{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T11:33:15Z","timestamp":1786707195324,"version":"build-2736575974"},"reference-count":157,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>\n                    Colorectal cancer (CRC) is one of the most common gastrointestinal tumors with elevated prevalence and high mortality rates, posing a serious threat to human health. As a commonly used classic prescription in the clinical treatment of CRC, Yi-Yi-Fu-Zi-Bai-Jiang-San (YYFZBJS), which is composed of\n                    <jats:italic>Coix lacryma-jobi L., Aconitum carmichaelii Debeaux,<\/jats:italic>\n                    and\n                    <jats:italic>Patrinia scabiosifolia Fisch. ex Trev.,<\/jats:italic>\n                    exerts anti-CRC effects by regulating inflammation-cancer transformation, alleviating oxidative stress, restoring gut microbiota balance, inhibiting CRC cell proliferation, promoting apoptosis, regulating autophagy, suppressing tumor angiogenesis. It demonstrates multi-targeted anti-CRC potential and holds promising clinical value as a chemotherapy adjuvant. However, the molecular mechanisms underlying its multi-target anti-CRC effects remain incompletely elucidated and require comprehensive synthesis. This review summarizes the research progress of YYFZBJS in recent years in the field of CRC. It will provide theoretical basis and ideas for further investigation of the role of YYFZBJS in anti-CRC, with the ultimate goal of benefiting the clinical practice.\n                  <\/jats:p>","DOI":"10.3389\/fphar.2026.1813778","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T10:57:40Z","timestamp":1786705060000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Therapeutic potential and molecular mechanisms of Yi-Yi-Fu-Zi-Bai-Jiang-San in the treatment of colorectal cancer"],"prefix":"10.3389","volume":"17","author":[{"given":"Jinxiao","family":"Li","sequence":"first","affiliation":[{"name":"Department of Clinical Nutrition, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]},{"name":"State Key Laboratory of Traditional Chinese Medicine Syndrome","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keke","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuju","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luorui","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangyuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianghua","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Yan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Traditional Chinese Medicine Syndrome","place":["Guangzhou, China"]},{"name":"The First Affiliated Hospital of Guangzhou University of Chinese Medicine","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenglan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"102662","DOI":"10.1016\/j.redox.2023.102662","article-title":"The role of oxidative stress, tumor and inflammatory markers in colorectal cancer patients: a one-year Follow-up study","volume":"62","author":"Acevedo-Leon","year":"2023","journal-title":"Redox Biol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"347","DOI":"10.13863\/j.issn1001-4454.2017.02.021","article-title":"Studies on the chemical constituents of Patrinia villosa","volume":"40","author":"Bao","year":"2017","journal-title":"J. Chin. Med. Mater."},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22094906","article-title":"Microencapsulated Bifidobacterium bifidum and Lactobacillus gasseri in combination with Quercetin inhibit colorectal cancer development in Apc(Min\/+) mice","volume":"22","author":"Benito","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.biopha.2012.10.008","article-title":"Resveratrol affects the cross talk between immune and Colon cancer cells","volume":"67","author":"Bergman","year":"2013","journal-title":"Biomed. Pharmacother."},{"key":"B6","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","article-title":"Global cancer statistics 2022: globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"B7","doi-asserted-by":"publisher","first-page":"155385","DOI":"10.1016\/j.phymed.2024.155385","article-title":"Xianlian jiedu decoction alleviates colorectal cancer by regulating metabolic profiles, intestinal microbiota and metabolites","volume":"128","author":"Cai","year":"2024","journal-title":"Phytomedicine"},{"key":"B8","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1186\/s13046-019-1244-6","article-title":"Isovitexin reduces carcinogenicity and stemness in hepatic carcinoma stem-like cells by modulating mnsod and Foxm1","volume":"38","author":"Cao","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"B9","doi-asserted-by":"publisher","first-page":"4759","DOI":"10.21873\/anticanres.11882","article-title":"Colorectal carcinogenesis: role of oxidative stress and antioxidants","volume":"37","author":"Carini","year":"2017","journal-title":"Anticancer Res."},{"key":"B10","first-page":"1001","article-title":"Literature analysis and review of studies on yyfzbjs","volume":"31","author":"Chai","year":"2020","journal-title":"Lishizhen Med. and Materia Medica Res."},{"key":"B11","first-page":"5338","article-title":"Yyfzbjs inhibits colorectal tumorigenesis by remodeling gut microbiota and influence on M2 macrophage polarization in vivo and in vitro","volume":"11","author":"Chai","year":"2021","journal-title":"Am. J. Cancer Res."},{"key":"B12","doi-asserted-by":"publisher","first-page":"3656","DOI":"10.1021\/jf021142a","article-title":"Antiproliferative and chemopreventive effects of adlay seed on lung cancer in vitro and in vivo","volume":"51","author":"Chang","year":"2003","journal-title":"J. Agric. Food Chem."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.3892\/or.2013.2582","article-title":"Patrinia scabiosaefolia inhibits colorectal cancer growth through suppression of tumor angiogenesis","volume":"30","author":"Chen","year":"2013","journal-title":"Oncol. Rep."