{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:35:38Z","timestamp":1792096538618,"version":"4.4.0"},"reference-count":103,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>Heat stroke (HS) is a life-threatening acute condition characterized by hyperthermia, central nervous system dysfunction, and multiple organ failure. Energy metabolism disruption serves as a pivotal link between hyperthermia and multi-organ injury. This review synthesizes current evidence on the mechanisms of energy metabolism dysregulation in HS and evaluates emerging intervention strategies. Mitochondrial dysfunction\u2014manifested as structural damage, oxidative phosphorylation impairment, and excessive fission\u2014represents an initiating event. This is followed by glucose-lipid metabolic restructuring, impaired substrate utilization, and energy depletion. These metabolic derangements mediate secondary injury in the intestine (barrier disruption and endotoxemia), brain (hypothalamic dysregulation), and lung (oxidative stress and barrier leakage). Intervention strategies are categorized into mitochondrial protection (e.g., astragaloside IV, curcumin), mitophagy modulation (e.g., melatonin, rapamycin), and substrate metabolism regulation (e.g., taurine, acetyl-L-carnitine). Notably, most current evidence for these interventions is derived from preclinical studies, and HS-validated human studies are still needed to confirm their efficacy and safety. While these approaches show promise in preclinical models, translational gaps remain, including limited validation in HS-specific models, lack of biomarker-guided patient stratification, and insufficient data on vulnerable populations. Future priorities include dynamic metabolic monitoring, identification of early-warning biomarkers, and development of personalized interventions tailored to age, comorbidity status, and metabolic phenotype.<\/jats:p>","DOI":"10.3389\/fphar.2026.1813630","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T04:38:05Z","timestamp":1778647085000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Energy metabolic dysregulation in heat stroke: from mitochondrial dysfunction to multi-organ failure mechanisms and targeted intervention"],"prefix":"10.3389","volume":"17","author":[{"given":"Qiqi","family":"Li","sequence":"first","affiliation":[{"name":"School of Pharmacy, Guangxi University of Chinese Medicine","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinquan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Maternity and Child Health Care of Guangxi Zhuang Autonomous Region","place":["Nanning, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojie","family":"Qin","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Guangxi University of Chinese Medicine","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biaochao","family":"Zhong","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Guangxi University of Chinese Medicine","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiantong","family":"Wei","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Guangxi University of Chinese Medicine","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhui","family":"Zeng","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Guangxi University of Chinese Medicine","place":["Nanning, China"]},{"name":"Guangxi Engineering Research Center for High-Value Utilization of Guangxi-Produced Authentic Medicinal Herbs, Guangxi University of Chinese Medicine","place":["Nanning, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Guangxi University of Chinese Medicine","place":["Nanning, China"]},{"name":"University Engineering Research Center of Characteristic Traditional Chinese Medicine and Ethnomedicine, Guangxi University of Chinese Medicine","place":["Nanning, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"104740","DOI":"10.1016\/j.psj.2024.104740","article-title":"Dietary incorporation of biological curcumin nanoparticles improved growth performance, ileal architecture, antioxidative status, serum lipid profile, and humoral immune response of heat-stressed broiler chickens","volume":"104","author":"Abdel-Moneim","year":"2025","journal-title":"Poult. 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