{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:27:29Z","timestamp":1790872049773,"version":"4.1.0"},"reference-count":56,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>\n                    Neutrophil extracellular traps (NETs) contribute to host defense but can also drive sterile inflammation and tissue injury. Among particulate inducers, monosodium urate and calcium crystals are potent triggers of NETosis. The role of the chemokine interleukin-8 (CXCL8) in NET formation, however, has remained controversial and context-dependent. Here we show that CXCL8 markedly amplifies NETosis induced by calcium carbonate (CaCO\n                    <jats:sub>3<\/jats:sub>\n                    ) and calcium pyrophosphate dihydrate (CPPD) crystals in human neutrophils. This cooperative effect was independent of crystal composition, required cytoskeletal rearrangements, and was abrogated by inhibition of Src family kinases, PI3K, or ERK1\/2, but not by blockade of NADPH oxidase. In a murine model, combined administration of CXCL8 and CaCO\n                    <jats:sub>3<\/jats:sub>\n                    crystals significantly increased serum citrullinated histone H3 compared with crystals alone, confirming the potentiating effect\n                    <jats:italic>in vivo<\/jats:italic>\n                    . These findings identify an unrecognized crosstalk between chemokine signaling and crystal-driven NETosis, providing mechanistic insight into sterile inflammatory diseases including gout, pseudogout, atherosclerosis, and pancreatitis, and supporting the concept that antagonists of CXCL8 receptors (CXCR1\/2) could limit pathological NET formation.\n                  <\/jats:p>","DOI":"10.3389\/fphar.2026.1794524","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T05:23:16Z","timestamp":1776662596000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["CXCL8 greatly enhances neutrophil extracellular traps formation induced by calcium crystals in vitro and in vivo"],"prefix":"10.3389","volume":"17","author":[{"given":"Irene","family":"Fasciani","sequence":"first","affiliation":[{"name":"Department of Biotechnological and Applied Clinical Sciences, University of L\u2019Aquila","place":["L\u2019Aquila, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"De Lucia","sequence":"additional","affiliation":[{"name":"Preclinical Research, Domp\u00e9 Farmaceutici S.p.a.","place":["L\u2019Aquila, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Conte","sequence":"additional","affiliation":[{"name":"Preclinical Research, Domp\u00e9 Farmaceutici S.p.a.","place":["L\u2019Aquila, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Apparente","sequence":"additional","affiliation":[{"name":"Preclinical Research, Domp\u00e9 Farmaceutici S.p.a.","place":["L\u2019Aquila, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida","family":"Cerqua","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II","place":["Naples, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chayakorn","family":"Petchakup","sequence":"additional","affiliation":[{"name":"School of Mechanical and Aerospace Engineering, Nanyang Technological University","place":["Singapore, Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Petragnano","sequence":"additional","affiliation":[{"name":"Department of Biotechnological and Applied Clinical Sciences, University of L\u2019Aquila","place":["L\u2019Aquila, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Aloisi","sequence":"additional","affiliation":[{"name":"Department of Biotechnological and Applied Clinical Sciences, University of L\u2019Aquila","place":["L\u2019Aquila, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giada","family":"Cremonesi","sequence":"additional","affiliation":[{"name":"Preclinical Research, Domp\u00e9 Farmaceutici S.p.a.","place":["L\u2019Aquila, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Detta","sequence":"additional","affiliation":[{"name":"Preclinical Research, Domp\u00e9 Farmaceutici S.p.a.","place":["L\u2019Aquila, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han Wei","family":"Hou","sequence":"additional","affiliation":[{"name":"School of Mechanical and Aerospace Engineering, Nanyang Technological University","place":["Singapore, Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Capasso","sequence":"additional","affiliation":[{"name":"Department