{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T06:13:13Z","timestamp":1779343993991,"version":"3.51.4"},"reference-count":79,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>\n                    Yinchenhao Decoction (YCHD) is a classic traditional Chinese medicine (TCM) formula composed of three botanical drugs:\n                    <jats:italic>Artemisia capillaris<\/jats:italic>\n                    Thunb,\n                    <jats:italic>Gardenia jasminoides<\/jats:italic>\n                    Ellis, and\n                    <jats:italic>Rheum palmatum<\/jats:italic>\n                    L. In modern research, it has demonstrated promising therapeutic effects against various diseases, including obstructive jaundice (OJ), hepatitis, liver cirrhosis, and hepatic carcinoma. From the perspective of TCM theory, YCHD possesses the properties of clearing heat and detoxifying as well as promoting diuresis to resolve jaundice, and is commonly used for the treatment of \u201cdamp-heat type\u201d jaundice, particularly OJ. This article reviews the efficacy, main active metabolites, and pharmacokinetic characteristics of YCHD as an adjuvant therapy for OJ, and analyzes in depth its multi-target mechanism of action, such as regulating bile acid (BA) metabolism, reducing liver cell damage, exerting anti-inflammatory effects, and regulating metabolic processes. Furthermore, it proposes reference suggestions for improving the practical application of YCHD from both basic research and clinical research perspectives.\n                  <\/jats:p>","DOI":"10.3389\/fphar.2026.1811123","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T05:43:56Z","timestamp":1779342236000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Adjuvant therapeutic effects and mechanisms of Yinchenhao decoction in obstructive jaundice: a narrative review"],"prefix":"10.3389","volume":"17","author":[{"given":"Si-Han","family":"Che","sequence":"first","affiliation":[{"name":"Division of Biliary Surgery, Department of General Surgery, West China Hospital, Sichuan University","place":["Chengdu, Sichuan, China"]},{"name":"Research Center for Biliary Diseases, West China Hospital, Sichuan University","place":["Chengdu, Sichuan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saud Ahmad","family":"Saad","sequence":"additional","affiliation":[{"name":"Division of Biliary Surgery, Department of General Surgery, West China Hospital, Sichuan University","place":["Chengdu, Sichuan, China"]},{"name":"Research Center for Biliary Diseases, West China Hospital, Sichuan University","place":["Chengdu, Sichuan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mao-Lin","family":"Ju","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Southwest Medical University, Southwest Medical University","place":["Luzhou, Sichuan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"You","sequence":"additional","affiliation":[{"name":"Division of Biliary Surgery, Department of General Surgery, West China Hospital, Sichuan University","place":["Chengdu, Sichuan, China"]},{"name":"Research Center for Biliary Diseases, West China Hospital, Sichuan University","place":["Chengdu, Sichuan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s11658-023-00528-8","article-title":"Multipronged regulation of autophagy and apoptosis: emerging role of TRIM proteins","volume":"29","author":"Ahsan","year":"2024","journal-title":"Cell. 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