{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:21:15Z","timestamp":1787836875711,"version":"build-2784847793"},"reference-count":214,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>Glutathione peroxidase 4 (GPX4) is a selenocysteine (Sec)-containing antioxidant enzyme and the only known mammalian enzyme capable of directly reducing membrane-embedded phospholipid and cholesterol hydroperoxides. It is recognized as a central regulator of ferroptosis, modulating cellular redox balance and influencing cell fate under oxidative stress. Despite a decade of research, critical gaps remain. Existing reviews largely focus on isolated diseases or single targeting strategies, and few provide an integrated framework that spans molecular regulation, physiological function, and clinical translation. The regulatory networks that control GPX4, from transcription to post-translational modifications and protein interactions, remain incompletely defined, and its ferroptosis-independent functions are underexplored. Moreover, the context-dependent and bidirectional roles of GPX4 across different diseases have not been systematically analyzed to guide appropriate therapeutic strategies. To address these gaps, this review delineates the structural basis and isoform-specific functions of GPX4, maps its multilayered regulatory network, and defines its roles across key physiological and pathological processes, including cancer, neurodegeneration, ischemia\u2013reperfusion (I\/R) injury, and autoimmune diseases. We also evaluate GPX4-targeted chemical strategies and analyze four core translational barriers: target specificity, systemic toxicity, acquired resistance, and tissue delivery, with evidence-based solutions for each. We conclude by identifying unresolved mechanistic questions and outlining priorities to accelerate clinical translation.<\/jats:p>","DOI":"10.3389\/fphar.2026.1834222","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T12:51:45Z","timestamp":1787835105000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Targeting glutathione peroxidase 4 in ferroptosis: from immune regulation to pharmacological development and translational applications"],"prefix":"10.3389","volume":"17","author":[{"given":"Qianyue","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University","place":["Nanjing, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfu","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Pathology, Changde Hospital, Xiangya School of Medicine, Central South University (The First People\u2019s Hospital of Changde City)","place":["Changde, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghe","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Changde Hospital, Xiangya School of Medicine, Central South University (The First People\u2019s Hospital of Changde City)","place":["Changde, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuting","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Pathology, Changde Hospital, Xiangya School of Medicine, Central South University (The First People\u2019s Hospital of Changde City)","place":["Changde, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganpeng","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Changde Hospital, Xiangya School of Medicine, Central South University (The First People\u2019s Hospital of Changde City)","place":["Changde, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyun","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University","place":["Nanjing, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1111\/j.1464-410X.2010.09344.x","article-title":"Single-nucleotide polymorphisms within the antioxidant defence system and associations with aggressive prostate cancer","volume":"107","author":"Abe","year":"2011","journal-title":"BJU Int."},{"key":"B2","doi-asserted-by":"publisher","first-page":"109213","DOI":"10.1016\/j.clim.2023.109213","article-title":"Kidney tubular epithelial cell ferroptosis links glomerular injury to tubulointerstitial pathology in lupus nephritis","volume":"248","author":"Alli","year":"2023","journal-title":"Clin. Immunol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"112946","DOI":"10.1016\/j.yexcr.2021.112946","article-title":"Hemin enhances radiosensitivity of lung cancer cells through ferroptosis","volume":"410","author":"Almahi","year":"2022","journal-title":"Exp. Cell Res."},{"key":"B4","doi-asserted-by":"publisher","first-page":"101824","DOI":"10.1016\/j.jbc.2022.101824","article-title":"Mitochondrial glutathione peroxidase 4 is indispensable for photoreceptor development and survival in mice","volume":"298","author":"Azuma","year":"2022","journal-title":"J. Biol. Chem."},{"key":"B5","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.neuro.2013.05.009","article-title":"Methamphetamine decreases levels of glutathione peroxidases 1 and 4 in SH-SY5Y neuronal cells: protective effects of selenium","volume":"37","author":"Barayuga","year":"2013","journal-title":"Neurotoxicology"},{"key":"B6","doi-asserted-by":"publisher","first-page":"15762","DOI":"10.3390\/ijms232415762","article-title":"The role of rs713041 glutathione peroxidase 4 (GPX4) single nucleotide polymorphism on disease susceptibility in humans: a systematic review and meta-analysis","volume":"23","author":"Barbosa","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B7","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.cancergen.2025.06.009","article-title":"GPX4 in triple-negative breast cancer: a key regulator of ferroptosis and therapeutic target","author":"Baskar","year":"2025","journal-title":"Cancer Genet."},{"key":"B8","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1677\/joe.1.05971","article-title":"Selenium and endocrine systems","volume":"184","author":"Beckett","year":"2005","journal-title":"J. Endocrinol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.jare.2023.02.012","article-title":"FUNDC1 interacts with GPx4 to govern hepatic ferroptosis and fibrotic injury through a mitophagy-dependent manner","volume":"55","author":"Bi","year":"2024","journal-title":"J. Adv. Res."},{"key":"B10","doi-asserted-by":"publisher","first-page":"2571","DOI":"10.1074\/jbc.M209064200","article-title":"Regulation of expression of the phospholipid hydroperoxide\/sperm nucleus glutathione peroxidase gene. Tissue-specific expression pattern and identification of functional cis- and trans-regulatory elements","volume":"278","author":"Borchert","year":"2003","journal-title":"J. Biol. Chem."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1016\/j.bbalip.2018.06.006","article-title":"Crystal structure and functional characterization of selenocysteine-containing glutathione peroxidase 4 suggests an alternative mechanism of peroxide reduction","volume":"1863","author":"Borchert","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"B12","doi-asserted-by":"publisher","first-page":"530.e1","DOI":"10.1016\/j.ajog.2008.12.031","article-title":"Specific systemic antioxidant response to preeclampsia in late pregnancy: the study of intracellular glutathione peroxidases in maternal and fetal blood","volume":"200","author":"Boutet","year":"2009","journal-title":"Am. J. Obstet. Gynecol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1136\/gutjnl-2014-307904","article-title":"Glutathione peroxidase 4 is reversibly induced by HCV to control lipid peroxidation and to increase virion infectivity","volume":"65","author":"Brault","year":"2016","journal-title":"Gut"},{"key":"B14","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.freeradbiomed.2023.05.027","article-title":"Interferon \u03b3 induces salivary gland epithelial cell ferroptosis in Sjogren\u2019s syndrome via JAK\/STAT1 mediated inhibition of system Xc-","volume":"205","author":"Cao","year":"2023","journal-title":"Free Radic. Biol. Med."},{"key":"B15","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.freeradbiomed.2024.02.008","article-title":"Roles of ferroptosis in type 1 diabetes induced spermatogenic dysfunction","volume":"214","author":"Cao","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"B16","doi-asserted-by":"publisher","first-page":"157117","DOI":"10.1016\/j.phymed.2025.157117","article-title":"Luteolin induces GPX4-dependent ferroptosis and enhances immune activation in colon cancer","volume":"146","author":"Cao","year":"","journal-title":"Phytomedicine"},{"key":"B17","doi-asserted-by":"publisher","first-page":"103788","DOI":"10.1016\/j.redox.2025.103788","article-title":"DHODH-mediated mitochondrial redox homeostasis: a novel ferroptosis regulator and promising therapeutic target","volume":"85","author":"Cao","year":"","journal-title":"Redox Biol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"4513","DOI":"10.1038\/s41467-019-12507-9","article-title":"The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis","volume":"10","author":"Capalbo","year":"2019","journal-title":"Nat. Commun."