{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T05:08:37Z","timestamp":1779253717044,"version":"3.51.4"},"reference-count":201,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>The ability to generate and regulate energy, maintain metabolic flux, and preserve redox homeostasis is the basis of all cellular processes in both healthy and diseased tissues. While the importance of glycolytic metabolism in cancer biology is well established, the clinical translation of metabolic targeting strategies remains limited. A deeper understanding of how energy flux is regulated and how metabolic enzymes contribute to cell survival, proliferation, differentiation, and therapy response will help identify cancer-specific metabolic dependencies and drive novel therapeutic approaches. Recent advances in molecular and metabolic profiling have highlighted the multifaceted roles of glycolytic enzymes beyond their canonical functions. In this review, we summarize current knowledge on glycolytic enzymes and their involvement in normal and malignant myelopoiesis, with a particular focus on acute myeloid leukemia (AML). AML cells exhibit high glycolytic activity and frequently overexpress key glycolytic enzymes. Beyond their metabolic functions, these enzymes also exert regulatory roles in signaling, transcriptional control, and redox balance. Here, we discuss both the canonical and non-canonical functions of glycolytic enzymes and evaluate their potential as therapeutic targets in AML.<\/jats:p>","DOI":"10.3389\/fphar.2026.1823211","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T04:35:37Z","timestamp":1779251737000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Glycolysis and glycolytic enzymes in acute myeloid leukemia: Warburg and beyond"],"prefix":"10.3389","volume":"17","author":[{"given":"Kristina","family":"Seiler","sequence":"first","affiliation":[{"name":"Institute of Tissue Medicine and Pathology, University of Bern","place":["Bern, Switzerland"]},{"name":"Graduate School of Cellular and Biomedical Sciences, University of Bern","place":["Bern, Switzerland"]},{"name":"Department of Pediatrics, School of Medicine, University of Washington","place":["Seattle, WA, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasmeen H.","family":"Mady","sequence":"additional","affiliation":[{"name":"Institute of Tissue Medicine and Pathology, University of Bern","place":["Bern, Switzerland"]},{"name":"Graduate School of Cellular and Biomedical Sciences, University of Bern","place":["Bern, Switzerland"]},{"name":"Department of Clinical Pathology, South Egypt Cancer Institute, Assiut University","place":["Assiut, Egypt"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce E.","family":"Torbett","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine, University of Washington","place":["Seattle, WA, United States"]},{"name":"Center for Immunity and Immunotherapies, Seattle Children\u2019s Research Institute","place":["Seattle, WA, United States"]},{"name":"Institute for Stem Cell and Regenerative Medicine","place":["Seattle, WA, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Emmanuel","family":"Sarry","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Toulouse, Centre de Recherches en Canc\u00e9rologie de Toulouse, Inserm, CNRS","place":["Toulouse, France"]},{"name":"Centre Hospitalier Universitaire de Toulouse","place":["Toulouse, France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario P.","family":"Tschan","sequence":"additional","affiliation":[{"name":"Institute of Tissue Medicine and Pathology, University of Bern","place":["Bern, Switzerland"]},{"name":"Graduate School of Cellular and Biomedical Sciences, University of Bern","place":["Bern, Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.3324\/haematol.2020.246843","volume":"106","author":"\u00c5backa","year":"2021","journal-title":"Target. GLUT1 Acute Myeloid Leukemia Overcome Cytarabine Resistance"},{"key":"B2","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1016\/j.leukres.2010.12.028","article-title":"Targeting glycolysis in leukemia: a novel inhibitor 3-BrOP in combination with rapamycin","volume":"35","author":"Akers","year":"2011","journal-title":"Leuk. Res."},{"key":"B3","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.ccell.2018.02.008","article-title":"Glucose metabolism in cancer - the Saga of pyruvate kinase continues","volume":"33","author":"Allen","year":"2018","journal-title":"Cancer Cell"},{"key":"B4","doi-asserted-by":"publisher","first-page":"20230587","DOI":"10.1098\/rsif.2023.0587","article-title":"Evolutionary dynamics of glucose-deprived cancer cells: insights from experimentally informed mathematical modelling","volume":"21","author":"Almeida","year":"2024","journal-title":"J. R. Soc. Interface."},{"key":"B5","doi-asserted-by":"publisher","first-page":"3597","DOI":"10.1158\/1078-0432.CCR-20-0184","article-title":"RNA splicing alterations induce a cellular stress response associated with poor prognosis in Acute Myeloid leukemia","volume":"26","author":"Anande","year":"2020","journal-title":"Clin. Cancer Res."},{"key":"B6","doi-asserted-by":"publisher","first-page":"56081","DOI":"10.18632\/oncotarget.9760","article-title":"Hexokinase 2 promotes tumor growth and metastasis by regulating lactate production in pancreatic cancer","volume":"8","author":"Anderson","year":"2017","journal-title":"Oncotarget"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1847","DOI":"10.4049\/jimmunol.1004085","article-title":"2-Deoxy d-Glucose prevents cell surface expression of NKG2D ligands through inhibition of N-Linked glycosylation","volume":"188","author":"Andresen","year":"2012","journal-title":"J. Immunol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1038\/s41591-019-0601-5","article-title":"Expansion of primitive human hematopoietic stem cells by culture in a zwitterionic hydrogel","volume":"25","author":"Bai","year":"2019","journal-title":"Nat. Med."},{"key":"B9","doi-asserted-by":"publisher","first-page":"eade7652","DOI":"10.1126\/sciimmunol.ade7652","article-title":"Hexokinase dissociation from mitochondria promotes oligomerization of VDAC that facilitates NLRP3 inflammasome assembly and activation","volume":"8","author":"Baik","year":"2023","journal-title":"Sci. Immunol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1038\/s41375-018-0252-4","article-title":"Targeting quiescent leukemic stem cells using second generation autophagy inhibitors","volume":"33","author":"Baquero","year":"2019","journal-title":"Leukemia"},{"key":"B11","doi-asserted-by":"publisher","first-page":"67639","DOI":"10.18632\/oncotarget.18797","article-title":"Acute myeloid leukemia cells require 6-phosphogluconate dehydrogenase for cell growth and NADPH-dependent metabolic reprogramming","volume":"8","author":"Bhanot","year":"2017","journal-title":"Oncotarget"},{"key":"B12","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1158\/0008-5472.CAN-24-0019","article-title":"Targeting metabolic dependencies fueling the TCA cycle to circumvent therapy resistance in Acute Myeloid leukemia","volume":"84","author":"Bo\u00ebt","year":"2024","journal-title":"Cancer Res."},{"key":"B13","doi-asserted-by":"publisher","first-page":"4591","DOI":"10.1016\/S0021-9258(18)96996-6","article-title":"The biosynthesis of serine in mouse brain extracts","volume":"240","author":"Bridgers","year":"1965","journal-title":"J. Biol. Chem."