{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T05:41:36Z","timestamp":1777354896585,"version":"3.51.4"},"reference-count":137,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>Tourism in high-altitude areas and high-altitude outdoor activities have seen a significant increase, and health threats centered around high-altitude pulmonary edema and high-altitude pulmonary hypertension have become increasingly prominent. Hypoxia, as the primary pathogenic trigger, initiates a cascade linking inflammatory responses, oxidative stress, and vascular dysfunction, culminating in a vicious cycle of injury. Leveraging its unique advantages of holistic regulation and multi-targeted synergistic effects, Chinese Herbal Medicines (CHM) shows promising potential in preventing and treating pulmonary injury associated with high-altitude hypoxia. Through single herbs or compound formulations, CHM targets the HIF-1\u03b1 pathway, scavenges reactive oxygen species, inhibits inflammatory cytokine release, protects the vascular endothelial barrier, and reverses abnormal vascular remodelling. This systematic review examines the core mechanisms by which high-altitude hypoxia causes acute and chronic pulmonary injury, and explores the action mechanisms of CHM in their prevention and treatment, aiming to provide a theoretical basis for the precise prevention and management of high-altitude hypoxia-related pulmonary diseases.<\/jats:p>","DOI":"10.3389\/fphar.2026.1799029","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T04:57:16Z","timestamp":1777352236000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Research progress on high-altitude hypoxia pulmonary injury: pathogenesis and Chinese herbal medicine for prevention and treatment"],"prefix":"10.3389","volume":"17","author":[{"given":"Jiale","family":"Song","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy, The 940th Hospital of Joint Logistics Support Force of Chinese People\u2019s Liberation Army","place":["Lanzhou, China"]},{"name":"School of Pharmacy, Gansu University of Traditional Chinese Medicine","place":["Lanzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, The 940th Hospital of Joint Logistics Support Force of Chinese People\u2019s Liberation Army","place":["Lanzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongfang","family":"Mu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The 940th Hospital of Joint Logistics Support Force of Chinese People\u2019s Liberation Army","place":["Lanzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuyixuan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, The 940th Hospital of Joint Logistics Support Force of Chinese People\u2019s Liberation Army","place":["Lanzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenbin","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Gansu University of Traditional Chinese Medicine","place":["Lanzhou, China"]},{"name":"Department of Pharmacy, The 940th Hospital of Joint Logistics Support Force of Chinese People\u2019s Liberation Army","place":["Lanzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, The 940th Hospital of Joint Logistics Support Force of Chinese People\u2019s Liberation Army","place":["Lanzhou, China"]},{"name":"School of Pharmacy, Gansu University of Traditional Chinese Medicine","place":["Lanzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"C589","DOI":"10.1152\/ajpcell.00235.2017","article-title":"Interleukin-6 promotes a sustained loss of endothelial barrier function via Janus kinase-mediated STAT3 phosphorylation and de novo protein synthesis","volume":"314","author":"Alsaffar","year":"2018","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1177\/2045894020936662","article-title":"The role of hypoxia-induced modulation of alveolar epithelial Na(+)- transport in hypoxemia at high altitude","volume":"10","author":"Baloglu","year":"2020","journal-title":"Pulm. Circ."},{"key":"B3","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1080\/019021400408308","article-title":"Effects of peroxynitrite on pulmonary edema and the oxidative state","volume":"26","author":"Beckman","year":"2000","journal-title":"Exp. Lung Res."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1083\/jcb.200609074","article-title":"The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production","volume":"177","author":"Bell","year":"2007","journal-title":"J. Cell Biol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1089\/ham.2008.1053","article-title":"Transpulmonary plasma ET-1 and nitrite differences in high altitude pulmonary hypertension","volume":"10","author":"Berger","year":"2009","journal-title":"High. Alt. Med. Biol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1152\/japplphysiol.00156.2015","article-title":"Remote ischemic preconditioning for prevention of high-altitude diseases: fact or fiction?","volume":"119","author":"Berger","year":"2015","journal-title":"J. Appl. Physiol. (1985)"},{"key":"B7","doi-asserted-by":"publisher","first-page":"4082","DOI":"10.1093\/emboj\/cdg392","article-title":"HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia","volume":"22","author":"Berra","year":"2003","journal-title":"Embo J."},{"key":"B8","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1177\/2045894020934625","article-title":"Long-term chronic intermittent hypoxia: a particular form of chronic high-altitude pulmonary hypertension","volume":"10","author":"Brito","year":"2020","journal-title":"Pulm. Circ."