},{"key":"B19","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1080\/10715760701286167","article-title":"Phospholipid hydroperoxide glutathione peroxidase (PHGPx) expression is downregulated in poorly differentiated breast invasive ductal carcinoma","volume":"41","author":"Cejas","year":"2007","journal-title":"Free Radic. Res."},{"key":"B20","doi-asserted-by":"publisher","first-page":"103864","DOI":"10.1016\/j.redox.2025.103864","article-title":"Low-GPX4 drives a sustained drug-tolerant persister state in TNBC by a targetable adaptive FSP1 upregulation","volume":"87","author":"Chaudhary","year":"2025","journal-title":"Redox Biol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"4683798","DOI":"10.1155\/2020\/4683798","article-title":"Haplotype analysis of candidate genes involved in inflammation and oxidative stress and the susceptibility to Preeclampsia","volume":"2020","author":"Chen","year":"2020","journal-title":"J. Immunol. Res."},{"key":"B22","doi-asserted-by":"publisher","first-page":"3644","DOI":"10.1038\/s41467-021-23902-6","article-title":"iPLA2\u03b2-mediated lipid detoxification controls p53-driven ferroptosis independent of GPX4","volume":"12","author":"Chen","year":"","journal-title":"Nat. Commun."},{"key":"B23","doi-asserted-by":"publisher","first-page":"16500","DOI":"10.18632\/aging.203172","article-title":"Circular RNA circKIF4A facilitates the malignant progression and suppresses ferroptosis by sponging miR-1231 and upregulating GPX4 in papillary thyroid cancer","volume":"13","author":"Chen","year":"","journal-title":"Aging (Albany NY)"},{"key":"B24","doi-asserted-by":"publisher","first-page":"113733","DOI":"10.1016\/j.yexcr.2023.113733","article-title":"IRF1 suppresses colon cancer proliferation by reducing SPI1-mediated transcriptional activation of GPX4 and promoting ferroptosis","volume":"431","author":"Chen","year":"","journal-title":"Exp. Cell Res."},{"key":"B25","doi-asserted-by":"publisher","first-page":"230","DOI":"10.18632\/aging.204473","article-title":"Increased expression of GPX4 promotes the tumorigenesis of thyroid cancer by inhibiting ferroptosis and predicts poor clinical outcomes","volume":"15","author":"Chen","year":"","journal-title":"Aging (Albany NY)"},{"key":"B26","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1038\/s41416-024-02574-1","article-title":"GSTM3 enhances radiosensitivity of nasopharyngeal carcinoma by promoting radiation-induced ferroptosis through USP14\/FASN axis and GPX4","volume":"130","author":"Chen","year":"","journal-title":"Br. J. Cancer"},{"key":"B27","doi-asserted-by":"publisher","first-page":"e170071","DOI":"10.1172\/JCI170071","article-title":"CD8+ T cells sustain antitumor response by mediating crosstalk between adenosine A2A receptor and glutathione\/GPX4","volume":"134","author":"Chen","year":"","journal-title":"J. Clin. Invest"},{"key":"B28","doi-asserted-by":"publisher","first-page":"e07080","DOI":"10.1002\/advs.202507080","article-title":"Patients-derived organoids sequencing-based FOXP4 facilitates radioresistance by transcriptionally modifying GPX4 to regulate ferroptosis in colorectal cancer","volume":"12","author":"Chen","year":"","journal-title":"Adv. Sci. (Weinh)"},{"key":"B29","doi-asserted-by":"publisher","first-page":"115681","DOI":"10.1016\/j.celrep.2025.115681","article-title":"OTUD4 inhibits ferroptosis by stabilizing GPX4 and suppressing autophagic degradation to promote tumor progression","volume":"44","author":"Chen","year":"","journal-title":"Cell Rep."},{"key":"B30","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1007\/s00018-025-05732-7","article-title":"African swine fever virus A151R downregulates cGAS-STING-mediated IFN-\u03b2 production by promoting lipid peroxidation through ferritinophagy-induced ferroptosis","volume":"82","author":"Chen","year":"","journal-title":"Cell Mol. Life Sci."},{"key":"B31","doi-asserted-by":"publisher","first-page":"e01042","DOI":"10.1002\/advs.202501042","article-title":"Targeting GPX4 to induce ferroptosis overcomes chemoresistance mediated by the PAX8-AS1\/GPX4 axis in intrahepatic cholangiocarcinoma","volume":"12","author":"Chen","year":"","journal-title":"Adv. Sci. (Weinh)"},{"key":"B32","doi-asserted-by":"publisher","first-page":"e02052","DOI":"10.1002\/advs.202502052","article-title":"PIEZO1-GPX4 axis mediates mechanical stress-induced vertebral growth plate dysplasia via ferroptosis activation","volume":"12","author":"Chen","year":"","journal-title":"Adv. Sci. (Weinh)"},{"key":"B33","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1038\/s41419-022-05069-0","article-title":"Semaphorin 5A suppresses ferroptosis through activation of PI3K-AKT-mTOR signaling in rheumatoid arthritis","volume":"13","author":"Cheng","year":"2022","journal-title":"Cell Death Dis."},{"key":"B34","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1038\/s41420-023-01463-5","article-title":"Drug-induced lactate confers ferroptosis resistance via p38-SGK1-NEDD4L-dependent upregulation of GPX4 in NSCLC cells","volume":"9","author":"Cheng","year":"","journal-title":"Cell Death Discov."},{"key":"B35","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1038\/s41419-023-05614-5","article-title":"SGK2 promotes prostate cancer metastasis by inhibiting ferroptosis via upregulating GPX4","volume":"14","author":"Cheng","year":"","journal-title":"Cell Death Dis."},{"key":"B36","doi-asserted-by":"publisher","first-page":"3693","DOI":"10.1074\/jbc.275.5.3693","article-title":"Molecular mechanism of decreased glutathione content in human immunodeficiency virus type 1 tat-transgenic mice","volume":"275","author":"Choi","year":"2000","journal-title":"J. Biol. Chem."},{"key":"B37","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.molcel.2023.11.027","article-title":"Multisite phosphorylation dictates selective E2-E3 pairing as revealed by Ubc8\/UBE2H-GID\/CTLH assemblies","volume":"84","author":"Chrustowicz","year":"2024","journal-title":"Mol. Cell"},{"key":"B38","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1038\/s41556-019-0305-6","article-title":"ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway","volume":"21","author":"Chu","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"8393","DOI":"10.1038\/s41467-023-44228-5","article-title":"Autophagy of OTUD5 destabilizes GPX4 to confer ferroptosis-dependent kidney injury","volume":"14","author":"Chu","year":"2023","journal-title":"Nat. Commun."},{"key":"B40","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s40779-024-00537-4","article-title":"Spatiotemporal multi-omics: exploring molecular landscapes in aging and regenerative medicine","volume":"11","author":"Chu","year":"2024","journal-title":"Mil. Med. Res."},{"key":"B41","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1016\/j.freeradbiomed.2012.05.029","article-title":"Glutathione peroxidase 4 has a major role in protecting mitochondria from oxidative damage and maintaining oxidative phosphorylation complexes in gut epithelial cells","volume":"53","author":"Cole-Ezea","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.2147\/DDDT.S509357","article-title":"Vaccarin ameliorates renal fibrosis by inhibiting ferroptosis via Nrf2\/SLC7A11\/GPX4 signaling pathway","volume":"19","author":"Cui","year":"2025","journal-title":"Drug Des. Devel Ther."},{"key":"B43","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.molcel.2014.11.026","article-title":"Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes","volume":"57","author":"Davis","year":"2015","journal-title":"Mol. Cell"},{"key":"B44","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1093\/neuonc\/noac233","article-title":"TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing","volume":"25","author":"Demirdizen","year":"2023","journal-title":"Neuro Oncol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1038\/s41419-024-06486-z","article-title":"Depletion of the N6-methyladenosine (m6A) reader protein IGF2BP3 induces ferroptosis in glioma by modulating the expression of GPX4","volume":"15","author":"Deng","year":"2024","journal-title":"Cell Death Dis."