{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T04:55:06Z","timestamp":1781758506938,"version":"3.54.5"},"reference-count":51,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Leonurus japonicus<\/jats:italic>\n                      Houtt. (Lamiaceae) has traditionally been used to treat respiratory disorders, including cough and dyspnea. The aim of this study was to investigate the therapeutic potential of a standardized hydroalcoholic extract from the aerial parts of\n                      <jats:italic>L. japonicus<\/jats:italic>\n                      in an\n                      <jats:italic>in vivo<\/jats:italic>\n                      model of allergic asthma.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Balb\/c mice were sensitized and challenged with ovalbumin (OVA) and then treated intraperitoneally with\n                      <jats:italic>L. japonicus<\/jats:italic>\n                      (at doses of 100, 200, or 400\u00a0mg\/kg), dexamethasone (at a dose of 2\u00a0mg\/kg), or saline for seven consecutive days during intranasal OVA challenges. Bronchial hyperresponsiveness, lung cytokine levels (IL-4, IL-5, IL-10, and IFN-\u03b3), inflammatory cells in bronchoalveolar lavage fluid (BAL), lung inflammation, and mucus production were evaluated. The chemical profile of the extract was determined by liquid chromatography coupled with tandem mass spectrometry (LC-MS\/MS).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Leonurus japonicus<\/jats:italic>\n                      significantly reduced bronchial hyperresponsiveness, eosinophil infiltration, peribronchial inflammation and mucus secretion at all tested doses. The 200\u00a0mg\/kg dose reduced IL-4 and IL-10 levels, and the 400\u00a0mg\/kg dose decreased IL-5 and IL-10 levels. Isoquercitrin was identified as the major constituent of the extract.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      These findings support the traditional use of\n                      <jats:italic>L. japonicus<\/jats:italic>\n                      and suggest its potential as an anti-inflammatory and immunomodulatory agent for treating allergic asthma.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphar.2026.1813430","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T04:33:50Z","timestamp":1781757230000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Leonurus japonicus Houtt. extract containing isoquercitrin reduces airway inflammation in mice with allergic asthma"],"prefix":"10.3389","volume":"17","author":[{"given":"Camila Carla","family":"Guimar\u00e3es","sequence":"first","affiliation":[{"name":"Faculdade de Tecnologia de Taquaritinga, Centro Estadual de Educa\u00e7\u00e3o Tecnol\u00f3gica Paula Souza","place":["Taquaritinga, S\u00e3o Paulo, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos De Carvalho","family":"Borges","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo","place":["Ribeir\u00e3o Preto, S\u00e3o Paulo, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre Todorovic","family":"Fabro","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo","place":["Ribeir\u00e3o Preto, S\u00e3o Paulo, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Henrique","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Departamento de Biodiversidade, Instituto de Bioci\u00eancias, Universidade Estadual Paulista (UNESP)","place":["Rio Claro, S\u00e3o Paulo, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanize","family":"Acunha","sequence":"additional","affiliation":[{"name":"Departamento de Biotecnologia em Plantas Medicinais, Universidade de Ribeir\u00e3o Preto","place":["Ribeir\u00e3o Preto, S\u00e3o Paulo, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00facia Helena","family":"Faccioli","sequence":"additional","affiliation":[{"name":"Departamento de An\u00e1lises Clinicas, Toxicol\u00f3gicas e Bromatol\u00f3gicas da Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo","place":["Ribeir\u00e3o Preto, S\u00e3o Paulo, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarazete Izidia Vaz","family":"Pereira","sequence":"additional","affiliation":[{"name":"Departamento de Biotecnologia em Plantas Medicinais, Universidade de Ribeir\u00e3o Preto","place":["Ribeir\u00e3o Preto, S\u00e3o Paulo, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia Helena Taleb","family":"Contini","sequence":"additional","affiliation":[{"name":"Departamento de Biotecnologia em Plantas Medicinais, Universidade de Ribeir\u00e3o Preto","place":["Ribeir\u00e3o Preto, S\u00e3o Paulo, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzelei De Castro","family":"Fran\u00e7a","sequence":"additional","affiliation":[{"name":"Departamento de Biotecnologia em Plantas Medicinais, Universidade de Ribeir\u00e3o Preto","place":["Ribeir\u00e3o Preto, S\u00e3o Paulo, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Carmona","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo","place":["Ribeir\u00e3o Preto, S\u00e3o Paulo, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Maria Soares","family":"Pereira","sequence":"additional","affiliation":[{"name":"Departamento de Biotecnologia em Plantas Medicinais, Universidade de Ribeir\u00e3o Preto","place":["Ribeir\u00e3o Preto, S\u00e3o Paulo, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"111467","DOI":"10.1016\/j.jep.2018.08.009","article-title":"The ethanolic extract from Erythrina mulungu Benth. flowers attenuates allergic airway inflammation and hyperresponsiveness in a murine model of asthma","volume":"242","author":"Amorim","year":"2018","journal-title":"J. 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