{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T01:23:33Z","timestamp":1790904213711,"version":"4.1.0"},"reference-count":131,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Methotrexate (MTX) is a widely used anticancer and immunosuppressive agent, but its clinical use is limited by lung injury associated with oxidative stress, inflammation, and fibrosis. Leaves of\n                      <jats:italic>Cordia dichotoma<\/jats:italic>\n                      and\n                      <jats:italic>Cordia myxa<\/jats:italic>\n                      traditionally have been used for respiratory disorders, suggesting potential anti-inflammatory benefits.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To characterize the chemical profile of defatted aqueous methanol extracts (DAME) of\n                      <jats:italic>C. dichotoma<\/jats:italic>\n                      and\n                      <jats:italic>C. myxa<\/jats:italic>\n                      leaves and evaluate their protective effects against MTX-induced pulmonary inflammation and injury.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Extracts were analyzed by HPLC\/MS. Rats were divided into control, MTX,\n                      <jats:italic>Cordia<\/jats:italic>\n                      -pretreated (250 or 500\u00a0mg\/kg), and dexamethasone groups. Lung tissues were assessed for oxidative stress (MDA, GSH, SOD), inflammatory mediators (TNF-\u03b1, IL-1\u03b2, IL-6), NF-\u03baB activation, fibrotic markers (TGF-\u03b21, \u03b1-SMA, hydroxyproline), and histopathology.\n                      <jats:italic>In vitro<\/jats:italic>\n                      , RAW 264.7 macrophages were used to assess cytotoxicity, nitric oxide production, and NF-\u03baB modulation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      HPLC\/MS identified 81 and 29 metabolites in\n                      <jats:italic>C. dichotoma<\/jats:italic>\n                      and\n                      <jats:italic>C. myxa<\/jats:italic>\n                      , respectively, mainly phenolic acids and flavonoids. MTX induced oxidative and inflammatory damage, with elevated cytokine levels and NF-\u03baB activation. Pretreatment with both extracts, particularly\n                      <jats:italic>C. dichotoma<\/jats:italic>\n                      (500\u00a0mg\/kg), significantly restored antioxidant balance, suppressed TGF-\u03b21\/\u03b1-SMA signaling, and preserved lung architecture.\n                      <jats:italic>In vitro<\/jats:italic>\n                      , the extracts inhibited LPS-induced NO release and NF-\u03baB activation, indicating direct macrophage-modulating activity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Phenolic-rich extracts of\n                      <jats:italic>C. dichotoma<\/jats:italic>\n                      and\n                      <jats:italic>C. myxa<\/jats:italic>\n                      exert anti-inflammatory, antioxidant, and anti-fibrotic effects by modulating macrophage-driven inflammation and restoring the pulmonary microenvironment, supporting their potential as a natural remedy for inflammation-associated lung injury.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphar.2026.1836019","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T15:21:55Z","timestamp":1782487315000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Modulation of NF-\u03baB and cytokine signaling by Cordia dichotoma and Cordia myxa attenuates methotrexate-induced pulmonary inflammation and oxidative injury in rats"],"prefix":"10.3389","volume":"17","author":[{"given":"Nermine M.","family":"Mohammed","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Capital University (Formerly Helwan University)","place":["Cairo, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoda M.","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Capital University (Formerly Helwan University)","place":["Cairo, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma A.","family":"Moharram","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Capital University (Formerly Helwan University)","place":["Cairo, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsayed K.","family":"El-Sayed","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Capital University (Formerly Helwan University)","place":["Cairo, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmaa A.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Capital University (Formerly Helwan University)","place":["Cairo, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Elbaz","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Capital University (Formerly Helwan University)","place":["Cairo, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merhan E.","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Veterinary Medicine, Cairo University","place":["Giza, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Ying","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Food Safety, Taipei Medical University","place":["Taipei, Taiwan"]},{"name":"School of Nutrition and Health Sciences, Taipei Medical University","place":["Taipei, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuei-Hung","family":"Lai","sequence":"additional","affiliation":[{"name":"Graduate Institute of Pharmacognosy, College of Pharmacy, Taipei Medical University","place":["Taipei, Taiwan"]},{"name":"Program in Clinical Drug Development of Herbal Medicine, College of Pharmacy, Taipei Medical University","place":["Taipei, Taiwan"]},{"name":"Traditional Herbal Medicine Research Center, Taipei Medical University Hospital","place":["Taipei, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahenda","family":"Mahgoub","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Helwan