{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T06:12:44Z","timestamp":1778739164830,"version":"3.51.4"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>In Brazil, benzodiazepines rank among the twenty most prescribed medications in primary healthcare. Beyond the lack of robust evidence supporting chronic use, there has been a growing utilization of this drug class for managing conditions that were previously not formally diagnosable or treatable, such as secondary insomnia and bereavement experiences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>In the context of benzodiazepine deprescription, the aim was to understand the trajectory of benzodiazepine use among older adults treated in Primary Health Care, identifying reasons for use and expectations related to its maintenance in pharmacotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>An exploratory qualitative study was conducted through semi-structured interviews with twenty-nine individuals aged 60 years or older who had been using benzodiazepines for at least 1\u00a0month. Data were recorded in a field diary and interviews were audio-recorded. Subsequently, the data were analyzed using thematic analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From the data analysis, two thematic categories emerged that together describe the trajectory of benzodiazepine use: the reasons related to initiation and the difficulties in discontinuation. In the first category, core meanings such as insomnia, life events, and work-related illness were identified, while in the second category the expectations regarding medication use stood out, reinforcing continuity and hindering deprescription.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Prescriptions were often not clinically justified or were based on a merely medicalizing logic. Furthermore, the deprescription process was found to be extremely complex for health professionals, as it is influenced by a series of biopsychosocial barriers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphar.2026.1826743","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T05:46:07Z","timestamp":1778737567000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Between prescription and deprescription: a qualitative study on the trajectory and challenges in the use of benzodiazepines among older adults"],"prefix":"10.3389","volume":"17","author":[{"given":"Silvio Jos\u00e9 Elisei","family":"Carvalho Junior","sequence":"first","affiliation":[{"name":"Universidade Federal de S\u00e3o Jo\u00e3o del-Rei","place":["Divin\u00f3polis, Minas Gerais, Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marlon Silva","family":"Tinoco","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Jo\u00e3o del-Rei","place":["Divin\u00f3polis, Minas Gerais, Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline Istefane","family":"de Camargos Ramos","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Jo\u00e3o del-Rei","place":["Divin\u00f3polis, Minas Gerais, Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciana Soares","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Centro Universit\u00e1rio de Formiga","place":["Formiga, Minas Gerais, Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise Alves","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Jo\u00e3o del-Rei","place":["Divin\u00f3polis, Minas Gerais, Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9 Oliveira","family":"Baldoni","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Jo\u00e3o del-Rei","place":["Divin\u00f3polis, Minas Gerais, Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana Linhares","family":"Pereira","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Jo\u00e3o del-Rei","place":["Divin\u00f3polis, Minas Gerais, Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1002\/mpr.138","article-title":"The epidemiology of major depressive episodes: results from the international consortium of psychiatric epidemiology (ICPE) surveys","volume":"11","author":"Andrade","year":"2012","journal-title":"Int. J. Methods Psychiatr. Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1590\/0101-6628.030","article-title":"The society of work-related illnesses","volume":"123","author":"Antunes","year":"2015","journal-title":"Serv. Soc. Soc."},{"key":"B3","volume-title":"Medicalization, world of work and capitalism: critical contributions to collective health","author":"Araujo","year":"2021"},{"key":"B4","doi-asserted-by":"publisher","first-page":"e0309984","DOI":"10.1371\/journal.pone.0309984","article-title":"Consumption patterns and factors associated with inappropriate prescribing of benzodiazepines in primary health care settings","volume":"19","author":"Barboza","year":"2024","journal-title":"PLoS One"},{"key":"B5","first-page":"280","volume-title":"Content analysis","author":"Bardin","year":"2011"},{"key":"B6","volume-title":"Use of medications and medicalization of life: recommendations and strategies","year":"2018"},{"key":"B7","volume-title":"Municipal data","year":"2026"},{"key":"B8","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1590\/2238-38752021v1128","article-title":"Field diary: a different cousin in the family of social sciences","volume":"11","author":"Cachado","year":"2021","journal-title":"Sociol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"e203871","DOI":"10.11606\/issn.1679-9836.v102iespe-203871","article-title":"Use of benzodiazepines in primary health care (PHC)","volume":"102","author":"Camargo","year":"2023","journal-title":"Rev. Med. (S\u00e3o Paulo)"},{"key":"B10","article-title":"Primary health care: stigma toward individuals with mental disorders","author":"Cassiano","year":"2019","journal-title":"Rev Enferm UFPE Line"},{"key":"B11","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1146\/annurev.so.18.080192.001233","article-title":"Medicalization and social control","volume":"18","author":"Conrad","year":"1992","journal-title":"Annu. Rev. Sociol."