},{"key":"B14","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1186\/s13045-021-01076-4","article-title":"Targeting the metabolic vulnerability of acute myeloid leukemia blasts with a combination of venetoclax and 8-chloro-adenosine","volume":"14","author":"Buettner","year":"2021","journal-title":"J. Hematol. and Oncol."},{"key":"B15","first-page":"1013","volume-title":"Principles of biochemistry","author":"Campbell","year":"1993"},{"key":"B16","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1158\/2159-8290.CD-12-0345","article-title":"Cancer cell metabolism: one hallmark, many faces","volume":"2","author":"Cantor","year":"2012","journal-title":"Cancer Discov."},{"key":"B17","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.cell.2017.03.023","article-title":"Physiologic Medium rewires cellular metabolism and reveals uric acid as an endogenous inhibitor of UMP synthase","volume":"169","author":"Cantor","year":"2017","journal-title":"Cell"},{"key":"B18","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1042\/bj3350691","article-title":"Demonstration of a RNA-dependent nuclear interaction between the promyelocytic leukaemia protein and glyceraldehyde-3-phosphate dehydrogenase","volume":"335","author":"Carlile","year":"1998","journal-title":"Biochem. J."},{"key":"B19","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1186\/1476-4598-13-164","article-title":"Aldolase positively regulates of the canonical Wnt signaling pathway","volume":"13","author":"Caspi","year":"2014","journal-title":"Mol. Cancer"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.1038\/s41375-023-01946-5","article-title":"MCL1 regulates AML cells metabolism via direct interaction with HK2. Metabolic signature at onset predicts overall survival in AMLs\u2019 patients","volume":"37","author":"Catalano","year":"2023","journal-title":"Leukemia"},{"key":"B21","doi-asserted-by":"publisher","first-page":"100966","DOI":"10.1016\/j.crmeth.2025.100966","article-title":"Refined culture conditions with increased physiological relevance uncover oncogene-dependent metabolic signatures in Ewing sarcoma spheroids","volume":"5","author":"Ceranski","year":"2025","journal-title":"Cell Rep. Methods"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2015\/690492","article-title":"Reviving lonidamine and 6-Diazo-5-oxo-L-norleucine to be used in combination for metabolic cancer therapy","volume":"2015","author":"Cervantes-Madrid","year":"2015","journal-title":"BioMed Res. Int."},{"key":"B23","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1016\/j.molcel.2015.10.037","article-title":"AMPK-Dependent phosphorylation of GAPDH triggers Sirt1 activation and is necessary for autophagy upon glucose starvation","volume":"60","author":"Chang","year":"","journal-title":"Mol. Cell"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1016\/j.cell.2015.08.016","article-title":"Metabolic competition in the tumor microenvironment is a driver of cancer progression","volume":"162","author":"Chang","year":"","journal-title":"Cell"},{"key":"B25","doi-asserted-by":"publisher","first-page":"4754","DOI":"10.1158\/0008-5472.CAN-18-4080","article-title":"Therapeutic targeting of aldolase A interactions inhibits lung cancer metastasis and prolongs survival","volume":"79","author":"Chang","year":"2019","journal-title":"Cancer Res."},{"key":"B26","doi-asserted-by":"publisher","first-page":"107059","DOI":"10.1016\/j.leukres.2023.107059","article-title":"Glucose induced-AKT\/mTOR activation accelerates glycolysis and promotes cell survival in acute myeloid leukemia","volume":"128","author":"Chen","year":"2023","journal-title":"Leukemia Res."},{"key":"B27","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1038\/s41420-024-01823-9","article-title":"Crosstalk between autophagy and metabolism: implications for cell survival in acute myeloid leukemia","volume":"10","author":"Chen","year":"2024","journal-title":"Cell Death Discov."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1589943","DOI":"10.3389\/fimmu.2025.1589943","article-title":"Driving innovations in cancer research through spatial metabolomics: a bibliometric review of trends and hotspot","volume":"16","author":"Chen","year":"2025","journal-title":"Front. Immunol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"44186","DOI":"10.1038\/srep44186","article-title":"ENOblock, a unique small molecule inhibitor of the non-glycolytic functions of enolase, alleviates the symptoms of type 2 diabetes","volume":"7","author":"Cho","year":"2017","journal-title":"Sci. Rep."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1016\/j.cellsig.2011.03.004","article-title":"Nuclear localization of pyruvate dehydrogenase complex-E2 (PDC-E2), a mitochondrial enzyme, and its role in signal transducer and activator of transcription 5 (STAT5)-dependent gene transcription","volume":"23","author":"Chueh","year":"2011","journal-title":"Cell Signal"},{"key":"B31","doi-asserted-by":"crossref","first-page":"11","DOI":"10.18388\/abp.2006_3360","article-title":"Metabolic enzymes that bind RNA: yet another level of cellular regulatory network?","volume":"53","author":"Cie\u015bla","year":"2006","journal-title":"Acta Biochim. Pol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"e49117","DOI":"10.15252\/embr.201949117","article-title":"Hexokinase 2 displacement from mitochondria-associated membranes prompts Ca2+-dependent death of cancer cells","volume":"21","author":"Ciscato","year":"2020","journal-title":"EMBO Reports"},{"key":"B33","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.molmed.2020.10.001","article-title":"Extinguishing the embers: targeting AML metabolism","volume":"27","author":"Culp-Hill","year":"2021","journal-title":"Trends Mol. Med."},{"key":"B34","doi-asserted-by":"publisher","first-page":"26894","DOI":"10.1074\/jbc.M804307200","article-title":"Histone 2B (H2B) expression is confined to a proper NAD+\/NADH redox status","volume":"283","author":"Dai","year":"2008","journal-title":"J. Biol. Chem."},{"key":"B35","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1038\/nature08617","article-title":"Cancer-associated IDH1 mutations produce 2-hydroxyglutarate","volume":"462","author":"Dang","year":"2009","journal-title":"Nature"},{"key":"B36","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.cmet.2016.01.007","article-title":"Environment impacts the metabolic dependencies of ras-driven non-small cell lung cancer","volume":"23","author":"Davidson","year":"2016","journal-title":"Cell Metab."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.3390\/ph16071021","article-title":"The effects of green tea catechins in hematological malignancies","volume":"16","author":"Della Via","year":"2023","journal-title":"Pharmaceuticals"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1038\/s41375-023-01912-1","article-title":"Glucose partitioning in the bone marrow micro-environment in acute myeloid leukaemia","volume":"37","author":"Deng","year":"2023","journal-title":"Leukemia"},{"key":"B39","doi-asserted-by":"publisher","first-page":"8202","DOI":"10.18632\/oncotarget.1159","article-title":"Tissue-specific isoform switch and DNA hypomethylation of the pyruvate kinase PKM gene in human cancers","volume":"5","author":"Desai","year":"2013","journal-title":"Oncotarget"},{"key":"B40","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1358\/dot.2003.39.3.799451","article-title":"Lonidamine: efficacy and safety in clinical trials for thetreatment of solid tumors","volume":"39","author":"Di Cosimo","year":"2003","journal-title":"Drugs Today"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1182\/blood.2022016867","article-title":"Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN","volume":"140","author":"D\u00f6hner","year":"2022","journal-title":"Blood"},{"key":"B42","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1038\/bjc.2016.26","article-title":"Hexokinase 2 is a determinant of neuroblastoma metastasis","volume":"114","author":"Edry Botzer","year":"2016","journal-title":"Br. J. Cancer"},{"key":"B43","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/j.tcb.2022.11.004","article-title":"Contribution of metabolic abnormalities to acute myeloid leukemia pathogenesis","volume":"33","author":"Egan","year":"2023","journal-title":"Trends Cell Biol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"35803","DOI":"10.1074\/jbc.M402768200","article-title":"Phosphoglycerate mutase-derived polypeptide inhibits glycolytic flux and induces cell growth arrest in tumor cell lines","volume":"279","author":"Engel","year":"2004","journal-title":"J. Biol. Chem."