University","place":["Cairo, Egypt"]},{"name":"Biochemistry Department, Faculty of Pharmacy, King Salman International University","place":["Ras Sudr, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanan G.","family":"Sary","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University","place":["Cairo, Egypt"]},{"name":"Department of Pharmaceutical Chemistry, College of Pharmacy","place":["Kuwait University, Kuwait"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heba T.","family":"Khazaal","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Capital University (Formerly Helwan University)","place":["Cairo, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1007\/s00210-023-02652-w","article-title":"Cinnamic acid mitigates methotrexate-induced lung fibrosis in rats: comparative study with pirfenidone","volume":"397","author":"Abdalhameid","year":"2024","journal-title":"Naunyn. Schmiedeb. Arch. Pharmacol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s40816-019-0125-z","article-title":"Total phenolic and flavonoid contents and antioxidant, anti-inflammatory, analgesic, antipyretic and antidiabetic activities of Cordia myxa L. leaves","volume":"5","author":"Abdel-Aleem","year":"2019","journal-title":"Clin. Phytoscience"},{"key":"B3","doi-asserted-by":"publisher","first-page":"7321","DOI":"10.1038\/s41598-023-34143-6","article-title":"The potential role of pumpkin seeds oil on methotrexate-induced lung toxicity","volume":"13","author":"Abosrea","year":"2023","journal-title":"Sci. Rep."},{"key":"B4","doi-asserted-by":"publisher","first-page":"173","DOI":"10.15406\/ppij.2024.12.00448","article-title":"LC-MS analysis of Urtica urens water extracts: active ingredients and their impact on beta-hematin formation","volume":"12","author":"Abu-Lafi","year":"2024","journal-title":"Pharm. Pharmacol. Int. J."},{"key":"B5","first-page":"2109","article-title":"Antioxidant activity of Cordia myxa L. and its hepatoprotective","volume":"6","author":"Afzal","year":"2007","journal-title":"Electron J. Environ. Agric. Food Chem."},{"key":"B6","doi-asserted-by":"publisher","first-page":"81","DOI":"10.2174\/157339809788190011","article-title":"Joshanda: a traditional herbal approach for treatment of respiratory catarrh","volume":"5","author":"Ahuja","year":"2009","journal-title":"Curr. Respir. Med. Rev."},{"key":"B7","doi-asserted-by":"publisher","first-page":"378","DOI":"10.36347\/sajb.2020.v08i11.006","article-title":"Nutraceautical wild fruit of India-capparis decidua (Forssek.) Edgew","volume":"8","author":"Ahuja","year":"2020","journal-title":"Caper Tree\/Karira. Sch. Acad. J. Biosci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"63","DOI":"10.3329\/bjp.v12i1.29735","article-title":"Antibacterial and anti-hemolytic activity of tannins from Pimenta Dioica against methicillin resistant Staphylococcus aureus","volume":"12","author":"Al-Harbi","year":"2017","journal-title":"Bangladesh J. Pharmacol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"97","DOI":"10.18502\/ijm.v14i1.8810","article-title":"In vitro study of antioxidant, antibacterial, and cytotoxicity properties of Cordia myxa fruit extract","volume":"14","author":"Al-Musawi","year":"2022","journal-title":"Iran. J. Microbiol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"10214","DOI":"10.3390\/molecules161210214","article-title":"Antioxidant, anti-glycation and anti-inflammatory activities of phenolic constituents from Cordia sinensis. Molecules","volume":"16","author":"Al-Musayeib","year":"2011","journal-title":"Molecules"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2020\/1730492","article-title":"Antidiabetic potency, antioxidant effects, and mode of actions of Citrus reticulata fruit peel hydroethanolic extract, hesperidin, and quercetin in nicotinamide\/streptozotocin-induced Wistar diabetic rats","volume":"2020","author":"Ali","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"B12","doi-asserted-by":"publisher","first-page":"721","DOI":"10.3390\/antiox10050721","article-title":"Comprehensive profiling of most widely used spices for their phenolic compounds through LC-ESI-QTOF-MS2 and their antioxidant potential","volume":"10","author":"Ali","year":"2021","journal-title":"Antioxidants"},{"key":"B13","doi-asserted-by":"publisher","first-page":"e23019","DOI":"10.1002\/jbt.23019","article-title":"Polydatin combats methotrexate\u2010induced pulmonary fibrosis in rats: involvement of biochemical and histopathological assessment","volume":"36","author":"Ali","year":"2022","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"36","DOI":"10.17221\/3369-CJFS","article-title":"TLC separation of methylated (-)-epigallocatechin-3-gallate","volume":"23","author":"Amarowicz","year":"2005","journal-title":"Czech J. Food Sci."},{"key":"B15","doi-asserted-by":"publisher","first-page":"181","DOI":"10.29356\/jmcs.v66i2.1643","article-title":"In-silico Studies of phytochemicals of Ashwagandha, harsingar, Meethi neem and Tulsi against Covid-19","volume":"66","author":"Anand","year":"2022","journal-title":"J. Mex. Chem. Soc."},{"key":"B17","first-page":"753","article-title":"Biological effect of crude hot aqueous extract of Cordia myxa l. leaves on some stages of musca domestica (diptera: muscidae)","volume":"18","author":"Atia","year":"2018","journal-title":"Plant Arch."},{"key":"B18","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1177\/09731296241277295","article-title":"Phytochemical profile and antioxidant, enzyme-inhibitory, and cytotoxic potential of endemic Cynoglottis chetikiana subsp. chetikiana","volume":"21","author":"Baran","year":"2024","journal-title":"Pharmacogn. Mag."