{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T05:01:26Z","timestamp":1781154086028,"version":"3.54.1"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>\n                    Ferroptosis is an iron-dependent programmed cell death mechanism triggered by the accumulation of lipid-based reactive oxygen species (ROS). It is closely implicated in the pathogenesis of asthma. Liproxstatin-1 (LIP-1) is a ferroptosis inhibitor that is beneficial for treating neutrophilic asthma. However, low water solubility, limited blood concentration, and poor mucus permeability and biocompatibility limit the therapeutic efficacy of LIP-1. In this study, we successfully constructed polydopamine\u2013polyethylene glycol\u2013LIP-1 nanoparticles (PDA-PEG-LIP-1 NPs) for the treatment of neutrophilic asthma. Inhalation of PDA-PEG-LIP-1 NPs effectively inhibited lipopolysaccharide (LPS)- and interleukin (IL)-13-induced ferroptosis by alleviating lipid peroxidation and ROS production and chelating free ferrous ions (Fe\n                    <jats:sup>2+<\/jats:sup>\n                    ). In addition, results from asthma mouse models demonstrated that inhalation of PDA-PEG-LIP-1 NPs could overcome the limitations of LIP-1 and effectively inhibit ferroptosis. This research suggests that PDA-PEG-LIP-1 NPs are an effective, practical, and safe option for treating neutrophilic asthma.\n                  <\/jats:p>","DOI":"10.3389\/fphar.2026.1809896","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T04:37:01Z","timestamp":1781152621000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Polydopamine\u2013polyethylene glycol\u2013liproxstatin-1 nanoparticles inhibit ferroptosis for enhanced treatment of neutrophilic asthma"],"prefix":"10.3389","volume":"17","author":[{"given":"Chen","family":"Bao","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Shanghai Geriatric Medical Center","place":["Shanghai, China"]},{"name":"Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University","place":["Shanghai, China"]},{"name":"Shanghai Respiratory Research 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