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.15252\/embj.201490379","article-title":"Aerobic glycolysis tunes YAP\/TAZ transcriptional activity","volume":"34","author":"Enzo","year":"2015","journal-title":"EMBO J."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1038\/s41467-022-28737-3","article-title":"The Glycolytic Gatekeeper PDK1 defines different metabolic states between genetically distinct subtypes of human acute myeloid leukemia","volume":"13","author":"Erdem","year":"2022","journal-title":"Nat. Commun."},{"key":"B47","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1038\/nbt1149","article-title":"Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling","volume":"23","author":"Evans","year":"2005","journal-title":"Nat. Biotechnol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1880","DOI":"10.1021\/pr501286b","article-title":"Most highly expressed protein-coding genes have a single dominant isoform","volume":"14","author":"Ezkurdia","year":"2015","journal-title":"J. Proteome Res."},{"key":"B49","doi-asserted-by":"publisher","first-page":"317","DOI":"10.3390\/cancers11030317","article-title":"Tumor energy metabolism and potential of 3-Bromopyruvate as an inhibitor of aerobic glycolysis: implications in tumor treatment","volume":"11","author":"Fan","year":"2019","journal-title":"Cancers"},{"key":"B50","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1158\/2159-8290.CD-16-0441","article-title":"Chemotherapy-Resistant human acute myeloid leukemia cells are not enriched for leukemic stem cells but require oxidative metabolism","volume":"7","author":"Farge","year":"2017","journal-title":"Cancer Discov."},{"key":"B51","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1016\/j.bbrc.2017.01.031","article-title":"mTOR up-regulation of PFKFB3 is essential for acute myeloid leukemia cell survival","volume":"483","author":"Feng","year":"2017","journal-title":"Biochem. Biophysical Res. Commun."},{"key":"B52","doi-asserted-by":"publisher","first-page":"3812","DOI":"10.1182\/blood-2006-07-035972","article-title":"Inhibitory effect of tumor cell\u2013derived lactic acid on human T cells","volume":"109","author":"Fischer","year":"2007","journal-title":"Blood"},{"key":"B53","first-page":"4661","article-title":"Effect of lonidamine on the energy metabolism of ehrlich ascites tumor cells","volume":"41","author":"Floridi","year":"1981","journal-title":"Cancer Res."},{"key":"B54","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1038\/nri1710","article-title":"Fuel feeds function: energy metabolism and the T-cell response","volume":"5","author":"Fox","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/S1074-7613(02)00323-0","article-title":"The CD28 signaling pathway regulates glucose metabolism","volume":"16","author":"Frauwirth","year":"2002","journal-title":"Immunity"},{"key":"B56","doi-asserted-by":"publisher","first-page":"115286","DOI":"10.1016\/j.ejmech.2023.115286","article-title":"Discovery of a spirocyclic 3-bromo-4,5-dihydroisoxazole covalent inhibitor of hGAPDH with antiproliferative activity against pancreatic cancer cells","volume":"254","author":"Galbiati","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"B57","first-page":"4909","article-title":"Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is pyruvylated during 3-bromopyruvate mediated cancer cell death","volume":"29","author":"Ganapathy-Kanniappan","year":"2009","journal-title":"Anticancer Res."},{"key":"B58","volume-title":"PGK1, a promising biomarker and therapeutic target for patients with acute myeloid leukemia who are susceptible to disease relapse","author":"Gao","year":"2021"},{"key":"B59","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41419-019-1968-4","article-title":"Targeting a moonlighting function of aldolase induces apoptosis in cancer cells","volume":"10","author":"Gizak","year":"2019","journal-title":"Cell Death and Dis."},{"key":"B60","doi-asserted-by":"publisher","first-page":"12193","DOI":"10.1021\/bi00038a013","article-title":"Rapid plasmenylethanolamine-selective fusion of membrane bilayers catalyzed by an isoform of glyceraldehyde-3-phosphate dehydrogenase: discrimination between glycolytic and fusogenic roles of individual isoforms","volume":"34","author":"Glaser","year":"1995","journal-title":"Biochemistry"},{"key":"B61","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1134\/S0026893322050077","article-title":"Physiological media in studies of cell metabolism","volume":"56","author":"Golikov","year":"2022","journal-title":"Mol. Biol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"R70","DOI":"10.1186\/gb-2013-14-7-r70","article-title":"Transcriptome analysis of human tissues and cell lines reveals one dominant transcript per gene","volume":"14","author":"Gonz\u00e0lez-Porta","year":"2013","journal-title":"Genome Biol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"2013","DOI":"10.1182\/blood-2005-05-1795","article-title":"Tumor-derived lactic acid modulates dendritic cell activation and antigen expression","volume":"107","author":"Gottfried","year":"2006","journal-title":"Blood"},{"key":"B64","doi-asserted-by":"publisher","first-page":"682461","DOI":"10.3389\/fonc.2021.682461","article-title":"PGK1 is a key target for anti-glycolytic therapy of ovarian cancer: based on the comprehensive analysis of glycolysis-related genes","volume":"11","author":"Gou","year":"2021","journal-title":"Front. Oncol."},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.3390\/cells9051155","article-title":"Targeting cellular metabolism in Acute Myeloid leukemia and the role of patient heterogeneity","volume":"9","author":"Gr\u00f8nnings\u00e6ter","year":"2020","journal-title":"Cells"},{"key":"B66","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1208\/s12248-020-00466-9","article-title":"In vitro and in vivo efficacy of AZD3965 and Alpha-Cyano-4-Hydroxycinnamic acid in the Murine 4T1 breast tumor model","volume":"22","author":"Guan","year":"2020","journal-title":"AAPS J."},{"key":"B67","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1084\/jem.20161087","article-title":"Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions","volume":"214","author":"Guitart","year":"2017","journal-title":"J. Exp. Med."},{"key":"B68","doi-asserted-by":"publisher","first-page":"104463","DOI":"10.1016\/j.phrs.2019.104463","article-title":"Pharmacological properties and derivatives of shikonin\u2014A review in recent years","volume":"149","author":"Guo","year":"2019","journal-title":"Pharmacol. Res."