},{"key":"B19","doi-asserted-by":"publisher","first-page":"5023","DOI":"10.3390\/ijms20205023","article-title":"Methotrexate an old drug with new tricks","volume":"20","author":"Bedoui","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"637","DOI":"10.32628\/IJSRST218499","article-title":"A comparative anthelmintic study on jasminum grandiflorum and cordia diachotoma","volume":"8","author":"Bhaldar","year":"2021","journal-title":"Int. J. Sci. Res. Sci. Technol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1590\/S0102-695X2013005000020","article-title":"Evaluation of reversible contraceptive potential of Cordia dichotoma leaves extract","volume":"23","author":"Bhattacharya","year":"2013","journal-title":"Rev. Bras. Farmacogn."},{"key":"B23","doi-asserted-by":"publisher","first-page":"101791","DOI":"10.1016\/j.jsps.2023.101791","article-title":"Neuroprotective potential of Cordia dichotoma in Parkinson\u2019s syndrome induced by haloperidol: an animal study","volume":"31","author":"Bhavani","year":"2023","journal-title":"Saudi Pharm. J."},{"key":"B24","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"B25","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1080\/10942912.2024.2344556","article-title":"Phytochemical and antibacterial assessment of essential oils extracted from aerial parts of Cordia dichotoma G. Forst","volume":"27","author":"Bughio","year":"2024","journal-title":"Int. J. Food Prop."},{"key":"B26","doi-asserted-by":"publisher","first-page":"2365","DOI":"10.3390\/molecules27072365","article-title":"Flavonoids in treatment of chronic kidney disease","volume":"27","author":"Cao","year":"2022","journal-title":"Molecules"},{"key":"B27","doi-asserted-by":"publisher","first-page":"2633","DOI":"10.3390\/foods14152633","article-title":"Morphometric, nutritional, and phytochemical characterization of eugenia (Syzygium paniculatum Gaertn): a Berry with Under-Discovered Potential","volume":"14","author":"Carrera-Cevallos","year":"2025","journal-title":"Foods"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2017\/7941347","article-title":"Profile of the phenolic compounds of Rosa rugosa Petals","volume":"2017","author":"Cendrowski","year":"2017","journal-title":"J. Food Qual."},{"key":"B30","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1080\/14786419.2010.482054","article-title":"Flavonoids: chemical properties and analytical methodologies of identification and quantitation in foods and plants","volume":"25","author":"Corradini","year":"2011","journal-title":"Nat. Prod. Res."},{"key":"B31","doi-asserted-by":"publisher","first-page":"63","DOI":"10.3109\/13880200903046146","article-title":"Determination of the phenolic content and antioxidant potential of crude extracts and isolated compounds from leaves of Cordia multispicata and Tournefortia bicolor","volume":"48","author":"Correia Da Silva","year":"2010","journal-title":"Pharm. Biol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"e1704","DOI":"10.32712\/2446-4775.2025.1704","article-title":"Isolation of scopoletin and biological activities from Warszewiczia coccinea (Rubiaceae)","volume":"19","author":"Crispim","year":"2025","journal-title":"Rev. Fitos"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1016\/j.biocel.2011.04.005","article-title":"Oxidative stress contributes to the induction and persistence of TGF-\u03b21 induced pulmonary fibrosis","volume":"43","author":"Cui","year":"2011","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"B34","volume-title":"Handbook of Histopathological and Histochemical Techniques","author":"Culling","year":"2013"},{"key":"B35","doi-asserted-by":"publisher","first-page":"2291","DOI":"10.3390\/foods13142291","article-title":"Assessing antioxidant properties, phenolic compound profiles, organic acids, and sugars in conventional apple cultivars (Malus domestica): a chemometric approach","volume":"13","author":"Cvetkovi\u0107","year":"2024","journal-title":"Foods"},{"key":"B36","doi-asserted-by":"publisher","first-page":"70","DOI":"10.3390\/ph17010070","article-title":"Researching new drug combinations with senolytic activity using senescent human lung fibroblasts MRC-5 cell line","volume":"17","author":"De Godoy","year":"2024","journal-title":"Pharmaceuticals"},{"key":"B37","doi-asserted-by":"publisher","first-page":"5812","DOI":"10.1021\/jf0007481","article-title":"Preparative isolation of anthocyanins by high-speed countercurrent chromatography and application of the color activity concept to red wine","volume":"48","author":"Degenhardt","year":"2000","journal-title":"J. Agric. Food Chem."},{"key":"B38","doi-asserted-by":"publisher","first-page":"57","DOI":"10.59518\/farabimedj.1484155","article-title":"The therapeutic effect of p-coumaric acid on lung toxicity induced by methotrexate in rats","volume":"3","author":"Demir","year":"2024","journal-title":"Farabi T\u0131p Derg."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1006\/taap.2002.9511","article-title":"Role of interferon-\u03b3 in the development of murine bronchus-associated lymphoid tissues induced by silica in vivo","volume":"185","author":"Desaki","year":"2002","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"6972","DOI":"10.3390\/ijms24086972","article-title":"Dual blockade of tgf-\u03b2 receptor and endothelin receptor synergistically inhibits angiotensin ii-induced myofibroblast differentiation: role of at1r\/g\u03b1q-mediated tgf-\u03b21 and et-1 signaling","volume":"24","author":"Duangrat","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B41","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3390\/blsf2024040002","article-title":"Lamiaceae plants and cardiovascular health: a patent-driven path to functional foods","volume-title":"Foods 2024","author":"El Boukhari","year":"2024"},{"key":"B42","doi-asserted-by":"publisher","first-page":"2103","DOI":"10.1080\/14786419.2019.1655411","article-title":"Bioassay-guided fractionation and identification of antidiabetic compounds from the rind of Punica Granatum Var. nana","volume":"35","author":"El Deeb","year":"2021","journal-title":"Nat. Prod. Res."