{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T07:05:11Z","timestamp":1784099111544,"version":"3.55.0"},"reference-count":79,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:sec>\n                    <jats:title>Ethnopharmacological Relevance<\/jats:title>\n                    <jats:p>\n                      Chuanxiong (\n                      <jats:italic>Ligusticum chuanxiong<\/jats:italic>\n                      Hort.) and Chishao (\n                      <jats:italic>Paeonia lactiflora<\/jats:italic>\n                      Pall.) are widely used in Traditional Chinese Medicine (TCM) for their ability to promote blood circulation and resolve blood stasis, particularly in the treatment of cardiovascular diseases such as atherosclerosis (AS).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim of The Study<\/jats:title>\n                    <jats:p>\n                      This review systematically summarizes the potential mechanisms by which\n                      <jats:italic>L. chuanxiong<\/jats:italic>\n                      and\n                      <jats:italic>P. lactiflora<\/jats:italic>\n                      modulate iron metabolism, inhibit ferroptosis, and enhance blood flow, offering innovative strategies for the treatment of AS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      A comprehensive literature search was performed using databases such as PubMed, Web of Science, and CNKI. We implemented a narrative review with explicit search strategies across regional databases that included specific keywords related to the pharmacological effects of Chuanxiong and Chishao, particularly their roles in iron metabolism and ferroptosis. Studies were selected based on predefined inclusion criteria, ensuring relevance and quality. The data were organized to summarize the mechanisms of action and therapeutic potential of these substances, while also incorporating insights from traditional medical texts, including classical TCM literature. Specific search strategy: SU=((\u201cAtherosclerosis\u201d [MeSH] OR \u201cAtherosclerotic plaque\u201d [Title\/Abstract] OR \u201cAS\u201d [Title\/Abstract] OR \u201cArteriosclerosis\u201d [Title\/Abstract]) AND (\u201cChuanxiong\u201d [Title\/Abstract] OR \u201cLigusticum chuanxiong\u201d [MeSH]) AND (\u201cChishao\u201d [Title\/Abstract] OR \u201cPaeonia lactiflora\u201d [MeSH])) AND ((\u201ciron metabolism\u201d [Title\/Abstract] OR \u201cferroptosis\u201d [MeSH] OR \u201clipid peroxidation\u201d [Title\/Abstract]) OR (\u201cJAK-STAT pathway\u201d OR \u201cPI3K\/AKT\u201d OR \u201cMAPK\/NF-\u03baB\u201d OR \u201cGPX4\u201d [Title\/Abstract]) AND (\u201crandomized controlled trial\u201d [Publication Type] OR \u201c\n                      <jats:italic>in vitro<\/jats:italic>\n                      \u201d [Title\/Abstract] OR \u201c\n                      <jats:italic>in vivo<\/jats:italic>\n                      \u201d [Title\/Abstract] OR \u201cclinical study\u201d [Title\/Abstract])).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ligusticum chuanxiong: and\n                      <jats:italic>P. lactiflora<\/jats:italic>\n                      modulate iron homeostasis by suppressing hepcidin and enhancing ferroportin, inhibit ferroptosis via GPX4 activation and System Xc\n                      <jats:sup>\u2212<\/jats:sup>\n                      upregulation, and mitigate oxidative stress\/inflammation through ROS scavenging and NF-\u03baB suppression, collectively reducing atherosclerotic plaque instability.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Chuanxiong and Chishao demonstrate significant potential as therapeutic agents for AS by targeting iron metabolism and ferroptosis. Their traditional use in TCM is supported by modern pharmacological evidence, highlighting their potential for integration into modern therapeutic frameworks.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphar.2026.1831703","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T06:10:38Z","timestamp":1784095838000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Ligusticum chuanxiong and Paeonia lactiflora: a review of their regulation of iron metabolism and ferroptosis in atherosclerosis therapy"],"prefix":"10.3389","volume":"17","author":[{"given":"Miao","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong","place":["Hong Kong, Hong Kong SAR, China"]},{"name":"Shenzhen Second People\u2019s Hospital, First Affiliated Hospital of Shenzhen University","place":["Shenzhen, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WenBo","family":"Wei","sequence":"additional","affiliation":[{"name":"Shenzhen Second People\u2019s Hospital, First Affiliated Hospital of Shenzhen University","place":["Shenzhen, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZongZheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Shenzhen Second People\u2019s Hospital, First Affiliated Hospital of Shenzhen University","place":["Shenzhen, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guipeng","family":"Xu","sequence":"additional","affiliation":[{"name":"Shenzhen Second People\u2019s Hospital, First Affiliated Hospital of Shenzhen University","place":["Shenzhen, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiting","family":"Chen","sequence":"additional","affiliation":[{"name":"Shenzhen Second People\u2019s Hospital, First Affiliated Hospital of Shenzhen University","place":["Shenzhen, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoshu","family":"Liu","sequence":"additional","affiliation":[{"name":"Liaoning Vocational College of Medicine","place":["Liaoning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FengQin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Disease, Beijing Xiyuan Hospital, China Academy of Chinese Medical Sciences","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZhiXiu","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong","place":["Hong Kong, Hong Kong SAR, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1038\/s41586-019-1705-2","article-title":"The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis","volume":"575","author":"Bersuker","year":"2019","journal-title":"Nature"},{"key":"B2","doi-asserted-by":"publisher","first-page":"4695","DOI":"10.3390\/ijms23094695","article-title":"Cardiovascular Diseases-A focus on atherosclerosis, its prophylaxis, complications and recent advancements in therapies","volume":"23","author":"Bu\u0142dak","year":"2022","journal-title":"Int. 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