},{"key":"B9","doi-asserted-by":"publisher","first-page":"541","DOI":"10.21037\/atm-22-2111","article-title":"The combined use of acetazolamide and rhodiola in the prevention and treatment of altitude sickness","volume":"10","author":"Cao","year":"2022","journal-title":"Ann. Transl. Med."},{"key":"B10","doi-asserted-by":"publisher","first-page":"152809","DOI":"10.1016\/j.imbio.2024.152809","article-title":"The involvement of oxidative stress and the TLR4\/NF-\u03baB\/NLRP3 pathway in acute lung injury induced by high-altitude hypoxia","volume":"229","author":"Cao","year":"2024","journal-title":"Immunobiology"},{"key":"B11","doi-asserted-by":"publisher","first-page":"2451","DOI":"10.1161\/circulationaha.117.028034","article-title":"Identification of MicroRNA-124 as a major regulator of enhanced endothelial cell glycolysis in pulmonary arterial hypertension via PTBP1 (polypyrimidine tract binding protein) and Pyruvate kinase M2","volume":"136","author":"Caruso","year":"2017","journal-title":"Circulation"},{"key":"B12","volume-title":"Study on the anti-hypoxia effect of tripterygium glycoside R1 on acute high-altitude hypoxia mice and its protective effects on the brain and lungs","author":"Chen","year":"2023"},{"key":"B13","first-page":"123","article-title":"Epidemiological investigation on cough among 1087 university students in Guangzhou area","volume":"27","author":"Chen","year":"2006","journal-title":"Chin. J. Epidemiol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"mjac073","DOI":"10.1093\/jmcb\/mjac073","article-title":"Histone lactylation driven by mROS-mediated glycolytic shift promotes hypoxic pulmonary hypertension","volume":"14","author":"Chen","year":"2023","journal-title":"J. Mol. Cell Biol."},{"key":"B15","first-page":"1058","article-title":"Meta-analysis of the prevalence and risk factors of chronic obstructive pulmonary disease in the plateau areas of China","volume":"38","author":"Chen","year":"2023","journal-title":"West China Med. Sci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"156479","DOI":"10.1016\/j.phymed.2025.156479","article-title":"Huayu Tongbi formula attenuates rheumatoid arthritis by inhibiting the HIF1A\/VEGFA\/ANGPT axis and suppressing angiogenesis","volume":"139","author":"Chen","year":"2025","journal-title":"Phytomedicine"},{"key":"B17","doi-asserted-by":"publisher","first-page":"e25397","DOI":"10.1371\/journal.pone.0025397","article-title":"Role of monoubiquitylation on the control of I\u03baB\u03b1 degradation and NF-\u03baB activity","volume":"6","author":"Da Silva-Ferrada","year":"2011","journal-title":"PLoS One"},{"key":"B18","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1038\/nrd4422","article-title":"Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases","volume":"13","author":"Eltzschig","year":"2014","journal-title":"Nat. Rev. Drug Discov."},{"key":"B19","volume-title":"Study on the preventive effect of Xiaoqinglong decoction pre-treatment on high-altitude pulmonary edema in SD rats","author":"Fan","year":"2024"},{"key":"B20","doi-asserted-by":"publisher","first-page":"157069","DOI":"10.1016\/j.phymed.2025.157069","article-title":"Multi-omics analyses reveal that hesperidin ameliorates high-altitude pulmonary hypertension by restoring gut-lung axis homeostasis","volume":"145","author":"Fang","year":"2025","journal-title":"Phytomedicine"},{"key":"B21","doi-asserted-by":"publisher","first-page":"3473","DOI":"10.1038\/s41598-017-03152-7","article-title":"Cell-specific expression of aquaporin-5 (Aqp5) in alveolar epithelium is directed by GATA6\/Sp1 via histone acetylation","volume":"7","author":"Flodby","year":"2017","journal-title":"Sci. Rep."},{"key":"B22","doi-asserted-by":"publisher","first-page":"12980","DOI":"10.1073\/pnas.1902165116","article-title":"Endothelial cell Piezo1 mediates pressure-induced lung vascular hyperpermeability via disruption of adherens junctions","volume":"116","author":"Friedrich","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B23","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1097\/00000542-199303000-00005","article-title":"Inhaled nitric oxide selectively reverses human hypoxic pulmonary vasoconstriction without causing systemic vasodilation","volume":"78","author":"Frostell","year":"1993","journal-title":"Anesthesiology"},{"key":"B24","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1165\/rcmb.2017-0167OC","article-title":"Hypoxia upregulates estrogen receptor \u03b2 in pulmonary artery endothelial cells in a HIF-1\u03b1-Dependent manner","volume":"59","author":"Frump","year":"2018","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"B25","first-page":"413","article-title":"Study on the effects and mechanisms of yunyao qilongtian on pulmonary vascular remodeling in low-pressure and low-oxygen rats","volume":"18","author":"Fu","year":"2025","journal-title":"Glob. Tradit. Chin. Med."