},{"key":"B46","doi-asserted-by":"publisher","first-page":"151990","DOI":"10.1016\/j.bbrc.2025.151990","article-title":"USP31 confers radio-resistance in cervical cancer cells via ferroptosis pathway by deubiquitinating and stabilizing GPX4","volume":"770","author":"Ding","year":"2025","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B47","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/s41392-025-02311-x","article-title":"Mitochondrial metabolism and cancer therapeutic innovation","volume":"10","author":"Du","year":"2025","journal-title":"Signal Transduct. Target Ther."},{"key":"B48","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1038\/s41556-025-01610-3","article-title":"PRMT5-mediated arginine methylation stabilizes GPX4 to suppress ferroptosis in cancer","volume":"27","author":"Fan","year":"2025","journal-title":"Nat. Cell Biol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1095\/biolreprod.102.003822","article-title":"Male fertility is linked to the selenoprotein phospholipid hydroperoxide glutathione peroxidase","volume":"67","author":"Foresta","year":"2002","journal-title":"Biol. Reprod."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1038\/ng.717","article-title":"Genome-wide meta-analysis increases to 71 the number of confirmed Crohn\u2019s disease susceptibility loci","volume":"42","author":"Franke","year":"2010","journal-title":"Nat. Genet."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1016\/j.fertnstert.2004.04.033","article-title":"Relationship among standard semen parameters, glutathione peroxidase\/glutathione reductase activity, and mRNA expression and reduced glutathione content in ejaculated spermatozoa from fertile and infertile men","volume":"82","author":"Garrido","year":"2004","journal-title":"Fertil. Steril."},{"key":"B52","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1038\/s41589-018-0031-6","article-title":"FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation","volume":"14","author":"Gaschler","year":"2018","journal-title":"Nat. Chem. Biol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"2121","DOI":"10.1101\/gr.2596504","article-title":"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)","volume":"14","author":"Gerhard","year":"2004","journal-title":"Genome Res."},{"key":"B54","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1038\/s41586-021-03592-2","article-title":"A proximity-dependent biotinylation map of a human cell","volume":"595","author":"Go","year":"2021","journal-title":"Nature"},{"key":"B55","doi-asserted-by":"publisher","first-page":"2022","DOI":"10.1038\/s41418-025-01528-1","article-title":"GPX4-AUTAC induces ferroptosis in breast cancer by promoting the selective autophagic degradation of GPX4 mediated by TRAF6-p62","volume":"32","author":"Gong","year":"2025","journal-title":"Cell Death Differ."},{"key":"B56","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1681\/ASN.2008040406","article-title":"Large-scale proteomics and phosphoproteomics of urinary exosomes","volume":"20","author":"Gonzales","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1038\/nature02399","article-title":"The DNA sequence and biology of human chromosome 19","volume":"428","author":"Grimwood","year":"2004","journal-title":"Nature"},{"key":"B58","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1038\/s41417-025-00927-3","article-title":"The dual role of GPX4 in breast cancer: mechanisms of therapeutic resistance and potential for novel targeted therapies","volume":"32","author":"Gu","year":"2025","journal-title":"Cancer Gene Ther."},{"key":"B59","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1002\/iub.1220","article-title":"Expression and characterization of recombinant human phospholipid hydroperoxide glutathione peroxidase","volume":"65","author":"Han","year":"2013","journal-title":"IUBMB Life"},{"key":"B60","doi-asserted-by":"publisher","first-page":"8839","DOI":"10.1002\/jcp.29727","article-title":"SIRT3 deficiency is resistant to autophagy-dependent ferroptosis by inhibiting the AMPK\/mTOR pathway and promoting GPX4 levels","volume":"235","author":"Han","year":"2020","journal-title":"J. Cell Physiol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1093\/carcin\/bgad094","article-title":"Ferroptosis-related gene glutathione peroxidase 4 promotes reprogramming of glucose metabolism via Akt-mTOR axis in intrahepatic cholangiocarcinoma","volume":"45","author":"Hori","year":"2024","journal-title":"Carcinogenesis"},{"key":"B62","doi-asserted-by":"publisher","first-page":"1866","DOI":"10.1016\/j.rmed.2009.06.016","article-title":"PTEN identified as important risk factor of chronic obstructive pulmonary disease","volume":"103","author":"Hosgood","year":"2009","journal-title":"Respir. Med."},{"key":"B63","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1093\/abbs\/gmaa180","article-title":"Metformin induces ferroptosis by targeting miR-324-3p\/GPX4 axis in breast cancer","volume":"53","author":"Hou","year":"2021","journal-title":"Acta Biochim. Biophys. Sin. (Shanghai)"},{"key":"B64","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1111\/jnc.14604","article-title":"Reduced expression of the ferroptosis inhibitor glutathione peroxidase-4 in multiple sclerosis and experimental autoimmune encephalomyelitis","volume":"148","author":"Hu","year":"2019","journal-title":"J. Neurochem."},{"key":"B65","doi-asserted-by":"publisher","first-page":"4602","DOI":"10.1016\/j.molcel.2025.11.023","article-title":"Targeting PRDX6-dependent localization and function of GPX4 enhances ferroptosis-mediated tumor suppression","volume":"85","author":"Hu","year":"","journal-title":"Mol. Cell"},{"key":"B66","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1038\/s41419-025-07883-8","article-title":"HIF-1\u03b1 alleviates ferroptosis in ulcerative colitis by regulation of GPX4","volume":"16","author":"Hu","year":"","journal-title":"Cell Death Dis."},{"key":"B67","doi-asserted-by":"publisher","first-page":"e18318","DOI":"10.1111\/jcmm.18318","article-title":"Orexin-A mediates glioblastoma proliferation inhibition by increasing ferroptosis triggered by unstable iron pools and GPX4 depletion","volume":"28","author":"Huan","year":"2024","journal-title":"J. Cell Mol. Med."},{"key":"B68","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1038\/s41467-025-56344-5","article-title":"Palmitoylation-dependent regulation of GPX4 suppresses ferroptosis","volume":"16","author":"Huang","year":"2025","journal-title":"Nat. Commun."},{"key":"B69","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1016\/j.ncrna.2024.05.007","article-title":"Non-coding RNA: a key regulator in the Glutathione-GPX4 pathway of ferroptosis","volume":"9","author":"Hussain","year":"2024","journal-title":"Noncoding RNA Res."},{"key":"B70","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.cell.2015.06.043","article-title":"The BioPlex network: a systematic exploration of the human interactome","volume":"162","author":"Huttlin","year":"2015","journal-title":"Cell"},{"key":"B71","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1038\/nature22366","article-title":"Architecture of the human interactome defines protein communities and disease networks","volume":"545","author":"Huttlin","year":"2017","journal-title":"Nature"},{"key":"B72","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.trecan.2025.05.001","article-title":"Targeting GPX4 palmitoylation to boost antitumor immunity","volume":"11","author":"Hwang","year":"2025","journal-title":"Trends Cancer"},{"key":"B73","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1186\/s12885-015-1680-4","article-title":"Lipid peroxidation and glutathione peroxidase activity relationship in breast cancer depends on functional polymorphism of GPX1","volume":"15","author":"Jablonska","year":"2015","journal-title":"BMC Cancer"},{"key":"B74","doi-asserted-by":"publisher","first-page":"e03869","DOI":"10.1002\/adhm.202503869","article-title":"Targeted GPX4 degradation mediated by hypoxia-overcoming nano-PDTACs for synergistic ferroptosis-immunotherapy","volume":"15","author":"Ji","year":"2026","journal-title":"Adv. Healthc. Mater"},{"key":"B75","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s00018-023-05067-1","article-title":"Selenium-SelK-GPX4 axis protects nucleus pulposus cells against mechanical overloading-induced ferroptosis and attenuates senescence of intervertebral disc","volume":"81","author":"Jia","year":"2024","journal-title":"Cell Mol. Life Sci."