},{"key":"B43","doi-asserted-by":"publisher","first-page":"105758","DOI":"10.1016\/j.jff.2023.105758","article-title":"Tomato-free wonder sauce: a functional product with health-boosting properties","volume":"109","author":"El Haggar","year":"2023","journal-title":"J. Funct. Foods"},{"key":"B44","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1007\/s10787-019-00609-1","article-title":"Protective anti-inflammatory activity of tovophyllin A against acute lung injury and its potential cytotoxicity to epithelial lung and breast carcinomas","volume":"28","author":"El-Agamy","year":"2020","journal-title":"Inflammopharmacology"},{"key":"B45","doi-asserted-by":"publisher","first-page":"5349","DOI":"10.1016\/j.sjbs.2021.05.064","article-title":"Chemical characteristics and targeted encapsulated Cordia myxa fruits extracts nanoparticles for antioxidant and cytotoxicity potentials","volume":"28","author":"El-Massry","year":"2021","journal-title":"Saudi J. Biol. Sci."},{"key":"B46","doi-asserted-by":"publisher","first-page":"19296","DOI":"10.1038\/s41598-025-04015-2","article-title":"Comparative metabolic profiling of Cordia myxa leaves and fruits based on UPLC-ESI\/MS-MS analysis and investigation of antioxidant activities and enzyme inhibitory properties","volume":"15","author":"El-Nashar","year":"2025","journal-title":"Sci. Rep."},{"key":"B47","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1007\/s11418-016-0973-5","article-title":"Hypolipidemic and antioxidant activity of the aqueous extract from the uneaten pulp of the fruit from Cordia dichotoma in healthy and hyperlipidemic Wistar albino rats","volume":"70","author":"El-Newary","year":"2016","journal-title":"J. Nat. Med."},{"key":"B48","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1080\/13880209.2021.2008455","article-title":"Sperm quality and testicular histopathology of Wistar albino male rats treated with hydroethanolic extract of Cordia dichotoma fruits","volume":"60","author":"El-Newary","year":"2022","journal-title":"Pharm. Biol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"114765","DOI":"10.1016\/j.biopha.2023.114765","article-title":"Quercus coccinea M\u00fcnchh leaves polyphenols: Appraisal acute lung injury induced by lipopolysaccharide in mice","volume":"164","author":"El-Sayed","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"B50","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1093\/jn\/135.4.729","article-title":"Mulberry (Morus alba L.) leaves and their major flavonol quercetin 3-(6-malonylglucoside) attenuate atherosclerotic lesion development in IDL receptor-deficient mice","volume":"135","author":"Enkhmaa","year":"2005","journal-title":"J. Nutr."},{"key":"B52","first-page":"245","article-title":"Leaf extracts of some Cordia species: analgesic and anti-inflammatory activities as well as their chromatographic analysis","volume":"50","author":"Ficarra","year":"1995","journal-title":"Farm. Soc. Chim. Ital. 1989"},{"key":"B53","doi-asserted-by":"publisher","first-page":"2242","DOI":"10.3390\/plants12122242","article-title":"Preparative fractionation of phenolic compounds and isolation of an enriched flavonol fraction from winemaking industry by-products by high-performance counter-current chromatography","volume":"12","author":"Fontana","year":"2023","journal-title":"Plants"},{"key":"B54","doi-asserted-by":"publisher","first-page":"238","DOI":"10.3389\/fmed.2019.00238","article-title":"Methotrexate-associated pneumonitis and rheumatoid arthritis-interstitial lung disease: current concepts for the diagnosis and treatment","volume":"6","author":"Fragoulis","year":"2019","journal-title":"Front. Med."},{"key":"B55","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s13318-021-00731-y","article-title":"Pharmacology of diosmin, a citrus flavone glycoside: an updated review","volume":"47","author":"Gerges","year":"2022","journal-title":"Eur. J. Drug Metab. Pharmacokinet."},{"key":"B57","doi-asserted-by":"publisher","first-page":"126","DOI":"10.4103\/0974-8490.147227","article-title":"Evaluation of analgesic, antipyretic and anti-inflammatory activity on Cordia dichotoma G. Forst. Leaf","volume":"7","author":"Gupta","year":"2015","journal-title":"Pharmacogn. Res."},{"key":"B58","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.biopha.2018.04.007","article-title":"Evidence for gastroprotective, anti-inflammatory and antioxidant potential of methanolic extract of Cordia dichotoma leaves on indomethacin and stress induced gastric lesions in Wistar rats","volume":"103","author":"Hatware","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"B59","doi-asserted-by":"publisher","first-page":"2793","DOI":"10.1021\/acs.chemrestox.0c00194","article-title":"6-Prenylnaringenin from hops disrupts ER\u03b1-mediated downregulation of CYP1A1 to facilitate estrogen detoxification","volume":"33","author":"Hitzman","year":"2020","journal-title":"Chem. Res. Toxicol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/j.tranon.2018.11.004","article-title":"Serological assessment of activated fibroblasts by alpha-smooth muscle actin (\u03b1-SMA): a noninvasive biomarker of activated fibroblasts in lung disorders","volume":"12","author":"Holm Nielsen","year":"2019","journal-title":"Transl. Oncol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"2093","DOI":"10.13005\/bpj\/2090","article-title":"Anti-inflammatory and antioxidant activities of Cordia Dichotoma Forst","volume":"13","author":"Hussain","year":"2020","journal-title":"Biomed. Pharmacol. J."