},{"key":"B14","doi-asserted-by":"publisher","first-page":"113388","DOI":"10.1016\/j.jep.2020.113388","article-title":"Kanglaite enhances the efficacy of cisplatin in suppression of hepatocellular carcinoma via inhibiting Cklf1 mediated Nf-Kappab pathway and regulating transporter mediated drug efflux","volume":"264","author":"Chen","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"B15","first-page":"1435","article-title":"Research progress on the pharmacological mechanisms of patriniae herba and its active ingredients in the treatment of colorectal cancer","volume":"45","author":"Chen","year":"2022","journal-title":"Drug Eval. Res."},{"key":"B16","first-page":"3118","article-title":"Effective targets of traditional Chinese medicine based on the pathogenesis of colorectal cancer prevention and treatment","volume":"18","author":"Chen","year":"","journal-title":"World Chin. Med."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1642","DOI":"10.3390\/antiox12081642","article-title":"A critical review of kaempferol in intestinal health and diseases","volume":"12","author":"Chen","year":"","journal-title":"Antioxidants (Basel)"},{"key":"B18","volume-title":"Pharmacopoeia of the People's Republic of China","year":"2020"},{"key":"B19","doi-asserted-by":"publisher","first-page":"9960","DOI":"10.1021\/acs.jafc.8b02656","article-title":"Reactive oxygen species and P53 mediated activation of P38 and caspases is critically involved in kaempferol induced apoptosis in colorectal cancer cells","volume":"66","author":"Choi","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1136\/gutjnl-2021-326789","article-title":"Gut microbiome and health: mechanistic insights","volume":"71","author":"de Vos","year":"2022","journal-title":"Gut"},{"key":"B21","doi-asserted-by":"publisher","first-page":"115","DOI":"10.2147\/PGPM.S511324","article-title":"Quercetin inhibits gastric cancer progression via Fam198b\/Mapk pathway modulation","volume":"18","author":"Deng","year":"2025","journal-title":"Pharmgenomics Pers. Med."},{"key":"B22","doi-asserted-by":"publisher","first-page":"3837","DOI":"10.7150\/ijbs.64077","article-title":"Immunotherapy in colorectal cancer: current achievements and future perspective","volume":"17","author":"Fan","year":"2021","journal-title":"Int. J. Biol. Sci."},{"key":"B23","doi-asserted-by":"publisher","first-page":"6005","DOI":"10.19540\/j.cnki.cjcmm.20220323.201","article-title":"Advances in chemical composition, pharmacological activity and quality control of Patrinia villosa","volume":"47","author":"Fan","year":"2022","journal-title":"Chin. J. Chin. Materia Medica"},{"key":"B24","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1038\/s41413-024-00390-0","article-title":"Isovitexin targets Sirt3 to prevent steroid-induced osteonecrosis of the femoral head by modulating mitophagy-mediated ferroptosis","volume":"13","author":"Fan","year":"2025","journal-title":"Bone Res."},{"key":"B25","doi-asserted-by":"publisher","first-page":"85","DOI":"10.13422\/j.cnki.syfjx.20181052","article-title":"Exploring the mechanism of action of Coix lacryma Epiphyllum septicum in the treatment of ulcerative colitis based on the Nrf2 pathway","volume":"24","author":"Fang","year":"2018","journal-title":"Chin. J. Exp. Chin. Med. Formulae"},{"key":"B26","first-page":"4147","article-title":"Extraction of polysaccharides from black smooth tablets of epiphyllum and studies on their immunologic activity","volume":"33","author":"Fu","year":"2018","journal-title":"China J. Chin. Med. and Pharm."},{"key":"B27","doi-asserted-by":"publisher","first-page":"193","DOI":"10.19879\/j.cnki.1005-5304.202309137","article-title":"Research progress in anti-breast cancer mechanism of quercetin","volume":"31","author":"Gao","year":"2024","journal-title":"Chin. J. Inf. on Traditional Chin. Med."},{"key":"B28","doi-asserted-by":"publisher","first-page":"115270","DOI":"10.1016\/j.jep.2022.115270","article-title":"Aconitine: a review of its pharmacokinetics, pharmacology, toxicology and detoxification","volume":"293","author":"Gao","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"129994","DOI":"10.1016\/j.ijbiomac.2024.129994","article-title":"In vitro fermentation characteristics of polysaccharides from coix seed and its effects on the gut microbiota","volume":"262","author":"Ge","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"404","DOI":"10.3390\/metabo13030404","article-title":"Anticancer potential of apigenin and isovitexin with focus on oncogenic metabolism in cancer stem cells","volume":"13","author":"Ghanbari-Movahed","year":"2023","journal-title":"Metabolites"},{"key":"B31","doi-asserted-by":"publisher","first-page":"113264","DOI":"10.1016\/j.jep.2020.113264","article-title":"The herba patriniae (caprifoliaceae): a review on traditional uses, phytochemistry, pharmacology and quality control","volume":"265","author":"Gong","year":"","journal-title":"J. Ethnopharmacol."},{"key":"B32","first-page":"273","article-title":"Effects of kanglet injection (Coix lacryma) on autophagy and apoptosis of human hepatocellular carcinoma cell line Smmc7721","volume":"56","author":"Gong","year":"","journal-title":"Jiangxi Med. J."},{"key":"B33","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.jnutbio.2016.12.011","article-title":"Quercetin induces apoptosis and autophagy in primary effusion lymphoma cells by inhibiting Pi3k\/Akt\/Mtor and Stat3 signaling pathways","volume":"41","author":"Granato","year":"2017","journal-title":"J. Nutr. Biochem."},{"key":"B35","doi-asserted-by":"publisher","first-page":"210","DOI":"10.13193\/j.issn.1673-7717.2024.09.040","article-title":"Research progress on chemical constituents and antitumor effects of Yiyiren (Coix seed)","volume":"42","author":"Han","year":"2024","journal-title":"Chin. Archives Traditional Chin. Med."},{"key":"B160","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.jncc.2024.01.006","article-title":"Cancer incidence and mortality in China, 2022","volume":"4","author":"Han","year":"2024","journal-title":"J. Natl. Cancer Cent."},{"key":"B36","first-page":"1490","article-title":"Live combined Bacillus subtilis and Enterococcus faecium improves glucose and lipid metabolism in type 2 diabetic mice with circadian rhythm disruption via the Scfas\/Gpr43\/Glp-1 pathway","volume":"45","author":"Han","year":"2025","journal-title":"J. South. Med. Univ."