},{"key":"B76","doi-asserted-by":"publisher","first-page":"e3526","DOI":"10.1002\/jgm.3526","article-title":"Circular RNA HIPK3 facilitates ferroptosis in gestational diabetes mellitus by regulating glutathione peroxidase 4 DNA methylation","volume":"25","author":"Jiang","year":"2023","journal-title":"J. Gene Med."},{"key":"B77","doi-asserted-by":"publisher","first-page":"4104","DOI":"10.1245\/s10434-015-4431-5","article-title":"Genetic variations in Glutathione pathway genes predict cancer recurrence in patients treated with transurethral resection and bacillus calmette-guerin instillation for non-muscle invasive bladder cancer","volume":"22","author":"Ke","year":"2015","journal-title":"Ann. Surg. Oncol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"8201","DOI":"10.3390\/ijms26178201","article-title":"NEDD4L-Mediated ubiquitination of GPX4 exacerbates doxorubicin-induced cardiotoxicity","volume":"26","author":"Ke","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"B79","doi-asserted-by":"publisher","first-page":"149776","DOI":"10.1016\/j.brainres.2025.149776","article-title":"Ferroptosis and its contribution to cognitive impairment in Alzheimer\u2019s disease: mechanisms and therapeutic potential","volume":"1864","author":"Khan","year":"2025","journal-title":"Brain Res."},{"key":"B80","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1038\/s41419-020-2618-6","article-title":"TGF-\u03b21-mediated repression of SLC7A11 drives vulnerability to GPX4 inhibition in hepatocellular carcinoma cells","volume":"11","author":"Kim","year":"2020","journal-title":"Cell Death Dis."},{"key":"B81","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1038\/s41374-017-0008-1","article-title":"Glutathione peroxidase 4 overexpression inhibits ROS-induced cell death in diffuse large B-cell lymphoma","volume":"98","author":"Kinowaki","year":"2018","journal-title":"Lab. Invest"},{"key":"B82","doi-asserted-by":"publisher","first-page":"5151","DOI":"10.3390\/ijms23095151","article-title":"Cullin 3 exon 9 deletion in familial hyperkalemic hypertension impairs Cullin3-Ring-E3 ligase (CRL3) dynamic regulation and cycling","volume":"23","author":"Kouranti","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B84","doi-asserted-by":"publisher","first-page":"2789","DOI":"10.1021\/acs.jproteome.7b00065","article-title":"A human tyrosine phosphatase interactome mapped by proteomic profiling","volume":"16","author":"Kumar","year":"2017","journal-title":"J. Proteome Res."},{"key":"B85","doi-asserted-by":"publisher","first-page":"6452","DOI":"10.3390\/ijms26136452","article-title":"Emerging therapeutic strategies targeting GPX4-mediated ferroptosis in head and neck cancer","volume":"26","author":"Lee","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"B86","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1038\/s41590-021-00993-3","article-title":"Glutathione peroxidase 4-regulated neutrophil ferroptosis induces systemic autoimmunity","volume":"22","author":"Li","year":"","journal-title":"Nat. Immunol."},{"key":"B87","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1007\/s00011-021-01495-6","article-title":"Significance of glutathione peroxidase 4 and intracellular iron level in ovarian cancer cells-\u201cutilization\u201d of ferroptosis mechanism","volume":"70","author":"Li","year":"","journal-title":"Inflamm. Res."},{"key":"B88","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/s41388-022-02537-x","article-title":"CST1 inhibits ferroptosis and promotes gastric cancer metastasis by regulating GPX4 protein stability via OTUB1","volume":"42","author":"Li","year":"2023","journal-title":"Oncogene"},{"key":"B89","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1186\/s12967-024-05112-y","article-title":"Overexpression of TNFSF11 reduces GPX4 levels and increases sensitivity to ferroptosis inducers in lung adenocarcinoma","volume":"22","author":"Li","year":"2024","journal-title":"J. Transl. Med."},{"key":"B90","doi-asserted-by":"publisher","first-page":"e70213","DOI":"10.1002\/prp2.70213","article-title":"Paeonol inhibits cell growth by inducing ferroptosis in human glioma cells","volume":"14","author":"Li","year":"2026","journal-title":"Pharmacol. Res. Perspect."},{"key":"B91","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1002\/tox.23992","article-title":"Ubiquitin-specific peptidase 10 attenuates the ferroptosis to promote thyroid cancer malignancy by facilitating GPX4 via elevating SIRT6","volume":"39","author":"Lian","year":"2024","journal-title":"Environ. Toxicol."},{"key":"B92","doi-asserted-by":"publisher","first-page":"30836","DOI":"10.1074\/jbc.M109.032839","article-title":"Short form glutathione peroxidase 4 is the essential isoform required for survival and somatic mitochondrial functions","volume":"284","author":"Liang","year":"2009","journal-title":"J. Biol. Chem."},{"key":"B93","doi-asserted-by":"publisher","first-page":"2934","DOI":"10.1038\/s41598-022-07065-y","article-title":"DJ-1 upregulates the Nrf2\/GPX4 signal pathway to inhibit trophoblast ferroptosis in the pathogenesis of preeclampsia","volume":"12","author":"Liao","year":"2022","journal-title":"Sci. Rep."},{"key":"B94","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.7150\/ijbs.80775","article-title":"Mitophagy alleviates cisplatin-induced renal tubular epithelial cell ferroptosis through ROS\/HO-1\/GPX4 axis","volume":"19","author":"Lin","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"B95","doi-asserted-by":"publisher","first-page":"e517","DOI":"10.1002\/ctm2.517","article-title":"Glutathione peroxidase 4-dependent glutathione high-consumption drives acquired platinum chemoresistance in lung cancer-derived brain metastasis","volume":"11","author":"Liu","year":"","journal-title":"Clin. Transl. Med."},{"key":"B96","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/s41417-020-0182-y","article-title":"Interplay between MTOR and GPX4 signaling modulates autophagy-dependent ferroptotic cancer cell death","volume":"28","author":"Liu","year":"","journal-title":"Cancer Gene Ther."},{"key":"B97","doi-asserted-by":"publisher","first-page":"e2301852","DOI":"10.1002\/advs.202301852","article-title":"Deubiquitinase OTUD5 as a novel protector against 4-HNE-Triggered ferroptosis in myocardial Ischemia\/Reperfusion Injury","volume":"10","author":"Liu","year":"2023","journal-title":"Adv. Sci. (Weinh)"},{"key":"B98","doi-asserted-by":"publisher","first-page":"4488","DOI":"10.1016\/j.cell.2024.07.040","article-title":"Spatiotemporal omics for biology and medicine","volume":"187","author":"Liu","year":"","journal-title":"Cell"},{"key":"B99","doi-asserted-by":"publisher","first-page":"e22245","DOI":"10.1002\/ddr.22245","article-title":"GSTO2 ameliorates human neuroblastoma cell apoptosis, inflammation, ferroptosis, and oxidative stress by upregulating GPX4 expression in intracerebral hemorrhage","volume":"85","author":"Liu","year":"","journal-title":"Drug Dev. Res."},{"key":"B100","doi-asserted-by":"publisher","first-page":"103008","DOI":"10.1016\/j.redox.2023.103008","article-title":"Heterogeneous ferroptosis susceptibility of macrophages caused by focal iron overload exacerbates rheumatoid arthritis","volume":"69","author":"Liu","year":"","journal-title":"Redox Biol."},{"key":"B101","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1021\/acschembio.5c00158","article-title":"Selective small-molecule activator of patient-derived GPX4 variant","volume":"20","author":"Liu","year":"","journal-title":"ACS Chem. Biol."},{"key":"B102","doi-asserted-by":"publisher","first-page":"5922","DOI":"10.7150\/ijbs.114075","article-title":"Smad3 mediates renal fibrosis via GPX4-dependent ferroptosis","volume":"21","author":"Liu","year":"","journal-title":"Int. J. Biol. Sci."},{"key":"B103","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s10495-026-02258-6","article-title":"Ferroptosis and its role in immune modulation in breast cancer","volume":"31","author":"Liu","year":"","journal-title":"Apoptosis"},{"key":"B104","doi-asserted-by":"publisher","first-page":"2328","DOI":"10.1182\/blood.2025029264","article-title":"DHODH as a targetable metabolic achilles\u2019 heel for chemo-resistant B-ALL","volume":"147","author":"Liu","year":"","journal-title":"Blood"},{"key":"B105","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1016\/j.cell.2025.12.002","article-title":"Extracellular GPX4 impairs antitumor immunity via dendritic ZP3 receptors","volume":"189","author":"Liu","year":"","journal-title":"Cell"},{"key":"B106","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.cell.2025.11.014","article-title":"A fin-loop-like structure in GPX4 underlies neuroprotection from ferroptosis","volume":"189","author":"Lorenz","year":"2026","journal-title":"Cell"},{"key":"B107","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.canlet.2021.09.014","article-title":"KLF2 inhibits cancer cell migration and invasion by regulating ferroptosis through GPX4 in clear cell renal cell carcinoma","volume":"522","author":"Lu","year":"2021","journal-title":"Cancer Lett."