{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T22:58:00Z","timestamp":1781132280320,"version":"3.54.1"},"reference-count":55,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004457","name":"The World Academy of Sciences","doi-asserted-by":"publisher","award":["20-254 RG\/BIO\/AF\/AC_G"],"award-info":[{"award-number":["20-254 RG\/BIO\/AF\/AC_G"]}],"id":[{"id":"10.13039\/100004457","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The management of diarrheal diseases involves the use of medicinal plants, particularly in developing countries, where access to conventional treatments remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The study evaluated the\n                      <jats:italic>in-vivo<\/jats:italic>\n                      antidiarrheal activity of aqueous and hydroethanolic extracts of\n                      <jats:italic>Khaya senegalensis<\/jats:italic>\n                      stem bark and\n                      <jats:italic>Anacardium occidentale<\/jats:italic>\n                      leaves using castor oil induced diarrhea model in male Wistar rats.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The hydroethanolic extracts of both plants studied delayed the onset of diarrhea, reduced stool frequency, decreased stool water content, and lowered the purgation index. Particularly, the hydroethanolic extract of\n                      <jats:italic>Khaya senegalensis<\/jats:italic>\n                      at 200\u00a0mg\/kg showed effects similar to Loperamide for certain specific parameters, including the percentage of diarrhea inhibition. However, no reduction in fecal weight was observed. The extracts also showed antioxidant activity associated with their polyphenol and tannin contents.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      These findings support the traditional use of\n                      <jats:italic>Khaya senegalensis<\/jats:italic>\n                      and\n                      <jats:italic>Anacardium occidentale<\/jats:italic>\n                      as an antidiarrheal protective effects may involve modulation of intestinal secretion, motility and oxidative stress. This study provides preliminary experimental evidence supporting the therapeutic potential of these botanical drugs, although further mechanistic investigations are required.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphar.2026.1812204","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T22:10:23Z","timestamp":1781129423000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["In-vivo antidiarrheal activity of aqueous and hydroethanolic extracts of Anacardium occidentale and Khaya senegalensis used in Benin (West Africa) in a castor oil-induced diarrhea model traditionally"],"prefix":"10.3389","volume":"17","author":[{"given":"Edna","family":"Hounsa","sequence":"first","affiliation":[{"name":"Research Unit in Applied Microbiology and Pharmacology of Natural Substances, Research Laboratory in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi","place":["Abomey-Calavi, Benin"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sedami M.","family":"Fagla","sequence":"additional","affiliation":[{"name":"Medicinal Organic Chemistry Laboratory (MOCL), Faculty of Health Sciences, University of Abomey-Calavi","place":["Abomey-Calavi, Benin"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Agbodjento","sequence":"additional","affiliation":[{"name":"Research Unit in Applied Microbiology and Pharmacology of Natural Substances, Research Laboratory in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi","place":["Abomey-Calavi, Benin"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Robert","family":"Klotoe","sequence":"additional","affiliation":[{"name":"Research Unit in Applied Microbiology and Pharmacology of Natural Substances, Research Laboratory in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi","place":["Abomey-Calavi, Benin"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victorien Tamegnon","family":"Dougnon","sequence":"additional","affiliation":[{"name":"Research Unit in Applied Microbiology and Pharmacology of Natural Substances, Research Laboratory in Applied Biology, Polytechnic School of Abomey-Calavi, University of Abomey-Calavi","place":["Abomey-Calavi, Benin"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"key":"B2","doi-asserted-by":"publisher","first-page":"333","DOI":"10.5138\/09750185.1784","article-title":"Phytochemical analysis and antibacterial activity of Khaya senegalensis bark extracts on Bacillus subtilis, Escherichia coli and Proteus mirabilis","volume":"8","author":"Abdullahi","year":"2016","journal-title":"Int. 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