{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T10:07:54Z","timestamp":1784196474385,"version":"3.55.0"},"reference-count":247,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>Endophytes are microorganisms that are concealed within the intracellular spaces of the plants in diverse ecological niches across varied habitats, are a prolific source of bioactive metabolites capable of inhibiting human pathogens responsible for mild to severe infections. The rising threat of antimicrobial resistance largely due to the indiscriminate use of antibiotics, has prompted the World Health Organization to advocate for rigorous stewardship of existing drugs while simultaneously urging the development of novel therapeutic alternatives. Several studies have reported emphasizing the application of multiple metabolites from endophytes however, exploring the mechanisms involved in the inhibition by a single effective metabolite which could help in unwinding the complexity during lead molecule synthesis. This review aims to present a comprehensive and strategic roadmap integrating upstream processes encompassing isolation, screening, and fermentation, with downstream methodologies for metabolite extraction, purification and structural elucidation, along with toxicity assessments for effective pharmaceutical applications. Furthermore, the discussion also considers the integration of predictive AI-ML models in accelerating the drug developmental pipeline for circumventing the traditional discovery bottlenecks highlighting the relevance to industrial translation and underlines the potential of endophyte-derived metabolites to target pathogenicity islands, offering a paradigm shift from bacterial eradication to anti-virulence strategies along with a focus on errors and limitations of endophytic research.<\/jats:p>","DOI":"10.3389\/fphar.2026.1837576","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T09:44:50Z","timestamp":1784195090000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A comprehensive review on bacterial endophytic secondary metabolites: a road map from crude extract to lead molecule production"],"prefix":"10.3389","volume":"17","author":[{"given":"Reshma","family":"Biju","sequence":"first","affiliation":[{"name":"School of Bio Sciences and Technology, Vellore Institute of Technology","place":["Vellore, Tamil Nadu, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Jabez","family":"Osborne","sequence":"additional","affiliation":[{"name":"School of Bio Sciences and Technology, Vellore Institute of Technology","place":["Vellore, Tamil Nadu, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"369","DOI":"10.3390\/cells14050369","article-title":"Isolation and functional characterization of endophytic bacteria from muscadine grape berries: a microbial treasure trove","volume":"14","author":"Agarwal","year":"2025","journal-title":"Cells"},{"key":"B2","first-page":"29","article-title":"Downstream processing; applications and recent updates","volume-title":"Bioprocessing for Biofuel Production: Strategies to Improve Process Parameters","author":"Agarwal","year":"2020"},{"key":"B3","doi-asserted-by":"publisher","first-page":"219","DOI":"10.22146\/ijp.7415","article-title":"Cytotoxicity screening of endophytic fungi from Phaleria macrocarpa (scheff) boerl collected in yogyakarta district","volume":"35","author":"Agustina","year":"2024","journal-title":"Indonesian J. Pharm."},{"key":"B4","doi-asserted-by":"publisher","first-page":"2654","DOI":"10.1016\/j.csbj.2023.04.020","article-title":"Machine learning-assisted medium optimization revealed the discriminated strategies for improved production of the foreign and native metabolites","volume":"21","author":"Aida","year":"2023","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"B5","doi-asserted-by":"publisher","first-page":"e0269962","DOI":"10.1371\/journal.pone.0269962","article-title":"Bioactive potentiality of secondary metabolites from endophytic bacteria against SARS-COV-2: an in-silico approach","volume":"17","author":"Akter","year":"2022","journal-title":"PLoS One"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1521091","DOI":"10.3389\/fcimb.2025.1521091","article-title":"Enhancing antibiotic therapy through comprehensive pharmacokinetic\/pharmacodynamic principles","volume":"15","author":"Alikhani","year":"2025","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/s41598-024-84647-y","article-title":"A quality by design HPLC method for cephalosporin analysis in pharmaceuticals and water samples with environmental impact assessment","volume":"15","author":"Alqahtani","year":"2025","journal-title":"Sci. Rep."},{"key":"B9","doi-asserted-by":"publisher","first-page":"102385","DOI":"10.1016\/j.bbrep.2025.102385","article-title":"Unlocking the potential of endophytes in enhancing plant secondary metabolite biosynthesis","volume":"45","author":"Alum","year":"2026","journal-title":"Biochem. Biophysics Rep."},{"key":"B10","doi-asserted-by":"publisher","first-page":"2276","DOI":"10.37871\/jbres1430","article-title":"Epigenetic strategies to discover novel fungal secondary metabolites","volume":"2766","author":"Anjum","year":"2022","journal-title":"J. ISSN"},{"key":"B11","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s13205-023-03859-7","article-title":"In-silico bioprospecting of secondary metabolites from endophytic streptomyces spp. against magnaporthe oryzae, a cereal killer fungus","volume":"14","author":"Antony","year":"2024","journal-title":"3 Biotech."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1515276","DOI":"10.3389\/fmolb.2025.1515276","article-title":"A multi-omics reciprocal analysis for characterization of bacterial metabolism","volume":"12","author":"Arini","year":"2025","journal-title":"Front. Mol. Biosci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1560492","DOI":"10.3389\/ftox.2025.1560492","article-title":"Model organisms in toxicology","volume":"7","author":"Aschner","year":"2025","journal-title":"Front. Toxicol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"103624","DOI":"10.1016\/j.micpath.2019.103624","article-title":"Bacterial endophytes from Artemisia nilagirica (clarke) pamp., with antibacterial efficacy against human pathogens","volume":"135","author":"Ashitha","year":"2019","journal-title":"Microb. Pathogenesis"},{"key":"B15","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.jiac.2015.02.001","article-title":"Applications of the pharmacokinetic\/pharmacodynamic (PK\/PD) analysis of antimicrobial agents","volume":"21","author":"As\u00edn-Prieto","year":"2015","journal-title":"J. Infect. Chemother."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1007\/s44211-022-00190-8","article-title":"A review of the modern principles and applications of solid-phase extraction techniques in chromatographic analysis","volume":"38","author":"Badawy","year":"2022","journal-title":"Anal. Sci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1038\/s41579-024-01083-5","article-title":"Achieving sustainable access to antibiotics is more than just a last mile challenge","volume":"22","author":"Balasegaram","year":"2024","journal-title":"Nat. Rev. Microbiol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/21501203.2025.2531886","article-title":"Endophytic fungi as a source of antimicrobial compounds against emerging methicillin-resistant Staphylococcus aureus","volume":"17","author":"Bansal","year":"2025","journal-title":"Mycology"},{"key":"B19","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.mib.2009.06.012","article-title":"Productive steps toward an antimicrobial targeting virulence","volume":"12","author":"Barczak","year":"2009","journal-title":"Curr. Opinion Microbiology"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12223-025-01318-9","article-title":"Bacillus toyonensis BAR1, a yellow-pigment producing endophyte of Berberis aristata DC: a potential source of bioactive and antimicrobial compounds","author":"Basit","year":"2025","journal-title":"Folia Microbiol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12649-025-03408-8","article-title":"Application of plackett-burman and response surface methodology for the optimization of carob juice-based culture media for the growth of two lactic acid bacteria strains","author":"Bencherif","year":"2025","journal-title":"Waste Biomass Valorization"},{"key":"B22","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1007\/s12010-020-03423-6","article-title":"Multifarious elicitors: invoking biosynthesis of various bioactive secondary metabolite in fungi","volume":"193","author":"Bharatiya","year":"2021","journal-title":"Appl. Biochemistry Biotechnology"},{"key":"B23","doi-asserted-by":"publisher","first-page":"17","DOI":"10.37398\/jsr.2025.690103","article-title":"Unlocking the bioactive prowess and in-silico prediction of pharmacokinetics and toxicity profiling of endophyte A. fumigatus","volume":"69","author":"Bhowmick","year":"2025","journal-title":"J. Sci. Res."},{"key":"B24","doi-asserted-by":"publisher","first-page":"31876","DOI":"10.1038\/s41598-025-17314-5","article-title":"GC-MS profiling, in vitro and in silico antibacterial and antioxidant potential of crude secondary metabolites of an endophytic bacterium isolated from enhydra fluctuans lour","volume":"15","author":"Bhuiyan","year":"2025","journal-title":"Sci. Rep."