},{"key":"B37","doi-asserted-by":"publisher","first-page":"643","DOI":"10.3945\/an.112.002303","article-title":"Chemopreventive properties of dietary rice bran: current status and future prospects","volume":"3","author":"Henderson","year":"2012","journal-title":"Adv. Nutr."},{"key":"B38","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1007\/s11655-025-3842-9","article-title":"Multifaceted role of quercetin in colorectal cancer: an integrative review on adipose tissue modulation and direct anti-tumor mechanisms","volume":"32","author":"Hsieh","year":"2025","journal-title":"Chin. J. Integr. Med."},{"key":"B39","first-page":"25","article-title":"Efficacy of yyfzbjs plus and minus retention enema in the treatment of ulcerative colitis and its effect on the expression of serum sod, Tnf-\u03b1 and Il-1\u03b2","volume":"40","author":"Hu","year":"2020","journal-title":"Chin. J. Coloproctology"},{"key":"B40","unstructured":"Huang\n              W.\n            \n          \n          Ganzhou, China: Gannan Medical University\n          Study on the the Effects of Yiyi Fuzi Baijiang Powder Onapoptosis and Autophagy in Colon Cancer Cells Based on Networkpharmacology\n          \n          2023"},{"key":"B41","doi-asserted-by":"publisher","first-page":"57","DOI":"10.13260\/j.cnki.jfjtcm.010575","article-title":"The effect of ethanol extract of patriniae herba on apoptosis and proliferation of human Colon cancer cells Caco-2","volume":"44","author":"Huang","year":"2013","journal-title":"Fujian J. Traditional Chin. Med."},{"key":"B42","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1007\/s11655-018-3002-6","article-title":"Patrinia scabiosaefolia inhibits growth of 5-Fu-Resistant colorectal carcinoma cells via induction of apoptosis and suppression of akt pathway","volume":"25","author":"Huang","year":"2019","journal-title":"Chin. J. Integr. Med."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.19930\/j.cnki.jmdt.2021.09.001","article-title":"Research progress on tumor necrosis Factor-\u03b1 in the diagnosis and treatment of malignant tumors","volume":"13","author":"Huang","year":"","journal-title":"J. Mol. Diagnostics and Ther."},{"key":"B44","first-page":"2525","article-title":"Effect of patriniae herba extract on proliferation and apoptosis of human colorectal cancer cells Sw480","volume":"43","author":"Huang","year":"","journal-title":"Chin. Tradit. Pat. Med."},{"key":"B45","doi-asserted-by":"publisher","first-page":"7333","DOI":"10.1021\/jf0340512","article-title":"Methanolic extract of adlay seed suppresses Cox-2 expression of human lung cancer cells via inhibition of gene transcription","volume":"51","author":"Hung","year":"2003","journal-title":"J. Agric. Food Chem."},{"key":"B46","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1038\/s41586-020-2729-3","article-title":"Host-microbiota maladaptation in colorectal cancer","volume":"585","author":"Janney","year":"2020","journal-title":"Nature"},{"key":"B47","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.lfs.2018.07.027","article-title":"Quercetin suppresses the mobility of breast cancer by suppressing glycolysis through akt-mtor pathway mediated autophagy induction","volume":"208","author":"Jia","year":"2018","journal-title":"Life Sci."},{"key":"B48","first-page":"313","article-title":"The effect of Coix lacryma injection on angiogenesis","volume":"20","author":"Jiang","year":"2000","journal-title":"TUMOR"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.13422\/j.cnki.syfjx.20251311","article-title":"Analysis of clinical fitting degrees on colorectal cancer liver metastasis animal models based on characteristics of disease of Western medicine and syndromes of traditional Chinese medicine","author":"Jiang","year":"2025","journal-title":"Chin. J. Exp. Traditional"},{"key":"B50","first-page":"120","article-title":"Isolation and purification of polysaccharides from Coix lacryma and their antioxidant activities","volume":"36","author":"Jin","year":"2023","journal-title":"Cereals and Oils"},{"key":"B51","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.3390\/ijms22041565","article-title":"The role of tumor microenvironment cells in colorectal cancer (crc) cachexia","volume":"22","author":"Kasprzak","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B52","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.stemcr.2017.12.019","article-title":"Bak\/bax-mediated apoptosis is a myc-induced roadblock to reprogramming","volume":"10","author":"Kim","year":"2018","journal-title":"Stem Cell. Rep."},{"key":"B53","doi-asserted-by":"publisher","first-page":"2722","DOI":"10.3390\/ijms15022722","article-title":"Mechanisms underlying apoptosis-inducing effects of kaempferol in Ht-29 human Colon cancer cells","volume":"15","author":"Lee","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"B54","doi-asserted-by":"publisher","first-page":"2975","DOI":"10.3390\/plants12162975","article-title":"Comparison of Quality, Antioxidant Capacity, and Anti-Inflammatory Activity of Adlay [Coix Lacryma-Jobi L. Var. Ma-Yuen (Rom. Caill.) Stapf.] Sprout at Several Harvest Time","volume":"12","author":"Lee","year":"2023","journal-title":"Plants (Basel)"},{"key":"B55","doi-asserted-by":"publisher","first-page":"3178","DOI":"10.3390\/ijms25063178","article-title":"Pi3k\/Akt\/Mtor signaling pathway as a target for colorectal cancer treatment","volume":"25","author":"Leiphrakpam","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"B56","first-page":"1993","article-title":"Research progress of anti-tumor angiogenesis of traditional Chinese medicine","volume":"22","author":"Li","year":"2014","journal-title":"J. Mod. Med. Oncol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"2059","DOI":"10.13288\/j.11-2166\/r.2017.23.018","article-title":"Research overview on the mechanisms of traditional Chinese medicine in modulating oxidative stress to prevent and treat intestinal cancer transformation","volume":"58","author":"Li","year":"2017","journal-title":"J. Traditional Chin. Med."