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Thus, the continued activation of these pathways represents a characteristic of oncogenesis as well as a suitable target for treatment. This review will highlight how natural products have been shown to modify the molecular pathways involved with these signalling cascades in preclinical cancer models. Data derived from an array of preclinical studies showcase how the bioactive phytochemicals that comprise these products are implemented in the form of targeting cancer cells through specific inhibition of signalling pathways, induction of apoptosis, inhibition of tumour growth and alteration of oncogenic crosstalk. Despite the significant body of evidence, there are still several limitations that exist in regards to variability between studies in terms of the methods used for validation of the mechanism by which these compounds function, differences in their bioavailability and overall robustness of those studies. Using a pathway-centered understanding of the mechanisms by which natural compounds exert their therapeutic effects will support the development of targeted phytopharmaceutical approaches and promote the integration of these therapies into evidence-based oncology practices.<\/jats:p>","DOI":"10.3389\/fphar.2026.1804164","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T04:42:28Z","timestamp":1779252148000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploiting signal transduction pathways for cancer therapy: insights from natural products in preclinical models"],"prefix":"10.3389","volume":"17","author":[{"given":"Sarad Pawar Naik","family":"Bukke","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics and Pharmaceutical Technology, Kampala International University","place":["Kampala, Uganda"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balakrishna","family":"Vuyyala","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Gurunanak College of Pharmacy, Gurunanak Institutions Technical Campus","place":["Hyderabad, Telangana, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandrashekar","family":"Thalluri","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Science, Assam Down Town University (AdtU)","place":["Guwahati, Assam, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ananda Kumar","family":"Chettupalli","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, School of Health and Medical Sciences, Adamas University","place":["Barbaria, West Bengal, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Aligarh College of Pharmacy","place":["Aligarh, Uttar Pradesh, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Ali","family":"Abdullah Almoyad","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, College of Applied Medical Sciences, Khamis Mushyt, King Khalid University","place":["Abha, Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safa A.","family":"Abdalla","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Pharmacy Practice, Kampala International University","place":["Kampala, Uganda"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod Kumar","family":"Yata","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, School of Allied and Healthcare Sciences, Malla Reddy University","place":["Hyderabad, Telangana, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alrazi","family":"Eisa Shogar","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Pharmacy Practice, Kampala International University","place":["Kampala, Uganda"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bayapa Reddy","family":"Narapureddy","sequence":"additional","affiliation":[{"name":"Department of Public Health, College of Applied Medical Sciences, King Khalid University","place":["Abha, Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zohre","family":"Eftekhari","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Pasteur Institute of Iran (IPI), Tehran Province","place":["Tehran, Iran"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick Maduabuchi","family":"Aja","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Biomedical Sciences, Kampala International University","place":["Kampala, Uganda"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadele Mekuriya","family":"Yadesa","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Pharmacy Practice, Kampala International University","place":["Kampala, Uganda"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"15280","DOI":"10.1039\/d3ra01367g","article-title":"A Review: Pharmacological Activity and Phytochemical Profile of Abelmoschus esculentus (2010-2022)","volume":"13","author":"Abdel-Razek","year":"2023","journal-title":"RSC Adv."},{"key":"B2","first-page":"71","volume-title":"National Cancer Institute\u2019s Precision Medicine Initiatives for the New National Clinical Trials Network","author":"Abrams","year":"2014"},{"key":"B4","doi-asserted-by":"publisher","first-page":"250","DOI":"10.3322\/caac.20114","article-title":"Photodynamic therapy of cancer: an update","volume":"61","author":"Agostinis","year":"2011","journal-title":"CA Cancer J. 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