},{"key":"B69","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1111\/j.1432-1033.1993.tb17637.x","article-title":"The role of the crabtree effect and an endogenous fuel in the energy metabolism of resting and proliferating thymocytes","volume":"212","author":"Guppy","year":"1993","journal-title":"Eur. J. Biochem."},{"key":"B70","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1042\/bj3640309","article-title":"Contribution by different fuels and metabolic pathways to the total ATP turnover of proliferating MCF-7 breast cancer cells","volume":"364","author":"Guppy","year":"2002","journal-title":"Biochem. J."},{"key":"B71","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1158\/1078-0432.CCR-22-2263","article-title":"A phase I dose-escalation study of AZD3965, an oral monocarboxylate transporter 1 inhibitor, in patients with advanced cancer","volume":"29","author":"Halford","year":"2023","journal-title":"Clin. Cancer Res."},{"key":"B72","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/s44324-024-00017-2","article-title":"Beyond glucose and Warburg: finding the sweet spot in cancer metabolism models","volume":"2","author":"Hammond","year":"2024","journal-title":"Npj Metab. Health Dis."},{"key":"B73","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"B74","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1038\/ncb1268","article-title":"S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding","volume":"7","author":"Hara","year":"2005","journal-title":"Nat. Cell Biol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"4004","DOI":"10.1038\/s41467-018-06353-4","article-title":"Cell-specific proteome analyses of human bone marrow reveal molecular features of age-dependent functional decline","volume":"9","author":"Hennrich","year":"2018","journal-title":"Nat. Commun."},{"key":"B76","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/j.cell.2015.12.034","article-title":"Metabolic heterogeneity in human lung tumors","volume":"164","author":"Hensley","year":"2016","journal-title":"Cell"},{"key":"B77","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1189\/jlb.0710417","article-title":"The level of glycolytic metabolism in acute myeloid leukemia blasts at diagnosis is prognostic for clinical outcome","volume":"89","author":"Herst","year":"2011","journal-title":"J. Leukoc. Biol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.ccr.2012.09.020","article-title":"Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth","volume":"22","author":"Hitosugi","year":"2012","journal-title":"Cancer Cell"},{"key":"B79","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1016\/j.cell.2015.08.012","article-title":"Phosphoenolpyruvate is a metabolic checkpoint of anti-tumor T cell responses","volume":"162","author":"Ho","year":"2015","journal-title":"Cell"},{"key":"B80","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1038\/nature21388","article-title":"Autophagy maintains the metabolism and function of young and old stem cells","volume":"543","author":"Ho","year":"2017","journal-title":"Nature"},{"key":"B81","doi-asserted-by":"publisher","first-page":"4829","DOI":"10.1128\/MCB.00175-08","article-title":"The activated Notch1 receptor cooperates with alpha-enolase and MBP-1 in modulating c-myc activity","volume":"28","author":"Hsu","year":"2008","journal-title":"Mol. Cell Biol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"4056","DOI":"10.7150\/thno.40860","article-title":"Tumor-intrinsic CD47 signal regulates glycolysis and promotes colorectal cancer cell growth and metastasis","volume":"10","author":"Hu","year":"2020","journal-title":"Theranostics"},{"key":"B83","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1038\/ni.2956","article-title":"Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages","volume":"15","author":"Huang","year":"2014","journal-title":"Nat. Immunol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"3332","DOI":"10.3390\/cancers12113332","article-title":"The potential of lonidamine in combination with chemotherapy and physical therapy in cancer treatment","volume":"12","author":"Huang","year":"2020","journal-title":"Cancers"},{"key":"B85","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1042\/bj1740703","article-title":"Aerobic glycolysis and lymphocyte transformation","volume":"174","author":"Hume","year":"1978","journal-title":"Biochem. J."},{"key":"B86","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1146\/annurev-biochem-061516-044820","article-title":"Mechanisms of autophagy initiation","volume":"86","author":"Hurley","year":"2017","journal-title":"Annu. Rev. Biochem."},{"key":"B87","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1046\/j.1471-4159.1996.66030928.x","article-title":"Evidence that glyceraldehyde-3-phosphate dehydrogenase is involved in age-induced apoptosis in mature cerebellar neurons in culture","volume":"66","author":"Ishitani","year":"1996","journal-title":"J. Neurochem."},{"key":"B88","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.exphem.2018.05.005","article-title":"Hematopoietic stem cell fate through metabolic control","volume":"64","author":"Ito","year":"2018","journal-title":"Exp. Hematol."},{"key":"B89","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1016\/j.ccell.2018.10.005","article-title":"Inhibition of amino acid metabolism selectively targets human leukemia stem cells","volume":"34","author":"Jones","year":"2018","journal-title":"Cancer Cell"},{"key":"B90","doi-asserted-by":"publisher","first-page":"2143","DOI":"10.1038\/leu.2017.45","article-title":"ITD mutation in FLT3 tyrosine kinase promotes warburg effect and renders therapeutic sensitivity to glycolytic inhibition","volume":"31","author":"Ju","year":"2017","journal-title":"Leukemia"},{"key":"B91","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1038\/cr.2015.68","article-title":"Metabolic reprogramming in macrophages and dendritic cells in innate immunity","volume":"25","author":"Kelly","year":"2015","journal-title":"Cell Res."},{"key":"B92","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1007\/s12272-019-01115-2","article-title":"Targeting cancer energy metabolism: a potential systemic cure for cancer","volume":"42","author":"Kim","year":"2019","journal-title":"Archives Pharmacal Res."},{"key":"B93","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/j.cmet.2019.08.013","article-title":"Mechanisms and implications of metabolic heterogeneity in cancer","volume":"30","author":"Kim","year":"2019","journal-title":"Cell Metab."},{"key":"B94","doi-asserted-by":"publisher","first-page":"3969","DOI":"10.1038\/s41598-019-40617-3","article-title":"A novel lactate dehydrogenase inhibitor, 1-(Phenylseleno)-4-(Trifluoromethyl) benzene, suppresses tumor growth through apoptotic cell death","volume":"9","author":"Kim","year":"2019","journal-title":"Sci. Rep."},{"key":"B95","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1038\/s42255-020-0256-z","article-title":"Metabolic conditioning of CD8 + effector T cells for adoptive cell therapy","volume":"2","author":"Klein Geltink","year":"2020","journal-title":"Nat. Metab."},{"key":"B96","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.ccr.2006.10.006","article-title":"Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia","volume":"10","author":"Konopleva","year":"2006","journal-title":"Cancer Cell"},{"key":"B97","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1093\/oxfordjournals.jbchem.a134260","article-title":"A porcine brain protein (35 K protein) which bundles microtubules and its identification as glyceraldehyde 3-phosphate dehydrogenase","volume":"93","author":"Kumagai","year":"1983","journal-title":"J. Biochem."