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1066515","DOI":"10.3389\/fphys.2022.1066515","article-title":"Loss of SOX18\/CLAUDIN5 disrupts the pulmonary endothelial barrier in ventilator-induced lung injury","volume":"13","author":"Garcia-Flores","year":"2022","journal-title":"Front. Physiol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"e13461","DOI":"10.1111\/apha.13461","article-title":"Deregulated hypoxic response in myeloid cells: a model for high-altitude pulmonary oedema (HAPE)","volume":"229","author":"Gojkovic","year":"2020","journal-title":"Acta Physiol. (Oxf)"},{"key":"B28","volume-title":"Clinical study on cerebrovascular disease-related cognitive impairment in high-altitude regions","author":"Gong","year":"2022"},{"key":"B29","doi-asserted-by":"publisher","first-page":"Cd012983","DOI":"10.1002\/14651858.Cd012983","article-title":"Interventions for preventing high altitude illness: part 2. Less commonly-used drugs","volume":"3","author":"Gonzalez Garay","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"key":"B30","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1089\/ham.2020.0022","article-title":"The prevalence and risk factors of high-altitude pulmonary hypertension among native Tibetans in Sichuan Province, China","volume":"21","author":"Gou","year":"2020","journal-title":"High. Alt. Med. Biol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.expneurol.2012.08.024","article-title":"Relationship of nitric oxide synthase induction to peroxynitrite-mediated oxidative damage during the first week after experimental traumatic brain injury","volume":"238","author":"Hall","year":"2012","journal-title":"Exp. Neurol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1164\/rccm.202009-3533SO","article-title":"Global initiative for the diagnosis, management, and prevention of chronic obstructive lung disease. The 2020 GOLD science committee report on COVID-19 and chronic obstructive pulmonary disease","volume":"203","author":"Halpin","year":"2021","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"B33","doi-asserted-by":"publisher","first-page":"116580","DOI":"10.1016\/j.lfs.2019.116580","article-title":"Chemerin influences endothelin- and serotonin-induced pulmonary artery vasoconstriction in rats","volume":"231","author":"Hanthazi","year":"2019","journal-title":"Life Sci."},{"key":"B34","doi-asserted-by":"publisher","first-page":"167244","DOI":"10.1016\/j.jmb.2021.167244","article-title":"HIF-1\u03b1 hydroxyprolines modulate oxygen-dependent protein stability Via single VHL interface with comparable effect on ubiquitination rate","volume":"433","author":"He","year":"2021","journal-title":"J. Mol. Biol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1644436","DOI":"10.3389\/fphar.2025.1644436","article-title":"Pharmacological targeting of ferroptosis in hypoxia-induced pulmonary edema: therapeutic potential of ginsenoside Rg3 through activation of the PI3K\/AKT pathway","volume":"16","author":"He","year":"2025","journal-title":"Front. Pharmacol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/s41577-020-00477-9","article-title":"Regulation of immune responses by the airway epithelial cell landscape","volume":"21","author":"Hewitt","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1144574","DOI":"10.3389\/fphys.2023.1144574","article-title":"Nitric oxide augments signaling for contraction in hypoxic pulmonary arterial smooth muscle-Implications for hypoxic pulmonary hypertension","volume":"14","author":"Hinton","year":"2023","journal-title":"Front. Physiol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1002\/embr.201337983","article-title":"The I\u03baB kinase complex in NF-\u03baB regulation and beyond","volume":"15","author":"Hinz","year":"2014","journal-title":"EMBO Rep."},{"key":"B39","doi-asserted-by":"publisher","first-page":"154568","DOI":"10.1016\/j.phymed.2022.154568","article-title":"Salidroside intensifies mitochondrial function of CoCl(2)-damaged HT22 cells by stimulating PI3K-AKT-MAPK signaling pathway","volume":"109","author":"Hou","year":"2023","journal-title":"Phytomedicine"},{"key":"B40","doi-asserted-by":"publisher","first-page":"519","DOI":"10.4196\/kjpp.2022.26.6.519","article-title":"Lactate promotes vascular smooth muscle cell switch to a synthetic phenotype by inhibiting miR-23b expression","volume":"26","author":"Hu","year":"2022","journal-title":"Korean J. Physiol. Pharmacol."},{"key":"B41","volume-title":"Study on the effect and mechanism of soluble guanylate cyclase stimulator sGC003 in improving high-altitude pulmonary edema in mice","author":"Huang","year":"2025"},{"key":"B42","doi-asserted-by":"publisher","first-page":"e0160875","DOI":"10.1371\/journal.pone.0160875","article-title":"Poly(I:C) induces human lung endothelial barrier dysfunction by disrupting tight junction expression of Claudin-5","volume":"11","author":"Huang","year":"2016","journal-title":"PLoS One"},{"key":"B43","doi-asserted-by":"publisher","first-page":"248","DOI":"10.13452\/j.cnki.jqmc.2022.04.004","article-title":"Based on the ACE-Ang II-AT1R and ACE2-Ang(1-7)-MAS signaling pathways, the mechanism of action of the active components of Tangguat Rhodiola against high-altitude hypoxic pulmonary hypertension in rats was studied","volume":"43","author":"Huang","year":"2022","journal-title":"Chin. J. Plateau Med. Biol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"2037","DOI":"10.16016\/j.2097-0927.202212175","article-title":"The main component of tripterygium glycosides inhibits platelet activation and aggregation induced by shear force","volume":"45","author":"Huang","year":"2023","journal-title":"J. Army Med. Univ."