},{"key":"B58","first-page":"171","article-title":"The effect of adding and subtracting Fu Zi Li Zhong Tang on serum tumor markers in patients with postoperative chemotherapy for gastric cancer of spleen and kidney yang deficiency type","volume":"40","author":"Li","year":"2019","journal-title":"Shaanxi J. Traditional Chin. Med."},{"key":"B59","doi-asserted-by":"publisher","first-page":"68","DOI":"10.13424\/j.cnki.mtcm.2017.02.027","article-title":"Discussion on the prevention and treatment of rectal cancer based on the idea of \u201cPreventive Treatment of Disease \u201d","volume":"37","author":"Li","year":"2017","journal-title":"Mod. Tradit. Chin. Med."},{"key":"B60","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1002\/ptr.6273","article-title":"Hif-1alpha\/Vegf signaling-mediated epithelial-mesenchymal transition and angiogenesis is critically involved in anti-metastasis effect of luteolin in melanoma cells","volume":"33","author":"Li","year":"2019","journal-title":"Phytother. Res."},{"key":"B61","first-page":"1436","article-title":"Generalization and outlook of epiphyllum in the treatment of malignant tumors","volume":"37","author":"Li","year":"","journal-title":"Tianjin J. Traditional Chin. Med."},{"key":"B62","doi-asserted-by":"publisher","first-page":"2323","DOI":"10.7150\/ijbs.46651","article-title":"The role of interleukins in colorectal cancer","volume":"16","author":"Li","year":"","journal-title":"Int. J. Biol. Sci."},{"key":"B63","first-page":"836","article-title":"Research progress on oxidative stress in inflammatory bowel disease and colitis-associated colorectal cancer","volume":"31","author":"Li","year":"","journal-title":"Chin. J. Gastroenterology and Hepatology"},{"key":"B64","doi-asserted-by":"publisher","first-page":"961653","DOI":"10.3389\/fonc.2022.961653","article-title":"Integrated network pharmacology and experimental verification to investigate the mechanisms of yyfzbjs against colorectal cancer via Cdk1\/Pi3k\/Akt signaling","volume":"12","author":"Li","year":"","journal-title":"Front. Oncol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"115690","DOI":"10.1016\/j.biopha.2023.115690","article-title":"Herba patriniae and its component isovitexin show anti-colorectal cancer effects by inducing apoptosis and cell-cycle arrest via P53 activation","volume":"168","author":"Li","year":"","journal-title":"Biomed. Pharmacother."},{"key":"B66","doi-asserted-by":"publisher","first-page":"116264","DOI":"10.1016\/j.jep.2023.116264","article-title":"Patrinia villosa treat colorectal cancer by activating Pi3k\/Akt signaling pathway","volume":"309","author":"Li","year":"","journal-title":"J. Ethnopharmacol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"62","DOI":"10.20116\/j.issn2095-0616.2023.19.13","article-title":"Advances in the study of gut microbiota in colorectal cancer","volume":"13","author":"Liang","year":"2023","journal-title":"Chin. Med. and Pharm."},{"key":"B68","doi-asserted-by":"publisher","first-page":"5119","DOI":"10.1002\/jcp.26356","article-title":"Reactive oxygen species and colorectal cancer","volume":"233","author":"Lin","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.13288\/j.11-2166\/r.2021.17.001","article-title":"Chinese journal of experimental traditional medical formulae","volume":"62","author":"Lin","year":"2021","journal-title":"J. Traditional Chin. Med."},{"key":"B70","doi-asserted-by":"publisher","first-page":"37","DOI":"10.13638\/j.issn.1671-4040.2023.21.010","article-title":"Effects of yyfzbjs combined with xelox regimen on immune function and intestinal flora of colorectal cancer patients","volume":"23","author":"Lin","year":"2023","journal-title":"Pract. Clin. J. Integr. Traditional Chin. and West. Med."},{"key":"B71","doi-asserted-by":"publisher","first-page":"897","DOI":"10.3892\/or.2013.2528","article-title":"Patrinia scabiosaefolia induces mitochondrial-dependent apoptosis in a mouse model of colorectal cancer","volume":"30","author":"Liu","year":"2013","journal-title":"Oncol. Rep."},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20193319","article-title":"The clinical efficacy and safety of kanglaite adjuvant therapy in the treatment of advanced hepatocellular carcinoma: a prisma-compliant meta-analysis","volume":"39","author":"Liu","year":"","journal-title":"Biosci. Rep."},{"key":"B73","doi-asserted-by":"publisher","first-page":"4614","DOI":"10.1038\/s41467-019-12573-z","article-title":"Brg1 attenuates colonic inflammation and tumorigenesis through autophagy-dependent oxidative stress sequestration","volume":"10","author":"Liu","year":"","journal-title":"Nat. Commun."},{"key":"B74","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1038\/nrmicro3344","article-title":"The gut microbiota, bacterial metabolites and colorectal cancer","volume":"12","author":"Louis","year":"2014","journal-title":"Nat. Rev. Microbiol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1016\/j.bbrc.2012.11.058","article-title":"A polysaccharide fraction of adlay seed (Coixlachryma-Jobi L.) induces apoptosis in human non-small cell lung cancer A549 cells","volume":"430","author":"Lu","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B76","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.phrs.2017.11.032","article-title":"Dact2 epigenetic stimulator exerts dual efficacy for colorectal cancer prevention and treatment","volume":"129","author":"Lu","year":"2018","journal-title":"Pharmacol. Res."},{"key":"B77","doi-asserted-by":"publisher","first-page":"309","DOI":"10.3892\/mmr.2016.5985","article-title":"Molecular inhibition mechanisms of cell migration and invasion by coix polysaccharides in A549 nsclc cells via targeting S100a4","volume":"15","author":"Luo","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"B78","doi-asserted-by":"publisher","first-page":"72","DOI":"10.7150\/ijbs.13188","article-title":"Isovitexin exerts anti-inflammatory and anti-oxidant activities on lipopolysaccharide-induced acute lung injury by inhibiting mapk and Nf-Kappab and activating Ho-1\/Nrf2 pathways","volume":"12","author":"Lv","year":"2016","journal-title":"Int. J. Biol. Sci."