},{"key":"B25","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1186\/s43141-023-00620-8","article-title":"Endophytic bacteria klebsiella spp. and bacillus spp. from Alternanthera philoxeroides in madiwala Lake exhibit additive plant growth-promoting and biocontrol activities","volume":"21","author":"Biswas","year":"2023","journal-title":"J. Genet. Eng. Biotechnol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"8","DOI":"10.3390\/metabo8010008","article-title":"Structure elucidation of unknown metabolites in metabolomics by combined NMR and MS\/MS prediction","volume":"8","author":"Boiteau","year":"2018","journal-title":"Metabolites"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1359151","DOI":"10.3389\/fntpr.2024.1359151","article-title":"On the part that NMR should play in mass spectrometry metabolomics in natural products studies","volume":"3","author":"Borges","year":"2024","journal-title":"Front. Nat. Prod."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1748","DOI":"10.3390\/biom13121748","article-title":"Investigating the stirred tank bioreactor co-cultures of the secondary metabolite producers Streptomyces noursei and Penicillium rubens","volume":"13","author":"Boruta","year":"2023","journal-title":"Biomolecules"},{"key":"B29","first-page":"51","article-title":"Molecular identification of rice bran isolate bacteria based on 16S rRNA gene: a comparative study of DNA extraction methods","volume":"1","author":"Budi","year":"2026","journal-title":"J. Integr. Biotechnol. Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"103003","DOI":"10.1016\/j.fbio.2023.103003","article-title":"In vitro studies on the inhibition of microbial pathogens by PPDHMP synthesized by bacillus sp.; an endophyte of citrus limon (kaji nemu)","volume":"55","author":"Buragohain","year":"2023","journal-title":"Food Biosci."},{"key":"B31","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1590\/s1517-83822014000300030","article-title":"A procedure to evaluate the efficiency of surface sterilization methods in culture-independent fungal endophyte studies","volume":"45","author":"Burgdorf","year":"2014","journal-title":"Braz. J. Microbiol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1039\/D5NP00031A","article-title":"Natural product-derived compounds in clinical trials and drug approvals","volume":"43","author":"Butler","year":"2026","journal-title":"Nat. Product. Rep"},{"key":"B33","doi-asserted-by":"publisher","first-page":"e01670-24","DOI":"10.1128\/jcm.01670-24","article-title":"Evaluation of long-read 16S rRNA next-generation sequencing for identification of bacterial isolates in a clinical diagnostic laboratory","volume":"63","author":"Campod\u00f3nico","year":"2025","journal-title":"J. Clinical Microbiology"},{"key":"B34","doi-asserted-by":"publisher","first-page":"5884","DOI":"10.1021\/bi700131x","article-title":"A novel lantibiotic acting on bacterial cell wall synthesis produced by the uncommon actinomycete planomonospora sp","volume":"46","author":"Castiglione","year":"2007","journal-title":"Biochemistry"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10123-025-00640-z","article-title":"Antagonistic activity of butanamine 2, 2-dinitro-N-methyl-synthesized by endosymbiotic Bacillus amyloliquefaciens VITAPRJS1 acquired from horse milk","volume":"28","author":"Chakraborty","year":"","journal-title":"Int. Microbiol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"103685","DOI":"10.1016\/j.bcab.2025.103685","article-title":"Unlocking Nature's vault: endophytes as plant-sourced biological treasures","volume":"67","author":"Chakraborty","year":"","journal-title":"Biocatal. Agric. Biotechnol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"201","DOI":"10.31830\/2454-1761.2025.cr-1027","article-title":"Identification and characterization of endophytic bacteria for antibacterial activity against multi drug resistant pathogens","volume":"60","author":"Chauhan","year":"2025","journal-title":"Crop Res. (0970-4884)"},{"key":"B38","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s44398-025-00004-7","article-title":"Application of artificial intelligence in bioprospecting for natural products for biopharmaceutical purposes","volume":"1","author":"Chigozie","year":"2025","journal-title":"BMC Artif. Intell."},{"key":"B39","doi-asserted-by":"publisher","first-page":"450","DOI":"10.3390\/antibiotics10040450","article-title":"Comparative analysis of gradient diffusion and disk diffusion with agar dilution for susceptibility testing of Elizabethkingia anophelis","volume":"10","author":"Chiu","year":"2021","journal-title":"Antibiotics"},{"key":"B40","doi-asserted-by":"publisher","first-page":"e70366","DOI":"10.1002\/jbt.70366","article-title":"Paracetamol induces apoptosis, reduces colony formation, and increases PTPRO gene expression in human embryonic kidney HEK 293 cells","volume":"39","author":"Coskun\u2010Demirkalp","year":"2025","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"102861","DOI":"10.1016\/j.hal.2025.102861","article-title":"Effects of cyanobacterium Phormidium nigroviride K3 on zebrafish embryos and genomic insights into its toxic potential","volume":"145","author":"Davidovi\u0107","year":"2025","journal-title":"Harmful Algae"},{"key":"B42","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1007\/s11033-018-4495-y","article-title":"Antimicrobial activity of bacteriocin-like inhibitory substance produced by pediococcus pentosaceus: from shake flasks to bioreactor","volume":"46","author":"De Azevedo","year":"2019","journal-title":"Mol. Biology Reports"},{"key":"B43","doi-asserted-by":"publisher","first-page":"e70268","DOI":"10.1002\/mbo3.70268","article-title":"Bridging the cultivation gap in plant microbiomes: a comparative study of aerial root mucilage microbiome characterization by conventional isolation, prospector high\u2010throughput cultivation, and molecular profiling","volume":"15","author":"De la Vega\u2010Camarillo","year":"2026","journal-title":"MicrobiologyOpen"},{"key":"B44","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.jbiotec.2020.07.019","article-title":"DNA demethylation overcomes attenuation of colchicine biosynthesis in an endophytic fungus diaporthe","volume":"323","author":"Deepika","year":"2020","journal-title":"J. Biotechnology"},{"key":"B45","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/978-3-319-66541-2_4","article-title":"Harnessing fungal endophytes for plant and human health","volume":"1","author":"Deka","year":"2017","journal-title":"Endophytes Biol. Biotechnol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"13145","DOI":"10.1038\/s41598-023-40478-x","article-title":"Identification and anti-bacterial property of endophytic actinobacteria from thymes kotschyanus, Allium hooshidaryae, and cerasus microcarpa","volume":"13","author":"Delbari","year":"2023","journal-title":"Sci. Rep."},{"key":"B47","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1007\/s00248-024-02398-9","article-title":"Spatial and temporal shifts of endophytic bacteria in conifer seedlings of abies religiosa (kunth) schltdl. and Cham","volume":"87","author":"Dendooven","year":"2024","journal-title":"Microb. Ecol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"15248","DOI":"10.1038\/s41598-023-41296-x","article-title":"Purification and biological analysis of antimicrobial compound produced by an endophytic streptomyces sp","volume":"13","author":"Devi","year":"2023","journal-title":"Sci. Rep."},{"key":"B49","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.procbio.2023.10.015","article-title":"Inhibition of microbial pathogens and toxicity assessment of noformicin synthesized by psychrobacter faecalis: an endophyte of Averrhoa carambola","volume":"134","author":"Dey","year":"2023","journal-title":"Process Biochem."},{"key":"B50","doi-asserted-by":"publisher","first-page":"148","DOI":"10.3390\/ddc3010009","article-title":"Revolutionizing drug discovery: a comprehensive review of AI applications","volume":"3","author":"Dhudum","year":"2024","journal-title":"Drugs Drug Candidates"},{"key":"B51","doi-asserted-by":"publisher","first-page":"1656","DOI":"10.1021\/acs.accounts.3c00183","article-title":"Structure elucidation of secondary metabolites: current frontiers and lingering pitfalls","volume":"56","author":"DiBello","year":"2023","journal-title":"Accounts Chemical Research"},{"key":"B52","doi-asserted-by":"publisher","first-page":"107432","DOI":"10.1016\/j.ejps.2026.107432","article-title":"Safety, tolerability, pharmacokinetics, pharmacodynamics, and immunogenicity of a novel anti-TSLP bispecific antibody (GR2002) in healthy Chinese adults: a randomized, placebo-controlled phase 1 trial","volume":"218","author":"Ding","year":"2026","journal-title":"Eur. J. Pharm. Sci."},{"key":"B53","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1039\/c7an01333g","article-title":"Sample preparation for polar metabolites in bioanalysis","volume":"143","author":"Drouin","year":"2018","journal-title":"Analyst"},{"key":"B54","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1556\/1326.2020.00790","article-title":"A review of micro-solid-phase extraction techniques and devices applied in sample pretreatment coupled with chromatographic analysis","volume":"33","author":"Dugheri","year":"2021","journal-title":"Acta Chromatogr."},{"key":"B55","doi-asserted-by":"publisher","first-page":"713","DOI":"10.18280\/ijdne.190301","article-title":"Synergistic antibacterial effects of combined phytochemicals of endophytic fungi extracts and \u0131ts pure compounds \u0131solated from sungkai (Peronema canescens) leaves","volume":"19","author":"Elfita","year":"2024","journal-title":"Int. J. Des. Nat. Ecodynamics"},{"key":"B56","doi-asserted-by":"publisher","first-page":"402","DOI":"10.3390\/ph18030402","article-title":"Combating antibiotic resistance: mechanisms, multidrug-resistant pathogens, and novel therapeutic approaches: an updated review","volume":"18","author":"Elshobary","year":"2025","journal-title":"Pharmaceuticals"},{"key":"B57","doi-asserted-by":"publisher","first-page":"123","DOI":"10.3390\/metabo9070123","article-title":"NMR spectroscopy for metabolomics research","volume":"9","author":"Emwas","year":"2019","journal-title":"Metabolites"},{"key":"B58","doi-asserted-by":"publisher","first-page":"S63","DOI":"10.1016\/j.toxac.2024.11.010","article-title":"LC-HRMS: benefits and limitations in clinical and forensic toxicology","volume":"37","author":"Fabresse","year":"2025","journal-title":"Toxicol. Anal. Clinique"},{"key":"B59","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1007\/s13353-021-00611-w","article-title":"Unveiling the putative functional genes present in root-associated endophytic microbiome from maize plant using the shotgun approach","volume":"62","author":"Fadiji","year":"2021","journal-title":"J. Appl. Genet."