{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T15:54:55Z","timestamp":1783698895928,"version":"3.55.0"},"reference-count":49,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Adolescence is a vulnerable window in which stress and alcohol exposure can induce long-lasting neuroimmune, endocrine, and cardiac molecular alterations. The fractalkine axis (CX\n                      <jats:sub>3<\/jats:sub>\n                      CL1\/CX\n                      <jats:sub>3<\/jats:sub>\n                      CR1) regulates neuron\u2013microglia signaling and inflammatory responses, but its role in linking adolescent stress\/alcohol exposure with adult anxiety-like behavior and cardiac biomarker\/molecular signatures remains unclear.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      To test whether genetic or pharmacological disruption of CX\n                      <jats:sub>3<\/jats:sub>\n                      CR1 modifies adult anxiety-like behavior, circulating biomarkers, and cardiac transcriptional responses after adolescent stress and\/or alcohol exposure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Male and female C57BL\/6J wild-type (WT) and CX\n                      <jats:sub>3<\/jats:sub>\n                      CR1 knockout (KO) mice were exposed to restraint stress (90\u00a0min) and\/or alcohol (2\u00a0g\/kg, 14 days) during adolescence. In adulthood, elevated plus maze (EPM) behavior was assessed; plasma cTnI\/cTnT, CX\n                      <jats:sub>3<\/jats:sub>\n                      CL1, ACTH, and corticosterone were quantified; and cardiac mRNA expression of chemokines, inflammatory receptor\/NF-\u03baB-related genes, glucocorticoid\/mineralocorticoid receptor-related genes, and RAAS-related transcripts was profiled. WT mice received the CX\n                      <jats:sub>3<\/jats:sub>\n                      CR1 antagonist AZD8797 (20\u00a0mg\/kg, i.p.) for behavioral validation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CX\n                      <jats:sub>3<\/jats:sub>\n                      CR1 loss or blockade was associated with increased anxiety index and reduced open-arm exploration under selected exposure conditions. CX\n                      <jats:sub>3<\/jats:sub>\n                      CR1 KO mice showed higher plasma cTnI\/cTnT, CX\n                      <jats:sub>3<\/jats:sub>\n                      CL1, and ACTH, and lower corticosterone, stress and alcohol were also associated with lower corticosterone. In cardiac tissue, alcohol exposure, mainly under the no-stress condition, increased\n                      <jats:italic>Cx3cl1<\/jats:italic>\n                      ,\n                      <jats:italic>Ccl2<\/jats:italic>\n                      ,\n                      <jats:italic>Ackr3<\/jats:italic>\n                      , and selected RAAS-related transcripts, whereas CX\n                      <jats:sub>3<\/jats:sub>\n                      CR1 deficiency was associated with broadly lower expression across chemokine, NF-\u03baB-related, mineralocorticoid receptor-related, and RAAS-related targets. Correlation analyses indicated a chemokine\/\n                      <jats:italic>Cxcl12<\/jats:italic>\n                      -anchored inflammatory\u2013RAAS transcriptional architecture in WT mice that was attenuated and shifted toward glucocorticoid\/mineralocorticoid receptor\u2013NF-\u03baB\/I\u03baB\u03b1\u2013RAAS-related associations in CX\n                      <jats:sub>3<\/jats:sub>\n                      CR1 KO mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      These findings suggest that CX\n                      <jats:sub>3<\/jats:sub>\n                      CR1 signaling contributes to the long-term coordination of behavioral stress-related responses, HPA-axis activity, circulating cardiac injury biomarkers, and cardiac inflammatory\/RAAS-related transcriptional programs after adolescent stress and alcohol exposure. Because cardiac function and histopathology were not assessed, these results should be interpreted as evidence of cardiac biomarker and molecular vulnerability rather than definitive myocardial pathology.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphar.2026.1850815","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T04:44:55Z","timestamp":1782276295000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Adolescent stress and alcohol are associated with CX3CR1-linked endocrine\u2013cardiac signatures and anxiety-like behavior in mice"],"prefix":"10.3389","volume":"17","author":[{"given":"Dina","family":"Medina-Vera","sequence":"first","affiliation":[{"name":"IBIMA Plataforma Bionand (Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga)","place":["M\u00e1laga, Spain"]},{"name":"Facultad de Medicina, Universidad de 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