},{"key":"B62","doi-asserted-by":"publisher","first-page":"0","DOI":"10.21608\/ejchem.2023.191642.7557","article-title":"An overview on botanical characteristics, phytochemical constituents and pharmacological effects of Cordia dichotoma (G. Forst.) and Cordia sebestena (L.) (Boraginaceae)","author":"Hussein","year":"2023","journal-title":"Egypt. J. Chem."},{"key":"B63","doi-asserted-by":"publisher","first-page":"40267","DOI":"10.1039\/D4RA06991A","article-title":"Cognitive-enhancing effect of Cordia dichotoma fruit on scopolamine-induced cognitive impairment in rats: metabolite profiling, in vivo, and in silico investigations","volume":"14","author":"Hussein","year":"","journal-title":"RSC Adv."},{"key":"B64","doi-asserted-by":"publisher","first-page":"0","DOI":"10.21608\/ejchem.2024.256819.9007","article-title":"New insight into the anticholinesterase potential of Cordia dichotoma G. Forst. and Cordia sebestena L. Lleaves, phenolic characterization of their active extracts by HPLC-DAD and molecular modeling","author":"Hussein","year":"","journal-title":"Egypt. J. Chem."},{"key":"B65","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.aoas.2019.05.008","article-title":"Antioxidant, cytotoxicity and anti-tumor activity of Cordia dichotoma fruits accompanied with its volatile and sugar composition","volume":"64","author":"Ibrahim","year":"2019","journal-title":"Ann. Agric. Sci."},{"key":"B66","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1007\/s12210-024-01283-4","article-title":"Cordia dichotoma G. Forst fruit prophylactic against Alzheimer\u2019s risk factors: in vitro study","volume":"35","author":"Ibrahim","year":"2024","journal-title":"Rendiconti Lincei Sci. Fis. E Nat."},{"key":"B67","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.bse.2013.08.004","article-title":"Flavones and anthocyanins from the leaves and flowers of Japanese Ajuga species (Lamiaceae)","volume":"51","author":"Inomata","year":"2013","journal-title":"Biochem. Syst. Ecol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1155\/2013\/527912","article-title":"Methotrexate-induced pulmonary toxicity","volume":"20","author":"Jakubovic","year":"2013","journal-title":"Can. Respir. J."},{"key":"B69","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1016\/S2221-1691(13)60194-X","article-title":"Plant profile, phytochemistry and pharmacology of Cordia dichotoma (Indian cherry): a review","volume":"3","author":"Jamkhande","year":"2013","journal-title":"Asian pac. J. Trop. Biomed."},{"key":"B70","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1111\/jphp.13077","article-title":"Mangiferin attenuates bleomycin-induced pulmonary fibrosis in mice through inhibiting TLR4\/p65 and TGF-\u03b21\/Smad2\/3 pathway","volume":"71","author":"Jia","year":"2019","journal-title":"J. Pharm. Pharmacol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s44187-024-00082-y","article-title":"Measurement of antioxidant synergy between phenolic bioactives in traditional food combinations (legume\/non-legume\/fruit) of (semi) arid regions: insights into the development of sustainable functional foods","volume":"4","author":"Joshi","year":"2024","journal-title":"Discov. Food"},{"key":"B73","doi-asserted-by":"publisher","first-page":"109949","DOI":"10.1016\/j.lwt.2020.109949","article-title":"Influence of species and processing techniques on phlorin in Citrus juices as quantified by 1H-NMR spectroscopy","volume":"134","author":"Jungen","year":"2020","journal-title":"LWT"},{"key":"B74","doi-asserted-by":"publisher","first-page":"99","DOI":"10.5152\/balkanmedj.2012.078","article-title":"Protective effects of erythropoietin and N-acetylcysteine on methotrexate-induced lung injury in rats","volume":"30","author":"Kahraman","year":"2013","journal-title":"Balk. Med. J."},{"key":"B75","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1186\/s12906-022-03693-z","article-title":"The effects of the ethanol extract of Cordia myxa leaves on the cognitive function in mice","volume":"22","author":"Kendir","year":"2022","journal-title":"BMC Complement. Med. Ther."},{"key":"B76","doi-asserted-by":"publisher","first-page":"3561","DOI":"10.1007\/s13197-014-1387-6","article-title":"Effect on oxidative stress, glucose uptake level and lipid droplet content by Apigenin 7, 4\u2019-dimethyl ether isolated from Piper longum L","volume":"52","author":"Krishna","year":"2015","journal-title":"J. Food Sci. Technol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1021\/acsfoodscitech.1c00398","article-title":"UHPLC-QTOF-IMS-based metabolite fingerprinting of underutilized Cordia myxa fruits and leaves: a nutraceutical source","volume":"2","author":"Kumar","year":"2022","journal-title":"ACS Food Sci. Technol."},{"key":"B78","first-page":"849","article-title":"Three basic flavonoids from the fruits of Cordia dichotoma Forst","volume":"4","author":"Kuppast","year":"2006","journal-title":"F. Int. J. of Chem. Sci."},{"key":"B79","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/j.arbr.2015.05.012","article-title":"Protective effects of infliximab on lung injury induced by methotrexate","volume":"51","author":"Kurt","year":"2015","journal-title":"Arch. Bronconeumol. Engl."},{"key":"B80","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1016\/j.sjbs.2016.05.014","article-title":"Variation of quercetin glycoside derivatives in three onion (Allium cepa L.) varieties","volume":"24","author":"Kwak","year":"2017","journal-title":"Saudi J. Biol. Sci."},{"key":"B81","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.3390\/antiox12051044","article-title":"Antioxidant and anti-inflammatory capacities of fractions and constituents from Vcia tetrasperma","volume":"12","author":"Le","year":"2023","journal-title":"Antioxidants"},{"key":"B82","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1038\/aps.2010.62","article-title":"Protective effects of luteolin against lipopolysaccharide-induced acute lung injury involves inhibition of MEK\/ERK and PI3K\/Akt pathways in neutrophils","volume":"31","author":"Lee","year":"2010","journal-title":"Acta Pharmacol. Sin."