},{"key":"B60","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1515\/revac-2022-0030","article-title":"Recent applications of quantitative analytical FTIR spectroscopy in pharmaceutical, biomedical, and clinical fields: a brief review","volume":"41","author":"Fahelelbom","year":"2022","journal-title":"Rev. Anal. Chem."},{"key":"B61","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-025-99709-y","article-title":"Metabolic profiling and antibacterial activity of secondary metabolites extracted from the endophytic bacteria of combretum erythrophyllum","volume":"15","author":"Fanoro","year":"2025","journal-title":"Sci. Rep."},{"key":"B62","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/s12298-025-01552-y","article-title":"Isolation and evaluation of growth-promoting endophytic bacteria from Zanthoxylum dissitum hemsl","volume":"31","author":"Fei","year":"2025","journal-title":"Physiology Mol. Biol. Plants"},{"key":"B63","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1093\/clinids\/2.1.129","article-title":"On the antibacterial action of cultures of a penicillium, with special reference to their use in the isolation of B. influenzae","volume":"10","author":"Fleming","year":"1929","journal-title":"Br. Journal Experimental Pathology"},{"key":"B64","doi-asserted-by":"publisher","first-page":"427","DOI":"10.3390\/antibiotics11040427","article-title":"Antimicrobial susceptibility testing: a comprehensive review of currently used methods","volume":"11","author":"Gajic","year":"2022","journal-title":"Antibiotics"},{"key":"B65","doi-asserted-by":"publisher","first-page":"308","DOI":"10.3390\/md21050308","article-title":"Advanced methods for natural products discovery: bioactivity screening, dereplication, metabolomics profiling, genomic sequencing, databases and informatic tools, and structure elucidation","volume":"21","author":"Gaud\u00eancio","year":"2023","journal-title":"Mar. Drugs"},{"key":"B246","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1039\/C4NP00134F","article-title":"Dereplication: racing to speed up the natural products discovery process","volume":"32","author":"Gaud\u00eancio","year":"2015","journal-title":"Nat. Prod. Repor."},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.4172\/2329-6836.1000205","article-title":"Isolation and identification of antibacterial compounds isolated from endophytic fungus emericella qaudrilineata","volume":"4","author":"Goutam","year":"2016","journal-title":"Nat. Prod. Chem. Res."},{"key":"B67","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12223-025-01312-1","article-title":"Isolation, biochemical characterization, and antimicrobial activities of EPS-producing bacterial endophytes from Moringa oleifera","author":"Gul","year":"2025","journal-title":"Folia Microbiol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.3390\/pr10122498","article-title":"UPLC technique in pharmacy\u2014an important tool of the modern analyst","volume":"10","author":"Gumu\u0142ka","year":"2022","journal-title":"Processes"},{"key":"B69","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1186\/s13578-024-01317-2","article-title":"Advances in drug-induced liver injury research: in vitro models, mechanisms, omics and gene modulation techniques","volume":"14","author":"Guo","year":"2024","journal-title":"Cell. and Biosci."},{"key":"B70","doi-asserted-by":"publisher","first-page":"224","DOI":"10.2478\/cipms-2022-0039","article-title":"A comparative review on high-performance liquid chromatography (HPLC), ultra performance liquid chromatography (UPLC) and high-performance thin layer chromatography (HPTLC) with current updates","volume":"35","author":"Gupta","year":"2022","journal-title":"Curr. Issues Pharm. Med. Sci."},{"key":"B71","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1128\/MMBR.00050-14","article-title":"The hidden world within plants: ecological and evolutionary considerations for defining functioning of microbial endophytes","volume":"79","author":"Hardoim","year":"2015","journal-title":"Microbiol. Molecular Biology Reviews"},{"key":"B72","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.3390\/pr12081621","article-title":"Isolation and characterization of Bacillus subtilis BSP1 from soil: antimicrobial activity and optimization of fermentation conditions","volume":"12","author":"Hellany","year":"2024","journal-title":"Processes"},{"key":"B73","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1007\/s13205-019-1838-x","article-title":"Metagenomic analysis of bacterial endophyte community structure and functions in Panax ginseng at different ages","volume":"9","author":"Hong","year":"2019","journal-title":"3 Biotech."},{"key":"B74","doi-asserted-by":"publisher","first-page":"79","DOI":"10.12691\/ajmr-12-4-1","article-title":"Antibiotic resistance genes detection in Escherichia coli isolated from raw meat in Rajshahi division of Bangladesh","volume":"12","author":"Hossain","year":"2024","journal-title":"Am. J. Microbiol. Res."},{"key":"B75","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1186\/s12866-024-03258-9","article-title":"Optimization of fermentation conditions and medium components for chrysomycin a production by streptomyces sp. 891-B6","volume":"24","author":"Hu","year":"2024","journal-title":"BMC Microbiology"},{"key":"B76","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s43088-024-00483-z","article-title":"Isolation and identification of associated endophytic bacteria from barely seeds harbour non-ribosomal peptides and enhance tolerance to salinity stress","volume":"13","author":"Hussein","year":"2024","journal-title":"Beni-Suef Univ. J. Basic Appl. Sci."},{"key":"B77","doi-asserted-by":"publisher","first-page":"2221","DOI":"10.1016\/s0140-6736(22)02185-7","article-title":"Global mortality associated with 33 bacterial pathogens in 2019: a systematic analysis for the global burden of disease study 2019","volume":"400","author":"Ikuta","year":"2022","journal-title":"Lancet"},{"key":"B78","doi-asserted-by":"publisher","first-page":"100553","DOI":"10.1016\/j.microb.2025.100553","article-title":"Bioactive metabolites from endophytes: focus on anticancer and antimicrobial potential","volume":"9","author":"Islam","year":"2025","journal-title":"Microbe"},{"key":"B79","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.mimet.2010.10.009","article-title":"A simple and rapid GC\/MS method for the simultaneous determination of gaseous metabolites","volume":"84","author":"Isobe","year":"2011","journal-title":"J. Microbiological Methods"},{"key":"B80","doi-asserted-by":"publisher","first-page":"28606","DOI":"10.1038\/s41598-025-14071-3","article-title":"Rapid and reliable species-level identification from clinical samples using 16S rRNA gene nanopore sequencing analysis","volume":"15","author":"Ivens","year":"2025","journal-title":"Sci. Rep."},{"key":"B81","doi-asserted-by":"publisher","first-page":"27865","DOI":"10.1038\/s41598-025-11212-6","article-title":"Phytobacter sp. RSE02 is a rice seed endophytic plant probiotic bacterium with human probiotic features and cholesterol-lowering ability","volume":"15","author":"Jana","year":"2025","journal-title":"Sci. Rep."},{"key":"B82","doi-asserted-by":"publisher","first-page":"e02569-25","DOI":"10.1128\/aem.02569-25","article-title":"An indole dimer antifungal metabolite from a rice seed endophyte inhibits ergosterol biosynthesis in fungal pathogens","volume":"92","author":"Jana","year":"2026","journal-title":"Appl. Environ. Microbiol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1007\/s00248-016-0753-5","article-title":"Surfactin, iturin, and fengycin biosynthesis by endophytic bacillus sp. from Bacopa monnieri","volume":"72","author":"Jasim","year":"2016","journal-title":"Microb. Ecol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.chemosphere.2017.01.116","article-title":"Equilibrium partitioning of organic compounds to OASIS HLB\u00ae as a function of compound concentration, pH, temperature and salinity","volume":"174","author":"Jeong","year":"2017","journal-title":"Chemosphere"},{"key":"B85","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1186\/s13068-023-02398-w","article-title":"Efficient ilamycins production utilizing Enteromorpha prolifera by metabolically engineered Streptomyces atratus","volume":"16","author":"Jiang","year":"2023","journal-title":"Biotechnol. Biofuels Bioprod."},{"key":"B86","doi-asserted-by":"publisher","first-page":"117117","DOI":"10.1016\/j.foodres.2025.117117","article-title":"Identification and fermentation optimization of a newly isolated strain Bacillus velezensis AmoreLumina for high-yield moranoline production","volume":"220","author":"Ju","year":"2025","journal-title":"Food Res. Int."},{"key":"B87","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1002\/fft2.44","article-title":"Guidelines for cell viability assays","volume":"1","author":"Kamiloglu","year":"2020","journal-title":"Food Frontiers"},{"key":"B88","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12088-025-01498-5","article-title":"Optimization and partial characterization of biopigment production from endophytic Mesobacillus subterraneus SGL and its antimicrobial activity","volume":"66","author":"Kandasamy","year":"2025","journal-title":"Indian J. Microbiol."