},{"key":"B45","doi-asserted-by":"publisher","first-page":"117512","DOI":"10.1016\/j.biopha.2024.117512","article-title":"Pre-treatment with notoginsenoside R1 from Panax notoginseng protects against high-altitude-induced pulmonary edema by inhibiting pyroptosis through the NLRP3\/caspase-1\/GSDMD pathway","volume":"180","author":"Huang","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"B46","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1677\/joe-10-0305","article-title":"Superoxide induced by a high-glucose concentration attenuates production of angiogenic growth factors in hypoxic mouse mesenchymal stem cells","volume":"208","author":"Ishizuka","year":"2011","journal-title":"J. Endocrinol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"105181","DOI":"10.1016\/j.tiv.2021.105181","article-title":"USP18 mitigates lipopolysaccharide-induced oxidative stress and inflammation in human pulmonary microvascular endothelial cells through the TLR4\/NF-\u03baB\/ROS signaling","volume":"75","author":"Jiang","year":"2021","journal-title":"Toxicol Vitro"},{"key":"B48","doi-asserted-by":"publisher","first-page":"867","DOI":"10.13294\/j.aps.2021.0079","article-title":"The TRPV4 channel mediates the increase in pulmonary microvascular endothelial permeability in rats with chronic hypoxic pulmonary hypertension","volume":"73","author":"Jiao","year":"2021","journal-title":"Acta Physiol. Sin."},{"key":"B49","doi-asserted-by":"publisher","first-page":"595","DOI":"10.3892\/ijmm.2020.4813","article-title":"Astragaloside IV blocks monocrotaline-induced pulmonary arterial hypertension by improving inflammation and pulmonary artery remodeling","volume":"47","author":"Jin","year":"2021","journal-title":"Int. J. Mol. Med."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1161\/hh2401.100426","article-title":"Contribution of the 5-HT(1B) receptor to hypoxia-induced pulmonary hypertension: converging evidence using 5-HT(1B)-receptor knockout mice and the 5-HT(1B\/1D)-receptor antagonist GR127935","volume":"89","author":"Keegan","year":"2001","journal-title":"Circ. Res."},{"key":"B51","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.cmet.2006.02.002","article-title":"HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia","volume":"3","author":"Kim","year":"2006","journal-title":"Cell Metab."},{"key":"B52","doi-asserted-by":"publisher","first-page":"33355","DOI":"10.1074\/jbc.M114.585356","article-title":"Novel peptide for attenuation of hyperoxia-induced disruption of lung endothelial barrier and pulmonary edema via modulating peroxynitrite formation","volume":"289","author":"Kondrikov","year":"2014","journal-title":"J. Biol. Chem."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1389454","DOI":"10.3389\/fnagi.2024.1389454","article-title":"Oxidative stress in the brain-lung crosstalk: cellular and molecular perspectives","volume":"16","author":"Kong","year":"2024","journal-title":"Front. Aging Neurosci."},{"key":"B54","doi-asserted-by":"publisher","first-page":"39018","DOI":"10.1038\/srep39018","article-title":"The protective role of MLCP-mediated ERM dephosphorylation in endotoxin-induced lung injury in vitro and in vivo","volume":"6","author":"Kovacs-Kasa","year":"2016","journal-title":"Sci. Rep."},{"key":"B55","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.freeradbiomed.2018.10.441","article-title":"Expression of human inducible nitric oxide synthase in response to cytokines is regulated by hypoxia-inducible factor-1","volume":"130","author":"Lee","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"B56","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1089\/ham.2005.6.147","article-title":"Consensus statement on chronic and subacute high altitude diseases","volume":"6","author":"Le\u00f3n-Velarde","year":"2005","journal-title":"High. Alt. Med. Biol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"9","DOI":"10.20455\/ros.2016.803","article-title":"Defining ROS in biology and medicine","volume":"1","author":"Li","year":"2016","journal-title":"React. Oxyg. Species (Apex)"},{"key":"B58","first-page":"674","article-title":"Research progress on the mechanism of hemoglobin in adaptation to low oxygen at high altitudes","volume":"48","author":"Li","year":"2019","journal-title":"J. Zhejiang Univ. Med. Sci."},{"key":"B59","doi-asserted-by":"publisher","first-page":"723922","DOI":"10.3389\/fphar.2021.723922","article-title":"Salidroside ameliorated intermittent hypoxia-aggravated endothelial barrier disruption and atherosclerosis via the cAMP\/PKA\/RhoA signaling pathway","volume":"12","author":"Li","year":"2021","journal-title":"Front. Pharmacol."},{"key":"B60","first-page":"862","article-title":"Study on the protective effect of Danqi jing granules on personnel ascending to high altitudes rapidly","volume":"44","author":"Li","year":"2023","journal-title":"J. PLA Med. Univ."},{"key":"B61","doi-asserted-by":"publisher","first-page":"116742","DOI":"10.1016\/j.taap.2023.116742","article-title":"Kaempferol and ginsenoside Rg1 ameliorate acute hypobaric hypoxia induced lung injury based on network pharmacology analysis","volume":"480","author":"Li","year":"2023","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1042\/cs20231508","article-title":"Intermittent short-duration reoxygenation relieves high-altitude pulmonary hypertension via NOX4\/H2O2\/PPAR-\u03b3 axis","volume":"138","author":"Li","year":"2024","journal-title":"Clin. Sci. (Lond)"},{"key":"B63","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1161\/circresaha.124.323698","article-title":"SMYD2-Methylated PPAR\u03b3 facilitates hypoxia-induced pulmonary hypertension by activating mitophagy","volume":"135","author":"Li","year":"2024","journal-title":"Circ. Res."},{"key":"B65","doi-asserted-by":"publisher","first-page":"9151","DOI":"10.2147\/dddt.S509270","article-title":"Enhancing Quercetin's potential: a nanoliposome delivery system for high altitude pulmonary edema","volume":"19","author":"Lin","year":"2025","journal-title":"Drug Des. Devel Ther."},{"key":"B66","first-page":"1","article-title":"Research progress on the preparation of effective components of astragalus root","author":"Liu","year":"2025","journal-title":"Northwest J. Pharm."