{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T10:45:35Z","timestamp":1791801935482,"version":"4.3.4"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>\n                    Emodin, a natural anthraquinone compound, exhibits anti-inflammatory, antioxidant, and broad-spectrum anti-tumor activities. Studies have shown that Emodin can inhibit the activation and functions of various immune cells, thereby being recognized as an important immunosuppressive agent. In this study, we conducted\n                    <jats:italic>in vitro<\/jats:italic>\n                    experiments to examine the effects of Emodin on the apoptosis, differentiation, and immunosuppressive functions of myeloid-derived suppressor cells (MDSCs), as well as its impacts on the migration, proliferation, and viability of mouse pancreatic cancer H7 cells. Furthermore, we established a mouse orthotopic pancreatic cancer model to evaluate Emodin\u2019s anti-pancreatic cancer effects\n                    <jats:italic>in vivo<\/jats:italic>\n                    and its modulation of immune cell subpopulations. The results revealed that Emodin exerts anti-pancreatic cancer effects through direct inhibition of tumor cells and regulation of MDSCs, although its modulation of the immune microenvironment exhibits concentration-dependent and subset-specific characteristics. These findings suggest that combination therapy and dose optimization are crucial directions for its clinical translation.\n                  <\/jats:p>","DOI":"10.3389\/fphar.2026.1840325","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T09:17:28Z","timestamp":1789377448000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect and mechanism of Emodin on mouse myeloid-derived suppressor cells"],"prefix":"10.3389","volume":"17","author":[{"given":"Yating","family":"Shu","sequence":"first","affiliation":[{"name":"Key Laboratory of Immune Microenvironment and Inflammatory Disease Research in Universities of Shandong Province, School of Basic Medical Sciences, Shandong Second Medical University","place":["Weifang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Ma","sequence":"additional","affiliation":[{"name":"Key Laboratory of Immune Microenvironment and Inflammatory Disease Research in Universities of Shandong Province, School of Basic Medical Sciences, Shandong Second Medical University","place":["Weifang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiling","family":"Xiao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Immune Microenvironment and Inflammatory Disease Research in Universities of Shandong Province, School of Basic Medical Sciences, Shandong Second Medical University","place":["Weifang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyue","family":"Li","sequence":"additional","affiliation":[{"name":"Digestive Disease Diagnosis and Treatment Center, Affiliated Hospital of Shandong Second Medical University","place":["Weifang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotian","family":"Qi","sequence":"additional","affiliation":[{"name":"Key Laboratory of Immune Microenvironment and Inflammatory Disease Research in Universities of Shandong Province, School of Basic Medical Sciences, Shandong Second Medical University","place":["Weifang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiyu","family":"Peng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Immune Microenvironment and Inflammatory Disease Research in Universities of Shandong Province, School of Basic Medical Sciences, Shandong Second Medical University","place":["Weifang, China"]},{"name":"Department of Nephrology, Affiliated Hospital of Shandong Second Medical University","place":["Weifang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1186\/s12964-024-01995-y","article-title":"MDSC: a new potential breakthrough in CAR-T therapy for solid tumors","volume":"22","author":"Abdalsalam","year":"2024","journal-title":"Cell Commun. 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