},{"key":"B83","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1139\/cjpp-2012-0432","article-title":"Quercetin provides greater cardioprotective effect than its glycoside derivative rutin on isoproterenol-induced cardiac fibrosis in the rat","volume":"91","author":"Li","year":"2013","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"e202200969","DOI":"10.1002\/cbdv.202200969","article-title":"Anti\u2010Inflammatory and neuroprotective effects of standardized fractions in herniarin and daphnoretin from Distictis buccinatoria","volume":"20","author":"Liliana Porras\u2010D\u00e1vila","year":"2023","journal-title":"Chem. Biodivers."},{"key":"B85","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1016\/j.biopha.2018.07.094","article-title":"Luteolin alleviates LPS-induced bronchopneumonia injury in vitro and in vivo by down-regulating microRNA-132 expression","volume":"106","author":"Liu","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"B86","doi-asserted-by":"publisher","first-page":"106812","DOI":"10.1016\/j.phrs.2023.106812","article-title":"Phenolic metabolites as therapeutic in inflammation and neoplasms: molecular pathways explaining their efficacy","volume":"193","author":"Liu","year":"2023","journal-title":"Pharmacol. Res."},{"key":"B87","doi-asserted-by":"publisher","first-page":"1586361","DOI":"10.3389\/fimmu.2025.1586361","article-title":"Adverse drug reactions related to methotrexate: a real-world pharmacovigilance study using the FAERS database from 2004 to 2024","volume":"16","author":"Liu","year":"2025","journal-title":"Front. Immunol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.3390\/antiox11061192","article-title":"Antioxidant, anti-inflammatory and cytotoxic activity of phenolic compound family extracted from raspberries (Rubus idaeus): a General Review","volume":"11","author":"Lopez-Corona","year":"2022","journal-title":"Antioxidants"},{"key":"B89","doi-asserted-by":"publisher","first-page":"283","DOI":"10.3390\/antiox10020283","article-title":"Dietary anti-aging polyphenols and potential mechanisms","volume":"10","author":"Luo","year":"2021","journal-title":"Antioxidants"},{"key":"B90","first-page":"325","article-title":"Chemical constituents and antidiabetic activity of Cordia dichotoma a valuable source for bioactive compounds","volume":"6","author":"Madhubala","year":"2021","journal-title":"Int. J. Bot. Stud."},{"key":"B91","doi-asserted-by":"publisher","first-page":"35","DOI":"10.3390\/antiox9010035","article-title":"Recent advances on the anti-inflammatory and antioxidant properties of red grape polyphenols: in vitro and in vivo studies","volume":"9","author":"Magrone","year":"2019","journal-title":"Antioxidants"},{"key":"B92","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.sajb.2022.05.043","article-title":"Chemo-profiling by UPLC-QTOF MS analysis and in vitro assessment of anti-inflammatory activity of Field Milkwort (Polygala arvensis Willd.)","volume":"149","author":"Mane","year":"2022","journal-title":"South Afr. J. Bot."},{"key":"B95","doi-asserted-by":"publisher","first-page":"103940","DOI":"10.1016\/j.etap.2022.103940","article-title":"Aprepitant exerts anti-fibrotic effect via inhibition of TGF-\u03b2\/Smad3 pathway in bleomycin-induced pulmonary fibrosis in rats","volume":"95","author":"Mohamed","year":"2022","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"B96","doi-asserted-by":"publisher","first-page":"e0329586","DOI":"10.1371\/journal.pone.0329586","article-title":"HPLC-MS profiling and protective potential of the defatted aqueous methanol extract of two Syzygium species against cadmium chloride-induced nephrotoxicity in rats","volume":"20","author":"Moharram","year":"2025","journal-title":"PLOS One"},{"key":"B97","first-page":"688","article-title":"Phytochemical and GC-MS analysis on leaves of selected medicinal plants in Boraginaceae family Cordia dichotoma L","volume":"9","author":"Mudhubala","year":"2019","journal-title":"Pramana Res. J."},{"key":"B98","doi-asserted-by":"publisher","first-page":"e480","DOI":"10.3989\/gya.0783211","article-title":"Effect of different extraction methods on saffron antioxidant activity, total phenolic and crocin contents and the protective effect of saffron extract on the oxidative stability of common vegetable oils","volume":"73","author":"Najafi","year":"2022","journal-title":"Grasas Aceites"},{"key":"B99","doi-asserted-by":"publisher","first-page":"11086","DOI":"10.3390\/molecules180911086","article-title":"First chemical constituents from Cordia exaltata Lam and antimicrobial activity of two neolignans","volume":"18","author":"Nogueira","year":"2013","journal-title":"Molecules"},{"key":"B100","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1111\/jphp.12715","article-title":"Traditional uses, phytochemistry and pharmacology of the medicinal species of the genus Cordia (Boraginaceae)","volume":"69","author":"Oza","year":"2017","journal-title":"J. Pharm. Pharmacol."},{"key":"B101","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.3945\/jn.111.157263","article-title":"Quercetin ameliorates cardiovascular, hepatic, and metabolic changes in diet-induced metabolic syndrome in rats","volume":"142","author":"Panchal","year":"2012","journal-title":"J. Nutr."},{"key":"B103","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1179\/135100002125000172","article-title":"Antioxidant properties of gallocatechin and prodelphinidins from pomegranate peel","volume":"7","author":"Plumb","year":"2002","journal-title":"Redox Rep."