{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T02:34:11Z","timestamp":1788834851781,"version":"build-2803163510"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Plant-Derived Exosome-Like nanoparticles (PELNs) are vital bioactive vesicles from medicinal plants, containing protective flavonoids, polyphenols, alkaloids, terpenoids, saponins, polysaccharides, and microRNAs. These compounds play crucial roles in PELNs\u2019 anti-inflammatory and other pharmacological effects. PELNs show promise as a treatment in animal experiments for ulcerative colitis (UC) due to their biocompatibility, low immunogenicity, and natural targeting abilities. This review examines their therapeutic effects on UC and the potential mechanisms behind their action.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study synthesises existing data through a meta-analysis, providing comprehensive preclinical evidence for the use of PELNs in ulcerative colitis. To identify studies examining the effects of PELNs on UC, the researchers conducted a comprehensive search of five databases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      This search identified a total of 25 eligible studies involving 304 animal subjects, with data up to 15 September 2025. According to the results of the meta-analysis, PELNs demonstrated significant effects in mitigating weight loss, increasing colon length, and reducing faecal consistency scores. Further mechanistic studies suggest that PELNs may exert their effects through multiple pathways. In addition to influencing inflammatory factors and the mucosal barrier, PELNs may also modulate the microbiota during the repair process of UC. PELNs intervention resulted in a statistically significant change in the Chao index (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.05) and a highly significant change in the Shannon index (\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt; 0.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This meta-analysis suggests that, in animal models of ulcerative colitis (UC), PELNs may be associated with antioxidant, anti-inflammatory, immunomodulatory and intestinal barrier-protective effects. This study only supports the correlational results derived from preclinical animal studies, and cannot confirm the definite action mechanisms nor clinical efficacy in humans. Further basic researches are still needed for in-depth exploration. Visit\n                      <jats:ext-link>https:\/\/inplasy.com\/inplasy-2025-11-0075\/<\/jats:ext-link>\n                      to access the systematic review registration, labeled as INPLASY2025110075.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Systematic Review Registration<\/jats:title>\n                    <jats:p>Identifier INPLASY2025110075.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphar.2026.1845981","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T04:35:16Z","timestamp":1782102916000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Meta-analysis of plant-derived exosome-like nanoparticles for the treatment of ulcerative colitis: efficacy and mechanisms insights"],"prefix":"10.3389","volume":"17","author":[{"given":"Xuefei","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Basic Medical Sciences, Tarim University","place":["Aral, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Tarim University","place":["Aral, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mao","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Tarim University","place":["Aral, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuang","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Tarim University","place":["Aral, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyang","family":"Wang","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Xinjiang Second Medical College","place":["Karamay, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junran","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Tarim University","place":["Aral, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Tarim University","place":["Aral, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuwen","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Tarim University","place":["Aral, China"]},{"name":"Huzhou Central Hospital, Affiliated Central Hospital Huzhou University","place":["Huzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e15553","DOI":"10.1111\/ped.15553","article-title":"Risk factors for intolerance of oral 5\u2010aminosalicylic acid preparations in pediatric ulcerative colitis","volume":"65","author":"Abe","year":"2023","journal-title":"Pediatr. 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