of Agricultural Sciences, University of Naples Federico II","place":["Naples, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Cypriano Dutra","sequence":"additional","affiliation":[{"name":"Preclinical Research, Domp\u00e9 Farmaceutici S.p.a.","place":["L\u2019Aquila, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Bertini","sequence":"additional","affiliation":[{"name":"ATREIUS S.a.s.","place":["L\u2019Aquila, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Aramini","sequence":"additional","affiliation":[{"name":"Preclinical Research, Domp\u00e9 Farmaceutici S.p.a.","place":["L\u2019Aquila, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello","family":"Allegretti","sequence":"additional","affiliation":[{"name":"Preclinical Research, Domp\u00e9 Farmaceutici S.p.a.","place":["L\u2019Aquila, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Maggio","sequence":"additional","affiliation":[{"name":"Department of Biotechnological and Applied Clinical Sciences, University of L\u2019Aquila","place":["L\u2019Aquila, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pier Giorgio","family":"Amendola","sequence":"additional","affiliation":[{"name":"Preclinical Research, Domp\u00e9 Farmaceutici S.p.a.","place":["L\u2019Aquila, Italy"]},{"name":"R&D Pharmacon, Consulting Services in Life Sciences & Pharma","place":["Sutri, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Rossi","sequence":"additional","affiliation":[{"name":"Department of Biotechnological and Applied Clinical Sciences, University of L\u2019Aquila","place":["L\u2019Aquila, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,20]]},"reference":[{"key":"B55","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1007\/s11739-025-03916-4","article-title":"Management of acute pancreatitis in the \u201cno man\u2019s land\u201d","volume":"20","author":"Amodio","year":"2025","journal-title":"Intern. Emerg. Med."},{"key":"B1","doi-asserted-by":"publisher","first-page":"2928","DOI":"10.1080\/15384101.2019.1662678","article-title":"Neutrophil extracellular traps induced by IL-8 aggravate atherosclerosis via activation NF-\u03baB signaling in macrophages","volume":"18","author":"An","year":"2019","journal-title":"Cell Cycle"},{"key":"B2","doi-asserted-by":"publisher","first-page":"11791","DOI":"10.1073\/pnas.0402090101","article-title":"Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: prevention of reperfusion injury","volume":"101","author":"Bertini","year":"2004","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B3","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1111\/j.1476-5381.2011.01566.x","article-title":"Receptor binding mode and pharmacological characterization of a potent and selective dual CXCR1\/CXCR2 non\u2010competitive allosteric inhibitor","volume":"165","author":"Bertini","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"2032","DOI":"10.1161\/ATVBAHA.113.301627","article-title":"Elevated levels of circulating DNA and chromatin are independently associated with severe coronary atherosclerosis and a prothrombotic state","volume":"33","author":"Borissoff","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1007\/s00281-013-0384-6","article-title":"Molecular mechanisms regulating NETosis in infection and disease","volume":"35","author":"Branzk","year":"2013","journal-title":"Semin. Immunopathol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1126\/science.1092385","article-title":"Neutrophil extracellular traps kill bacteria","volume":"303","author":"Brinkmann","year":"2004","journal-title":"Sci. (1979)"},{"key":"B7","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1186\/ar2952","article-title":"Mechanisms of inflammation in gout","volume":"12","author":"Busso","year":"2010","journal-title":"Arthritis Res. Ther."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1083\/jcb.105.4.1473","article-title":"Effects of cytochalasin and phalloidin on actin","volume":"105","author":"Cooper","year":"1987","journal-title":"J. Cell Biol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"33","DOI":"10.2147\/OARRR.S389664","article-title":"Diagnosis and treatment of calcium pyrophosphate deposition (CPPD) disease: a review","volume":"15","author":"Cowley","year":"2023","journal-title":"Open Access Rheumatol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1161\/CIRCRESAHA.116.309692","article-title":"Neutrophil extracellular traps in atherosclerosis and atherothrombosis","volume":"120","author":"D\u00f6ring","year":"2017","journal-title":"Circ. Res."