},{"key":"B89","doi-asserted-by":"publisher","first-page":"1304081","DOI":"10.3389\/fmicb.2023.1304081","article-title":"Applications of fourier transform-infrared spectroscopy in microbial cell biology and environmental microbiology: advances, challenges, and future perspectives","volume":"14","author":"Kassem","year":"2023","journal-title":"Front. Microbiology"},{"key":"B90","doi-asserted-by":"publisher","first-page":"e1013181","DOI":"10.1371\/journal.pcbi.1013181","article-title":"A novel transformer-based platform for the prediction and design of biosynthetic gene clusters for (un) natural products","volume":"22","author":"Kawano","year":"2026","journal-title":"PLOS Comput. Biol."},{"key":"B91","doi-asserted-by":"publisher","first-page":"1866","DOI":"10.1021\/cb300316n","article-title":"In vivo validation of thymidylate kinase (TMK) with a rationally designed, selective antibacterial compound","volume":"7","author":"Keating","year":"2012","journal-title":"ACS Chemical Biology"},{"key":"B92","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1038\/nrmicro1286","article-title":"Fungal secondary metabolism\u2014from biochemistry to genomics","volume":"3","author":"Keller","year":"2005","journal-title":"Nat. Reviews Microbiology"},{"key":"B93","doi-asserted-by":"publisher","first-page":"10","DOI":"10.7454\/mss.v29i1.2574","article-title":"Antibacterial activity of endophytic actinobacteria isolated from Ziziphus mauritiana against multidrug-resistant strains","volume":"29","author":"Khairani","year":"2025","journal-title":"Makara J. Sci."},{"key":"B94","doi-asserted-by":"publisher","first-page":"1","DOI":"10.47134\/pslse.v2i3.388","article-title":"Exploring the principles of GC-MS: techniques and applications","volume":"2","author":"Khalifea","year":"2025","journal-title":"Phys. Sci. Life Sci. Eng."},{"key":"B95","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1007\/s10482-025-02236-z","article-title":"Challenges, adaptations, and biotechnological potential of oligophilic bacteria","volume":"119","author":"Khan","year":"2026","journal-title":"Antonie Van Leeuwenhoek"},{"key":"B96","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.21608\/ejvs.2024.282284.2009","article-title":"Isolation endophytic bacteria from leaf glands and seeds of Ardisia crenata plant and its molecular detection","volume":"56","author":"Khuder","year":"2025","journal-title":"Egypt. J. Veterinary Sci."},{"key":"B97","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1007\/s43188-025-00289-w","article-title":"Advancing hepatotoxicity assessment: current advances and future directions","volume":"41","author":"Kim","year":"2025","journal-title":"Toxicol. Res."},{"key":"B98","doi-asserted-by":"publisher","first-page":"458","DOI":"10.5281\/zenodo.15082659","article-title":"Ultra performance liquid chromatography (Uplc): a new trend in analysis","volume":"2","author":"Kiran","year":"2025","journal-title":"Int. J. Sci. Res. Technol."},{"key":"B99","doi-asserted-by":"publisher","first-page":"108282","DOI":"10.1016\/j.petrol.2020.108282","article-title":"Oilfield produced water treatment by liquid-liquid extraction: a review","volume":"199","author":"Klemz","year":"2021","journal-title":"J. Petroleum Sci. Eng."},{"key":"B100","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1038\/nrd2378","article-title":"The application of discovery toxicology and pathology towards the design of safer pharmaceutical lead candidates","volume":"6","author":"Kramer","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"key":"B101","first-page":"3","article-title":"Isolation and cultivation of novel microorganisms for drug prospecting","volume-title":"Machine Learning in Microbial Drug Development","author":"Kumar","year":"2026"},{"key":"B102","doi-asserted-by":"publisher","first-page":"prot095505","DOI":"10.1101\/pdb.prot095505","article-title":"Analysis of cell viability by the MTT assay","volume":"2018","author":"Kumar","year":"2018","journal-title":"Cold Spring Harbor Protocols"},{"key":"B103","doi-asserted-by":"publisher","first-page":"100015","DOI":"10.1016\/j.temicr.2025.100015","article-title":"Functional characterization and alleviation of Cadmium stress by endophytic bacteria isolated from Cynodon dactylon (L.) pers","volume":"1","author":"Kumar","year":"2025","journal-title":"Total Environ. Microbiol."},{"key":"B104","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11274-025-04455-y","article-title":"Seed inhabiting bacterial endophyte Bacillus amyloliquefaciens (SS7) defends sorghum Sudan grass seedlings from a phytopathogen Rhizoctonia solani","volume":"41","author":"Kumar","year":"2025","journal-title":"World J. Microbiol. Biotechnol."},{"key":"B105","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/j.sajb.2021.02.020","article-title":"Isolation and purification of bioactive metabolites from an endophytic fungus Penicillium citrinum of Azadirachta indica","volume":"139","author":"Kumari","year":"2021","journal-title":"South Afr. J. Bot."},{"key":"B106","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1039\/D5NP00036J","article-title":"Streptomyces as a versatile host platform for heterologous production of microbial natural products","volume":"43","author":"Lasch","year":"2026","journal-title":"Nat. Product. Rep"},{"key":"B107","doi-asserted-by":"publisher","first-page":"2094","DOI":"10.1038\/s41598-024-84893-0","article-title":"Antibacterial and antioxidant potentials, detection of host origin compounds, and metabolic profiling of endophytic bacillus spp. isolated from Rauvolfia serpentina (L.) benth. ex Kurz","volume":"15","author":"Lata","year":"2025","journal-title":"Sci. Rep."},{"key":"B108","doi-asserted-by":"publisher","first-page":"928967","DOI":"10.3389\/fmicb.2022.928967","article-title":"Biosynthetic mechanisms of secondary metabolites promoted by the interaction between endophytes and plant hosts","volume":"13","author":"Li","year":"2022","journal-title":"Front. Microbiology"},{"key":"B109","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.jpha.2023.04.007","article-title":"Spatiotemporal pharmacometabolomics based on ambient mass spectrometry imaging to evaluate the metabolism and hepatotoxicity of amiodarone in HepG2 spheroids","volume":"13","author":"Li","year":"2023","journal-title":"J. Pharm. Analysis"},{"key":"B110","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10526-025-10330-4","article-title":"Biocontrol of the black-spot disease pathogen (Alternaria alternata) in Dioscorea opposita by native endophytic bacterium bacillus sp. E-Do8","volume":"70","author":"Li","year":"2025","journal-title":"BioControl"},{"key":"B111","doi-asserted-by":"publisher","first-page":"21585","DOI":"10.1021\/acs.jafc.4c04237","article-title":"The antiphytopathogenic metabolites and the synergy of endophytes paraphaeosphaeria sp., Nigrospora oryzae from the same ginkgo biloba host","volume":"72","author":"Liao","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"B112","doi-asserted-by":"publisher","first-page":"114411","DOI":"10.1016\/j.phytochem.2025.114411","article-title":"HDAC inhibitor SAHA triggers the production of previously undescribed sesquiterpenes and undergoes biotransformation by the fungus Robillarda sessilis from Verbena officinalis L","volume":"233","author":"Liao","year":"2025","journal-title":"Phytochemistry"},{"key":"B113","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.addr.2016.04.029","article-title":"Rule of five in 2015 and beyond: target and ligand structural limitations, ligand chemistry structure and drug discovery project decisions","volume":"101","author":"Lipinski","year":"2016","journal-title":"Adv. Drug Delivery Reviews"},{"key":"B114","doi-asserted-by":"publisher","first-page":"36167","DOI":"10.1039\/c8ra07349j","article-title":"Efficient production of high-molecular-weight hyaluronic acid with a two-stage fermentation","volume":"8","author":"Liu","year":"2018","journal-title":"RSC Advances"},{"key":"B115","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40643-019-0269-1","article-title":"Optimized sampling protocol for mass spectrometry-based metabolomics in streptomyces","volume":"6","author":"Liu","year":"2019","journal-title":"Bioresour. Bioprocess."},{"key":"B116","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1080\/12298093.2023.2216944","article-title":"Metabolite chemical composition of the Bletilla striata (thunb.) reichb. f. Endophyte Penicillium oxalicum","volume":"51","author":"Liu","year":"2023","journal-title":"Mycobiology"},{"key":"B117","doi-asserted-by":"publisher","first-page":"540","DOI":"10.3390\/md22120540","article-title":"Recent advances of the zebrafish model in the discovery of marine bioactive molecules","volume":"22","author":"Liu","year":"2024","journal-title":"Mar. Drugs"},{"key":"B118","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s40779-024-00510-1","article-title":"Antimicrobial resistance crisis: could artificial intelligence be the solution?","volume":"11","author":"Liu","year":"2024","journal-title":"Mil. Med. Res."},{"key":"B119","doi-asserted-by":"publisher","first-page":"100871","DOI":"10.1016\/j.xinn.2025.100871","article-title":"Addressing challenges in microbial manufacturing: systematic microbial biotechnology","volume":"6","author":"Liu","year":"2025","journal-title":"Innovation"},{"key":"B120","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.trac.2016.12.006","article-title":"Trends in LC-MS and LC-HRMS analysis and characterization of polyphenols in food","volume":"88","author":"Lucci","year":"2017","journal-title":"TrAC Trends Anal. Chem."