{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T06:03:08Z","timestamp":1781071388434,"version":"3.54.1"},"reference-count":19,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Aspirin-induced gastritis results from reduced prostaglandin synthesis and increased oxidative stress, compromising gastric mucosal integrity. While omeprazole effectively suppresses gastric acid secretion, it does not directly promote mucosal regeneration. Striatin, a bioactive fraction of\n                      <jats:italic>Channa striata<\/jats:italic>\n                      , has anti-inflammatory and regenerative properties and may enhance mucosal healing.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study aimed to evaluate whether adjunctive striatin at escalating doses enhances the therapeutic effect of omeprazole in aspirin-induced gastric injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A controlled experimental study was conducted in 30 male Wistar rats randomly assigned into six groups (n = 5 each): healthy control, negative control, omeprazole monotherapy (20\u00a0mg\/kg BW), and three combination groups receiving omeprazole plus striatin (500, 1,000, and 1,500\u00a0mg\/kg BW). Gastric injury was induced using aspirin. Vascular endothelial growth factor (VEGF; day 2) and intestinal trefoil factor (ITF; day 14) were measured as markers of angiogenesis and epithelial restitution, respectively. Histological and macroscopic assessments were performed at the end of treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results and Discussion<\/jats:title>\n                    <jats:p>\n                      VEGF levels did not significantly differ across groups. In contrast, ITF significantly increased in the highest-dose striatin group (1,500\u00a0mg\/kg BW,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.007), which also demonstrated improved epithelial thickness, reduced ulcer area, and lower inflammation scores. Lower doses did not produce significant changes in ITF levels.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Adjunctive striatin, particularly at higher doses, enhances gastric mucosal healing primarily through epithelial restitution rather than angiogenesis. These findings suggest potential adjunctive benefits, although further studies are needed to establish optimal dosing and clinical relevance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphar.2026.1816185","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T05:41:57Z","timestamp":1781070117000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative effects of combined omeprazole and dose-escalated striatin therapy versus monotherapy on VEGF, ITF, gastric ulcer area, epithelial thickness, and inflammatory response in rats with aspirin-induced gastric injury"],"prefix":"10.3389","volume":"17","author":[{"given":"Hery Djagat","family":"Purnomo","sequence":"first","affiliation":[{"name":"Division of Gastroentero-Hepatology, Department of Medicine, Faculty of Medicine, Universitas Diponegoro\/Dr. Kariadi Central General Hospital","place":["Semarang, Indonesia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meita","family":"Hendrianingtyas","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Faculty of Medicine, Universitas Diponegoro","place":["Semarang, Indonesia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Rachman","sequence":"additional","affiliation":[{"name":"Specialist Medical Education Program, Department of Medicine, Faculty of Medicine, Universitas Diponegoro\/Dr. Kariadi Central General Hospital","place":["Semarang, Indonesia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah Nadya","family":"Roosana","sequence":"additional","affiliation":[{"name":"Specialist Medical Education Program, Department of Medicine, Faculty of Medicine, Universitas Diponegoro\/Dr. Kariadi Central General Hospital","place":["Semarang, Indonesia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didik","family":"Indiarso","sequence":"additional","affiliation":[{"name":"Division of Gastroentero-Hepatology, Department of Medicine, Faculty of Medicine, Universitas Diponegoro\/Dr. Kariadi Central General Hospital","place":["Semarang, Indonesia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hesti Triwahyu","family":"Hutami","sequence":"additional","affiliation":[{"name":"Division of Gastroentero-Hepatology, Department of Medicine, Faculty of Medicine, Universitas Diponegoro\/Dr. Kariadi Central General Hospital","place":["Semarang, Indonesia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia Oktaria","family":"Permatadewi","sequence":"additional","affiliation":[{"name":"Division of Gastroentero-Hepatology, Department of Medicine, Faculty of Medicine, Universitas Diponegoro\/Dr. Kariadi Central General Hospital","place":["Semarang, Indonesia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermawan","family":"Istiadi","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology, Faculty of Medicine, Universitas Diponegoro","place":["Semarang, Indonesia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pulong Wijang","family":"Pralampita","sequence":"additional","affiliation":[{"name":"Coordinator of Animal Laboratory, Faculty of Medicine, Universitas Diponegoro, Dr. Kariadi Central General Hospital","place":["Semarang, Indonesia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Dharminto","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Population, Faculty of Public Health, Universitas Diponegoro","place":["Semarang, Indonesia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond R.","family":"Tjandrawinata","sequence":"additional","affiliation":[{"name":"School of Bioscience, Technology and Innovation, Atma Jaya Catholic University of Indonesia","place":["Jakarta, Indonesia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"327606","DOI":"10.1155\/2014\/327606","article-title":"Gastroprotective effect of freeze-dried stripped snakehead fish (Channa striata Bloch.) aqueous extract against aspirin-induced ulcerogenesis in pylorus ligated rats","volume":"2014","author":"Ali Khan","year":"2014","journal-title":"ISRN Pharmacol."},{"key":"B2","first-page":"143","article-title":"Antiulcer activity of methanol-chloroform extract of Channa striatus fillet","volume":"31","author":"Azemi","year":"2018","journal-title":"Pak J. 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