},{"key":"B10","doi-asserted-by":"publisher","first-page":"2817","DOI":"10.1073\/pnas.1414055112","article-title":"SK3 channel and mitochondrial ROS mediate NADPH oxidase-independent NETosis induced by calcium influx","volume":"112","author":"Douda","year":"2015","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B11","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1016\/j.semnephrol.2020.12.004","article-title":"Hyperuricemia in kidney disease: a major risk factor for cardiovascular events, vascular calcification, and renal damage","volume":"40","author":"Ejaz","year":"2020","journal-title":"Semin. Nephrol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1083\/jcb.200606027","article-title":"Novel cell death program leads to neutrophil extracellular traps","volume":"176","author":"Fuchs","year":"2007","journal-title":"J. Cell Biol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1016\/S0016-5085(89)80091-5","article-title":"Calcium carbonate saturation in human pancreatic juice: possible role of ductal H+ secretion","volume":"96","author":"Gerolami","year":"1989","journal-title":"Gastroenterology"},{"key":"B15","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1124\/jpet.106.118927","article-title":"Pharmacological characterization of Sch527123, a potent allosteric CXCR1\/CXCR2 antagonist","volume":"322","author":"Gonsiorek","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B16","doi-asserted-by":"publisher","first-page":"e97088","DOI":"10.1371\/journal.pone.0097088","article-title":"Efficient neutrophil extracellular trap induction requires mobilization of both intracellular and extracellular calcium pools and is modulated by cyclosporine A","volume":"9","author":"Gupta","year":"2014","journal-title":"PLoS One"},{"key":"B17","doi-asserted-by":"publisher","first-page":"869","DOI":"10.4049\/jimmunol.1700905","article-title":"A high-throughput real-time imaging technique to quantify NETosis and distinguish mechanisms of cell death in human neutrophils","volume":"200","author":"Gupta","year":"2018","journal-title":"J. Immunol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1084\/jem.182.6.2019","article-title":"Inflammatory microcrystals differentially regulate the secretion of macrophage inflammatory protein 1 and interleukin 8 by human neutrophils: a possible mechanism of neutrophil recruitment to sites of inflammation in synovitis","volume":"182","author":"Hachicha","year":"1995","journal-title":"J. Exp. Med."},{"key":"B20","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1002\/JLB.3RU0719-241R","article-title":"Calcium signaling and regulation of neutrophil functions: still a long way to go","volume":"107","author":"Hann","year":"2020","journal-title":"J. Leukoc. Biol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"2737","DOI":"10.1093\/cvr\/cvab329","article-title":"Neutrophil extracellular traps: from physiology to pathology","volume":"118","author":"Hidalgo","year":"2022","journal-title":"Cardiovasc Res."},{"key":"B22","doi-asserted-by":"publisher","first-page":"e0176472","DOI":"10.1371\/journal.pone.0176472","article-title":"In vitro induction of NETosis: comprehensive live imaging comparison and systematic review","volume":"12","author":"Hoppenbrouwers","year":"2017","journal-title":"PLoS One"},{"key":"B23","doi-asserted-by":"publisher","first-page":"e162","DOI":"10.1002\/mco2.162","article-title":"Molecular mechanisms and therapeutic target of NETosis in diseases","volume":"3","author":"Huang","year":"2022","journal-title":"MedComm (Beijing)"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1136\/gutjnl-2012-304224","article-title":"Recent advances in autoimmune pancreatitis: type 1 and type 2","volume":"62","author":"Kamisawa","year":"2013","journal-title":"Gut"},{"key":"B25","doi-asserted-by":"publisher","first-page":"2051","DOI":"10.1111\/febs.16902","article-title":"Metabolite\u2010derived damage\u2010associated molecular patterns in immunological diseases","volume":"291","author":"Kang","year":"2024","journal-title":"FEBS J."