},{"key":"B12","doi-asserted-by":"crossref","DOI":"10.56021\/9780801885846","volume-title":"The medicalization of society: on the transformation of human conditions into treatable disorders","author":"Conrad","year":"2007"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1177\/17562872211039034","article-title":"Update on the management of overactive bladder","volume":"31","author":"Fontaine","year":"2021","journal-title":"Ther. Adv. Urol."},{"key":"B14","first-page":"79","article-title":"The birth of social medicine","volume-title":"Microphysics of power.","author":"Foucault","year":"1984"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.11606\/s1518-8787.2022056003740","article-title":"Use of benzodiazepines among Brazilian older adults: a population-based study","volume":"56","author":"Freire","year":"2022","journal-title":"Rev. Saude Publica"},{"key":"B16","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1111\/j.1360-0443.2007.01788.x","article-title":"Biomedicalization of alcohol studies: ideological changes and institutional challenges","volume":"102","author":"Hall","year":"2007","journal-title":"Addiction"},{"key":"B17","volume-title":"Medication as symbolic commodity","author":"Lefevre","year":"1991"},{"key":"B18","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1590\/1516-4446-2018-0088","article-title":"Prevalence of and pathways to benzodiazepine use in Brazil: the role of depression, sleep, and sedentary lifestyle","volume":"41","author":"Madruga","year":"2019","journal-title":"Braz J. Psychiatry"},{"key":"B19","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1136\/bmj.311.6997.109","article-title":"Qualitative research: rigor and qualitative research","volume":"311","author":"Mays","year":"1995","journal-title":"BMJ"},{"key":"B20","volume-title":"The challenge of knowledge: qualitative research in health","author":"Minayo","year":"2014"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1590\/1982-3703001782013","article-title":"Mental health care: operating changes in primary health care","volume":"35","author":"Min\u00f3ia","year":"2015","journal-title":"Psicol. Ci\u00eancia Profiss\u00e3o."},{"key":"B22","first-page":"254","volume-title":"Qualitative research methods for health professionals","author":"Morse","year":"1995"},{"key":"B23","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/0376-8716(93)90028-o","article-title":"Preliminary findings: benzodiazepine consumption in Brazil during 1988 and 1989","volume":"33","author":"Nappo","year":"1993","journal-title":"Drug Alcohol Depend."},{"key":"B24","doi-asserted-by":"publisher","first-page":"e00060520","DOI":"10.1590\/0102-311X00060520","article-title":"Description of psychotropic drug consumption in primary health care in ribeir\u00e3o preto, S\u00e3o Paulo, Brazil","volume":"37","author":"Oliveira","year":"2021","journal-title":"Cad. Sa\u00fade P\u00fablica"},{"key":"B25","first-page":"339","article-title":"Deprescribing benzodiazepine receptor agonists: evidence-based clinical practice guideline","volume":"64","author":"Pottie","year":"2018","journal-title":"Can. Fam. Physician"},{"key":"B26","doi-asserted-by":"publisher","first-page":"2430","DOI":"10.5712\/rbmfc16(43)2430","article-title":"Quaternary prevention in mental health: drug-centered model as a tool for demedicalization","volume":"16","author":"Pulhiez","year":"2021","journal-title":"Rev. Bras. Med. Fam. Comunidade"},{"key":"B27","doi-asserted-by":"publisher","first-page":"384","DOI":"10.11606\/issn.1679-9836.v99i4p384-388","article-title":"Prescribing deprescription: a review for a virtuous circle","volume":"99","author":"Rossi","year":"2020","journal-title":"Rev. Med. (S\u00e3o Paulo)"},{"key":"B28","volume-title":"Anatomy of an epidemic","author":"Whitaker","year":"2017"},{"key":"B29","doi-asserted-by":"publisher","first-page":"538","DOI":"10.4140\/TCP.n.2013.538","article-title":"The history of benzodiazepines","volume":"28","author":"Wick","year":"2013","journal-title":"Consult Pharm."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2026.1826743\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T05:46:10Z","timestamp":1778737570000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2026.1826743\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,14]]},"references-count":29,"alternative-id":["10.3389\/fphar.2026.1826743"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2026.1826743","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,14]]},"article-number":"1826743"}}