},{"key":"B79","first-page":"32","article-title":"A network pharmacology-based study on the molecular mechanism of the treatment of colorectal cancer by yyfzbjs","volume":"12","author":"Lv","year":"2022","journal-title":"China Med. and Pharm."},{"key":"B80","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1080\/13880209.2024.2312217","article-title":"Comparative efficacy and safety of Chinese medicine injections as an adjunctive therapy for cervical cancer in Chinese patients: a network meta-analysis","volume":"62","author":"Ma","year":"2024","journal-title":"Pharm. Biol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"2952","DOI":"10.3390\/ijms24032952","article-title":"Targets involved in the anti-cancer activity of quercetin in breast, colorectal and liver neoplasms","volume":"24","author":"Maugeri","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B82","doi-asserted-by":"publisher","first-page":"3195","DOI":"10.13210\/j.cnki.jhmu.20171130.001","article-title":"Effects of luteolin on proliferation and vascularization viability of hepatocellular carcinoma Hepg2 cells in vitro","volume":"23","author":"Meng","year":"2017","journal-title":"J. Hainan Med. Univ."},{"key":"B83","doi-asserted-by":"publisher","first-page":"110583","DOI":"10.1016\/j.cbi.2023.110583","article-title":"Isovitexin prevents Dss-Induced colitis through inhibiting inflammation and preserving intestinal barrier integrity through activating ahr","volume":"382","author":"Mu","year":"2023","journal-title":"Chem. Biol. Interact."},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.3390\/foods10112833","article-title":"Anti-cancer properties of coix seed oil against Ht-29 Colon cells through regulation of the Pi3k\/Akt signaling pathway","volume":"10","author":"Ni","year":"2021","journal-title":"Foods"},{"key":"B85","unstructured":"Nie\n              D.\n            \n          \n          Chengdu, China: Chengdu University of Traditional Chinese Medicine\n          Clinical Study of Yiyi Fuzi Baijiang San Combined Withxelox Chemotherapy Regimen in the Treatment of Stageiv Colorectal Cancer (Cold-Heat Mixed Syndrome)\n          \n          2020"},{"key":"B86","doi-asserted-by":"publisher","first-page":"107","DOI":"10.13193\/j.issn.1673-7717.2024.02.023","article-title":"Exploring mechanism of treating colorectal cancer from spleen and kidney based on intestinal bacteria","volume":"42","author":"Ning","year":"2024","journal-title":"Chin. Archives Traditional Chin. Med."},{"key":"B87","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/S0140-6736(19)32545-0","article-title":"Colorectal cancer in ulcerative colitis: a Scandinavian population-based cohort study","volume":"395","author":"Olen","year":"2020","journal-title":"Lancet"},{"key":"B88","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.reprotox.2016.03.041","article-title":"Zinc attenuates ethanol-induced sertoli cell toxicity and apoptosis through Caspase-3 mediated pathways","volume":"61","author":"Pourhassanali","year":"2016","journal-title":"Reprod. Toxicol."},{"key":"B89","first-page":"2819","article-title":"Inhibitory effect of yyfzbjs on ovarian cancer and its network pharmacological mechanism","volume":"37","author":"Pan","year":"2022","journal-title":"Chin. J. Traditional Chin. Med. and Pharm."},{"key":"B90","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1038\/nrc3239","article-title":"The blockade of immune checkpoints in cancer immunotherapy","volume":"12","author":"Pardoll","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"B91","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1038\/s41385-019-0176-y","article-title":"The Il-33\/St2 pathway shapes the regulatory T cell phenotype to promote intestinal cancer","volume":"12","author":"Pastille","year":"2019","journal-title":"Mucosal Immunol."},{"key":"B92","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.foodchem.2016.07.083","article-title":"Contribution of trans-aconitic acid to dpph scavenging ability in different media","volume":"214","author":"Piang-Siong","year":"2017","journal-title":"Food Chem."},{"key":"B93","doi-asserted-by":"publisher","first-page":"e52279","DOI":"10.1371\/journal.pone.0052279","article-title":"Luteolin inhibits human prostate tumor growth by suppressing vascular endothelial growth factor receptor 2-Mediated angiogenesis","volume":"7","author":"Pratheeshkumar","year":"2012","journal-title":"PLoS One"},{"key":"B94","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.16368\/j.issn.1674-8999.2017.07.305","article-title":"Effect of injectable Coix lacryma oil on immune function and progression-free survival of postoperative patients with colorectal cancer","volume":"32","author":"Qu","year":"2017","journal-title":"J. Chin. Med."},{"key":"B95","first-page":"99","article-title":"Progress in the study of chemical composition and anti-inflammatory and anti-tumor effects of Patrinia scabiosifolia","volume":"24","author":"Quan","year":"2021","journal-title":"J. Guangxi Univ. Chin. Med."},{"key":"B96","doi-asserted-by":"publisher","first-page":"34","DOI":"10.16367\/j.issn.1003-5028.2008.11.050","article-title":"Experimental study on the effect of extracts of epiphyllum on apoptosis of transplanted hepatocellular carcinoma H22 cells","volume":"28","author":"Ren","year":"2008","journal-title":"Henan Tradit. Chin. Med."},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20133177","article-title":"The anti-cancer effect of quercetin: molecular implications in cancer metabolism","volume":"20","author":"Reyes-Farias","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B98","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.addr.2015.11.004","article-title":"Studying the influence of angiogenesis in in vitro cancer model systems","volume":"97","author":"Roudsari","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"B99","doi-asserted-by":"publisher","first-page":"5473","DOI":"10.1158\/0008-5472.CAN-13-0525","article-title":"Chemopreventive activity of plant flavonoid isorhamnetin in colorectal cancer is mediated by oncogenic src and beta-catenin","volume":"73","author":"Saud","year":"2013","journal-title":"Cancer Res."