},{"key":"B104","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.joim.2023.05.001","article-title":"A comprehensive overview on the role of phytocompounds in human immunodeficiency virus treatment","volume":"21","author":"Priyadarsani Mandhata","year":"2023","journal-title":"J. Integr. Med."},{"key":"B105","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.3390\/ijms24021275","article-title":"Endothelin-1 as a biomarker of idiopathic pulmonary fibrosis and interstitial lung disease associated with autoimmune diseases","volume":"24","author":"Pulito-Cueto","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B106","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.toxlet.2019.02.005","article-title":"Kaempferol reduces K63-linked polyubiquitination to inhibit nuclear factor-\u03baB and inflammatory responses in acute lung injury in mice","volume":"306","author":"Qian","year":"2019","journal-title":"Toxicol. Lett."},{"key":"B107","doi-asserted-by":"publisher","first-page":"16","DOI":"10.7324\/JAPS.2015.58.S3","article-title":"Chemical constituents of Cordia dichotoma G. Forst","volume":"5","author":"Ragasa","year":"2015","journal-title":"J. Appl. Pharm. Sci."},{"key":"B108","doi-asserted-by":"publisher","first-page":"113400","DOI":"10.1016\/j.biopha.2022.113400","article-title":"Phytochemistry, and pharmacological efficacy of Cordia dichotoma G. Forst. (Lashuda): a therapeutic medicinal plant of Himachal Pradesh","volume":"153","author":"Raghuvanshi","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"B109","doi-asserted-by":"publisher","first-page":"2265","DOI":"10.1080\/14786419.2016.1163694","article-title":"A new linoleiyl arabinopyranoside from the bark of Bauhinia racemosa Lam and a new flavonoidal glycoside from the leaves of Cordia dichotoma Linn","volume":"30","author":"Rahman","year":"2016","journal-title":"Nat. Prod. Res."},{"key":"B110","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.jtcme.2016.11.002","article-title":"Evaluation of anticancer activity of Cordia dichotoma leaves against a human prostate carcinoma cell line, PC3","volume":"7","author":"Rahman","year":"2017","journal-title":"J. Tradit. Complement. Med."},{"key":"B111","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3329\/bjp.v10i1.20883","article-title":"Anticancer activity and apoptosis inducing effect of methanolic extract of Cordia dichotoma against human cancer cell line","volume":"10","author":"Rahman","year":"2015","journal-title":"Bangladesh J. Pharmacol."},{"key":"B112","doi-asserted-by":"publisher","first-page":"2066","DOI":"10.3923\/pjbs.2013.2066.2069","article-title":"Study on analgesic and anti-inflammatory properties of Cordia myxa fruit hydro-alcoholic extract","volume":"16","author":"Ranjbar","year":"2013","journal-title":"Pak. J. Biol. Sci."},{"key":"B113","first-page":"55","article-title":"Effect of crude alkaloid extract of the leaves of C. myxa on some biological aspects of Culex pipienes","volume":"23","author":"Rashid","year":"2015","journal-title":"Babylon Sci. J. Pure Appl. Sci."},{"key":"B114","doi-asserted-by":"publisher","first-page":"2895","DOI":"10.13040\/IJPSR.0975-8232.5(7).2895-99","article-title":"Antioxidant activity of taxifolin obtained from methanolic extracts of Cordia dichotoma Linn seeds","volume":"5","author":"Roy","year":"2014","journal-title":"Int. J. Pharm. Sci. Res."},{"key":"B115","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.cyto.2018.03.042","article-title":"Luteolin attenuates acute lung injury in experimental mouse model of sepsis","volume":"110","author":"Rungsung","year":"2018","journal-title":"Cytokine"},{"key":"B117","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1080\/17458080.2019.1687883","article-title":"Antioxidant, cytotoxic and catalytic degradation efficiency of controllable phyto-synthesised silver nanoparticles with high stability using Cordia myxa extract","volume":"14","author":"Samari","year":"2019","journal-title":"J. Exp. Nanosci."},{"key":"B118","doi-asserted-by":"publisher","first-page":"108776","DOI":"10.1016\/j.biopha.2019.108776","article-title":"Epicatechin protective effects on bleomycin-induced pulmonary oxidative stress and fibrosis in mice","volume":"114","author":"Shariati","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"B119","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/S2305-0500(15)30004-X","article-title":"Antifertility potential of hydroalcoholic extract of Cordia dichotoma G Forst. leaves: a folklore medicine used by Meena community in Rajasthan state in India","volume":"4","author":"Sharma","year":"2015","journal-title":"Asian pac. J. Reprod."},{"key":"B120","first-page":"1748","article-title":"Anti-arthritic and thrombolytic activity of leaves of Cordia dichotoma","volume":"23","author":"Shembade","year":"2021","journal-title":"J. Univ. Shanghai Sci. Technol."},{"key":"B121","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1590\/S0102-695X2010005000006","article-title":"Flavanones from aerial parts of Cordia globosa (Jacq.) Kunth, Boraginaceae","volume":"20","author":"Silva","year":"2010","journal-title":"Rev. Bras. Farmacogn."},{"key":"B122","first-page":"21","article-title":"Role of Cordia dichotoma seeds and leaves extract in degenerative disorders","volume":"2","author":"Singh","year":"2010","journal-title":"Int. J. Pharm. Sci. Rev. Res."