},{"key":"B121","doi-asserted-by":"publisher","first-page":"33688","DOI":"10.1038\/s41598-025-18768-3","article-title":"Comparative analysis of illumina and oxford nanopore sequencing platforms for 16S rRNA profiling of respiratory microbial communities","volume":"15","author":"Macip","year":"2025","journal-title":"Sci. Rep."},{"key":"B122","doi-asserted-by":"publisher","first-page":"07","DOI":"10.5281\/zenodo.17936994","article-title":"Medicinal plant associated endophytes: a new horizon in herbal drug discovery","volume":"1","author":"Madagundi","year":"2025","journal-title":"Biopress J. Ethnobot. Innovations Herb. Ther. (BJEIHT)"},{"key":"B123","doi-asserted-by":"publisher","first-page":"220","DOI":"10.3390\/ijms26010220","article-title":"An overview of the current state of cell viability assessment methods using OECD classification","volume":"26","author":"Madorran","year":"2024","journal-title":"Int. Journal Molecular Sciences"},{"key":"B124","doi-asserted-by":"publisher","first-page":"18236","DOI":"10.1038\/s41598-022-23073-4","article-title":"Identification and antibacterial evaluation of endophytic actinobacteria from Luffa cylindrica","volume":"12","author":"Mahdi","year":"2022","journal-title":"Sci. Reports"},{"key":"B125","doi-asserted-by":"publisher","first-page":"107431","DOI":"10.1016\/j.micpath.2025.107431","article-title":"Endophytic bacteria of Gracilaria edulis in combating human bacterial pathogens by PPDHMP-A crude to single molecule product development approach","volume":"202","author":"Manam","year":"","journal-title":"Microb. Pathog."},{"key":"B126","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.sajb.2025.01.045","article-title":"Inhibitory effects of endophytic bacterial metabolite (gougerotin) of Ziziphus mauritiana (ber fruit) against human bacterial pathogens","volume":"178","author":"Manam","year":"","journal-title":"South Afr. J. Bot."},{"key":"B127","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/s10529-008-9868-1","article-title":"Significance of the zebrafish model in the discovery of bioactive molecules from nature","volume":"31","author":"Mandrekar","year":"2009","journal-title":"Biotechnol. Letters"},{"key":"B128","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00203-025-04429-6","article-title":"DNA gyrase-inhibitory antimicrobial anthraquinone from the endophytic Sordariomycetes fungus Diaporthe perseae","volume":"207","author":"Manzano","year":"2025","journal-title":"Archives Microbiol."},{"key":"B129","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1017\/s0021859616000113","article-title":"Germination and seedling emergence responses of common bean and cowpea to plant extract seed treatments","volume":"155","author":"Masangwa","year":"2017","journal-title":"J. Agric. Sci."},{"key":"B130","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1128\/IAI.00595-18","article-title":"Characterization of the mode of action of aurodox, a type III secretion system inhibitor from streptomyces goldiniensis","volume":"87","author":"McHugh","year":"2019","journal-title":"Infect. Immunity"},{"key":"B131","doi-asserted-by":"publisher","first-page":"4154","DOI":"10.3390\/foods13244154","article-title":"Advances in bioprocess engineering for optimising Chlorella vulgaris fermentation: biotechnological innovations and applications","volume":"13","author":"Mendes","year":"2024","journal-title":"Foods"},{"key":"B132","doi-asserted-by":"publisher","first-page":"560","DOI":"10.3390\/md19100560","article-title":"Antioxidant bioactivity of extracts from beach cast leaves of Posidonia oceanica (L.) delile","volume":"19","author":"Messina","year":"2021","journal-title":"Mar. Drugs"},{"key":"B133","doi-asserted-by":"publisher","first-page":"117941","DOI":"10.1016\/j.trac.2024.117941","article-title":"Novel materials and approaches for solid-phase (micro) extraction in LC-MS-based metabolomics","volume":"180","author":"M\u0142ynarczyk","year":"2024","journal-title":"TrAC Trends Anal. Chem."},{"key":"B134","doi-asserted-by":"publisher","first-page":"9186536","DOI":"10.1155\/2022\/9186536","article-title":"Bacterial metabolomics: sample preparation methods","volume":"2022","author":"Mohd Kamal","year":"2022","journal-title":"Biochem. Research International"},{"key":"B135","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/s00203-024-03891-y","article-title":"Endophytes: a uniquely tailored source of potential antibiotic adjuvants","volume":"206","author":"Moussa","year":"2024","journal-title":"Archives Microbiol."},{"key":"B136","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1038\/s41573-023-00774-7","article-title":"Artificial intelligence for natural product drug discovery","volume":"22","author":"Mullowney","year":"2023","journal-title":"Nat. Rev. Drug Discov."},{"key":"B137","doi-asserted-by":"publisher","first-page":"012029","DOI":"10.1088\/1755-1315\/1494\/1\/012029","article-title":"Endophytic bacteria isolated from anthocephalus cadamba Miq, Albizia chinensis (osbeck) Merr. and Mimusops elengi L for the biological control of meloidogyne sp. on tomato","volume":"1494","author":"Munif","year":"2025","journal-title":"IOP Conf. Ser. Earth Environ. Sci."},{"key":"B138","doi-asserted-by":"publisher","first-page":"104303","DOI":"10.1016\/j.resmic.2025.104303","article-title":"Emerging concept of genomic islands in bacterial adaptation and pathogenicity","volume":"176","author":"Munshi","year":"2025","journal-title":"Res. Microbiol."},{"key":"B139","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s13659-025-00589-6","article-title":"Nature meets machine: the AI renaissance in natural product drug discovery","volume":"16","author":"Muthuraj","year":"2026","journal-title":"Nat. Prod. Bioprospecting"},{"key":"B140","doi-asserted-by":"publisher","first-page":"e17705","DOI":"10.1590\/s2175-97902019000317705","article-title":"Characterization of bacterial endophytes from Myanmar medicinal plants for antimicrobial activity against human and plant pathogens","volume":"56","author":"Myo","year":"2020","journal-title":"Braz. J. Pharm. Sci."},{"key":"B141","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1002\/pca.2906","article-title":"A review on the recent advances in HPLC, UHPLC and UPLC analyses of naturally occurring cannabinoids (2010\u20132019)","volume":"31","author":"Nahar","year":"2020","journal-title":"Phytochem. Anal."},{"key":"B142","doi-asserted-by":"publisher","first-page":"2140","DOI":"10.3390\/foods12112140","article-title":"Metagenomics: an effective approach for exploring microbial diversity and functions","volume":"12","author":"Nam","year":"2023","journal-title":"Foods"},{"key":"B143","doi-asserted-by":"publisher","first-page":"9054","DOI":"10.1038\/s41598-023-35360-9","article-title":"Exploring the antimicrobial, antioxidant, anticancer, biocompatibility, and larvicidal activities of selenium nanoparticles fabricated by endophytic fungal strain Penicillium verhagenii","volume":"13","author":"Nassar","year":"2023","journal-title":"Sci. Reports"},{"key":"B144","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.procbio.2023.04.027","article-title":"Ultraperformance liquid chromatography-based metabolite profiling and cytotoxic activity of the ethyl acetate extract of two endophytic penicillium sp","volume":"130","author":"Naveen","year":"2023","journal-title":"Process Biochem."},{"key":"B145","doi-asserted-by":"publisher","first-page":"e01325-24","DOI":"10.1128\/aem.01325-24","article-title":"A modified iChip for in situ cultivation of bacteria in arid environments","volume":"91","author":"Nazipi Bushi","year":"2025","journal-title":"Appl. Environ. Microbiol."},{"key":"B146","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s43994-025-00233-6","article-title":"Bacterial endophytes and their secondary metabolites: mechanisms of biosynthesis and applications in sustainable agriculture","author":"Nimbulkar","year":"2025","journal-title":"J. Umm Al-Qura Univ. Appl. Sci."},{"key":"B147","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1007\/s00203-022-02795-z","article-title":"Screening of secondary metabolites and antioxidant potential of endophytic fungus Penicillium citrinum and host Digitaria bicornis by spectrophotometric and electrochemical methods","volume":"204","author":"Nischitha","year":"2022","journal-title":"Archives Microbiol."},{"key":"B148","doi-asserted-by":"publisher","first-page":"16121","DOI":"10.1038\/s41598-025-00099-y","article-title":"Bioactivity and chemical screening of endophytic fungi associated with seaweeds gracilaria sp. and sargassum sp. of the Bay of Bengal, Bangladesh","volume":"15","author":"Noor","year":"2025","journal-title":"Sci. Rep."},{"key":"B149","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.3390\/metabo12121228","article-title":"Bioactive compounds from endophytic bacteria Bacillus subtilis strain EP1 with their antibacterial activities","volume":"12","author":"Numan","year":"2022","journal-title":"Metabolites"},{"key":"B150","doi-asserted-by":"publisher","first-page":"100014","DOI":"10.1016\/j.temicr.2025.100014","article-title":"Diversity and hydrocarbon degradative potential of endophytic bacteria isolated from Hibiscus cannabinus and zea mays grown on crude oil-polluted soil from egbema, Nigeria","volume":"1","author":"Nwajiobi","year":"2025","journal-title":"Total Environ. Microbiol."},{"key":"B151","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12906-020-03095-z","article-title":"Isolation of endophytic bacteria from the leaves of Anredera cordifolia CIX1 for metabolites and their biological activities","volume":"20","author":"Nxumalo","year":"2020","journal-title":"BMC Complementary Med. Ther."