},{"key":"B108","doi-asserted-by":"publisher","first-page":"110831","DOI":"10.1016\/j.cellsig.2023.110831","article-title":"TCFL5 knockdown sensitizes DLBCL to doxorubicin treatment via regulation of GPX4","volume":"110","author":"Lu","year":"2023","journal-title":"Cell Signal"},{"key":"B109","doi-asserted-by":"publisher","first-page":"e20744","DOI":"10.1002\/anie.202520744","article-title":"Unnatural amino acid and emerging chemistry approaches to map RNA-Protein interactions","volume":"65","author":"Lundrigan","year":"2026","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"B110","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1007\/s00204-025-04198-7","article-title":"piR-16404 drives ferroptotic liver injury via CASTOR1\/mTORC1\/GPX4 dysregulation in HepG2 cells and mice: a novel toxicity mechanism of N, N-dimethylformamide","volume":"100","author":"Ma","year":"2026","journal-title":"Arch. Toxicol."},{"key":"B112","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1095\/biolreprod.102.007500","article-title":"Genetic variations of gpx-4 and male infertility in humans","volume":"68","author":"Maiorino","year":"2003","journal-title":"Biol. Reprod."},{"key":"B113","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1038\/s41586-021-03539-7","article-title":"DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer","volume":"593","author":"Mao","year":"2021","journal-title":"Nature"},{"key":"B114","doi-asserted-by":"publisher","first-page":"1376","DOI":"10.1016\/j.fertnstert.2006.03.053","article-title":"Effect of sperm glutathione peroxidases 1 and 4 on embryo asymmetry and blastocyst quality in oocyte donation cycles","volume":"86","author":"Meseguer","year":"2006","journal-title":"Fertil. Steril."},{"key":"B115","doi-asserted-by":"publisher","first-page":"2464","DOI":"10.1016\/j.cmet.2021.11.001","article-title":"Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context","volume":"33","author":"Morgenstern","year":"2021","journal-title":"Cell Metab."},{"key":"B116","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1016\/j.freeradbiomed.2025.10.286","article-title":"GPX4 ortholog regulates the O-GlcNAc-DDR pathway to preserve intestinal stem cell homeostasis during aging and oxidative stress","volume":"241","author":"Na","year":"2025","journal-title":"Free Radic. Biol. Med."},{"key":"B117","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1006\/abbi.1997.0566","article-title":"Glutathione depletion associated with the HIV-1 TAT protein mediates the extracellular appearance of acidic fibroblast growth factor","volume":"351","author":"Opalenik","year":"1998","journal-title":"Arch. Biochem. Biophys."},{"key":"B118","doi-asserted-by":"publisher","first-page":"5666","DOI":"10.1182\/bloodadvances.2020003100","article-title":"A new role of glutathione peroxidase 4 during human erythroblast enucleation","volume":"4","author":"Ouled-Haddou","year":"2020","journal-title":"Blood Adv."},{"key":"B119","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1111\/andr.13520","article-title":"The role of hepatitis B virus surface protein in inducing Sertoli cell ferroptosis","volume":"12","author":"Pan","year":"2024","journal-title":"Andrology"},{"key":"B120","doi-asserted-by":"publisher","first-page":"e18377","DOI":"10.1111\/jcmm.18377","article-title":"Glutathione peroxidase 4 restrains temporomandibular joint osteoarthritis progression by inhibiting ferroptosis","volume":"28","author":"Pang","year":"2024","journal-title":"J. Cell Mol. Med."},{"key":"B121","doi-asserted-by":"publisher","first-page":"103539","DOI":"10.1016\/j.redox.2025.103539","article-title":"The protective role of GPX4 in naive ESCs is highlighted by induced ferroptosis resistance through GPX4 expression","volume":"81","author":"Park","year":"2025","journal-title":"Redox Biol."},{"key":"B122","doi-asserted-by":"publisher","first-page":"33300","DOI":"10.1038\/srep33300","article-title":"Evaluation of glutathione peroxidase 4 role in Preeclampsia","volume":"6","author":"Peng","year":"2016","journal-title":"Sci. Rep."},{"key":"B123","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.3892\/or.2018.6905","article-title":"Glutathione peroxidase 4 maintains a stemness phenotype, oxidative homeostasis and regulates biological processes in Panc-1 cancer stem-like cells","volume":"41","author":"Peng","year":"2019","journal-title":"Oncol. Rep."},{"key":"B124","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1158\/1055-9965.EPI-07-2947","article-title":"Variation in the selenoenzyme genes and risk of advanced distal colorectal adenoma","volume":"17","author":"Peters","year":"2008","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"B125","doi-asserted-by":"publisher","first-page":"101265","DOI":"10.1016\/j.redox.2019.101265","article-title":"Oxygen-dependent bond formation with FIH regulates the activity of the client protein OTUB1","volume":"26","author":"Pickel","year":"2019","journal-title":"Redox Biol."},{"key":"B126","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1038\/hr.2011.213","article-title":"The C718T polymorphism in the 3'-untranslated region of glutathione peroxidase-4 gene is a predictor of cerebral stroke in patients with essential hypertension","volume":"35","author":"Polonikov","year":"2012","journal-title":"Hypertens. Res."},{"key":"B127","doi-asserted-by":"publisher","first-page":"117015","DOI":"10.1016\/j.ejmech.2024.117015","article-title":"A prospective therapeutic strategy: GPX4-targeted ferroptosis mediators","volume":"281","author":"Qian","year":"","journal-title":"Eur. J. Med. Chem."},{"key":"B128","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1186\/s13046-025-03548-8","article-title":"FASN inhibits ferroptosis in breast cancer via USP5 palmitoylation-dependent regulation of GPX4 deubiquitination","volume":"44","author":"Qian","year":"","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"B129","doi-asserted-by":"publisher","first-page":"11358","DOI":"10.1038\/s41598-023-32992-9","article-title":"GPX4 is a key ferroptosis biomarker and correlated with immune cell populations and immune checkpoints in childhood sepsis","volume":"13","author":"Qu","year":"2023","journal-title":"Sci. Rep."},{"key":"B130","doi-asserted-by":"publisher","first-page":"15968","DOI":"10.1038\/s41598-024-65079-0","article-title":"Silencing CK19 regulates ferroptosis by affecting the expression of GPX4 and ACSL4 in oral squamous cell carcinoma in vivo and in vitro","volume":"14","author":"Rao","year":"2024","journal-title":"Sci. Rep."},{"key":"B131","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1006\/abbi.2000.2197","article-title":"Human immunodeficiency virus type 1 Tat protein impairs selenoglutathione peroxidase expression and activity by a mechanism independent of cellular selenium uptake: consequences on cellular resistance to UV-A radiation","volume":"386","author":"Richard","year":"2001","journal-title":"Arch. Biochem. Biophys."},{"key":"B132","doi-asserted-by":"publisher","first-page":"111697","DOI":"10.1016\/j.cbi.2025.111697","article-title":"Cigarette smoke-induced glycerophospholipid DLPC promotes macrophage ferroptosis through the USP7\/GPX4 regulatory axis in chronic obstructive pulmonary disease","volume":"420","author":"Ruan","year":"2025","journal-title":"Chem. Biol. Interact."},{"key":"B133","doi-asserted-by":"publisher","first-page":"102655","DOI":"10.1016\/j.redox.2023.102655","article-title":"miR-125b-5p in adipose derived stem cells exosome alleviates pulmonary microvascular endothelial cells ferroptosis via Keap1\/Nrf2\/GPX4 in sepsis lung injury","volume":"62","author":"Shen","year":"2023","journal-title":"Redox Biol."},{"key":"B134","doi-asserted-by":"publisher","first-page":"5710403","DOI":"10.1155\/2016\/5710403","article-title":"The cellular response to oxidatively induced DNA damage and polymorphism of some DNA repair genes associated with clinicopathological features of bladder cancer","volume":"2016","author":"Savina","year":"2016","journal-title":"Oxid. Med. Cell Longev."