},{"key":"B123","doi-asserted-by":"publisher","first-page":"669","DOI":"10.3390\/antiox9080669","article-title":"Interaction of Polyphenols as antioxidant and anti-inflammatory compounds in brain\u2013liver\u2013gut axis","volume":"9","author":"Singh","year":"2020","journal-title":"Antioxidants"},{"key":"B124","doi-asserted-by":"publisher","first-page":"117499","DOI":"10.1016\/j.lwt.2025.117499","article-title":"Uncovering bioactive flavones and volatiles in rice (Oryza sativa L.) leaf tea through dual-platform metabolomics","volume":"218","author":"Sirijan","year":"2025","journal-title":"LWT"},{"key":"B125","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.fct.2018.01.031","article-title":"High resolution UPLC-MS\/MS profiling of polyphenolics in the methanol extract of Syzygium samarangense leaves and its hepatoprotective activity in rats with CCl4-induced hepatic damage","volume":"113","author":"Sobeh","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"B126","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.13057\/biodiv\/d220351","article-title":"Identification of bioactive compounds in gambier (Uncaria gambir) liquid by-product in West Sumatra, Indonesia","volume":"22","author":"Soleh Ismail","year":"2021","journal-title":"Biodiversitas J. Biol. Divers."},{"key":"B127","doi-asserted-by":"publisher","first-page":"260","DOI":"10.5829\/idosi.wjdfs.2014.9.2.1143","article-title":"Hypolipidemic effect of Cordia dichotoma forst. pulp in high-fat diet-fed rats","volume":"9","author":"Sulieman","year":"2014","journal-title":"World J. Dairy & Food Sci."},{"key":"B150","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.3390\/molecules28041845","article-title":"Therapeutic potential of phenolic compounds in medicinal plants\u2014natural health products for human health","volume":"28","author":"Sun","year":"2023","journal-title":"Molecules"},{"key":"B128","doi-asserted-by":"publisher","first-page":"105898","DOI":"10.1016\/j.fitote.2024.105898","article-title":"Underutilized fruit lasoda (Cordia myxa L.): review on bioactive compounds, antioxidant potentiality and applications in health bioactivities and food","volume":"175","author":"Tak","year":"2024","journal-title":"Fitoterapia"},{"key":"B129","doi-asserted-by":"publisher","first-page":"3846","DOI":"10.3390\/molecules25173846","article-title":"Flavonoids and related members of the aromatic polyketide group in human health and disease: do they really work?","volume":"25","author":"Tauchen","year":"2020","journal-title":"Molecules"},{"key":"B130","doi-asserted-by":"publisher","first-page":"113","DOI":"10.3390\/antiox12010113","article-title":"Molecular and antioxidant characterization of Opuntia robusta fruit extract and its protective effect against diclofenac-induced acute liver injury in an in vivo rat model","volume":"12","author":"Villa-Jaimes","year":"2023","journal-title":"Antioxid. Basel Switz."},{"key":"B131","doi-asserted-by":"publisher","first-page":"156708","DOI":"10.1016\/j.scitotenv.2022.156708","article-title":"Changes in the concentration, distribution, and speciation of arsenic in the hyperaccumulator Pteris vittata at different growth stages","volume":"841","author":"Wan","year":"2022","journal-title":"Sci. Total Environ."},{"key":"B132","first-page":"367","article-title":"Flavonol glycosides and phenolics from leaves of Cordia dichotoma (Natural Medicine Note)","volume":"50","author":"Wang","year":"1996","journal-title":"Nat. Med."},{"key":"B133","doi-asserted-by":"publisher","first-page":"12915","DOI":"10.1039\/D2FO02758E","article-title":"Component analysis and anti-pulmonary fibrosis effects of Rosa sterilis juice","volume":"13","author":"Wang","year":"2022","journal-title":"Food Funct."},{"key":"B134","doi-asserted-by":"publisher","first-page":"186","DOI":"10.22105\/cand.2024.437572.1086","article-title":"The pharmacognostic profile and pharmacological importance of cordia myxa. A review","volume":"2","author":"Wani","year":"2023","journal-title":"Comput. Algorithms Numer. Dimens."},{"key":"B135","first-page":"240","article-title":"Phenolic compounds from the seeds of Cordia dichotoma","volume-title":"XIII International Symposium on the Chemistry of Natural Compounds (ISCNC 2019)","author":"Yaermaimaiti","year":"2019"},{"key":"B136","doi-asserted-by":"publisher","first-page":"113977","DOI":"10.1016\/j.indcrop.2021.113977","article-title":"Bioassay-guided isolation of antioxidant, antimicrobial, and antiviral constituents of Cordia dichotoma fruits","volume":"172","author":"Yaermaimaiti","year":"2021","journal-title":"Ind. Crops Prod."},{"key":"B137","doi-asserted-by":"publisher","first-page":"392","DOI":"10.5603\/FM.a2020.0075","article-title":"Febuxostat ameliorates methotrexate-induced lung damage","volume":"80","author":"Zaki","year":"2021","journal-title":"Folia Morphol."},{"key":"B139","doi-asserted-by":"publisher","first-page":"122","DOI":"10.3389\/fphar.2018.00122","article-title":"Therapeutic potential of polyphenols in cardiac fibrosis","volume":"9","author":"Zhang","year":"2018","journal-title":"Front. Pharmacol."},{"key":"B140","doi-asserted-by":"publisher","first-page":"6666","DOI":"10.3390\/ijms26146666","article-title":"Kaempferol alleviates carbon tetrachloride-induced liver fibrosis in mice by regulating intestinal short-chain fatty acids","volume":"26","author":"Zhang","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"B141","doi-asserted-by":"publisher","first-page":"6914","DOI":"10.1038\/s41598-021-86379-9","article-title":"Bioactivity-guided separation of potential \u03b1-glycosidase inhibitor from clerodendranthus spicatus based on HSCCC coupled with molecular docking","volume":"11","author":"Zhu","year":"2021","journal-title":"Sci. Rep."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2026.1836019\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T15:21:59Z","timestamp":1782487319000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2026.1836019\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,26]]},"references-count":131,"alternative-id":["10.3389\/fphar.2026.1836019"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2026.1836019","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,26]]},"article-number":"1836019"}}