{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:42:42Z","timestamp":1786117362862,"version":"build-2736575974"},"reference-count":59,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Coronary heart disease (CHD) is a major cardiovascular disease.\n                      <jats:italic>Cinnamomum migao<\/jats:italic>\n                      volatile oil (CM-VO) is traditionally used for CHD, but its active basis and mechanisms remain unclear.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To clarify the chemical basis and potential anti-CHD mechanisms of CM-VO.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>GC\u2013MS was used to identify CM-VO constituents and serum-related metabolites. A mouse CHD model was established to evaluate pharmacodynamic effects. Network analysis was used for full-component mechanism prediction, while transcriptomics was used to screen treatment-responsive genes. UniProt standardization, deep learning, molecular docking, and H9c2 cell experiments were further performed for target prediction and validation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 68 CM-VO constituents and 8 serum-related metabolites were identified. CM-VO improved myocardial injury, inflammation, oxidative stress, endothelial dysfunction, and lipid-related abnormalities in CHD mice. Network analysis predicted 39 bioactive compounds and 58 key targets, while transcriptomics identified 44 DEGs and 101 CHD-related enriched genes. After UniProt standardization, 19 human genes were analyzed, and GADD45A, MTHFS, and ALAS2 were prioritized as high-affinity targets. In H9c2 cells, CM-VO-containing serum reduced lipid accumulation and injury markers, enhanced antioxidant capacity, and regulated GADD45A, MTHFS, and ALAS2 expression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CM-VO may protect against CHD mainly by regulating inflammation, oxidative stress, endothelial function, and lipid metabolism. This study provides integrated evidence for the pharmacological basis and molecular mechanisms of CM-VO against CHD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphar.2026.1823482","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T13:43:31Z","timestamp":1786023811000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrating multi-omics and deep learning to explore the active ingredients and molecular mechanisms of Cinnamomum migao volatile oil in the treatment of coronary heart disease"],"prefix":"10.3389","volume":"17","author":[{"given":"Xiaomei","family":"Zeng","sequence":"first","affiliation":[{"name":"School of Pharmacy, Guizhou University of Traditional Chinese Medicine","place":["Guiyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangtao","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Guizhou University of Traditional Chinese Medicine","place":["Guiyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Guizhou University of Traditional Chinese Medicine","place":["Guiyang, China"]},{"name":"National Engineering Research Center of Miao\u2019s Medicines","place":["Guiyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongping","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Guizhou University of Traditional Chinese Medicine","place":["Guiyang, China"]},{"name":"National Engineering Research Center of Miao\u2019s Medicines","place":["Guiyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoting","family":"Zhu","sequence":"additional","affiliation":[{"name":"AVIC 303 Hospital","place":["Anshun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Guizhou University of Traditional Chinese Medicine","place":["Guiyang, China"]},{"name":"National Engineering Research Center of Miao\u2019s Medicines","place":["Guiyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1038\/s41419-024-07166-8","article-title":"Inflammation in atherosclerosis: pathophysiology and mechanisms","volume":"15","author":"Ajoolabady","year":"2024","journal-title":"Cell Death and Disease"},{"key":"B2","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s12968-015-0136-y","article-title":"Characterization of myocardial T1-mapping bias caused by intramyocardial fat in inversion recovery and saturation recovery techniques","volume":"17","author":"Arai","year":"2015","journal-title":"J. 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