{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T05:14:19Z","timestamp":1783314859389,"version":"3.54.6"},"reference-count":146,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>The relationship between neuroimmune processes and drug addiction is currently unclear, although long-term drug use affects neuroimmune signalling. Currently, how neuroinflammation and neuroimmune signalling are linked to addiction is unclear. Therefore, the purpose of this review is to elucidate the roles of neuroimmune signalling, its interaction with neuroinflammation resulting from long-term drug use, and the possible influence of this interaction on the use of pharmacotherapeutic approaches for treating drug addiction. In this review, we address the roles of chemokines and cytokines in the rewarding and reinforcing effects of psychostimulants. Additionally, we provide an overview of novel anti-inflammatory therapeutic strategies that differ from conventional strategies by focusing on cytokines and chemokines. Understanding the role that neuroimmune signalling plays in drug addiction may help researchers develop innovative strategies for addressing this serious social problem.<\/jats:p>","DOI":"10.3389\/fphar.2026.1830998","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T04:20:32Z","timestamp":1783311632000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The effect of neuroimmune signalling on drug addiction"],"prefix":"10.3389","volume":"17","author":[{"given":"Qianzhao","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Liang jiang Hospital of Chongqing Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoran","family":"Chi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Liang jiang Hospital of Chongqing Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Liang jiang Hospital of Chongqing Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Xindu District People\u2019s Hospital of Chengdu","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/nrn1824","article-title":"Astrocyte-endothelial interactions at the blood-brain barrier","volume":"7","author":"Abbott","year":"2006","journal-title":"Nat. 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