},{"key":"B67","doi-asserted-by":"publisher","first-page":"118861","DOI":"10.1016\/j.jep.2024.118861","article-title":"Preconditioning with Ginsenoside Rg3 mitigates cardiac injury induced by high-altitude hypobaric hypoxia exposure in mice by suppressing ferroptosis through inhibition of the RhoA\/ROCK signaling pathway","volume":"337","author":"Liu","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1016\/j.wem.2019.04.006","article-title":"Wilderness Medical society clinical practice guidelines for the prevention and treatment of acute altitude illness: 2019 update","volume":"30","author":"Luks","year":"2019","journal-title":"Wilderness Environ. Med."},{"key":"B70","doi-asserted-by":"publisher","first-page":"20251279","DOI":"10.1515\/med-2025-1279","article-title":"TGF-\u03b2-Smad2\/3 signaling in high-altitude pulmonary hypertension in rats: role and mechanisms via macrophage M2 polarization","volume":"20","author":"Ma","year":"2025","journal-title":"Open Med. (Wars)"},{"key":"B71","doi-asserted-by":"publisher","first-page":"113755","DOI":"10.1016\/j.yexcr.2023.113755","article-title":"NLRC3 deficiency promotes hypoxia-induced pulmonary hypertension development via IKK\/NF-\u03baB p65\/HIF-1\u03b1 pathway","volume":"431","author":"Maimaitiaili","year":"2023","journal-title":"Exp. Cell Res."},{"key":"B72","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1038\/s41434-024-00457-x","article-title":"Superoxide dismutase 1-modified dental pulp stem cells alleviate high-altitude pulmonary edema by inhibiting oxidative stress through the Nrf2\/HO-1 pathway","volume":"31","author":"Mao","year":"2024","journal-title":"Gene Ther."},{"key":"B73","doi-asserted-by":"publisher","first-page":"1033875","DOI":"10.3389\/fmicb.2022.1033875","article-title":"Astragalus polysaccharides alleviates lipopolysaccharides-induced inflammatory lung injury by altering intestinal microbiota in mice","volume":"13","author":"Ming","year":"2022","journal-title":"Front. Microbiol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"4901","DOI":"10.1113\/jp272032","article-title":"AMP-activated protein kinase inhibits Kv 1.5 channel currents of pulmonary arterial myocytes in response to hypoxia and inhibition of mitochondrial oxidative phosphorylation","volume":"594","author":"Moral-Sanz","year":"2016","journal-title":"J. Physiol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"101674","DOI":"10.1016\/j.redox.2020.101674","article-title":"Mitochondrial electron transport chain: oxidative phosphorylation, oxidant production, and methods of measurement","volume":"37","author":"Nolfi-Donegan","year":"2020","journal-title":"Redox Biol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/s0002-9440(10)65284-4","article-title":"Vascular endothelial growth factor (VEGF)-mediated angiogenesis is associated with enhanced endothelial cell survival and induction of Bcl-2 expression","volume":"154","author":"N\u00f6r","year":"1999","journal-title":"Am. J. Pathol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1038\/bjp.2008.239","article-title":"Therapeutic potential of RhoA\/Rho kinase inhibitors in pulmonary hypertension","volume":"155","author":"Oka","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"176065","DOI":"10.1016\/j.ejphar.2023.176065","article-title":"Notoginsenoside R1 protects against hypobaric hypoxia-induced high-altitude pulmonary edema by inhibiting apoptosis via ERK1\/2-P90rsk-BAD ignaling pathway","volume":"959","author":"Pei","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"B79","doi-asserted-by":"publisher","first-page":"5657","DOI":"10.1002\/ptr.8333","article-title":"Eleutheroside B pretreatment attenuates hypobaric hypoxia-induced high-altitude pulmonary edema by regulating autophagic flux via the AMPK\/mTOR pathway","volume":"38","author":"Pei","year":"2024","journal-title":"Phytother. Res."},{"key":"B80","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.vph.2015.06.005","article-title":"Asymmetric dimethyl arginine induces pulmonary vascular dysfunction via activation of signal transducer and activator of transcription 3 and stabilization of hypoxia-inducible factor 1-alpha","volume":"73","author":"Pekarova","year":"2015","journal-title":"Vasc. Pharmacol."},{"key":"B81","volume-title":"The influence of high-altitude environment on the cognitive functions and operational capabilities of soldiers","author":"Peng","year":"2018"},{"key":"B82","doi-asserted-by":"publisher","first-page":"676782","DOI":"10.3389\/fphys.2021.676782","article-title":"Hypoxia and inflammation: insights from high-altitude physiology","volume":"12","author":"Pham","year":"2021","journal-title":"Front. Physiol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"e2121385119","DOI":"10.1073\/pnas.2121385119","article-title":"IRF3 inhibits nuclear translocation of NF-\u03baB to prevent viral inflammation","volume":"119","author":"Popli","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B84","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1093\/toxsci\/kft253","article-title":"Loss of hypoxia-inducible factor 2 alpha in the lung alveolar epithelium of mice leads to enhanced eosinophilic inflammation in cobalt-induced lung injury","volume":"137","author":"Proper","year":"2014","journal-title":"Toxicol. Sci."