},{"key":"B152","doi-asserted-by":"publisher","first-page":"638","DOI":"10.3390\/plants12030638","article-title":"Growth-promoting characteristics of fungal and bacterial endophytes isolated from a drought-tolerant mint species Endostemon obtusifolius (E. Mey. ex benth.) NE Br","volume":"12","author":"Ogbe","year":"2023","journal-title":"Plants"},{"key":"B153","doi-asserted-by":"publisher","first-page":"e40525","DOI":"10.1016\/j.heliyon.2024.e40525","article-title":"Bioactivity and metabolic profiling of crude extracts from endophytic bacteria linked to Solanum mauritianum scope: discovery of antibacterial and anticancer properties","volume":"11","author":"Ogofure","year":"2025","journal-title":"Heliyon"},{"key":"B154","volume-title":"Antimicrobial Susceptibility Bioassays: A Comprehensive Review on Advanced Methodologies and Techniques","author":"Ojha","year":"2025"},{"key":"B155","doi-asserted-by":"publisher","first-page":"888079","DOI":"10.3389\/fphar.2022.888079","article-title":"The importance of pharmacokinetics and pharmacodynamics in antimicrobial drug development and their influence on the success of agents developed to combat resistant gram negative pathogens: a review","volume":"13","author":"Palmer","year":"2022","journal-title":"Front. Pharmacol."},{"key":"B156","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1186\/s12870-022-03615-8","article-title":"Plant organ-and growth stage-diversity of endophytic bacteria with potential as biofertilisers isolated from wheat (Triticum aestivum L.)","volume":"22","author":"Pang","year":"2022","journal-title":"BMC Plant Biol."},{"key":"B157","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.sajb.2021.07.044","article-title":"In vitro characterization of antimicrobial activity of an endophytic bacterium Enterobacter cloacae (MG001451) isolated from Ocimum sanctum","volume":"143","author":"Panigrahi","year":"2021","journal-title":"South Afr. J. Bot."},{"key":"B158","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.sajb.2019.09.017","article-title":"Characterization of endophytic bacteria Enterobacter cloacae MG00145 isolated from Ocimum sanctum with indole acetic acid (IAA) production and plant growth promoting capabilities against selected crops","volume":"134","author":"Panigrahi","year":"2020","journal-title":"South Afr. J. Bot."},{"key":"B159","doi-asserted-by":"publisher","first-page":"684","DOI":"10.3390\/molecules30030684","article-title":"Application of fourier transform infrared (FTIR) spectroscopy in characterization of green synthesized nanoparticles","volume":"30","author":"Pasieczna-Patkowska","year":"2025","journal-title":"Molecules"},{"key":"B160","doi-asserted-by":"publisher","first-page":"100249","DOI":"10.1016\/j.phyplu.2022.100249","article-title":"Endophytes: an unexplored treasure to combat multidrug resistance","volume":"2","author":"Pasrija","year":"2022","journal-title":"Phytomedicine Plus"},{"key":"B161","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.3389\/fmicb.2019.01100","article-title":"Relationship between quorum sensing and secretion systems","volume":"10","author":"Pena","year":"2019","journal-title":"Front. Microbiology"},{"key":"B162","doi-asserted-by":"publisher","first-page":"1429423","DOI":"10.3389\/fphar.2024.1429423","article-title":"Optimization of culture conditions for endophytic bacteria in mangrove plants and isolation and identification of bacteriocin","volume":"15","author":"Peng","year":"2024","journal-title":"Front. Pharmacol."},{"key":"B163","doi-asserted-by":"publisher","first-page":"986","DOI":"10.3390\/antibiotics11080986","article-title":"Pharmacokinetic\/pharmacodynamic modeling and application in antibacterial and antifungal pharmacotherapy: a narrative review","volume":"11","author":"Pereira","year":"2022","journal-title":"Antibiotics"},{"key":"B164","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-3-031-59567-7_1","article-title":"Natural products dereplication: databases and analytical methods","volume":"124","author":"P\u00e9rez-Victoria","year":"2024","journal-title":"Prog. Chem. Org. Nat. Prod."},{"key":"B165","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1186\/s12864-024-10475-z","article-title":"In silico prediction of polyketide biosynthetic gene clusters in the genomes of Hypericum-borne endophytic fungi","volume":"25","author":"Petijov\u00e1","year":"2024","journal-title":"BMC Genomics"},{"key":"B166","doi-asserted-by":"publisher","first-page":"7824","DOI":"10.1039\/d4sc00933a","article-title":"Supramolecular chemistry of liquid\u2013liquid extraction","volume":"15","author":"Pramanik","year":"2024","journal-title":"Chem. Sci."},{"key":"B167","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s42535-025-01389-6","article-title":"Isolation and characterization of Xanthomonas campestris pv. campestris from cabbage and its inhibition using endophytic bacteria","author":"Preethi","year":"2025","journal-title":"Vegetos"},{"key":"B168","doi-asserted-by":"publisher","first-page":"6653","DOI":"10.1007\/s12010-023-04382-4","article-title":"The antibacterial and antibiofilm activities of the endophytic bacteria associated with Archidendron pauciflorum against multidrug-resistant strains","volume":"195","author":"Priyanto","year":"2023","journal-title":"Appl. Biochem. Biotechnol."},{"key":"B169","doi-asserted-by":"publisher","first-page":"157","DOI":"10.3390\/molecules28010157","article-title":"MS\/MS-based molecular networking: an efficient approach for natural products dereplication","volume":"28","author":"Qin","year":"2022","journal-title":"Molecules"},{"key":"B170","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1007\/s11101-024-09928-w","article-title":"Advanced high-resolution chromatographic strategies for efficient isolation of natural products from complex biological matrices: from metabolite profiling to pure chemical entities","volume":"23","author":"Queiroz","year":"2024","journal-title":"Phytochem. Rev."},{"key":"B171","first-page":"181","article-title":"A potential surface sterilization technique and culture media for the isolation of endophytic bacteria from Acalypha indica and its antibacterial activity","volume":"6","author":"Ramalashmi","year":"2018","journal-title":"J. Med. Plant Stud."},{"key":"B172","doi-asserted-by":"publisher","first-page":"10605","DOI":"10.1007\/s11033-023-08880-w","article-title":"The untapped potential of actinobacterial lanthipeptides as therapeutic agents","volume":"50","author":"Ram\u00edrez-Rend\u00f3n","year":"2023","journal-title":"Mol. Biol. Rep."},{"key":"B173","article-title":"Green nanoparticles synthesized from endophytic fungi (Colletotrichum gloeosporioides) break antibiotic resistance in pathogenic E. Coli","author":"Ranjani","year":"2021"},{"key":"B174","doi-asserted-by":"publisher","first-page":"1744","DOI":"10.3390\/polym16121744","article-title":"The seed germination test as a valuable tool for the short-term phytotoxicity screening of water-soluble polyamidoamines","volume":"16","author":"Ranucci","year":"2024","journal-title":"Polymers"},{"key":"B175","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1080\/10408444.2023.2168178","article-title":"Nephrotoxicity induced by natural compounds from herbal medicines\u2013a challenge for clinical application","volume":"52","author":"Rao","year":"2022","journal-title":"Crit. Reviews Toxicology"},{"key":"B176","doi-asserted-by":"publisher","first-page":"22335","DOI":"10.1039\/c8ra01574k","article-title":"Advances in mass spectrometry-based metabolomics for investigation of metabolites","volume":"8","author":"Ren","year":"2018","journal-title":"RSC Advances"},{"key":"B177","doi-asserted-by":"publisher","first-page":"244","DOI":"10.3390\/md16070244","article-title":"Extending the \u201cone strain many compounds\u201d(OSMAC) principle to marine microorganisms","volume":"16","author":"Romano","year":"2018","journal-title":"Mar. Drugs"},{"key":"B178","first-page":"3320","article-title":"Antibacterial activity of endophytic bacterial extracts isolated from pineapple peel (Ananas comosus L.)","volume":"7","author":"Rustini","year":"2023","journal-title":"Trop. J. Nat. Prod. Res."},{"key":"B179","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1038\/nrmicro3496","article-title":"Discovery of microbial natural products by activation of silent biosynthetic gene clusters","volume":"13","author":"Rutledge","year":"2015","journal-title":"Nat. Reviews Microbiology"},{"key":"B180","doi-asserted-by":"publisher","first-page":"87","DOI":"10.3168\/jds.2018-14881","article-title":"Bacteriocin production by Lactobacillus plantarum ST16Pa in supplemented whey powder formulations","volume":"102","author":"Sabo","year":"2019","journal-title":"J. Dairy Sci."},{"key":"B181","doi-asserted-by":"publisher","first-page":"2470","DOI":"10.3389\/fmicb.2019.02470","article-title":"From petri dish to patient: bioavailability estimation and mechanism of action for antimicrobial and immunomodulatory natural products","volume":"10","author":"Sadgrove","year":"2019","journal-title":"Front. Microbiology"},{"key":"B182","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1002\/jobm.202100462","article-title":"Surface sterilization for isolation of endophytes: ensuring what (not) to grow","volume":"62","author":"Sahu","year":"2022","journal-title":"J. Basic Microbiol."},{"key":"B183","doi-asserted-by":"publisher","first-page":"63","DOI":"10.3390\/antibiotics14010063","article-title":"Unseen enemy: mechanisms of multidrug antimicrobial resistance in Gram-negative ESKAPE pathogens","volume":"14","author":"Sakalauskien\u0117","year":"2025","journal-title":"Antibiotics"},{"key":"B184","doi-asserted-by":"publisher","first-page":"bat029","DOI":"10.1093\/database\/bat029","article-title":"The MetaboLights repository: curation challenges in metabolomics","volume":"2013","author":"Salek","year":"2013","journal-title":"Database"},{"key":"B185","doi-asserted-by":"publisher","first-page":"018","DOI":"10.7324\/japs.2022.120702","article-title":"Application of metabolomics on marine sponges and sponge-associated microorganisms: a review","volume":"12","author":"Samirana","year":"2022","journal-title":"J. Appl. Pharm. Sci."