},{"key":"B98","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.stem.2012.12.013","article-title":"BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells","volume":"12","author":"Lagadinou","year":"2013","journal-title":"Cell Stem Cell"},{"key":"B99","doi-asserted-by":"publisher","first-page":"2364","DOI":"10.1158\/1535-7163.MCT-15-0163","article-title":"Antileukemic activity of 2-Deoxy-d-Glucose through inhibition of N-Linked glycosylation in acute myeloid leukemia with FLT3-ITD or c-KIT mutations","volume":"14","author":"Larrue","year":"2015","journal-title":"Mol. Cancer Ther."},{"key":"B100","doi-asserted-by":"publisher","first-page":"3991","DOI":"10.1128\/MCB.00165-09","article-title":"Glycolytic flux signals to mTOR through glyceraldehyde-3-phosphate dehydrogenase-mediated regulation of Rheb","volume":"29","author":"Lee","year":"2009","journal-title":"Mol. Cell Biol."},{"key":"B101","doi-asserted-by":"publisher","first-page":"100740","DOI":"10.1016\/j.omto.2023.100740","article-title":"Targeting the lactic acid metabolic pathway for antitumor therapy","volume":"31","author":"Li","year":"2023","journal-title":"Mol. Ther. - Oncolytics"},{"key":"B102","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1038\/nature13557","article-title":"Fructose-1,6-bisphosphatase opposes renal carcinoma progression","volume":"513","author":"Li","year":"2014","journal-title":"Nature"},{"key":"B103","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1016\/j.molcel.2016.02.009","article-title":"Mitochondria-Translocated PGK1 functions as a protein kinase to coordinate glycolysis and the TCA cycle in tumorigenesis","volume":"61","author":"Li","year":"2016","journal-title":"Mol. Cell"},{"key":"B104","doi-asserted-by":"publisher","first-page":"325","DOI":"10.3389\/fphar.2017.00325","article-title":"Identification of Epigallocatechin-3- gallate as an inhibitor of phosphoglycerate mutase 1","volume":"8","author":"Li","year":"2017","journal-title":"Front. Pharmacol."},{"key":"B105","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1016\/j.cmet.2017.08.017","article-title":"A predictive model for selective targeting of the warburg effect through GAPDH inhibition with a natural product","volume":"26","author":"Liberti","year":"2017","journal-title":"Cell Metab."},{"key":"B106","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1038\/s41568-019-0198-5","article-title":"A framework for examining how diet impacts tumour metabolism","volume":"19","author":"Lien","year":"2019","journal-title":"Nat. Rev. Cancer"},{"key":"B107","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1021\/acsmedchemlett.5b00214","article-title":"Discovery of a novel 2,6-Disubstituted glucosamine series of potent and selective hexokinase 2 inhibitors","volume":"7","author":"Lin","year":"2016","journal-title":"ACS Med. Chem. Lett."},{"key":"B108","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1038\/s42255-020-00313-3","article-title":"An enolase inhibitor for the targeted treatment of ENO1-deleted cancers","volume":"2","author":"Lin","year":"2020","journal-title":"Nat. Metab."},{"key":"B109","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1111\/j.1432-1033.1969.tb00721.x","article-title":"Mechanism of peroxide-inactivation of the sulphydryl enzyme Glyceraldehyde-3-Phosphate dehydrogenase","volume":"10","author":"Little","year":"1969","journal-title":"Eur. J. Biochem."},{"key":"B110","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.3727\/096504018X15166223632406","article-title":"Phosphoglycerate mutase 1 (PGAM1) promotes pancreatic ductal adenocarcinoma (PDAC) metastasis by acting as a novel downstream target of the PI3K\/Akt\/mTOR pathway","volume":"26","author":"Liu","year":"","journal-title":"Oncol. Res."},{"key":"B111","doi-asserted-by":"publisher","first-page":"4429","DOI":"10.1038\/s41467-018-06841-7","article-title":"Nuclear lactate dehydrogenase A senses ROS to produce \u03b1-hydroxybutyrate for HPV-induced cervical tumor growth","volume":"9","author":"Liu","year":"","journal-title":"Nat. Commun."},{"key":"B112","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1038\/s41419-022-04655-6","article-title":"Elevated nuclear localization of glycolytic enzyme TPI1 promotes lung adenocarcinoma and enhances chemoresistance","volume":"13","author":"Liu","year":"2022","journal-title":"Cell Death Dis."},{"key":"B113","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1083\/jcb.112.3.385","article-title":"Modulation of hexokinase association with mitochondria analyzed with quantitative three-dimensional confocal microscopy","volume":"112","author":"Lynch","year":"1991","journal-title":"J. Cell Biol."},{"key":"B114","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/j.molcel.2004.11.014","article-title":"Hexokinase-mitochondria interaction mediated by akt is required to inhibit apoptosis in the presence or absence of bax and bak","volume":"16","author":"Majewski","year":"2004","journal-title":"Mol. Cell"},{"key":"B115","doi-asserted-by":"crossref","first-page":"4706","DOI":"10.1016\/S0021-9258(19)67706-9","article-title":"Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance","volume":"266","author":"Marshall","year":"1991","journal-title":"J. Biol. Chem."},{"key":"B116","doi-asserted-by":"publisher","first-page":"8460","DOI":"10.1073\/pnas.88.19.8460","article-title":"A human nuclear uracil DNA glycosylase is the 37-kDa subunit of glyceraldehyde-3-phosphate dehydrogenase","volume":"88","author":"Meyer-Siegler","year":"1991","journal-title":"Proc. Natl. Acad. Sci."},{"key":"B117","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1038\/s41420-024-02106-z","article-title":"GLUT1 inhibitor BAY-876 induces apoptosis and enhances anti-cancer effects of bitter receptor agonists in head and neck squamous carcinoma cells","volume":"10","author":"Miller","year":"2024","journal-title":"Cell Death Discov."},{"key":"B118","doi-asserted-by":"publisher","first-page":"340","DOI":"10.3390\/ijms24010340","article-title":"Therapeutic effects of green tea polyphenol (\u2012)-Epigallocatechin-3-Gallate (EGCG) in relation to molecular pathways controlling inflammation, oxidative stress, and apoptosis","volume":"24","author":"Mokra","year":"2022","journal-title":"IJMS"},{"key":"B119","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1158\/0008-5472.CAN-23-0291","article-title":"Lactate utilization enables metabolic escape to confer resistance to BET inhibition in acute myeloid leukemia","volume":"84","author":"Monteith","year":"2024","journal-title":"Cancer Res."},{"key":"B120","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1111\/j.1742-4658.2007.05686.x","article-title":"Energy metabolism in tumor cells","volume":"274","author":"Moreno-S\u00e1nchez","year":"2007","journal-title":"FEBS J."},{"key":"B121","doi-asserted-by":"publisher","first-page":"e740","DOI":"10.1097\/HS9.0000000000000740","article-title":"Metabolic regulation of hematopoietic stem cells","volume":"6","author":"Morganti","year":"2022","journal-title":"HemaSphere"},{"key":"B122","doi-asserted-by":"publisher","first-page":"1175532","DOI":"10.3389\/fonc.2023.1175532","article-title":"Lactate mediated metabolic crosstalk between cancer and immune cells and its therapeutic implications","volume":"13","author":"Mortazavi Farsani","year":"2023","journal-title":"Front. Oncol."