},{"key":"B100","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.chom.2014.02.007","article-title":"Microbes, microbiota, and Colon cancer","volume":"15","author":"Sears","year":"2014","journal-title":"Cell. Host Microbe"},{"key":"B101","doi-asserted-by":"publisher","first-page":"4826","DOI":"10.1158\/0008-5472.CAN-05-4062","article-title":"Luteolin promotes degradation in signal transducer and activator of transcription 3 in human hepatoma cells: an implication for the antitumor potential of flavonoids","volume":"66","author":"Selvendiran","year":"2006","journal-title":"Cancer Res."},{"key":"B102","doi-asserted-by":"publisher","first-page":"156262","DOI":"10.1016\/j.phymed.2024.156262","article-title":"Autocrine and paracrine lif signals to collaborate Sorafenib-Resistance in hepatocellular carcinoma and effects of kanglaite injection","volume":"136","author":"Shao","year":"2025","journal-title":"Phytomedicine"},{"key":"B103","doi-asserted-by":"publisher","first-page":"64","DOI":"10.13422\/j.cnki.syfjx.20240921","article-title":"Research progress of traditional Chinese medicine compounds in prevention and treatment of colorectal adenoma: a review","volume":"30","author":"Shen","year":"2024","journal-title":"Chin. J. Exp. Traditional Med. Formulae"},{"key":"B104","doi-asserted-by":"publisher","first-page":"6771","DOI":"10.18632\/oncotarget.23645","article-title":"Kanglaite inhibits emt caused by tnf-alpha via Nf-Kappabeta inhibition in colorectal cancer cells","volume":"9","author":"Shi","year":"2018","journal-title":"Oncotarget"},{"key":"B105","doi-asserted-by":"publisher","first-page":"e70067","DOI":"10.3322\/caac.70067","article-title":"Colorectal cancer statistics, 2026","volume":"76","author":"Siegel","year":"2026","journal-title":"CA Cancer J. Clin."},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.3390\/jpm10040237","article-title":"The road So far in colorectal cancer pharmacogenomics: are we closer to individualised treatment?","volume":"10","author":"Simoes","year":"2020","journal-title":"J. Pers. Med."},{"key":"B107","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.cancergen.2024.06.002","article-title":"Cancer treatments: past, present, and future","author":"Sonkin","year":"2024","journal-title":"Cancer Genet."},{"key":"B108","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1158\/1078-0432.CCR-06-1528","article-title":"Pterostilbene, an active constituent of blueberries, suppresses aberrant crypt foci formation in the azoxymethane-induced Colon carcinogenesis model in rats","volume":"13","author":"Suh","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"B109","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1186\/s12964-020-00596-9","article-title":"Yyfzbjs ameliorates colorectal cancer progression in Apc(Min\/+) mice by remodeling gut microbiota and inhibiting regulatory T-Cell generation","volume":"18","author":"Sui","year":"2020","journal-title":"Cell. Commun. Signal"},{"key":"B110","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1007\/s11655-015-2086-5","article-title":"Pi (Spleen)-Deficiency syndrome in tumor microenvironment is the pivotal pathogenesis of colorectal cancer immune escape","volume":"22","author":"Sun","year":"2016","journal-title":"Chin. J. Integr. Med."},{"key":"B111","doi-asserted-by":"publisher","first-page":"1","DOI":"10.19288\/j.cnki.issn.1000-2723.2019.05.001","article-title":"Experimental study on the effect of yyfzbjs against hepatocellular carcinoma","volume":"42","author":"Sun","year":"2019","journal-title":"J. Yunnan Univ. Chin. Med."},{"key":"B112","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1186\/s13046-020-01705-9","article-title":"Mir-103a-3p promotes tumour glycolysis in colorectal cancer via Hippo\/Yap1\/Hif1a axis","volume":"39","author":"Sun","year":"2020","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"B113","first-page":"1614","article-title":"Progress in the study of chemical composition and pharmacological effects of epiphyllum","volume":"37","author":"Tang","year":"2017","journal-title":"GUIHALA"},{"key":"B114","doi-asserted-by":"publisher","first-page":"119","DOI":"10.13412\/j.cnki.zyyl.20230105.001","article-title":"Research progress of traditional Chinese medicine combined with chemotherapy and targeted therapy for advanced intestinal cancer","volume":"40","author":"Tian","year":"2024","journal-title":"Pharmacol. and Clin. Chin. Materia Medica"},{"key":"B115","doi-asserted-by":"publisher","first-page":"966","DOI":"10.4161\/auto.7.9.15863","article-title":"Quercetin induces protective autophagy in gastric cancer cells: involvement of Akt-Mtor- and hypoxia-induced factor 1alpha-Mediated signaling","volume":"7","author":"Wang","year":"2011","journal-title":"Autophagy"},{"key":"B116","first-page":"217","article-title":"Therapeutic effects of total saponins of patriniae herba on ulcerative colitis in rats and a preliminary study on metabolomics","volume":"26","author":"Wang","year":"2015","journal-title":"Traditional Chin. Drug Res. and Clin. Pharmacol."},{"key":"B117","doi-asserted-by":"publisher","first-page":"7777","DOI":"10.2147\/OTT.S159095","article-title":"Resveratrol, an activator of Sirt1, induces protective autophagy in non-small-cell lung cancer via inhibiting akt\/mtor and activating P38-Mapk","volume":"11","author":"Wang","year":"2018","journal-title":"Onco Targets Ther."