},{"key":"B186","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.3390\/molecules27051459","article-title":"Production of bioactive compounds with broad spectrum bactericidal action, bio-film inhibition and antilarval potential by the secondary metabolites of the endophytic fungus Cochliobolus sp. APS1 isolated from the Indian medicinal herb Andrographis paniculata","volume":"27","author":"Santra","year":"2022","journal-title":"Molecules"},{"key":"B187","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1038\/s41420-022-01207-x","article-title":"Drug toxicity assessment: cell proliferation versus cell death","volume":"8","author":"Sazonova","year":"2022","journal-title":"Cell. Death Discov."},{"key":"B247","doi-asserted-by":"crossref","first-page":"8839490","DOI":"10.1155\/2020\/8839490","article-title":"Antibacterial and anticancer activity and untargeted secondary metabolite profiling of crude bacterial endophyte extracts from Crinum macowanii Baker leaves","volume":"2020","author":"Sebola","year":"2020","journal-title":"Intern. J. Microbiol."},{"key":"B188","doi-asserted-by":"publisher","first-page":"111","DOI":"10.31083\/j.fbl2903111","article-title":"Antibacterial properties of bacterial endophytes isolated from the medicinal plant Origanum heracleoticum L","volume":"29","author":"Semenzato","year":"2024","journal-title":"Front. Bioscience-Landmark"},{"key":"B189","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.4014\/jmb.2403.03036","article-title":"Hplc, nmr based characterization, antioxidant and anticancer activities of chemical constituents from therapeutically active fungal endophytes","volume":"34","author":"Shah","year":"2024","journal-title":"J. Microbiol. Biotechnol."},{"key":"B190","doi-asserted-by":"publisher","first-page":"233","DOI":"10.5281\/zenodo.17951616","article-title":"A comprehensive review on high performance liquid chromatography (HPLC): introduction, theory, instrumentation, advantages, limitations and applications","volume":"3","author":"Shah","year":"2025","journal-title":"Int. J. Sci. Res. Technol."},{"key":"B191","doi-asserted-by":"publisher","first-page":"e13541","DOI":"10.55251\/jmbfs.13541","article-title":"High-performance liquid chromatography (Hplc): principle, applications, and the role of artificial Intelligence\u2013A review","volume":"15","author":"Shaikh","year":"2026","journal-title":"J. Microbiology, Biotechnology Food Sciences"},{"key":"B192","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/978-981-97-1451-3_7","article-title":"Downstream processing for bio-product recovery and purification","volume-title":"Recent Advances in Bioprocess Engineering and Bioreactor Design","author":"Shanu","year":"2024"},{"key":"B193","doi-asserted-by":"publisher","first-page":"15714","DOI":"10.1021\/acs.langmuir.2c02520","article-title":"Interactions of surfactants with the bacterial cell wall and inner membrane: revealing the link between aggregation and antimicrobial activity","volume":"38","author":"Sharma","year":"2022","journal-title":"Langmuir"},{"key":"B194","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1007\/s10529-024-03478-z","article-title":"Epigenetic modifiers as inducer of bioactive secondary metabolites in fungi","volume":"46","author":"Sharma","year":"2024","journal-title":"Biotechnol. Lett."},{"key":"B195","first-page":"78","article-title":"Ultra performance liquid chromatography (Uplc): a modern chromatography technique","volume":"4","author":"Sheliya","year":"2013","journal-title":"Pharma Sci. Monit."},{"key":"B196","doi-asserted-by":"publisher","first-page":"827","DOI":"10.3390\/ph16060827","article-title":"Application of zebrafish as a model for anti-cancer activity evaluation and toxicity testing of natural products","volume":"16","author":"Shen","year":"2023","journal-title":"Pharmaceuticals"},{"key":"B197","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/978-981-96-4100-0_6","article-title":"Unlocking endophytic mysteries by leveraging multi-omics technologies","volume-title":"Multi-Omics Approach to Investigate Endophyte Diversity","author":"Shishodia","year":"2025"},{"key":"B198","doi-asserted-by":"publisher","first-page":"290","DOI":"10.3390\/microorganisms10020290","article-title":"Isolation and characterization of endophytes bacterial strains of Momordica charantia L. and their possible approach in stress management","volume":"10","author":"Singh","year":"2022","journal-title":"Microorganisms"},{"key":"B199","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11274-025-04326-6","article-title":"Whole genome analysis and biocontrol potential of endophytic Bacillus cereus EMS1 against fusarium wilt in banana","volume":"41","author":"Singh","year":"2025","journal-title":"World J. Microbiol. Biotechnol."},{"key":"B200","doi-asserted-by":"publisher","first-page":"e30848","DOI":"10.1371\/journal.pone.0030848","article-title":"PIPS: pathogenicity island prediction software","volume":"7","author":"Soares","year":"2012","journal-title":"PloS One"},{"key":"B201","doi-asserted-by":"publisher","first-page":"35575","DOI":"10.1039\/c8ra06824k","article-title":"Endophytic fungus Pseudofusicoccum stromaticum produces cyclopeptides and plant-related bioactive rotenoids","volume":"8","author":"Sobreira","year":"2018","journal-title":"RSC Advances"},{"key":"B202","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.3390\/biology11101390","article-title":"Evaluation of the antifungal activity of Bacillus amyloliquefaciens and B. velezensis and characterization of the bioactive secondary metabolites produced against plant pathogenic fungi","volume":"11","author":"Soliman","year":"2022","journal-title":"Biology"},{"key":"B203","doi-asserted-by":"publisher","first-page":"961","DOI":"10.22207\/jpam.18.2.11","article-title":"Optimization of sterilization parameters for isolation of endophytes from Allium sativum and exploring its antibacterial activity","volume":"18","author":"Srivastava","year":"2024","journal-title":"J. Pure and Appl. Microbiol."},{"key":"B204","doi-asserted-by":"publisher","first-page":"651","DOI":"10.13005\/bbra\/2948","article-title":"GC-MS profiling and antifungal activity of secondary metabolite from endophytic fungus of giloy","volume":"18","author":"Sriwastava","year":"2021","journal-title":"Biosci. Biotech. Res. Asia"},{"key":"B205","doi-asserted-by":"publisher","first-page":"012034","DOI":"10.1088\/1755-1315\/308\/1\/012034","article-title":"Screening of antimicrobial and toxicity activity of endophytic bacteria associated with Curcuma zedoaria","volume":"308","author":"Sulistiyani","year":"2019","journal-title":"IOP Conf. Ser. Earth Environ. Sci."},{"key":"B206","doi-asserted-by":"publisher","first-page":"463937","DOI":"10.1016\/j.chroma.2023.463937","article-title":"Advances in solid-phase extraction techniques: role of nanosorbents for the enrichment of antibiotics for analytical quantification","volume":"1695","author":"Suseela","year":"2023","journal-title":"J. Chromatogr. A"},{"key":"B207","article-title":"Effects of tapping the Styrax paralleloneurus tree on Indole-3-Acetic acid production by the endophytic bacterium Kocuria palustris","author":"Susilowati","year":"2025"},{"key":"B208","doi-asserted-by":"publisher","first-page":"15","DOI":"10.3390\/fermentation9010015","article-title":"Biotechnological production of optically pure 2, 3-butanediol by Bacillus subtilis based on dissolved oxygen control strategy","volume":"9","author":"Suttikul","year":"2022","journal-title":"Fermentation"},{"key":"B209","first-page":"1056","article-title":"Ultra performance liquid chromatography (UPLC)-a review","volume":"2","author":"Taleuzzaman","year":"2015","journal-title":"Austin J. Anal. Pharm. Chem."},{"key":"B210","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1007\/s00284-026-04820-6","article-title":"Actinotalea endophytica sp. Nov., a novel endophytic actinobacterium isolated from Sonneratia apetala","volume":"83","author":"Tang","year":"2026","journal-title":"Curr. Microbiol."},{"key":"B211","doi-asserted-by":"publisher","first-page":"10976","DOI":"10.1038\/s41598-024-61490-9","article-title":"Multifunctional in vitro,, in silico and DFT analyses on antimicrobial BagremycinA biosynthesized by Micromonospora chokoriensis CR3 from Hieracium canadense","volume":"14","author":"Tanvir","year":"2024","journal-title":"Sci. Rep."},{"key":"B212","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1080\/10408347.2023.2299280","article-title":"Recent advances in dispersive liquid-liquid microextraction for pharmaceutical analysis","volume":"55","author":"Tay","year":"2025","journal-title":"Crit. Rev. Anal. Chem."},{"key":"B213","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1007\/s10123-026-00796-2","article-title":"Effect of epigenetic modulation on metabolites from endophytes isolated from Embelia ribes","volume":"29","author":"Terkar","year":"2026","journal-title":"Int. Microbiol."},{"key":"B214","doi-asserted-by":"publisher","first-page":"D10","DOI":"10.1093\/nar\/gkaf1078","article-title":"EMBL\u2019s European bioinformatics institute (EMBL-EBI) in 2025","volume":"54","author":"Thakur","year":"2026","journal-title":"Nucleic Acids Research"},{"key":"B215","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1007\/s00203-024-04121-1","article-title":"A comprehensive review on microbial diversity and anticancer compounds derived from seaweed endophytes: a pharmacokinetic and pharmacodynamic approach","volume":"206","author":"Tharani","year":"2024","journal-title":"Archives Microbiol."