},{"key":"B123","doi-asserted-by":"publisher","first-page":"e0120531","DOI":"10.1371\/journal.pone.0120531","article-title":"Inhibition of KIT-Glycosylation by 2-Deoxyglucose abrogates KIT-Signaling and combination with ABT-263 synergistically induces apoptosis in gastrointestinal stromal tumor","volume":"10","author":"M\u00fchlenberg","year":"2015","journal-title":"PLOS ONE"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20020238","article-title":"HIF-1-Dependent reprogramming of Glucose Metabolic pathway of cancer cells and its therapeutic significance","volume":"20","author":"Nagao","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B125","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1002\/mc.21863","article-title":"Metabolic symbiosis in cancer: refocusing the Warburg lens","volume":"52","author":"Nakajima","year":"2013","journal-title":"Mol. Carcinog."},{"key":"B126","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1002\/nbm.2824","article-title":"31P and 1H MRS of DB-1 melanoma xenografts: Lonidamine selectively decreases tumor intracellular pH and energy status and sensitizes tumors to melphalan","volume":"26","author":"Nath","year":"2013","journal-title":"NMR Biomed."},{"key":"B127","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.bbcan.2016.08.001","article-title":"Mechanism of antineoplastic activity of lonidamine","volume":"1866","author":"Nath","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"B128","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1161\/CIRCRESAHA.110.227371","article-title":"Deacetylation of FoxO by Sirt1 plays an essential role in mediating starvation-induced autophagy in cardiac myocytes","volume":"107","author":"Nirmala","year":"2010","journal-title":"Circulation Res."},{"key":"B129","doi-asserted-by":"publisher","first-page":"234","DOI":"10.3390\/ijms21010234","article-title":"2-Deoxy-d-Glucose and its analogs: from diagnostic to therapeutic agents","volume":"21","author":"Pajak","year":"2019","journal-title":"IJMS"},{"key":"B130","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMoa1516192","volume-title":"Genomic classification and prognosis in acute Myeloid leukemia","author":"Papaemmanuil","year":"2016"},{"key":"B131","doi-asserted-by":"publisher","first-page":"5255","DOI":"10.1158\/1078-0432.CCR-14-1019","article-title":"A phase I Study of the first-in-class anti-mitochondrial metabolism agent, CPI-613, in patients with advanced hematologic malignancies","volume":"20","author":"Pardee","year":"2014","journal-title":"Clin. Cancer Res."},{"key":"B132","doi-asserted-by":"publisher","first-page":"2060","DOI":"10.1158\/1078-0432.CCR-17-2282","article-title":"A phase I Study of CPI-613 in combination with high-dose cytarabine and mitoxantrone for relapsed or refractory acute Myeloid leukemia","volume":"24","author":"Pardee","year":"2018","journal-title":"Clin. Cancer Res."},{"key":"B133","doi-asserted-by":"publisher","first-page":"100009","DOI":"10.1016\/j.bneo.2024.100009","article-title":"Devimistat plus chemotherapy vs chemotherapy alone for older relapsed or refractory patients with AML: results of the ARMADA trial","volume":"1","author":"Pardee","year":"2024","journal-title":"Blood Neoplasia"},{"key":"B134","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/s10863-008-9148-8","article-title":"Regulation of hexokinase binding to VDAC","volume":"40","author":"Pastorino","year":"2008","journal-title":"J. Bioenerg. Biomembr."},{"key":"B135","doi-asserted-by":"publisher","first-page":"7610","DOI":"10.1074\/jbc.M109950200","article-title":"Mitochondrial binding of hexokinase II inhibits bax-induced cytochrome c release and apoptosis","volume":"277","author":"Pastorino","year":"2002","journal-title":"J. Biol. Chem."},{"key":"B136","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/nchembio.1720","article-title":"A proton relay enhances H2O2 sensitivity of GAPDH to facilitate metabolic adaptation","volume":"11","author":"Peralta","year":"2015","journal-title":"Nat. Chem. Biol."},{"key":"B137","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1042\/BJ20080805","article-title":"Inhibition of energy-producing pathways of HepG2 cells by 3-bromopyruvate","volume":"417","author":"Pereira da Silva","year":"2009","journal-title":"Biochem. J."},{"key":"B138","doi-asserted-by":"publisher","first-page":"2326","DOI":"10.1038\/leu.2017.81","article-title":"High mTORC1 activity drives glycolysis addiction and sensitivity to G6PD inhibition in acute myeloid leukemia cells","volume":"31","author":"Poulain","year":"2017","journal-title":"Leukemia"},{"key":"B139","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1016\/j.cmet.2019.10.004","article-title":"Lactate buildup at the site of chronic inflammation promotes disease by inducing CD4+ T cell metabolic rewiring","volume":"30","author":"Pucino","year":"2019","journal-title":"Cell Metab."},{"key":"B140","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1016\/j.molcel.2017.01.027","article-title":"Phosphoglycerate kinase 1 phosphorylates Beclin1 to induce autophagy","volume":"65","author":"Qian","year":"2017","journal-title":"Mol. Cell"},{"key":"B141","doi-asserted-by":"publisher","first-page":"3712","DOI":"10.1016\/j.bmc.2015.04.004","article-title":"Anticancer activity of koningic acid and semisynthetic derivatives","volume":"23","author":"Rahier","year":"2015","journal-title":"Bioorg. and Med. Chem."},{"key":"B142","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/jbiol61","article-title":"Dynamic rerouting of the carbohydrate flux is key to counteracting oxidative stress","volume":"6","author":"Ralser","year":"2007","journal-title":"J. Biol."},{"key":"B143","doi-asserted-by":"publisher","first-page":"2321","DOI":"10.1002\/ejoc.201901353","article-title":"Development of glucose transporter (GLUT) inhibitors","volume":"2020","author":"Reckzeh","year":"2020","journal-title":"Eur. J. Org. Chem."},{"key":"B144","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1124\/dmd.121.000726","article-title":"In vitro and in vivo metabolism of a novel antimitochondrial cancer metabolism agent, CPI-613, in rat and human","volume":"50","author":"Reddy","year":"2022","journal-title":"Drug Metabolism Dispos."},{"key":"B145","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1038\/s41586-021-03442-1","article-title":"Cell-programmed nutrient partitioning in the tumour microenvironment","volume":"593","author":"Reinfeld","year":"2021","journal-title":"Nature"},{"key":"B146","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1111\/febs.13962","article-title":"Mechanistic roles of autophagy in hematopoietic differentiation","volume":"284","author":"Riffelmacher","year":"2017","journal-title":"FEBS J."},{"key":"B147","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1083\/jcb.130.5.1093","article-title":"A mutation in glyceraldehyde 3-phosphate dehydrogenase alters endocytosis in CHO cells","volume":"130","author":"Robbins","year":"1995","journal-title":"J. Cell Biol."},{"key":"B148","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.molcel.2013.12.019","article-title":"Hexokinase-II positively regulates glucose starvation-induced autophagy through TORC1 inhibition","volume":"53","author":"Roberts","year":"2014","journal-title":"Mol. Cell"},{"key":"B149","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1038\/s41419-020-02867-2","article-title":"Venetoclax causes metabolic reprogramming independent of BCL-2 inhibition","volume":"11","author":"Roca-Portoles","year":"2020","journal-title":"Cell Death and Disease"},{"key":"B150","doi-asserted-by":"publisher","first-page":"5382","DOI":"10.1182\/bloodadvances.2023009967","article-title":"Combined GLUT1 and OXPHOS inhibition eliminates acute myeloid leukemia cells by restraining their metabolic plasticity","volume":"7","author":"Rodriguez-Zabala","year":"2023","journal-title":"Blood Adv."