},{"key":"B118","doi-asserted-by":"publisher","first-page":"6704","DOI":"10.7150\/jca.45176","article-title":"Curcumin induces G2\/M arrest and triggers autophagy, ros generation and cell senescence in cervical cancer cells","volume":"11","author":"Wang","year":"2020","journal-title":"J. Cancer"},{"key":"B119","doi-asserted-by":"publisher","first-page":"999935","DOI":"10.3389\/fphar.2022.999935","article-title":"Analysis of the absorbed constituents and mechanism of liquidambaris fructus extract on hepatocellular carcinoma","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"B120","doi-asserted-by":"publisher","first-page":"155492","DOI":"10.1016\/j.phymed.2024.155492","article-title":"Astragalus polysaccharides attenuate chemotherapy-induced immune injury by modulating gut microbiota and polyunsaturated fatty acid metabolism","volume":"128","author":"Wang","year":"","journal-title":"Phytomedicine"},{"key":"B121","first-page":"44","article-title":"Effects of Co-Administration of coix seed oil and oxaliplatin on proliferation and apoptosis in Colon cancer cells","author":"Wang","year":"","journal-title":"Chin. J. Gerontology"},{"key":"B122","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1016\/j.ccell.2025.02.023","article-title":"Fusobacterium nucleatum facilitates Anti-Pd-1 therapy in microsatellite stable colorectal cancer","volume":"43","author":"Wang","year":"","journal-title":"Cancer Cell."},{"key":"B123","doi-asserted-by":"publisher","first-page":"1537325","DOI":"10.3389\/fimmu.2025.1537325","article-title":"Thlaspi arvense suppresses gut microbiota related tnf inflammatory pathway to alleviates ulcerative colitis","volume":"16","author":"Wang","year":"","journal-title":"Front. Immunol."},{"key":"B124","first-page":"26","article-title":"Inhibition of Pi3k\/Akt activation by luteolin down-Regulates Mmp-9 activity in Colon cancer cells","volume":"17","author":"Wei","year":"2019","journal-title":"J. China Prescr. Drug"},{"key":"B125","doi-asserted-by":"publisher","first-page":"4893","DOI":"10.19540\/j.cnki.cjcmm.20230601.503","article-title":"Progress in the clinical application and pharmacological effects of yyfzbjs","volume":"48","author":"Wei","year":"2023","journal-title":"China J. Chin. Materia Medica"},{"key":"B126","doi-asserted-by":"publisher","first-page":"2576","DOI":"10.13863\/j.issn1001-4454.2016.11.035","article-title":"Study on polysaccharide extraction process and antioxidant activity of Aconitum septentrionale koelle","volume":"39","author":"Wen","year":"2016","journal-title":"J. Chin. Med. Mater."},{"key":"B127","doi-asserted-by":"publisher","first-page":"a026120","DOI":"10.1101\/cshperspect.a026120","article-title":"Autophagy and P53","volume":"6","author":"White","year":"2016","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"B128","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1038\/s41571-023-00766-x","article-title":"Gut microbiota in colorectal cancer development and therapy","volume":"20","author":"Wong","year":"2023","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"B129","doi-asserted-by":"publisher","first-page":"2005","DOI":"10.4161\/cbt.6.12.5168","article-title":"Coix seed extract, a commonly used treatment for cancer in China, inhibits nfkappab and protein kinase C signaling","volume":"6","author":"Woo","year":"2007","journal-title":"Cancer Biol. Ther."},{"key":"B130","doi-asserted-by":"publisher","first-page":"111","DOI":"10.13375\/j.cnki.wcjps.2010.01.019","article-title":"Progress in the study of chemical composition and pharmacological activity of Coix lacryma","volume":"25","author":"Wu","year":"2010","journal-title":"West China J. Pharm. Sci."},{"key":"B131","first-page":"212","article-title":"Progress in the study of chemical and biological activities of epimedium","volume":"20","author":"Wu","year":"2014","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"key":"B132","doi-asserted-by":"publisher","first-page":"3544","DOI":"10.3390\/ijms23073544","article-title":"Kaempferol can reverse the 5-Fu resistance of colorectal cancer cells by inhibiting Pkm2-Mediated glycolysis","volume":"23","author":"Wu","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B133","doi-asserted-by":"publisher","first-page":"9155","DOI":"10.2147\/IJN.S518174","article-title":"Quercetin: a natural ally in combating breast cancer","volume":"20","author":"Wu","year":"2025","journal-title":"Int. J. Nanomedicine"},{"key":"B134","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.canlet.2009.02.041","article-title":"Luteolin, quercetin and ursolic acid are potent inhibitors of proliferation and inducers of apoptosis in both kras and braf mutated human colorectal cancer cells","volume":"281","author":"Xavier","year":"2009","journal-title":"Cancer Lett."},{"key":"B135","doi-asserted-by":"publisher","first-page":"2152","DOI":"10.1016\/j.bbrc.2018.08.005","article-title":"Effects of saponins of Patrinia villosa against invasion and metastasis in colorectal cancer cell through Nf-Kappab signaling pathway and emt","volume":"503","author":"Xia","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B136","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/s41392-020-0116-z","article-title":"Comprehensive review of targeted therapy for colorectal cancer","volume":"5","author":"Xie","year":"2020","journal-title":"Signal Transduct. Target Ther."},{"key":"B137","doi-asserted-by":"publisher","first-page":"748149","DOI":"10.3389\/fphar.2021.748149","article-title":"Targeting autophagy with natural compounds in cancer: a renewed perspective from molecular mechanisms to targeted therapy","volume":"12","author":"Xie","year":"2021","journal-title":"Front. Pharmacol."},{"key":"B138","first-page":"332","article-title":"Effectiveness of yyfzbjs and its effect on oxidative stress and inflammatory factors in the treatment of acute gouty arthritis with damp-heat paralysis and obstruction type","volume":"58","author":"Xie","year":"","journal-title":"Zhejiang J. Traditional Chin. Med."},{"key":"B139","doi-asserted-by":"publisher","first-page":"332","DOI":"10.13633\/j.cnki.zjtcm.2023.05.005","article-title":"The effect of modified coix seed, aconite, and patrinia powder on wet-heat Bi-Syndrome in acute gouty arthritis and its influence on oxidative stress and inflammatory factors","volume":"58","author":"Xie","year":"","journal-title":"Zhejiang J. Traditional Chin. Med."