},{"key":"B135","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.neuroscience.2017.05.050","article-title":"Alterations in neuronal control of body weight and anxiety behavior by glutathione peroxidase 4 deficiency","volume":"357","author":"Schriever","year":"2017","journal-title":"Neuroscience"},{"key":"B136","doi-asserted-by":"publisher","first-page":"102593","DOI":"10.1016\/j.redox.2022.102593","article-title":"Side-by-side comparison of recombinant human glutathione peroxidases identifies overlapping substrate specificities for soluble hydroperoxides","volume":"59","author":"Schwarz","year":"2023","journal-title":"Redox Biol."},{"key":"B137","doi-asserted-by":"publisher","first-page":"112591","DOI":"10.1016\/j.biopha.2021.112591","article-title":"Association of genetic variants in the GPX1 and GPX4 genes with the activities of glutathione-dependent enzymes, their interaction with smoking and the risk of acute pancreatitis","volume":"146","author":"\u015aciskalska","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"B138","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1038\/nchembio.2386","article-title":"Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase","volume":"13","author":"Scott","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"B139","doi-asserted-by":"publisher","first-page":"19396","DOI":"10.1038\/s41598-022-23906-2","article-title":"Glutathione peroxidase 4 inhibition induces ferroptosis and mTOR pathway suppression in thyroid cancer","volume":"12","author":"Sekhar","year":"2022","journal-title":"Sci. Rep."},{"key":"B140","doi-asserted-by":"publisher","first-page":"103560","DOI":"10.1016\/j.ebiom.2021.103560","article-title":"Predictive and prognostic impact of ferroptosis-related genes ACSL4 and GPX4 on breast cancer treated with neoadjuvant chemotherapy","volume":"71","author":"Sha","year":"2021","journal-title":"EBioMedicine"},{"key":"B141","doi-asserted-by":"publisher","first-page":"e202401052","DOI":"10.1002\/cbic.202401052","article-title":"Fine-tuning ferroptosis by modulating GPX4 and its potential in mitigating neuronal degeneration in Parkinson\u2019s disease","volume":"26","author":"Shahid","year":"2025","journal-title":"Chembiochem."},{"key":"B142","doi-asserted-by":"publisher","first-page":"2322","DOI":"10.1038\/s41418-023-01221-1","article-title":"The E3 ubiquitin ligase TRIM17 promotes gastric cancer survival and progression via controlling BAX stability and antagonizing apoptosis","volume":"30","author":"Shen","year":"2023","journal-title":"Cell Death Differ."},{"key":"B143","doi-asserted-by":"publisher","first-page":"101928","DOI":"10.1016\/j.xcrm.2025.101928","article-title":"Targeting pancreatic cancer glutamine dependency confers vulnerability to GPX4-dependent ferroptosis","volume":"6","author":"Shen","year":"2025","journal-title":"Cell Rep. Med."},{"key":"B144","doi-asserted-by":"publisher","first-page":"116800","DOI":"10.1016\/j.bcp.2025.116800","article-title":"Targeting GPX4 alleviates ferroptosis and retards abdominal aortic aneurysm formation","volume":"234","author":"Shi","year":"2025","journal-title":"Biochem. Pharmacol."},{"key":"B145","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1016\/j.freeradbiomed.2018.10.426","article-title":"Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer","volume":"129","author":"Shin","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"B146","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1136\/jmedgenet-2013-102218","article-title":"Mutations in the enzyme glutathione peroxidase 4 cause sedaghatian-type spondylometaphyseal dysplasia","volume":"51","author":"Smith","year":"2014","journal-title":"J. Med. Genet."},{"key":"B147","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.atherosclerosis.2003.08.008","article-title":"Regulation of selenoprotein GPx4 expression and activity in human endothelial cells by fatty acids, cytokines and antioxidants","volume":"171","author":"Sneddon","year":"2003","journal-title":"Atherosclerosis"},{"key":"B148","doi-asserted-by":"publisher","first-page":"941","DOI":"10.4049\/jimmunol.2400246","article-title":"Gpx4 regulates invariant NKT cell homeostasis and function by preventing lipid peroxidation and ferroptosis","volume":"213","author":"Sok","year":"2024","journal-title":"J. Immunol."},{"key":"B149","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.cell.2009.04.042","article-title":"Defining the human deubiquitinating enzyme interaction landscape","volume":"138","author":"Sowa","year":"2009","journal-title":"Cell"},{"key":"B150","doi-asserted-by":"publisher","first-page":"10764","DOI":"10.1074\/jbc.M110.216028","article-title":"Induction of glutathione peroxidase 4 expression during enterocytic cell differentiation","volume":"286","author":"Speckmann","year":"2011","journal-title":"J. Biol. Chem."},{"key":"B151","doi-asserted-by":"publisher","first-page":"3016","DOI":"10.3390\/ijms25053016","article-title":"Targeted RNAseq revealed the gene expression signature of ferroptosis-related processes associated with disease severity in patients with multiple sclerosis","volume":"25","author":"Stojkovic","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"B152","doi-asserted-by":"publisher","first-page":"101518","DOI":"10.1016\/j.redox.2020.101518","article-title":"Simultaneous detection of the enzyme activities of GPx1 and GPx4 guide optimization of selenium in cell biological experiments","volume":"32","author":"Stolwijk","year":"2020","journal-title":"Redox Biol."},{"key":"B153","doi-asserted-by":"publisher","first-page":"102073","DOI":"10.1016\/j.redox.2021.102073","article-title":"Red blood cells contain enzymatically active GPx4 whose abundance anticorrelates with hemolysis during blood bank storage","volume":"46","author":"Stolwijk","year":"2021","journal-title":"Redox Biol."},{"key":"B154","doi-asserted-by":"publisher","first-page":"16899","DOI":"10.1073\/pnas.242603899","article-title":"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences","volume":"99","author":"Strausberg","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B155","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1186\/s12985-024-02346-6","article-title":"Hypermethylation of the glutathione peroxidase 4 gene promoter is associated with the occurrence of immune tolerance phase in chronic hepatitis B","volume":"21","author":"Su","year":"2024","journal-title":"Virol. J."},{"key":"B156","doi-asserted-by":"publisher","first-page":"121608","DOI":"10.1016\/j.lfs.2023.121608","article-title":"TRIM21 ubiquitylates GPX4 and promotes ferroptosis to aggravate ischemia\/reperfusion-induced acute kidney injury","volume":"321","author":"Sun","year":"2023","journal-title":"Life Sci."},{"key":"B157","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1042\/bj3530091","article-title":"Evidence for the presence of phospholipid hydroperoxide glutathione peroxidase in human platelets: implications for its involvement in the regulatory network of the 12-lipoxygenase pathway of arachidonic acid metabolism","volume":"353","author":"Sutherland","year":"2001","journal-title":"Biochem. J."},{"key":"B158","doi-asserted-by":"publisher","first-page":"1796","DOI":"10.18632\/aging.205460","article-title":"Circ0060467 sponges miR-6805 to promote hepatocellular carcinoma progression through regulating AIFM2 and GPX4 expression","volume":"16","author":"Tan","year":"2024","journal-title":"Aging (Albany NY)"},{"key":"B159","doi-asserted-by":"publisher","first-page":"e70078","DOI":"10.1002\/jcp.70078","article-title":"Targeting GPX4 to overcome sorafenib resistance of human hepatocellular carcinoma by inducing ferroptosis","volume":"240","author":"Tang","year":"2025","journal-title":"J. Cell Physiol."},{"key":"B160","doi-asserted-by":"publisher","first-page":"651","DOI":"10.55563\/clinexprheumatol\/kylvva","article-title":"Ferroptosis in peripheral blood mononuclear cells of systemic lupus erythematosus","volume":"42","author":"Tao","year":"2024","journal-title":"Clin. Exp. Rheumatol."},{"key":"B161","doi-asserted-by":"publisher","first-page":"26356","DOI":"10.1021\/acs.jafc.5c05677","article-title":"Selenium-GPX4 axis relieves arachidonic acid-induced sperm damage","volume":"73","author":"Tian","year":"2025","journal-title":"J. Agric. Food Chem."