},{"key":"B151","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1038\/nrc.2016.89","article-title":"The multifaceted roles of fatty acid synthesis in cancer","volume":"16","author":"R\u00f6hrig","year":"2016","journal-title":"Nat. Rev. Cancer"},{"key":"B152","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/2049-3002-1-8","article-title":"Balancing glycolytic flux: the role of 6-phosphofructo-2-kinase\/fructose 2,6-bisphosphatases in cancer metabolism","volume":"1","author":"Ros","year":"2013","journal-title":"Cancer and Metabolism"},{"key":"B153","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1016\/j.cmet.2020.11.016","article-title":"Neutrophils fuel effective immune responses through gluconeogenesis and glycogenesis","volume":"33","author":"Sadiku","year":"2020","journal-title":"Cell Metab."},{"key":"B154","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.stem.2015.08.019","article-title":"AMPK protects leukemia-initiating cells in myeloid leukemias from metabolic stress in the bone marrow","volume":"17","author":"Saito","year":"2015","journal-title":"Cell Stem Cell"},{"key":"B155","doi-asserted-by":"publisher","first-page":"621458","DOI":"10.3389\/fonc.2020.621458","article-title":"Targeting lactate metabolism by inhibiting MCT1 or MCT4 impairs leukemic cell proliferation, induces two different related death-pathways and increases chemotherapeutic sensitivity of acute myeloid leukemia cells","volume":"10","author":"Saulle","year":"2021","journal-title":"Front. Oncol."},{"key":"B156","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1006\/cbir.2001.0819","article-title":"Glyceraldehyde-3-phosphate dehydrogenase associates with actin filaments in serum deprived NIH 3T3 cells only","volume":"26","author":"Schmitz","year":"2002","journal-title":"Cell Biol. Int."},{"key":"B157","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1093\/nar\/gku1392","article-title":"Detection of recurrent alternative splicing switches in tumor samples reveals novel signatures of cancer","volume":"43","author":"Sebesty\u00e9n","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"B158","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1038\/nm.4493","article-title":"H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers","volume":"24","author":"Seiler","year":"2018","journal-title":"Nat. Med."},{"key":"B159","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1038\/s41419-022-04891-w","article-title":"Hexokinase 3 enhances myeloid cell survival via non-glycolytic functions","volume":"13","author":"Seiler","year":"2022","journal-title":"Cell Death and Dis."},{"key":"B160","doi-asserted-by":"publisher","first-page":"2024.12.02.626357","DOI":"10.1101\/2024.12.02.626357","article-title":"RNA binding of GAPDH controls transcript stability and protein translation in acute myeloid leukemia","volume":"2024","author":"Shamloo","year":"2024","journal-title":"bioRxiv"},{"key":"B161","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1126\/science.8420004","article-title":"Sequence-specific binding of transfer RNA by glyceraldehyde-3-phosphate dehydrogenase","volume":"259","author":"Singh","year":"1993","journal-title":"Science"},{"key":"B162","doi-asserted-by":"publisher","first-page":"334","DOI":"10.3892\/ol.2016.4600","article-title":"Resistance to chemotherapy is associated with altered glucose metabolism in acute myeloid leukemia","volume":"12","author":"Song","year":"2016","journal-title":"Oncol. Lett."},{"key":"B163","doi-asserted-by":"publisher","first-page":"3930","DOI":"10.1172\/JCI36843","article-title":"Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice","volume":"118","author":"Sonveaux","year":"2008","journal-title":"J. Clin. Invest"},{"key":"B164","doi-asserted-by":"publisher","first-page":"5534","DOI":"10.1038\/s41598-018-23863-9","article-title":"Distinct metabolic features differentiating FLT3-ITD AML from FLT3-WT childhood acute myeloid leukemia","volume":"8","author":"Stockard","year":"2018","journal-title":"Sci. Rep."},{"key":"B165","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s12915-019-0670-4","article-title":"Exploiting metabolic vulnerabilities for personalized therapy in acute myeloid leukemia","volume":"17","author":"Stuani","year":"2019","journal-title":"BMC Biol."},{"key":"B166","doi-asserted-by":"publisher","first-page":"e20200924","DOI":"10.1084\/jem.20200924","article-title":"Mitochondrial metabolism supports resistance to IDH mutant inhibitors in acute myeloid leukemia","volume":"218","author":"Stuani","year":"2021","journal-title":"J. Exp. Med."},{"key":"B167","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1158\/0008-5472.CAN-23-2659","article-title":"The imipridone ONC213 targets \u03b1-Ketoglutarate dehydrogenase to induce mitochondrial stress and suppress oxidative phosphorylation in acute myeloid leukemia","volume":"84","author":"Su","year":"2024","journal-title":"Cancer Res."},{"key":"B168","doi-asserted-by":"publisher","first-page":"5958","DOI":"10.1074\/jbc.275.8.5958","article-title":"Structural analysis of \u03b1-enolase: mapping the functional domains involved in down-regulation of the c-myc protooncogene","volume":"275","author":"Subramanian","year":"2000","journal-title":"J. Biol. Chem."},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11121958","article-title":"Notch signaling molecules as prognostic biomarkers for acute myeloid leukemia","volume":"11","author":"Takam Kamga","year":"2019","journal-title":"Cancers (Basel)"},{"key":"B170","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.stem.2012.10.011","article-title":"Regulation of glycolysis by pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells","volume":"12","author":"Takubo","year":"2013","journal-title":"Cell Stem Cell"},{"key":"B171","doi-asserted-by":"publisher","first-page":"2606","DOI":"10.1038\/sj.onc.1210074","article-title":"GAPDH, a novel regulator of the pro-apoptotic mitochondrial membrane permeabilization","volume":"26","author":"Tarze","year":"2007","journal-title":"Oncogene"},{"key":"B172","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1038\/s41556-022-00925-9","article-title":"The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal haematopoietic stem and progenitor cells to maintain stemness","volume":"24","author":"Thomas","year":"2022","journal-title":"Nat. Cell Biol."},{"key":"B173","doi-asserted-by":"publisher","first-page":"2480","DOI":"10.1074\/jbc.M007567200","article-title":"Glyceraldehyde-3-phosphate dehydrogenase is required for vesicular transport in the early secretory pathway","volume":"276","author":"Tisdale","year":"2001","journal-title":"J. Biol. Chem."},{"key":"B174","doi-asserted-by":"publisher","first-page":"3334","DOI":"10.1074\/jbc.M109744200","article-title":"Glyceraldehyde-3-phosphate dehydrogenase is phosphorylated by protein kinase ciota\/lambda and plays a role in microtubule dynamics in the early secretory pathway","volume":"277","author":"Tisdale","year":"2002","journal-title":"J. Biol. Chem."},{"key":"B175","doi-asserted-by":"publisher","first-page":"8436","DOI":"10.1074\/jbc.M513031200","article-title":"Src-dependent aprotein kinase C iota\/lambda (aPKCiota\/lambda) tyrosine phosphorylation is required for aPKCiota\/lambda association with Rab2 and glyceraldehyde-3-phosphate dehydrogenase on pre-golgi intermediates","volume":"281","author":"Tisdale","year":"2006","journal-title":"J. Biol. Chem."