{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T06:13:50Z","timestamp":1778739230258,"version":"3.51.4"},"reference-count":189,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>Osteoporosis (OP) is a chronic metabolic disease characterized by reduced bone mass and impaired bone microstructure, posing a significant global health threat. Mitochondria, as the body\u2019s energy regulators, participate in numerous critical biological processes, and their dysfunction is a precipitating factor in various diseases. Accumulating evidence indicates that mitochondrial dysfunction\u2014including abnormalities in mitochondrial biogenesis, dynamics, oxidative stress, and mitophagy\u2014play a pivotal role in OP pathogenesis. Chinese botanical drugs (CBDs), leveraging their advantages of \u201cmultiple targets, multi-levels, and holistic regulation,\u201d are widely applied to modulate mitochondrial function and alleviate mitochondrial dysfunction, emerging as a novel therapeutic direction for OP prevention and treatment. This review summarizes the core mechanisms by which mitochondrial dysfunction drives OP, and systematically catalogs CBD-derived natural chemical metabolites (e.g., resveratrol) and classic formulations (e.g., Zuogui Pill) that target and ameliorate mitochondrial dysfunction. This review aims to establish a \u201cCBD-mitochondrial-bone\u201d research paradigm, highlight the most promising CBD candidates for alleviating mitochondrial dysfunction, and provide a theoretical basis and novel insights for developing precision treatment strategies for OP based on ameliorating mitochondrial dysfunction.<\/jats:p>","DOI":"10.3389\/fphar.2026.1809770","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T05:46:09Z","timestamp":1778737569000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Mitigating mitochondrial dysfunction: a novel strategy for Chinese botanical drugs against osteoporosis"],"prefix":"10.3389","volume":"17","author":[{"given":"Shiyu","family":"Li","sequence":"first","affiliation":[{"name":"Rehabilitation Department, Central Hospital of Dalian University of Technology, Dalian Municipal Central Hospital","place":["Dalian, Liaoning, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Central Hospital of Guangdong Prison","place":["Guangzhou, Guangdong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e21620","DOI":"10.1096\/fj.202100067R","article-title":"Mitochondrial fusion and fission: the fine\u2010tune balance for cellular homeostasis","volume":"35","author":"Adebayo","year":"2021","journal-title":"FASEB J."},{"key":"B2","doi-asserted-by":"publisher","first-page":"3576","DOI":"10.3390\/ijms20143576","article-title":"Reactive oxygen species in osteoclast differentiation and possible pharmaceutical targets of ROS-mediated osteoclast diseases","volume":"20","author":"Agidigbi","year":"2019","journal-title":"Int. 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