},{"key":"B85","first-page":"3199","article-title":"Research on the chemical components of Rhodiola crenulata","volume":"42","author":"Qu","year":"2020","journal-title":"Chin. Patent Medicine"},{"key":"B86","doi-asserted-by":"publisher","first-page":"L155","DOI":"10.1152\/ajplung.00292.2022","article-title":"High-altitude pulmonary edema: the intercellular network hypothesis","volume":"325","author":"Richalet","year":"2023","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"B87","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.phrs.2012.04.005","article-title":"ERK1\/2 MAP kinases: structure, function, and regulation","volume":"66","author":"Roskoski","year":"2012","journal-title":"Pharmacol. Res."},{"key":"B88","doi-asserted-by":"publisher","first-page":"154667","DOI":"10.1016\/j.phymed.2023.154667","article-title":"Astragalus polysaccharide ameliorates vascular endothelial dysfunction by stimulating macrophage M2 polarization via potentiating Nrf2\/HO-1 signaling pathway","volume":"112","author":"Sha","year":"2023","journal-title":"Phytomedicine"},{"key":"B89","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1186\/s13148-022-01338-z","article-title":"Differential methylation in EGLN1 associates with blood oxygen saturation and plasma protein levels in high-altitude pulmonary edema","volume":"14","author":"Sharma","year":"2022","journal-title":"Clin. Epigenetics"},{"key":"B90","doi-asserted-by":"publisher","first-page":"115607","DOI":"10.1016\/j.biopha.2023.115607","article-title":"Protective effects of Eleutheroside E against high-altitude pulmonary edema by inhibiting NLRP3 inflammasome-mediated pyroptosis","volume":"167","author":"Shen","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"B91","volume-title":"Study on the effects of ligustrazine on indicators related to chronic pulmonary heart disease","author":"Shi","year":"2003"},{"key":"B92","doi-asserted-by":"publisher","first-page":"111669","DOI":"10.1016\/j.biopha.2021.111669","article-title":"Polysaccharide from Potentilla anserina L ameliorate pulmonary edema induced by hypobaric hypoxia in rats","volume":"139","author":"Shi","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"B93","doi-asserted-by":"publisher","first-page":"102727","DOI":"10.1016\/j.tice.2025.102727","article-title":"Tissue remodeling during high-altitude pulmonary edema in rats: biochemical and histomorphological analysis","volume":"93","author":"Shushanyan","year":"2025","journal-title":"Tissue Cell"},{"key":"B94","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/978-94-024-1057-0_7","article-title":"Aquaporins in respiratory system","volume":"969","author":"Song","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"B95","doi-asserted-by":"publisher","first-page":"341","DOI":"10.3390\/ijms26010341","article-title":"Aldose reductase: a promising therapeutic target for high-altitude pulmonary edema","volume":"26","author":"Song","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"B96","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1084\/jem.20111343","article-title":"VEGFR2 induces c-Src signaling and vascular permeability in vivo via the adaptor protein TSAd","volume":"209","author":"Sun","year":"2012","journal-title":"J. Exp. Med."},{"key":"B97","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.biopha.2018.09.002","article-title":"Ginsenoside Rb3 protects cardiomyocytes against hypoxia\/reoxygenation injury via activating the antioxidation signaling pathway of PERK\/Nrf2\/HMOX1","volume":"109","author":"Sun","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"B98","doi-asserted-by":"publisher","first-page":"1692","DOI":"10.3390\/ijerph18041692","article-title":"Pulmonary hypertension in acute and chronic high altitude maladaptation disorders","volume":"18","author":"Sydykov","year":"2021","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"B99","doi-asserted-by":"publisher","first-page":"2932","DOI":"10.3390\/cells11192932","article-title":"Circulating microparticles are differentially increased in lowlanders and highlanders with high altitude induced pulmonary hypertension during the cold season","volume":"11","author":"Sydykov","year":"2022","journal-title":"Cells"},{"key":"B101","volume-title":"Epidemiological investigation of cough among troops conducting training on the Plateau","author":"Tang","year":"2024"},{"key":"B102","doi-asserted-by":"publisher","first-page":"114920","DOI":"10.1016\/j.biopha.2023.114920","article-title":"Ginsenoside Rg1 ameliorates hypoxia-induced pulmonary arterial hypertension by inhibiting endothelial-to-mesenchymal transition and inflammation by regulating CCN1","volume":"164","author":"Tang","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"B103","doi-asserted-by":"publisher","first-page":"2274","DOI":"10.1002\/eji.202049029","article-title":"Differential Interleukin-8 thresholds for chemotaxis and netosis in human neutrophils","volume":"51","author":"Teijeira","year":"2021","journal-title":"Eur. J. Immunol."},{"key":"B104","doi-asserted-by":"publisher","first-page":"56","DOI":"10.3892\/ijmm.2023.5259","article-title":"Ginsenoside Rg1 regulates autophagy and endoplasmic reticulum stress via the AMPK\/mTOR and PERK\/ATF4\/CHOP pathways to alleviate alcohol-induced myocardial injury","volume":"52","author":"Tian","year":"2023","journal-title":"Int. J. Mol. Med."},{"key":"B105","doi-asserted-by":"publisher","first-page":"1155414","DOI":"10.3389\/fphar.2023.1155414","article-title":"Low-dose of caffeine alleviates high altitude pulmonary edema via regulating mitochondrial quality control process in AT1 cells","volume":"14","author":"Tian","year":"2023","journal-title":"Front. Pharmacol."