascular, neuropsychiatric, metabolic, and oncological diseases, emphasizing how optical transparency and genetic tractability enable real-time quantification of multi-target interactions - for instance, dose-dependent heart rate changes, neutrophil migration distances, and tumor fluorescence intensities - thereby linking molecular pathways to whole-organism phenotypic outcomes. A dedicated section critically evaluates its role in mechanistic safety assessment, moving beyond descriptive toxicology toward elucidation of adverse outcome pathways. We then identify current limitations where the zebrafish\u2019s potential is underutilized, such as in resolving the spatiotemporal dynamics of herbal formula compatibility. Finally,we propose \u201czebrafish-plus\u201d paradigms integrating organoids, single-cell multi-omics, and AI-driven phenotypic analytics. These frameworks are designed to generate testable mechanistic hypotheses and perform early efficacy\/safety profiling, while explicitly recognizing that all zebrafish-derived findings require rigorous validation in mammalian models before clinical interpretation.\n                  <\/jats:p>","DOI":"10.3389\/fphar.2026.1785275","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T04:39:03Z","timestamp":1782448743000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Zebrafish as a translational platform for investigating multi-organ pharmacological interactions of traditional Chinese medicine"],"prefix":"10.3389","volume":"17","author":[{"given":"Jianhua","family":"Guo","sequence":"first","affiliation":[{"name":"Key Lab of Artificial Organs and Computational Medicine, Institute of Translational Medicine, Shulan International Medical College, Zhejiang Shuren University","place":["Hangzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinmin","family":"Ma","sequence":"additional","affiliation":[{"name":"Medical Frontier Innovation Research Center, The First Hospital of Lanzhou University","place":["Lanzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guobao","family":"Li","sequence":"additional","affiliation":[{"name":"School of Resources and Environment, Baoshan University","place":["Baoshan, Yunnan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Pi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Engineering, National Demonstration Center for Experimental Biology Education, School of Life Sciences, Fudan University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e104560","DOI":"10.7554\/elife.104560","article-title":"Balancing microbial composition through diet","volume":"13","author":"Acuff","year":"2024","journal-title":"Elife"},{"key":"B2","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1182\/blood-2024-206256","article-title":"Large-scale in vivo zebrafish drug screen Uncovers novel insights into leukemia stem cell biology","volume":"144","author":"AL-Hamaly","year":"2024","journal-title":"Blood"},{"key":"B3","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.jddst.2025.107276","article-title":"Salvia macilenta Boiss extract: phytochemical analysis, nanoformulation in Eudragit-coated liposomes and evaluation of antioxidant\/inflammatory response in vitro","author":"Alizadeh","year":"2025","journal-title":"J. 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