{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:18:07Z","timestamp":1791591487104,"version":"4.3.4"},"reference-count":37,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Perinatal depression (PND) is a prevalent and serious mental health concern affecting women during pregnancy and the postpartum period. Although several drugs have been implicated in PND etiology in previous studies, large-scale systematic evaluations of drug-associated PND using real-world pharmacovigilance data remain scarce.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective pharmacovigilance study utilizing the FDA Adverse Event Reporting System data spanning from Q1 2004 to Q2 2025. Disproportionality analysis, logistic regression, LASSO regression, and time-to-onset analysis were employed to examine drug-PND associations from multiple analytical perspectives.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Disproportionality analyses identified 28 drugs with positive signals as potentially associated with PND. Multi-factor analysis identified age under 26 years, weight exceeding 74\u00a0kg, and use of sodium oxybate, levonorgestrel, ethinylestradiol\/etonogestrel, or lurasidone as independent risk factors for drug-related PND. The model achieved a ROC-AUC of 0.907, indicating excellent discriminatory performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study identified specific drugs and demographic factors associated with PND risk, offering valuable insights for pharmacovigilance and clinical medication management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphar.2026.1820606","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T05:42:18Z","timestamp":1777009338000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Real world pharmacovigilance assessment of drug related perinatal depression risks"],"prefix":"10.3389","volume":"17","author":[{"given":"Jie-Hai","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Dongguan Maternal and Child Healthcare Hospital","place":["Dongguan, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Ming","family":"Luo","sequence":"additional","affiliation":[{"name":"Dongguan Maternal and Child Healthcare Hospital","place":["Dongguan, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Yan","family":"Tu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Dongguan Maternal and Child Healthcare Hospital","place":["Dongguan, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e208","DOI":"10.1097\/AOG.0000000000002927","article-title":"757: screening for perinatal depression","volume":"132","year":"2018","journal-title":"Obstetrics and Gynecol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1007\/s00127-022-02386-9","article-title":"Prevalence and correlates of perinatal depression","volume":"58","author":"Al-abri","year":"2023","journal-title":"Soc. 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