},{"key":"B106","doi-asserted-by":"publisher","first-page":"18657","DOI":"10.1074\/jbc.M100322200","article-title":"Tumor necrosis factor-alpha inhibits aquaporin 5 expression in mouse lung epithelial cells","volume":"276","author":"Towne","year":"2001","journal-title":"J. Biol. Chem."},{"key":"B107","doi-asserted-by":"publisher","first-page":"1883963","DOI":"10.1080\/21688370.2021.1883963","article-title":"Quercetin: a savior of alveolar barrier integrity under hypoxic microenvironment","volume":"9","author":"Tripathi","year":"2021","journal-title":"Tissue Barriers"},{"key":"B108","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1186\/s12974-023-02817-7","article-title":"Lung infection by Pseudomonas aeruginosa induces neuroinflammation and blood-brain barrier dysfunction in mice","volume":"20","author":"Villalba","year":"2023","journal-title":"J. Neuroinflammation"},{"key":"B109","volume-title":"Study on the therapeutic effects of rhodioloside on rats with high-altitude pulmonary edema","author":"Wang","year":"2023"},{"key":"B110","doi-asserted-by":"publisher","first-page":"1209438","DOI":"10.3389\/fimmu.2023.1209438","article-title":"The role of macrophages polarization in sepsis-induced acute lung injury","volume":"14","author":"Wang","year":"2023","journal-title":"Front. Immunol."},{"key":"B111","doi-asserted-by":"publisher","first-page":"3171","DOI":"10.1111\/bph.12660","article-title":"Ginsenoside Rb3 attenuates oxidative stress and preserves endothelial function in renal arteries from hypertensive rats","volume":"171","author":"Wang","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"B112","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1159\/000373966","article-title":"Ginsenoside Rb1 attenuates agonist-induced contractile response via inhibition of store-operated calcium entry in pulmonary arteries of normal and pulmonary hypertensive rats","volume":"35","author":"Wang","year":"2015","journal-title":"Cell Physiol. Biochem."},{"key":"B113","doi-asserted-by":"publisher","first-page":"113982","DOI":"10.1016\/j.biopha.2022.113982","article-title":"Eleutheroside B ameliorated high altitude pulmonary edema by attenuating ferroptosis and necroptosis through Nrf2-antioxidant response signaling","volume":"156","author":"Wang","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"B114","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.3390\/cells13211807","article-title":"Hypoxia-induced mitochondrial ROS and function in pulmonary arterial endothelial cells","volume":"13","author":"Wang","year":"2024","journal-title":"Cells"},{"key":"B115","doi-asserted-by":"publisher","first-page":"3619","DOI":"10.1038\/s41598-025-88258-z","article-title":"Halofuginone prevents inflammation and proliferation of high-altitude pulmonary hypertension by inhibiting the TGF-\u03b21\/Smad signaling pathway","volume":"15","author":"Wang","year":"2025","journal-title":"Sci. Rep."},{"key":"B116","doi-asserted-by":"publisher","first-page":"1","DOI":"10.13422\/j.cnki.syfjx.20251119","article-title":"Exploring the mechanism of Xiaoqinglong Decoction in preventing and treating high-altitude pulmonary edema based on the integrated pharmacology model","author":"Wang","year":"2025","journal-title":"Chin. J. Exp. Pharmacol. Ther."},{"key":"B117","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1007\/s00424-018-2232-y","article-title":"Aquaporins in the lung","volume":"471","author":"Wittekindt","year":"2019","journal-title":"Pflugers Arch."},{"key":"B118","doi-asserted-by":"publisher","first-page":"253","DOI":"10.24920\/j1001-9294.2017.037","article-title":"Role of ROS\/Kv\/HIF axis in the development of hypoxia-induced pulmonary hypertension","volume":"32","author":"Wu","year":"2017","journal-title":"Chin. Med. Sci. J."},{"key":"B119","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1186\/s12871-023-02306-7","article-title":"Blood-nerve barrier enhances chronic postsurgical pain via the HIF-1\u03b1\/aquaporin-1 signaling axis","volume":"23","author":"Wu","year":"2023","journal-title":"BMC Anesthesiol."},{"key":"B120","doi-asserted-by":"publisher","first-page":"182","DOI":"10.13302\/j.cnki.fi.2025.15.026","article-title":"Research on the immune regulatory targets and pathways of Lycium barbarum polysaccharides based on network pharmacology","volume":"46","author":"Xiang","year":"2025","journal-title":"Feed Ind."},{"key":"B121","first-page":"1","article-title":"Analysis of the clinical characteristics of patients with high-altitude pulmonary edema in Nagqu region at an altitude of 4500 meters","author":"Xu","year":"2020"},{"key":"B122","doi-asserted-by":"publisher","first-page":"2060","DOI":"10.3390\/antiox12122060","article-title":"Contribution of mitochondrial reactive oxygen species to chronic hypoxia-induced pulmonary hypertension","volume":"12","author":"Yan","year":"2023","journal-title":"Antioxidants (Basel)"},{"key":"B123","doi-asserted-by":"publisher","first-page":"116093","DOI":"10.1016\/j.bcp.2024.116093","article-title":"CGRP attenuates pulmonary vascular remodeling by inhibiting the cGAS-STING-NF\u03baB pathway in pulmonary arterial hypertension","volume":"222","author":"Yan","year":"2024","journal-title":"Biochem. Pharmacol."