{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T06:27:47Z","timestamp":1786429667043,"version":"build-2736575974"},"reference-count":79,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Chronic hormonal imbalances and associated symptoms characterize ovarian cancer. PARP-1 inhibitors, such as olaparib and ruparib, are used to treat it, but new drugs are needed to overcome toxicity and resistance issues. PARP inhibition in\n                      <jats:italic>BRCA1\/2<\/jats:italic>\n                      -mutated cancer cells leads to apoptosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We synthesized silver nanoparticles (AgNPs) from\n                      <jats:italic>S. bryopteris<\/jats:italic>\n                      leaf extract, using it as a stabilizing and reducing agent. The extract was added to the AgNO\n                      <jats:sub>3<\/jats:sub>\n                      solution and maintained at room temperature for 24\u00a0h. The AgNPs were characterized using various techniques, including UV-visible and FTIR spectroscopy, SEM, EDX, Transmission Electron Microscopy, and ICP-MS analysis. The stability of AgNPs was evaluated under different pH and temperature conditions, and their anticancer activity was evaluated against SKOV3 and OVCAR-3 ovarian cancer cells using MTT assay, while IOSE80 cells were used as a non-tumorigenic ovarian epithelial cell model. The binding mechanism of phytochemicals from\n                      <jats:italic>Selaginella bryopteris<\/jats:italic>\n                      to PARP-1 was investigated using computational methods.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Selaginella bryopteris<\/jats:italic>\n                      -derived AgNPs showed stronger cytotoxicity than the plant extract against SKOV3 and OVCAR-3 ovarian cancer cells, with IC\n                      <jats:sub>50<\/jats:sub>\n                      values of 9.56 and 10.45\u00a0\u03bcg\/mL, respectively, and lower toxicity toward IOSE80 cells (IC\n                      <jats:sub>50<\/jats:sub>\n                      = 19.75\u00a0\u03bcg\/mL). AgNP treatment increased intracellular Reactive Oxygen Species levels, suggesting oxidative-stress-mediated cell death, while\n                      <jats:italic>in silico<\/jats:italic>\n                      analyses highlighted rhamnetin as a promising PARP-1-interacting phytoconstituent.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>\n                      The anticancer properties of AgNPs from\n                      <jats:italic>S<\/jats:italic>\n                      .\n                      <jats:italic>bryopteris<\/jats:italic>\n                      were investigated using analytical, pharmacological, and computational methods. Results showed the stability of AgNPs and their effectiveness against ovarian cancer cells. AgNPs from the\n                      <jats:italic>S. bryopteris<\/jats:italic>\n                      leaf extract showed stronger anticancer activity than the plant extract alone, whereas their possible use as targeted drug delivery or controlled-release platforms remains a future perspective requiring dedicated experimental investigation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphar.2026.1814120","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T05:35:10Z","timestamp":1786426510000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Selaginella bryopteris-derived silver nanoparticles against ovarian cancer cells: green synthesis, in vitro anticancer activity, and exploratory in silico analysis"],"prefix":"10.3389","volume":"17","author":[{"given":"Sangita","family":"Dey","sequence":"first","affiliation":[{"name":"Department of Biotechnology, North Bengal University","place":["Darjeeling, West Bengal, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khushbu","family":"Wadhwa","sequence":"additional","affiliation":[{"name":"Fungal Biology Laboratory, Ramjas College, University of Delhi","place":["Delhi, India"]},{"name":"Chemical Biology Lab, Hindu College, University of Delhi","place":["Delhi, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha","family":"Kumari","sequence":"additional","affiliation":[{"name":"Chemical Biology Lab, Hindu College, University of Delhi","place":["Delhi, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chetan","family":"Pandey","sequence":"additional","affiliation":[{"name":"Chemical Biology Lab, Hindu College, University of Delhi","place":["Delhi, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anoop","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, North Bengal University","place":["Darjeeling, West Bengal, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Calderone","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Pisa","place":["Pisa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Brogi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Pisa","place":["Pisa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha","family":"Kapoor","sequence":"additional","affiliation":[{"name":"Chemical Biology Lab, Hindu College, University of Delhi","place":["Delhi, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2121","DOI":"10.1002\/jemt.24587","article-title":"Radical scavenging potential of spectrophotometric, spectroscopic, microscopic, and EDX observed zinc oxide nanoparticles from leaves, buds, and flowers extract of Bauhinia Variegata Linn: a thorough comparative insight","volume":"87","author":"Abbas","year":"2024","journal-title":"Microsc. 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