},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.24437","article-title":"Diverse stimuli engage different neutrophil extracellular trap pathways","volume":"6","author":"Kenny","year":"2017","journal-title":"Elife"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1039\/f19848001181","article-title":"Precipitation of calcium carbonate in aqueous solutions","volume":"80","author":"Koutsoukos","year":"1984","journal-title":"J. Chem. Soc. Faraday Trans."},{"key":"B28","doi-asserted-by":"publisher","first-page":"10973","DOI":"10.1038\/ncomms10973","article-title":"Externalized decondensed neutrophil chromatin occludes pancreatic ducts and drives pancreatitis","volume":"7","author":"Leppkes","year":"2016","journal-title":"Nat. Commun."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.3389\/fimmu.2018.01559","article-title":"Neutrophil extracellular traps formation and aggregation orchestrate induction and resolution of sterile crystal-mediated inflammation","volume":"9","author":"Li","year":"2018","journal-title":"Front. Immunol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.jbspin.2004.12.010","article-title":"Monosodium urate and calcium pyrophosphate dihydrate (CPPD) crystals, inflammation, and cellular signaling","volume":"72","author":"Liu-Bryan","year":"2005","journal-title":"Jt. Bone Spine"},{"key":"B57","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1016\/j.molmed.2024.05.010","article-title":"Neutrophils and extracellular traps in crystal-associated diseases","volume":"30","author":"Ma","year":"2024","journal-title":"Trends Mol. Med."},{"key":"B31","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.cca.2016.05.029","article-title":"NETosis markers: quest for specific, objective, and quantitative markers","volume":"459","author":"Masuda","year":"2016","journal-title":"Clin. Chim. Acta"},{"key":"B32","doi-asserted-by":"publisher","first-page":"155828","DOI":"10.1016\/j.cyto.2022.155828","article-title":"Interleukin-8: an evolving chemokine","volume":"153","author":"Matsushima","year":"2022","journal-title":"Cytokine"},{"key":"B58","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1007\/s00109-015-1295-x","article-title":"How neutrophil extracellular traps orchestrate the local immune response in gout","volume":"93","author":"Mauer\u00f6der","year":"2015","journal-title":"J. Mol. Med."},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2025.287877","article-title":"The dual non-competitive CXCR1\/2 inhibitor ladarixin impairs neutrophil extravasation without altering intravascular adhesion","author":"Napoli","year":"2025","journal-title":"Haematologica"},{"key":"B34","doi-asserted-by":"publisher","first-page":"3767","DOI":"10.1038\/s41467-018-06263-5","article-title":"Chromatin swelling drives neutrophil extracellular trap release","volume":"9","author":"Neubert","year":"2018","journal-title":"Nat. Commun."},{"key":"B35","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1002\/jlb.62.4.444","article-title":"Attenuation of monosodium urate crystal-induced arthritis in rabbits by a neutralizing antibody against interleukin-8","volume":"62","author":"Nishimura","year":"1997","journal-title":"J. Leukoc. Biol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"363","DOI":"10.3389\/fimmu.2016.00363","article-title":"Neutrophil integrins and matrix ligands and NET release","volume":"7","author":"O\u2019Brien","year":"2016","journal-title":"Front. Immunol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"e791","DOI":"10.1016\/S2665-9913(24)00122-X","article-title":"Calcium pyrophosphate deposition disease","volume":"6","author":"Pascart","year":"2024","journal-title":"Lancet Rheumatol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"16628","DOI":"10.1038\/s41598-017-16778-4","article-title":"Mineral particles stimulate innate immunity through neutrophil extracellular traps containing HMGB1","volume":"7","author":"Peng","year":"2017","journal-title":"Sci. Rep."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.1039\/C9LC00250B","article-title":"Integrated inertial-impedance cytometry for rapid label-free leukocyte isolation and profiling of neutrophil extracellular traps (NETs)","volume":"19","author":"Petchakup","year":"2019","journal-title":"Lab. Chip"},{"key":"B40","doi-asserted-by":"publisher","first-page":"e2104822","DOI":"10.1002\/smll.202104822","article-title":"Microfluidic impedance\u2010deformability cytometry for label\u2010free single neutrophil mechanophenotyping","volume":"18","author":"Petchakup","year":"2022","journal-title":"Small"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2017\/2896380","article-title":"Neutrophil extracellular traps and microcrystals","volume":"2017","author":"Rada","year":"2017","journal-title":"J. Immunol. Res."