},{"key":"B124","volume-title":"Research on the intervention of tanggu hongjing Tian on HAPH equivalent component groups and its mechanism of action","author":"Yang","year":"2025"},{"key":"B125","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.tiv.2018.10.017","article-title":"Copper induces oxidative stress and apoptosis through mitochondria-mediated pathway in chicken hepatocytes","volume":"54","author":"Yang","year":"2019","journal-title":"Toxicol Vitro"},{"key":"B126","doi-asserted-by":"publisher","first-page":"154762","DOI":"10.1016\/j.phymed.2023.154762","article-title":"Salidroside alleviates cognitive impairment by inhibiting ferroptosis via activation of the Nrf2\/GPX4 axis in SAMP8 mice","volume":"114","author":"Yang","year":"2023","journal-title":"Phytomedicine"},{"key":"B127","doi-asserted-by":"publisher","first-page":"1582677","DOI":"10.3389\/fphar.2025.1582677","article-title":"Bioactive compound combinations from Rhodiola tangutica alleviate pulmonary vascular remodeling in high-altitude pulmonary hypertension rats through the PI3K-AKT pathway","volume":"16","author":"Yang","year":"2025","journal-title":"Front. Pharmacol."},{"key":"B128","doi-asserted-by":"publisher","first-page":"101834","DOI":"10.1016\/j.redox.2020.101834","article-title":"Sustained IKK\u03b2 phosphorylation and NF-\u03baB activation by superoxide-induced peroxynitrite-mediated nitrotyrosine modification of B56\u03b33 and PP2A inactivation","volume":"41","author":"Yee","year":"2021","journal-title":"Redox Biol."},{"key":"B129","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1007\/s00424-021-02590-7","article-title":"Oxygen-dependent regulation of ion channels: acute responses, post-translational modification, and response to chronic hypoxia","volume":"473","author":"Yoo","year":"2021","journal-title":"Pflugers Arch."},{"key":"B130","doi-asserted-by":"publisher","first-page":"75","DOI":"10.13729\/j.issn.1671-7813.Z20240409","article-title":"Based on the \u201clung deficiency and blood stasis\u201d theory and through network pharmacology and molecular docking analysis, the mechanism of action of the Huangqi-Danxin drug pair in treating pulmonary fibrosis is explored","volume":"38","author":"Yu","year":"2024","journal-title":"Pract. J. Traditional Chin. Intern. Med."},{"key":"B131","doi-asserted-by":"publisher","first-page":"118109","DOI":"10.1016\/j.biopha.2025.118109","article-title":"Methyleugenol alleviates pulmonary vascular remodeling in rats with high-altitude pulmonary hypertension by improving pulmonary smooth muscle cell function","volume":"187","author":"Yu","year":"2025","journal-title":"Biomed. Pharmacother."},{"key":"B132","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/s41419-020-2481-5","article-title":"Role of pyruvate kinase M2-mediated metabolic reprogramming during podocyte differentiation","volume":"11","author":"Yuan","year":"2020","journal-title":"Cell Death Dis."},{"key":"B133","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ejphar.2017.12.010","article-title":"Danshensu prevents hypoxic pulmonary hypertension in rats by inhibiting the proliferation of pulmonary artery smooth muscle cells via TGF-\u03b2-smad3-associated pathway","volume":"820","author":"Zhang","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"B134","first-page":"718","article-title":"Danshentoxin II A improves pulmonary hypertension in rats caused by digitoxin by mediating the PI3K\/Akt-eNOS signaling pathway","volume":"42","author":"Zhang","year":"2022","journal-title":"J. South. Med. Univ."},{"key":"B135","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.jgr.2024.10.002","article-title":"Ginsenoside Rg1 improves hypoxia-induced pulmonary vascular endothelial dysfunction through TXNIP\/NLRP3 pathway-modulated mitophagy","volume":"49","author":"Zhang","year":"2025","journal-title":"J. Ginseng Res."},{"key":"B136","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s11658-021-00283-8","article-title":"HIF-1\u03b1\/JMJD1A signaling regulates inflammation and oxidative stress following hyperglycemia and hypoxia-induced vascular cell injury","volume":"26","author":"Zhao","year":"2021","journal-title":"Cell Mol. Biol. Lett."},{"key":"B137","first-page":"397","article-title":"Study on the effect of the combination of ligustrazine and shenmai injection on pulmonary arterial hypertension in patients with pulmonary heart disease","volume":"20","author":"Zheng","year":"2012","journal-title":"J. Pract. Cardiac, Cereb. Vasc. Dis."},{"key":"B138","doi-asserted-by":"publisher","first-page":"33","DOI":"10.13704\/j.cnki.jyyx.2020.09.011","article-title":"Clinical analysis of 43 cases of acute high-altitude pulmonary edema treated on site at an altitude of 4300 meters","volume":"38","author":"Zheng","year":"2020","journal-title":"J. Mil. Prev. Med."},{"key":"B139","first-page":"2834","article-title":"Rhodioloside targets the VEGF\/HIF-1\u03b1 signaling pathway to regulate hypoxia-induced pulmonary hypertension in rats","volume":"43","author":"Zhou","year":"2021","journal-title":"Guangxi Med."},{"key":"B140","doi-asserted-by":"publisher","first-page":"e1197","DOI":"10.1002\/iid3.1197","article-title":"Pyroptosis and polarization of macrophages in septic acute lung injury induced by lipopolysaccharide in mice","volume":"12","author":"Zhou","year":"2024","journal-title":"Immun. Inflamm. Dis."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2026.1799029\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T04:57:26Z","timestamp":1777352246000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2026.1799029\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,28]]},"references-count":137,"alternative-id":["10.3389\/fphar.2026.1799029"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2026.1799029","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,28]]},"article-number":"1799029"}}