{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T06:24:20Z","timestamp":1787293460137,"version":"build-2736575974"},"reference-count":37,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Polycystic ovary syndrome (PCOS) is one of the most common endocrine and metabolic disorders affecting women of reproductive age.\n                      <jats:italic>Dendrobium officinale<\/jats:italic>\n                      polysaccharides (DOP) have shown multiple pharmacological activities, but their therapeutic effects and underlying mechanisms in PCOS remain incompletely understood.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A dehydroepiandrosterone (DHEA)-induced mouse model of PCOS was established to evaluate the effects of DOP. Estrous cyclicity, ovarian histopathology, serum hormone levels, RT-qPCR, and Western blot analyses were performed to assess reproductive function, endocrine changes, and MAPK\/ERK-related signaling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>DOP treatment restored estrous cyclicity, improved ovarian morphology, and partially normalized serum luteinizing hormone, follicle-stimulating hormone, and testosterone levels. In addition, DOP reduced ERK1\/2 phosphorylation and downregulated the expression of CYP17A1 and CYP19A1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>DOP ameliorated reproductive and endocrine abnormalities in a DHEA-induced mouse model of PCOS. The findings suggest that modulation of MAPK\/ERK signaling may contribute to the biological effects of DOP, although further mechanistic studies are required to establish causal relationships.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphar.2026.1786264","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T05:37:26Z","timestamp":1787290646000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Dendrobium officinale polysaccharide ameliorates polycystic ovary syndrome by modulating the MAPK\/ERK signaling pathway"],"prefix":"10.3389","volume":"17","author":[{"given":"Xueyu","family":"Qin","sequence":"first","affiliation":[{"name":"Guizhou Medical University Clinical Medical College","place":["Guiyang, China"]},{"name":"Gynecology Department, Anshun People\u2019s Hospital","place":["Anshun, China"]},{"name":"Guizhou Natural Products Research Center","place":["Guiyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongyan","family":"Lu","sequence":"additional","affiliation":[{"name":"Guizhou Medical University Clinical Medical College","place":["Guiyang, China"]},{"name":"Guizhou Natural Products Research Center","place":["Guiyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zeng","sequence":"additional","affiliation":[{"name":"Guizhou Medical University Clinical Medical College","place":["Guiyang, China"]},{"name":"Gynecology Department, Anshun People\u2019s Hospital","place":["Anshun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanyou","family":"Huang","sequence":"additional","affiliation":[{"name":"Guizhou Medical University Clinical Medical College","place":["Guiyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Luo","sequence":"additional","affiliation":[{"name":"Guizhou Natural Products Research Center","place":["Guiyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Guizhou Medical University Clinical Medical College","place":["Guiyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e13186","DOI":"10.1111\/aji.13186","article-title":"Resveratrol treatment in patients with polycystic ovary syndrome decreased pro-inflammatory and endoplasmic reticulum stress markers","volume":"83","author":"Brenjian","year":"2020","journal-title":"Am. 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