},{"key":"B162","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1042\/BJ20040974","article-title":"cAMP-response element modulator-tau activates a distinct promoter element for the expression of the phospholipid hydroperoxide\/sperm nucleus glutathione peroxidase gene","volume":"383","author":"Tramer","year":"2004","journal-title":"Biochem. J."},{"key":"B163","doi-asserted-by":"publisher","first-page":"2076","DOI":"10.4049\/jimmunol.1801232","article-title":"Involvement of GPx4-Regulated lipid peroxidation in idiopathic pulmonary fibrosis pathogenesis","volume":"203","author":"Tsubouchi","year":"2019","journal-title":"J. Immunol."},{"key":"B164","doi-asserted-by":"publisher","first-page":"3108","DOI":"10.1038\/s41380-026-03445-2","article-title":"Ferroptosis in neurological diseases: moving towards therapeutic intervention","volume":"19","author":"Tuo","year":"2026","journal-title":"Mol. Psychiatry"},{"key":"B165","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1126\/science.285.5432.1393","article-title":"Dual function of the selenoprotein PHGPx during sperm maturation","volume":"285","author":"Ursini","year":"1999","journal-title":"Science"},{"key":"B166","doi-asserted-by":"publisher","first-page":"e183219","DOI":"10.1172\/JCI183219","article-title":"Ferroptosis of select skin epithelial cells initiates and maintains chronic systemic immune-mediated psoriatic disease","volume":"135","author":"Vats","year":"2025","journal-title":"J. Clin. Invest"},{"key":"B167","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1038\/nature14877","article-title":"Panorama of ancient metazoan macromolecular complexes","volume":"525","author":"Wan","year":"2015","journal-title":"Nature"},{"key":"B168","doi-asserted-by":"publisher","first-page":"114074","DOI":"10.1016\/j.yexcr.2024.114074","article-title":"PITX2 functions as a transcription factor for GPX4 and protects pancreatic cancer cells from ferroptosis","volume":"439","author":"Wang","year":"2024","journal-title":"Exp. Cell Res."},{"key":"B169","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1080\/1071576031000088283","article-title":"Phospholipid hydroperoxide glutathione peroxidase induces a delay in G1 of the cell cycle","volume":"37","author":"Wang","year":"2003","journal-title":"Free Radic. Res."},{"key":"B170","doi-asserted-by":"publisher","first-page":"5750","DOI":"10.1021\/pr400753f","article-title":"Mapping of the N-linked glycoproteome of human spermatozoa","volume":"12","author":"Wang","year":"2013","journal-title":"J. Proteome Res."},{"key":"B171","doi-asserted-by":"publisher","first-page":"88","DOI":"10.3892\/or.2021.8039","article-title":"CREB stimulates GPX4 transcription to inhibit ferroptosis in lung adenocarcinoma","volume":"45","author":"Wang","year":"2021","journal-title":"Oncol. Rep."},{"key":"B172","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1038\/s41419-023-06222-z","article-title":"The E3 ligase TRIM26 suppresses ferroptosis through catalyzing K63-linked ubiquitination of GPX4 in glioma","volume":"14","author":"Wang","year":"2023","journal-title":"Cell Death Dis."},{"key":"B173","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1038\/s41392-025-02216-9","article-title":"STING aggravates ferroptosis-dependent myocardial ischemia-reperfusion injury by targeting GPX4 for autophagic degradation","volume":"10","author":"Wang","year":"","journal-title":"Signal Transduct. Target Ther."},{"key":"B174","doi-asserted-by":"publisher","first-page":"e2419625121","DOI":"10.1073\/pnas.2419625121","article-title":"Deciphering the role of the MALT1-RC3H1 axis in regulating GPX4 protein stability","volume":"122","author":"Wang","year":"","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B175","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.jare.2024.11.036","article-title":"Asperosaponin VI inhibition of DNMT alleviates GPX4 suppression-mediated osteoblast ferroptosis and diabetic osteoporosis","volume":"75","author":"Wei","year":"2025","journal-title":"J. Adv. Res."},{"key":"B176","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1007\/s00011-025-02047-y","article-title":"Melatonin inhibits salivary gland epithelial cell ferroptosis via the NRF2\/HO-1\/GPX4 signaling pathway in primary Sjogren\u2019s syndrome","volume":"74","author":"Weng","year":"2025","journal-title":"Inflamm. Res."},{"key":"B177","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1111\/1471-0528.17327","article-title":"High co-expression of SLC7A11 and GPX4 as a predictor of platinum resistance and poor prognosis in patients with epithelial ovarian cancer","volume":"129","author":"Wu","year":"","journal-title":"BJOG"},{"key":"B178","doi-asserted-by":"publisher","first-page":"5438","DOI":"10.7150\/ijbs.74675","article-title":"Downregulation of PPAR\u03b1 mediates FABP1 expression, contributing to IgA nephropathy by stimulating ferroptosis in human mesangial cells","volume":"18","author":"Wu","year":"","journal-title":"Int. J. Biol. Sci."},{"key":"B179","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1038\/s41556-023-01133-9","article-title":"Creatine kinase B suppresses ferroptosis by phosphorylating GPX4 through a moonlighting function","volume":"25","author":"Wu","year":"2023","journal-title":"Nat. Cell Biol."},{"key":"B180","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1007\/s10534-025-00706-5","article-title":"Overexpression of GPX4 in diabetic rat kidney alleviates renal injury induced by ferroptosis","volume":"38","author":"Wu","year":"2025","journal-title":"Biometals"},{"key":"B181","doi-asserted-by":"publisher","first-page":"113841","DOI":"10.1016\/j.jconrel.2025.113841","article-title":"Mitochondria-specific GPX4 inhibition enhances ferroptosis and antitumor immunity","volume":"383","author":"Xiao","year":"2025","journal-title":"J. Control Release"},{"key":"B182","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1007\/s00403-025-03903-x","article-title":"Double-edged sword effect of GPX4 in skin homeostasis and diseases","volume":"317","author":"Xu","year":"","journal-title":"Arch. Dermatol Res."},{"key":"B183","doi-asserted-by":"publisher","first-page":"5826","DOI":"10.7150\/thno.108817","article-title":"GPX4 knockdown suppresses M2 macrophage polarization in gastric cancer by modulating kynurenine metabolism","volume":"15","author":"Xu","year":"","journal-title":"Theranostics"},{"key":"B184","doi-asserted-by":"publisher","first-page":"1982","DOI":"10.1080\/15548627.2023.2165323","article-title":"Copper-dependent autophagic degradation of GPX4 drives ferroptosis","volume":"19","author":"Xue","year":"2023","journal-title":"Autophagy"},{"key":"B185","doi-asserted-by":"publisher","first-page":"118046","DOI":"10.1016\/j.bmc.2024.118046","article-title":"An overview of GPX4-targeting TPDs for cancer therapy","volume":"118","author":"Yang","year":"2025","journal-title":"Bioorg Med. Chem."},{"key":"B186","doi-asserted-by":"publisher","first-page":"e2300871","DOI":"10.1002\/adhm.202300871","article-title":"Exploiting cancer vulnerabilities by blocking of the DHODH and GPX4 pathways: a multifunctional Bodipy\/PROTAC nanoplatform for the efficient synergistic ferroptosis therapy","volume":"12","author":"Yao","year":"2023","journal-title":"Adv. Healthc. Mater"},{"key":"B187","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1186\/s12967-024-05714-6","article-title":"KLF14 directly downregulates the expression of GPX4 to exert antitumor effects by promoting ferroptosis in cervical cancer","volume":"22","author":"Ye","year":"2024","journal-title":"J. Transl. Med."},{"key":"B188","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.freeradbiomed.2025.02.040","article-title":"Nrf2 alleviates acute ischemic stroke induced ferroptosis via regulating xCT\/GPX4 pathway","volume":"231","author":"Ye","year":"","journal-title":"Free Radic. Biol. Med."},{"key":"B189","doi-asserted-by":"publisher","first-page":"103615","DOI":"10.1016\/j.redox.2025.103615","article-title":"GPX4 deficiency-induced ferroptosis drives endometrial epithelial fibrosis in polycystic ovary syndrome","volume":"83","author":"Ye","year":"","journal-title":"Redox Biol."},{"key":"B190","doi-asserted-by":"publisher","first-page":"5513245","DOI":"10.1155\/2023\/5513245","article-title":"lnc-MRGPRF-6:1 promotes ox-LDL-Induced macrophage ferroptosis via suppressing GPX4","volume":"2023","author":"You","year":"2023","journal-title":"Mediat. Inflamm."