},{"key":"B216","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.1021\/mp400720w","article-title":"Drug-induced nephrotoxicity: clinical impact and preclinical in vitro models","volume":"11","author":"Tiong","year":"2014","journal-title":"Mol. Pharmaceutics"},{"key":"B217","doi-asserted-by":"publisher","first-page":"52","DOI":"10.3390\/microorganisms6020052","article-title":"Chemical elicitors of antibiotic biosynthesis in actinomycetes","volume":"6","author":"Tyurin","year":"2018","journal-title":"Microorganisms"},{"key":"B218","doi-asserted-by":"publisher","first-page":"3010","DOI":"10.1007\/s12010-023-04669-6","article-title":"GC-MS-guided antimicrobial defense responsive secondary metabolites from the endophytic Fusarium solani isolated from Tinospora cordifolia and their multifaceted biological properties","volume":"196","author":"Uzma","year":"2024","journal-title":"Appl. Biochem. Biotechnol."},{"key":"B219","doi-asserted-by":"publisher","first-page":"1407289","DOI":"10.3389\/fmicb.2024.1407289","article-title":"Genomic insights into an endophytic Streptomyces sp. VITGV156 for antimicrobial compounds","volume":"15","author":"Veilumuthu","year":"2024","journal-title":"Front. Microbiol."},{"key":"B220","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1007\/s11033-024-09511-8","article-title":"Marine seaweed endophytic fungi-derived active metabolites promote reactive oxygen species-induced cell cycle arrest and apoptosis in human breast cancer cells","volume":"51","author":"Venkatachalam","year":"2024","journal-title":"Mol. Biol. Rep."},{"key":"B221","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.2147\/DDDT.S228381","article-title":"In silico design and synthesis of tetrahydropyrimidinones and tetrahydropyrimidinethiones as potential thymidylate kinase inhibitors exerting anti-TB activity against Mycobacterium tuberculosis","volume":"14","author":"Venugopala","year":"2020","journal-title":"Drug Des. Dev. Ther."},{"key":"B222","doi-asserted-by":"publisher","first-page":"1146650","DOI":"10.3389\/fmicb.2023.1146650","article-title":"Bioengineering of fungal endophytes through the CRISPR\/Cas9 system","volume":"14","author":"Verma","year":"2023","journal-title":"Front. Microbiol."},{"key":"B223","doi-asserted-by":"publisher","first-page":"233","DOI":"10.3390\/life14020233","article-title":"Integrating artificial intelligence for drug discovery in the context of revolutionizing drug delivery","volume":"14","author":"Visan","year":"2024","journal-title":"Life"},{"key":"B224","doi-asserted-by":"publisher","first-page":"102353","DOI":"10.1016\/j.mib.2023.102353","article-title":"Emergent CRISPR\u2013Cas-based technologies for engineering non-model bacteria","volume":"75","author":"Volke","year":"2023","journal-title":"Curr. Opin. Microbiol."},{"key":"B225","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1007\/s13205-024-04001-x","article-title":"Deciphering the enhanced translocation of Pb, Ni and Cd from artificially polluted soil to Chrysopogon zizanioides augmented with Bacillus xiamenensis VITMSJ3","volume":"14","author":"Wagh","year":"2024","journal-title":"3 Biotech."},{"key":"B226","doi-asserted-by":"publisher","first-page":"3568","DOI":"10.3390\/toxins6123568","article-title":"Indole alkaloids from fischerella inhibit vertebrate development in the zebrafish (Danio rerio) embryo model","volume":"6","author":"Walton","year":"2014","journal-title":"Toxins"},{"key":"B227","doi-asserted-by":"publisher","first-page":"246","DOI":"10.54097\/0az5b017","article-title":"Analysis on the impact of antibiotic abuse on public health and its pharmaceutical intervention measures","volume":"162","author":"Wang","year":"2026","journal-title":"Highlights Sci. Eng. Technol."},{"key":"B228","doi-asserted-by":"publisher","first-page":"1476","DOI":"10.3390\/plants14101476","article-title":"Identification and functional analysis of endophytic bacteria bacillus cereus in Sphagnum palustre","volume":"14","author":"Wang","year":"2025","journal-title":"Plants"},{"key":"B229","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.3390\/microorganisms11051276","article-title":"Endophytes in agriculture: potential to improve yields and tolerances of agricultural crops","volume":"11","author":"Watts","year":"2023","journal-title":"Microorganisms"},{"key":"B230","doi-asserted-by":"publisher","first-page":"1161486","DOI":"10.3389\/fmolb.2023.1161486","article-title":"Genomic and pathogenicity islands of listeria Monocytogenes\u2014overview of selected aspects","volume":"10","author":"Wiktorczyk-Kapischke","year":"2023","journal-title":"Front. Mol. Biosci."},{"key":"B245","doi-asserted-by":"crossref","first-page":"102793","DOI":"10.1016\/j.copbio.2022.102793","article-title":"Continuous biomanufacturing with microbes \u2014upstream progresses and challenges","volume":"78","author":"Xie","year":"2022","journal-title":"Curr. Opinion Biotechnol"},{"key":"B231","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1002\/jssc.201200801","article-title":"Ionic liquid\u2010based microwave\u2010assisted surfactant\u2010improved dispersive liquid\u2013liquid microextraction and derivatization of aminoglycosides in milk samples","volume":"36","author":"Xu","year":"2013","journal-title":"J. Separation Science"},{"key":"B232","doi-asserted-by":"publisher","first-page":"341","DOI":"10.3390\/md20060341","article-title":"Recent advances in the heterologous expression of biosynthetic gene clusters for marine natural products","volume":"20","author":"Xu","year":"2022","journal-title":"Mar. Drugs"},{"key":"B233","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1186\/s12864-024-10950-7","article-title":"Hifibgc: an ensemble approach for improved biosynthetic gene cluster detection in PacBio HiFi-read metagenomes","volume":"25","author":"Yadav","year":"2024","journal-title":"BMC Genomics"},{"key":"B234","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/978-981-97-6270-5_2","article-title":"Fermentation technology for microbial products and their process optimization","volume-title":"Industrial Microbiology and Biotechnology: A New Horizon of the Microbial World","author":"Yadav","year":"2024"},{"key":"B235","first-page":"210","article-title":"Upstream and downstream processing in pharmaceutical bioprocessing","volume":"12","author":"Yasu","year":"2024","journal-title":"Pharm. Bioprocess."},{"key":"B300","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.sajb.2020.02.033","article-title":"Isolation of potential antimicrobial metabolites from endophytic fungus Cladosporium cladosporioides from endemic plant Zygophyllum mandavillei","volume":"134","author":"Yehia","year":"2020","journal-title":"South African J. Bot."},{"key":"B236","doi-asserted-by":"publisher","first-page":"404","DOI":"10.22377\/ajp.v19i2.6424","article-title":"A review article of UPLC and its emerging application and challenges and opportunities","volume":"19","author":"Yenugukesava","year":"2025","journal-title":"Asian J. Pharm. (AJP)"},{"key":"B237","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1038\/s41596-025-01237-6","article-title":"A versatile toolkit for drug metabolism studies with GNPS2: from drug development to clinical monitoring","volume":"21","author":"Yu","year":"2026","journal-title":"Nat. Protoc."},{"key":"B238","doi-asserted-by":"publisher","first-page":"D640","DOI":"10.1093\/nar\/gkad1045","article-title":"MetaboLights: open data repository for metabolomics","volume":"52","author":"Yurekten","year":"2024","journal-title":"Nucleic Acids Research"},{"key":"B239","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/s42269-024-01199-x","article-title":"Progress in endophytic fungi secondary metabolites: biosynthetic gene cluster reactivation and advances in metabolomics","volume":"48","author":"Zakariyah","year":"2024","journal-title":"Bull. Natl. Res. Centre"},{"key":"B240","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1007\/s11274-022-03360-y","article-title":"Actinomycin D: a novel Pseudomonas aeruginosa quorum sensing inhibitor from the endophyte Streptomyces cyaneochromogenes RC1","volume":"38","author":"Zeng","year":"2022","journal-title":"World J. Microbiol. Biotechnol."},{"key":"B241","doi-asserted-by":"publisher","first-page":"bbaf533","DOI":"10.1093\/bib\/bbaf533","article-title":"Computational toxicology in drug discovery: applications of artificial intelligence in ADMET and toxicity prediction","volume":"26","author":"Zhang","year":"2025","journal-title":"Briefings Bioinforma."},{"key":"B242","doi-asserted-by":"publisher","first-page":"600","DOI":"10.37532\/2048-9145.2024.12(4).210-211","article-title":"A two-stage metabolome refining pipeline for natural products discovery","volume":"10","author":"Zhang","year":"2025","journal-title":"Syn. Sys. Biotechnol."},{"key":"B243","doi-asserted-by":"publisher","first-page":"779","DOI":"10.3390\/microorganisms12040779","article-title":"Current advances in the functional diversity and mechanisms underlying endophyte\u2013plant interactions","volume":"12","author":"Zhao","year":"2024","journal-title":"Microorganisms"},{"key":"B244","doi-asserted-by":"publisher","first-page":"125","DOI":"10.3390\/molecules23010125","article-title":"Effects of agitation, aeration and temperature on production of a novel glycoprotein GP-1 by Streptomyces kanasenisi ZX01 and scale-up based on volumetric oxygen transfer coefficient","volume":"23","author":"Zhou","year":"2018","journal-title":"Molecules"}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2026.1837576\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T09:44:56Z","timestamp":1784195096000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2026.1837576\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,16]]},"references-count":247,"alternative-id":["10.3389\/fphar.2026.1837576"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2026.1837576","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,16]]},"article-number":"1837576"}}