},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2025.288835","article-title":"Taming neutrophil extravasation: a promising therapeutic approach to dampen inflammation?","author":"Rizo-T\u00e9llez","year":"2025","journal-title":"Haematologica"},{"key":"B43","doi-asserted-by":"publisher","first-page":"152042","DOI":"10.1016\/j.imbio.2020.152042","article-title":"Effect of pathogenic crystals on the production of pro- and anti-inflammatory cytokines by different leukocyte populations","volume":"226","author":"Scanu","year":"2021","journal-title":"Immunobiology"},{"key":"B59","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1038\/nm.3547","article-title":"Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines","volume":"20","author":"Schauer","year":"2014","journal-title":"Nat. Med."},{"key":"B44","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1038\/s41418-023-01124-1","article-title":"Moonlighting chromatin: when DNA escapes nuclear control","volume":"30","author":"Singh","year":"2023","journal-title":"Cell Death Differ."},{"key":"B45","doi-asserted-by":"publisher","first-page":"3166","DOI":"10.1182\/blood.2021013565","article-title":"Formation of neutrophil extracellular traps requires actin cytoskeleton rearrangements","volume":"139","author":"Sprenkeler","year":"2022","journal-title":"Blood"},{"key":"B46","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1002\/path.4555","article-title":"CXCR2 inhibition suppresses acute and chronic pancreatic inflammation","volume":"237","author":"Steele","year":"2015","journal-title":"J. Pathol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"109642","DOI":"10.1016\/j.intimp.2022.109642","article-title":"Novel perception of neutrophil extracellular traps in gouty inflammation","volume":"115","author":"Tan","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"e111888","DOI":"10.1371\/journal.pone.0111888","article-title":"In vivo characterization of neutrophil extracellular traps in various organs of a murine sepsis model","volume":"9","author":"Tanaka","year":"2014","journal-title":"PLoS One"},{"key":"B50","doi-asserted-by":"publisher","first-page":"2274","DOI":"10.1002\/eji.202049029","article-title":"Differential Interleukin\u20108 thresholds for chemotaxis and netosis in human neutrophils","volume":"51","author":"Teijeira","year":"2021","journal-title":"Eur. J. Immunol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"7326","DOI":"10.1073\/pnas.1909546117","article-title":"NETosis proceeds by cytoskeleton and endomembrane disassembly and PAD4-mediated chromatin decondensation and nuclear envelope rupture","volume":"117","author":"Thiam","year":"2020","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B52","doi-asserted-by":"publisher","first-page":"3076","DOI":"10.3389\/fimmu.2018.03076","article-title":"Hyperglycemia induces neutrophil extracellular traps formation through an NADPH oxidase-dependent pathway in diabetic retinopathy","volume":"9","author":"Wang","year":"2019","journal-title":"Front. Immunol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1126\/science.aaa8064","article-title":"Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis","volume":"349","author":"Warnatsch","year":"2015","journal-title":"Sci. (1979)"},{"key":"B60","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/s12959-731022-00421-y","article-title":"Clinical significance of neutrophil extracellular traps biomarkers in thrombosis","volume":"20","author":"Xu","year":"2022","journal-title":"Thromb. J."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2026.1794524\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T05:23:17Z","timestamp":1776662597000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2026.1794524\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,20]]},"references-count":56,"alternative-id":["10.3389\/fphar.2026.1794524"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2026.1794524","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,20]]},"article-number":"1794524"}}