},{"key":"B176","doi-asserted-by":"publisher","first-page":"54046","DOI":"10.1074\/jbc.M409472200","article-title":"Glyceraldehyde-3-phosphate dehydrogenase interacts with Rab2 and plays an essential role in endoplasmic reticulum to golgi transport exclusive of its glycolytic activity","volume":"279","author":"Tisdale","year":"2004","journal-title":"J. Biol. Chem."},{"key":"B177","doi-asserted-by":"publisher","first-page":"5876","DOI":"10.1074\/jbc.M807756200","article-title":"Rab2 utilizes glyceraldehyde-3-phosphate dehydrogenase and protein kinase C{iota} to associate with microtubules and to recruit dynein","volume":"284","author":"Tisdale","year":"2009","journal-title":"J. Biol. Chem."},{"key":"B178","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.3390\/antiox9121288","article-title":"The writers, readers, and erasers in redox regulation of GAPDH","volume":"9","author":"Tossounian","year":"2020","journal-title":"Antioxidants"},{"key":"B179","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.cmet.2006.05.011","article-title":"Oxidative metabolism and PGC-1\u03b2 attenuate macrophage-mediated inflammation","volume":"4","author":"Vats","year":"2006","journal-title":"Cell Metab."},{"key":"B180","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aau7314","article-title":"Improving the metabolic fidelity of cancer models with a physiological cell culture medium","volume":"15","author":"Voorde","year":"2019","journal-title":"Sci. Adv."},{"key":"B181","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/j.immuni.2011.09.021","article-title":"The transcription factor myc controls metabolic reprogramming upon T lymphocyte activation","volume":"35","author":"Wang","year":"2011","journal-title":"Immunity"},{"key":"B182","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1016\/j.cell.2014.07.048","article-title":"Cell-state-specific metabolic dependency in hematopoiesis and leukemogenesis","volume":"158","author":"Wang","year":"2014","journal-title":"Cell"},{"key":"B183","doi-asserted-by":"publisher","first-page":"882","DOI":"10.7150\/ijbs.30290","article-title":"Glycolytic enzyme PKM2 mediates autophagic activation to promote cell survival in NPM1-Mutated leukemia","volume":"15","author":"Wang","year":"2019","journal-title":"Int. J. Biol. Sci."},{"key":"B184","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1038\/s41401-020-0465-8","article-title":"Pharmacologically inhibiting phosphoglycerate kinase 1 for glioma with NG52","volume":"42","author":"Wang","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"key":"B185","volume-title":"\u00dcber den Stoffwechsel der Tumoren","author":"Warburg","year":"1926"},{"key":"B186","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1126\/science.123.3191.309","article-title":"On the origin of cancer cells","volume":"123","author":"Warburg","year":"1956","journal-title":"Science"},{"key":"B187","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1038\/nature11895","article-title":"FOXO3A directs a protective autophagy program in haematopoietic stem cells","volume":"494","author":"Warr","year":"2013","journal-title":"Nature"},{"key":"B188","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1126\/science.1102160","article-title":"Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia","volume":"306","author":"Weng","year":"2004","journal-title":"Science"},{"key":"B189","doi-asserted-by":"publisher","first-page":"e242513","DOI":"10.1155\/2013\/242513","article-title":"PKM2, a central point of regulation in cancer metabolism","volume":"2013","author":"Wong","year":"2013","journal-title":"Int. J. Cell Biol."},{"key":"B190","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41419-021-03400-9","article-title":"SUMOylation disassembles the tetrameric pyruvate kinase M2 to block myeloid differentiation of leukemia cells","volume":"12","author":"Xia","year":"2021","journal-title":"Cell Death and Dis."},{"key":"B191","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.ccr.2010.12.014","article-title":"Oncometabolite 2-Hydroxyglutarate is a competitive inhibitor of \u03b1-Ketoglutarate-Dependent dioxygenases","volume":"19","author":"Xu","year":"2011","journal-title":"Cancer Cell"},{"key":"B192","doi-asserted-by":"publisher","first-page":"e24102","DOI":"10.1371\/journal.pone.0024102","article-title":"Efficient elimination of cancer cells by Deoxyglucose-ABT-263\/737 combination therapy","volume":"6","author":"Yamaguchi","year":"2011","journal-title":"PLoS One"},{"key":"B193","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/j.cell.2012.07.018","article-title":"PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis","volume":"150","author":"Yang","year":"","journal-title":"Cell"},{"key":"B194","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1038\/ncb2629","article-title":"ERK1\/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the warburg effect","volume":"14","author":"Yang","year":"","journal-title":"Nat. Cell Biol."},{"key":"B195","doi-asserted-by":"publisher","first-page":"e35721","DOI":"10.1016\/j.heliyon.2024.e35721","article-title":"Glycolysis and chemoresistance in acute myeloid leukemia","volume":"10","author":"Yang","year":"2024","journal-title":"Heliyon"},{"key":"B196","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/j.ccell.2018.08.016","article-title":"Subversion of systemic glucose metabolism as a mechanism to support the growth of leukemia cells","volume":"34","author":"Ye","year":"2018","journal-title":"Cancer Cell"},{"key":"B197","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1038\/nature10496","article-title":"Frequent pathway mutations of splicing machinery in myelodysplasia","volume":"478","author":"Yoshida","year":"2011","journal-title":"Nature"},{"key":"B198","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1007\/s00109-011-0785-8","article-title":"Non-redox-active lipoate derivates disrupt cancer cell mitochondrial metabolism and are potent anticancer agents in vivo","volume":"89","author":"Zachar","year":"2011","journal-title":"J. Mol. Med. Berl."},{"key":"B199","doi-asserted-by":"publisher","first-page":"2900","DOI":"10.1038\/onc.2016.446","article-title":"Phosphoglycerate mutase 1 promotes cancer cell migration independent of its metabolic activity","volume":"36","author":"Zhang","year":"2017","journal-title":"Oncogene"},{"key":"B200","doi-asserted-by":"publisher","first-page":"14517","DOI":"10.1038\/s41598-018-31615-y","article-title":"Shikonin inhibits tumor growth in mice by suppressing pyruvate kinase M2-mediated aerobic glycolysis","volume":"8","author":"Zhao","year":"2018","journal-title":"Sci. Rep."},{"key":"B201","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1038\/s41580-019-0123-5","article-title":"Metabolic regulation of cell growth and proliferation","volume":"20","author":"Zhu","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2026.1823211\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T04:36:06Z","timestamp":1779251766000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2026.1823211\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,20]]},"references-count":201,"alternative-id":["10.3389\/fphar.2026.1823211"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2026.1823211","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,20]]},"article-number":"1823211"}}