},{"key":"B140","doi-asserted-by":"publisher","first-page":"28","DOI":"10.19945\/j.cnki.issn.1006-3250.2022.03.001","article-title":"Correlation between clinical characteristics, gut microbiome and immune function of patients","author":"Yan","year":"2022","journal-title":"J. Basic Chin. Med"},{"key":"B141","doi-asserted-by":"publisher","first-page":"154900","DOI":"10.1016\/j.phymed.2023.154900","article-title":"Mechanistic insights into the anti-tumor and anti-metastatic effects of Patrinia villosa aqueous extract in Colon cancer via modulation of Tgf-Beta R1-Smad2\/3-E-Cadherin and fak-rhoa-cofilin pathways","volume":"117","author":"Yang","year":"","journal-title":"Phytomedicine"},{"key":"B142","first-page":"4131","article-title":"Effect of yyfzbjs on Colon carcinogenesis in mice with colitis cancer transformation model by modulating Nf-\u03bab signaling pathway","volume":"45","author":"Yang","year":"","journal-title":"Chin. Tradit. Pat. Med."},{"key":"B143","first-page":"504","article-title":"Tnf-\u03b1 promotes the proliferation of Colon cancer cells through the Wnt\/\u03b2-Catenin signaling pathway","volume":"39","author":"Yu","year":"2018","journal-title":"J. Xi'an Jiaot. Univ. Sci."},{"key":"B144","first-page":"1075","article-title":"Expression and clinical significance of Tirna-1___33-Gly-Gcc-1 in colorectal adenocarcinoma tissues","volume":"32","author":"Zhai","year":"2024","journal-title":"J. Mod. Oncol."},{"key":"B145","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.cancergen.2025.11.007","article-title":"Wdr54 enhances Nf-Kappab signaling to promote progression of hepatocellular carcinoma","author":"Zhai","year":"2025","journal-title":"Cancer Genet."},{"key":"B146","doi-asserted-by":"publisher","first-page":"856","DOI":"10.3892\/or.2014.3663","article-title":"Patrinia scabiosaefolia inhibits the proliferation of colorectal cancer in vitro and in vivo via G1\/S cell cycle arrest","volume":"33","author":"Zhang","year":"2015","journal-title":"Oncol. Rep."},{"key":"B147","doi-asserted-by":"publisher","first-page":"2642","DOI":"10.3969\/j.issn.1001-1528.2019.11.017","article-title":"Clinical effects of Yiyi Fuzi Baijiang Powder combined with mesalazine on patients with ulcerative colitis","volume":"41","author":"Zhang","year":"2019","journal-title":"Chin. Tradit. Pat. Med."},{"key":"B149","doi-asserted-by":"publisher","first-page":"870282","DOI":"10.3389\/fphar.2022.870282","article-title":"Aconiti lateralis radix praeparata as potential anticancer herb: bioactive compounds and molecular mechanisms","volume":"13","author":"Zhang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"B150","doi-asserted-by":"publisher","first-page":"240","DOI":"10.13422\/j.cnki.syfjx.20230825","article-title":"Progress on the mechanism of action of flavonoids in patriniae herba affecting colorectal cancer development","volume":"30","author":"Zhang","year":"","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"key":"B151","doi-asserted-by":"publisher","first-page":"1465387","DOI":"10.3389\/fphar.2024.1465387","article-title":"Inspired by an ancient Chinese medicine prescription: the modern significance and potential of Yiyi Fuzi Baijiang San in treating diseases","volume":"15","author":"Zhang","year":"","journal-title":"Front. Pharmacol."},{"key":"B152","first-page":"887","article-title":"Mechanism of yi-yi-fu-zi-bai-jiang-san inhibiting colorectal cancer progression in Villin-Creert2krasg12d\/+Apcflox\/+ mice: based on network pharmacology and experimental verification","volume":"48","author":"Zhang","year":"","journal-title":"Drug Eval. Res."},{"key":"B153","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.3390\/foods14071145","article-title":"Patrinia scabiosaefolia L. modulates the intestinal microecology to treat Dss-Induced ulcerative colitis: uhplc-oe-ms\/ms, network pharmacology, and experimental validation","volume":"14","author":"Zhang","year":"","journal-title":"Foods"},{"key":"B154","doi-asserted-by":"publisher","first-page":"122829","DOI":"10.1016\/j.carbpol.2024.122829","article-title":"Astragalus polysaccharides alleviate Dss-Induced ulcerative colitis in mice by restoring scfa production and regulating Th17\/Treg cell homeostasis in a microbiota-dependent manner","volume":"349","author":"Zhang","year":"","journal-title":"Carbohydr. Polym."},{"key":"B155","doi-asserted-by":"publisher","first-page":"1","DOI":"10.13193\/j.issn.1673-7717.2026.01.021","article-title":"Basing on \u201cYang Transforming Qi, Yin Shaping up Body \u201dTheory to explore the regulatory mechanism of naringenin on hepatic fibrosis","volume":"44","author":"Zhang","year":"2026","journal-title":"Chin. Archives Traditional Chin. Med."},{"key":"B156","doi-asserted-by":"crossref","unstructured":"Zheng\n              X.\n            \n          \n          Hangzhou, China: Zhejiang Chinese Medical University\n          Quercetin Inhibits Colorectal Cancer Progression by Regulating the Polarization of Tumor-Associated Macrophages Via the Fam198b Signaling Pathway\n          \n          2023","DOI":"10.1080\/21655979.2022.2075300"},{"key":"B157","article-title":"Process optimization and quality analysis of supercritical carbon dioxide extraction of coix seed oil","author":"Zheng","year":"2024","journal-title":"Sino\u2010Foreign Food Ind"},{"key":"B158","first-page":"45","article-title":"Screening of flavonoid parts of Patrinia villosa for anti-intestinal tumor activity based on spectral-effect relationship","volume":"17","author":"Zhou","year":"2021","journal-title":"Asia-Pacific Tradit. Med."},{"key":"B159","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1002\/med.21989","article-title":"The triangular relationship between traditional Chinese medicines, intestinal flora, and colorectal cancer","volume":"44","author":"Zou","year":"2024","journal-title":"Med. Res. Rev."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2026.1813778\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T10:58:06Z","timestamp":1786705086000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2026.1813778\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,14]]},"references-count":157,"alternative-id":["10.3389\/fphar.2026.1813778"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2026.1813778","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,14]]},"article-number":"1813778"}}