{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T05:52:44Z","timestamp":1775713964273,"version":"3.50.1"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>\n                    Dilated cardiomyopathy (DCM) is currently the most prevalent form of cardiomyopathy; it poses a severe threat to human health and is characterized by poor prognosis and high mortality. In this study, we prepared macrophage-membrane-coated and astragaloside-IV-loaded mesoporous silica nanoparticles (AS@MSN\/TA\/MM) and assessed their therapeutic effects\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    . The designed AS@MSN\/TA\/MM were spherical and had an average particle size of approximately 234\u00a0nm, a zeta potential of \u221224.5\u00a0mV, a drug loading capacity (LC) of 9.5% \u00b1 0.04%, and an encapsulation efficiency (EE) of 98.9% \u00b1 0.1%. The particles showed remarkable colloidal stability with phosphate-buffered saline or fetal bovine serum\n                    <jats:italic>in vitro<\/jats:italic>\n                    ; they also improved the doxorubicin hydrochloride (DOX)-induced oxidative stress of H9C2 cells and promoted cell proliferation. In the DOX-induced DCM mouse model, AS@MSN\/TA\/MM ameliorated cardiac dysfunction and hypertrophy, alleviated cardiomyocyte fibrosis, as well as suppressed serum levels of aldosterone, angiotensin II, and suppression of tumorigenicity 2. The present work sheds light on a promising therapeutic strategy for DCM and provides a robust platform for developing advanced astragaloside-IV-based nanotherapeutics.\n                  <\/jats:p>","DOI":"10.3389\/fphar.2026.1790522","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T05:20:35Z","timestamp":1775712035000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Biomimetic astragaloside-IV-loaded mesoporous silica nanoparticles for treatment of dilated cardiomyopathy"],"prefix":"10.3389","volume":"17","author":[{"given":"Chenghua","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cardiology, Affiliated People\u2019s Hospital of Jiangsu University","place":["Zhenjiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Affiliated People\u2019s Hospital of Jiangsu University","place":["Zhenjiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Affiliated People\u2019s Hospital of Jiangsu University","place":["Zhenjiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiantian","family":"Xie","sequence":"additional","affiliation":[{"name":"Jiangsu Medical College","place":["Yancheng, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junqing","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Affiliated People\u2019s Hospital of Jiangsu University","place":["Zhenjiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiwen","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Affiliated People\u2019s Hospital of Jiangsu University","place":["Zhenjiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifen","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Affiliated Traditional Chinese Medicine Hospital, Guangzhou Medical University","place":["Guangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangyong","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Affiliated People\u2019s Hospital of Jiangsu University","place":["Zhenjiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,9]]},"reference":[{"key":"B1","first-page":"786","article-title":"Determination of astragalus saponins from oral adhesion released tablets by ultraviolet spectrophotometry","volume":"18","year":"2012","journal-title":"Chin. 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