{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T13:50:12Z","timestamp":1782309012769,"version":"3.54.5"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Menopause is associated with neuroendocrine changes and a variety of climacteric symptoms. While hormone replacement therapy (HRT) remains a standard treatment, safety concerns increase global interest in non-hormonal alternatives like ERr 731\u00ae, an extract from\n                      <jats:italic>Rheum rhaponticum<\/jats:italic>\n                      to alleviate climacteric complaints.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the long-term effectiveness of ERr 731\u00ae in reducing menopausal climacteric symptoms during a 12-week randomized controlled (RCT) trial followed by a 52-week open-label observational study (OS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>One hundred and twelve perimenopausal women (aged 45\u201355 years) with climacteric complaints (Menopausal Rating Scale (MRS) \u226518) participated in this RCT while eighty-nine of these study participants continued in the OS. During the RCT patients received either ERr 731\u00ae (4\u00a0mg daily) or a placebo. During the OS, all participants received ERr 731\u00ae and were assessed every 13 weeks for headache\/migraine, dizziness, paresthesia, fluor vaginalis, and general well-being. Descriptive statistics and exploratory t-tests compared symptom severity between day 0 and day 84 as well as day 364.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During the RCT, climacteric complaints were significantly reduced in the ERr 731\u00ae group compared to placebo. Symptom severity also decreased across all domains from baseline to week 52 of the OS. Headache\/migraine and paresthesia improvements were notable. Since all participants received ERr 731\u00ae during the OS, no significant differences between the prior ERr 731\u00ae and placebo groups were present (\n                      <jats:italic>p<\/jats:italic>\n                      &amp;gt; 0.05). Dizziness reduction remained significant between groups (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.0086). General well-being improved markedly, with &amp;gt;90% of participants reporting to be \u201cgood\u201d or \u201cvery good spirits\u201d at week 52.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ERr 731\u00ae demonstrated sustained symptom relief and improved well-being over 52 weeks, supporting its role as a non-hormonal option for managing climacteric complaints in perimenopausal women.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphar.2026.1831343","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T09:16:11Z","timestamp":1782292571000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The special extract ERr 731\u00ae from the root of rhapontic rhubarb (Rheum rhaponticum): efficacy in headache\/migraine and further climacteric complaints in women in the perimenopause"],"prefix":"10.3389","volume":"17","author":[{"given":"Peter W.","family":"Heger","sequence":"first","affiliation":[{"name":"Health Research Services GmbH","place":["Ubstadt-Weiher, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilka","family":"Meinert","sequence":"additional","affiliation":[{"name":"Health Research Services GmbH","place":["Ubstadt-Weiher, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Hotz","sequence":"additional","affiliation":[{"name":"Health Research Services GmbH","place":["Ubstadt-Weiher, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"160","DOI":"10.3389\/FENDO.2015.00160","article-title":"Oxytocin and estrogen receptor \u03b2 in the brain: an overview","volume":"6","author":"Acevedo-Rodriguez","year":"2015","journal-title":"Front. 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