},{"key":"B191","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/s41392-025-02296-7","article-title":"Acevaltrate as a novel ferroptosis inducer with dual targets of PCBP1\/2 and GPX4 in colorectal cancer","volume":"10","author":"Yu","year":"2025","journal-title":"Signal Transduct. Target Ther."},{"key":"B192","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1038\/s41418-022-00939-8","article-title":"EBV infection-induced GPX4 promotes chemoresistance and tumor progression in nasopharyngeal carcinoma","volume":"29","author":"Yuan","year":"2022","journal-title":"Cell Death Differ."},{"key":"B193","doi-asserted-by":"publisher","first-page":"3968","DOI":"10.7150\/ijbs.113213","article-title":"Multi-cohort validation of a lipid metabolism and ferroptosis-associated index for prognosis and immunotherapy response prediction in hormone receptor-positive breast cancer","volume":"21","author":"Zeng","year":"2025","journal-title":"Int. J. Biol. Sci."},{"key":"B194","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/j.freeradbiomed.2022.11.002","article-title":"IRF1\/ZNF350\/GPX4-mediated ferroptosis of renal tubular epithelial cells promote chronic renal allograft interstitial fibrosis","volume":"193","author":"Zhang","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"B195","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/s13577-022-00820-3","article-title":"TRIM59 promotes steatosis and ferroptosis in non-alcoholic fatty liver disease via enhancing GPX4 ubiquitination","volume":"36","author":"Zhang","year":"2023","journal-title":"Hum. Cell"},{"key":"B196","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.virs.2023.09.001","article-title":"Ancient dormant virus remnant ERVW-1 drives ferroptosis via degradation of GPX4 and SLC3A2 in schizophrenia","volume":"39","author":"Zhang","year":"2024","journal-title":"Virol. Sin."},{"key":"B197","doi-asserted-by":"publisher","first-page":"103635","DOI":"10.1016\/j.redox.2025.103635","article-title":"Noscapine derivative 428 suppresses ferroptosis through targeting GPX4","volume":"83","author":"Zhang","year":"","journal-title":"Redox Biol."},{"key":"B198","doi-asserted-by":"publisher","first-page":"14233","DOI":"10.1021\/acsnano.5c00730","article-title":"Synchronously evoking disulfidptosis and ferroptosis via systematical glucose deprivation targeting SLC7A11\/GSH\/GPX4 antioxidant axis","volume":"19","author":"Zhang","year":"","journal-title":"ACS Nano"},{"key":"B199","doi-asserted-by":"publisher","first-page":"153117","DOI":"10.1016\/j.bbrc.2025.153117","article-title":"Targeting DHODH promoter G-quadruplex to induce ferroptosis in melanoma cells","volume":"795","author":"Zhang","year":"2026","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B200","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1038\/s42003-023-04959-z","article-title":"KLF11 regulates lung adenocarcinoma ferroptosis and chemosensitivity by suppressing GPX4","volume":"6","author":"Zhao","year":"","journal-title":"Commun. Biol."},{"key":"B201","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.reprotox.2022.12.002","article-title":"Sphingosine 1-phosphate alleviates radiation-induced ferroptosis in ovarian granulosa cells by upregulating glutathione peroxidase 4","volume":"115","author":"Zhao","year":"","journal-title":"Reprod. Toxicol."},{"key":"B202","doi-asserted-by":"publisher","first-page":"110944","DOI":"10.1016\/j.cbi.2024.110944","article-title":"Selenium binding protein 1 protects renal tubular epithelial cells from ferroptosis by upregulating glutathione peroxidase 4","volume":"393","author":"Zhao","year":"2024","journal-title":"Chem. Biol. Interact."},{"key":"B203","doi-asserted-by":"publisher","first-page":"3605","DOI":"10.1038\/s41467-025-58992-z","article-title":"Targeting PLK1-CBX8-GPX4 axis overcomes BRAF\/EGFR inhibitor resistance in BRAFV600E colorectal cancer via ferroptosis","volume":"16","author":"Zhao","year":"2025","journal-title":"Nat. Commun."},{"key":"B204","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1038\/s41598-024-51259-5","article-title":"Selenoprotein P expression in glioblastoma as a regulator of ferroptosis sensitivity: preservation of GPX4 via the cycling-selenium storage","volume":"14","author":"Zheng","year":"","journal-title":"Sci. Rep."},{"key":"B205","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.freeradbiomed.2023.12.047","article-title":"P21 resists ferroptosis in osteoarthritic chondrocytes by regulating GPX4 protein stability","volume":"212","author":"Zheng","year":"","journal-title":"Free Radic. Biol. Med."},{"key":"B206","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1038\/s41589-025-01887-3","article-title":"PSAT1 impairs ferroptosis and reduces immunotherapy efficacy via GPX4 hydroxylation","volume":"21","author":"Zheng","year":"2025","journal-title":"Nat. Chem. Biol."},{"key":"B207","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1186\/s12951-025-03861-6","article-title":"YTHDF1 transcriptionally activated by TCF4 suppresses osteoblast ferroptosis in titanium nanoparticle-induced osteolysis by accelerating GPX4 and SLC7A11 translation","volume":"23","author":"Zhong","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"B208","doi-asserted-by":"publisher","first-page":"1588","DOI":"10.3748\/wjg.v30.i11.1588","article-title":"Silent information regulator sirtuin 1 ameliorates acute liver failure via the p53\/glutathione peroxidase 4\/gasdermin D axis","volume":"30","author":"Zhou","year":"","journal-title":"World J. Gastroenterol."},{"key":"B209","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2024.03.012","article-title":"Downregulated GPX4 in salivary gland epithelial cells contributes to salivary secretion dysfunction in Sjogren\u2019s syndrome via lipid ROS\/pSTAT4\/AQP5 axis","volume":"218","author":"Zhou","year":"","journal-title":"Free Radic. Biol. Med."},{"key":"B210","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.7150\/ijbs.106690","article-title":"TRIM32 promotes neuronal ferroptosis by enhancing K63-linked ubiquitination and subsequent p62-selective autophagic degradation of GPX4","volume":"21","author":"Zhou","year":"","journal-title":"Int. J. Biol. Sci."},{"key":"B211","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1038\/s43018-025-00937-y","article-title":"Palmitoylation of GPX4 via the targetable ZDHHC8 determines ferroptosis sensitivity and antitumor immunity","volume":"6","author":"Zhou","year":"","journal-title":"Nat. Cancer"},{"key":"B212","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/j.jare.2025.01.010","article-title":"Antioxidant taurine inhibits chondrocyte ferroptosis through upregulation of OGT\/Gpx4 signaling in osteoarthritis induced by anterior cruciate ligament transection","volume":"77","author":"Zhou","year":"","journal-title":"J. Adv. Res."},{"key":"B213","doi-asserted-by":"publisher","first-page":"2646383","DOI":"10.1080\/13510002.2025.2646383","article-title":"Ferroptosis inhibition and mitochondrial rescue: a novel mechanism of emodin in rheumatoid arthritis","volume":"31","author":"Zhou","year":"2026","journal-title":"Redox Rep."},{"key":"B214","doi-asserted-by":"publisher","first-page":"6551069","DOI":"10.1155\/2021\/6551069","article-title":"GPX4-Regulated ferroptosis mediates S100-Induced experimental Autoimmune Hepatitis associated with the Nrf2\/HO-1 signaling pathway","volume":"2021","author":"Zhu","year":"2021","journal-title":"Oxid. Med. Cell Longev."},{"key":"B215","doi-asserted-by":"publisher","first-page":"2871","DOI":"10.1111\/liv.15462","article-title":"FBXO31 sensitizes cancer stem cells-like cells to cisplatin by promoting ferroptosis and facilitating proteasomal degradation of GPX4 in cholangiocarcinoma","volume":"42","author":"Zhu","year":"2022","journal-title":"Liver Int."},{"key":"B216","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1016\/j.tcb.2025.01.005","article-title":"Autophagy-dependent versus autophagy-independent ferroptosis","volume":"35","author":"Zhu","year":"2025","journal-title":"Trends Cell Biol."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2026.1834222\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T12:51:47Z","timestamp":1787835107000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2026.1834222\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,27]]},"references-count":214,"alternative-id":["10.3389\/fphar.2026.1834222"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2026.1834222","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,27]]},"article-number":"1834222"}}