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Pharmacol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Alcoholic liver disease (ALD) is a serious global health burden with limited effective therapies. 4,5-Dicaffeoylquinic acid (DCA-C), a monomer from Artemisia scoparia, exhibits multiple bioactivities, but its protective effects and exact mechanisms against ALD remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Ethanol-induced ALD mouse models were treated with DCA-C at 10, 30, and 100 mg\/kg. Liver injury, lipid accumulation, and inflammation were evaluated. Transcriptomic sequencing and molecular docking were used to identify key targets. PLA2G4B overexpression models in vitro and in vivo were constructed to validate the mechanism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      DCA-C dose-dependently alleviated alcoholic liver injury, with the 100 mg\/kg dose being most effective, as shown by reduced serum ALT\/AST, decreased hepatic triglycerides, and suppressed pro-inflammatory cytokines. PLA2G4B was identified as a core target of DCA-C. DCA-C directly bound PLA2G4B, downregulated its expression, and reduced arachidonic acid (AA) release, thereby inhibiting MAPK signaling (ERK, p38, JNK phosphorylation). PLA2G4B overexpression abolished the protective effects of DCA-C\n                      <jats:italic>in vitro<\/jats:italic>\n                      and\n                      <jats:italic>in vivo<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>DCA-C protects against ALD via targeting PLA2G4B and inhibiting the AA-MAPK pathway. DCA-C is a promising candidate for ALD treatment and warrants further development.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphar.2026.1823992","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T04:52:35Z","timestamp":1780030355000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Dicaffeoylquinic acid alleviates alcoholic liver disease by targeting PLA2G4B and inhibiting the MAPK signaling pathway"],"prefix":"10.3389","volume":"17","author":[{"given":"Linlin","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, and the Key Laboratory of Chemistry of Plant Resources in Arid Regions Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences","place":["Urumqi, China"]},{"name":"Xinjiang Key Laboratory of Uygur Medicine, Xinjiang Institute of Materia Medica","place":["Urumqi, China"]},{"name":"University of Chinese Academy of Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailong","family":"Wang","sequence":"additional","affiliation":[{"name":"Xinjiang Medical University","place":["Urumqi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Miao","sequence":"additional","affiliation":[{"name":"State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, and the Key Laboratory of Chemistry of Plant Resources in Arid Regions Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences","place":["Urumqi, China"]},{"name":"University of Chinese Academy of Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamulati","family":"Hasimu","sequence":"additional","affiliation":[{"name":"Xinjiang Key Laboratory of Uygur Medicine, Xinjiang Institute of Materia Medica","place":["Urumqi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tengfei","family":"Ji","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College and Beijing Key Laboratory of Drug Target and Screening Research","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Huang","sequence":"additional","affiliation":[{"name":"Xinjiang Key Laboratory of Uygur Medicine, Xinjiang Institute of Materia Medica","place":["Urumqi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanhua","family":"Du","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College and Beijing Key Laboratory of Drug Target and Screening Research","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haji Akber","family":"Aisa","sequence":"additional","affiliation":[{"name":"State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, and the Key Laboratory of Chemistry of Plant Resources in Arid Regions Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences","place":["Urumqi, China"]},{"name":"University of Chinese Academy of Sciences","place":["Beijing, China"]},{"name":"Xinjiang Medical University","place":["Urumqi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuelei","family":"Xin","sequence":"additional","affiliation":[{"name":"State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, and the Key Laboratory of Chemistry of Plant Resources in Arid Regions Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences","place":["Urumqi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.jhep.2018.09.014","article-title":"Burden of liver diseases in the world","volume":"70","author":"Asrani","year":"2019","journal-title":"J. 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