{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T05:52:23Z","timestamp":1785909143439,"version":"3.56.0"},"reference-count":178,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012542","name":"Sichuan Provincial Science and Technology Support Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>Post-COVID syndrome is predominantly characterized by persistent fatigue that cannot be attributed to other underlying diseases or relieved by conventional rest. Such symptoms may last for weeks to months, substantially impairing patients\u2019 health status and quality of life. Nevertheless, current understanding of the pathogenesis of post-COVID syndrome remains insufficient, posing major challenges to its effective clinical management. Therefore, this review elaborates comprehensively on the pathogenesis, potential therapeutic targets, and pharmacological interventions for post-COVID syndrome, aiming to provide evidence for drug research and development as well as clinical application. Four interrelated pathogenic mechanisms sustaining chronic inflammation after viral clearance are collectively involved in disease progression, including immune dysregulation accompanied by chronic low-grade inflammation, mitochondrial dysfunction and impaired energy metabolism, renin-angiotensin system imbalance, and gut microbiota dysbiosis with disrupted gut-brain axis function. Based on these mechanistic findings, this review highlights potential therapeutic targets such as TLR4\/TLR7, the JAK\/STAT pathway, the NLRP3 inflammasome, the AMPK\/NRF2 axis, and the PINK1\/Parkin pathway. Accordingly, we summarize mechanism-targeted candidate drugs, including Toll-like receptor antagonists, JAK inhibitors, probiotics, mitochondria-targeted agents and drugs correcting renin-angiotensin system imbalance. In addition, this review summarizes other therapeutic candidates acting via distinct mechanisms, such as fluvoxamine, coenzyme Q10 combined with alpha-lipoic acid, astragalus root extracts, other medicinal herbs and traditional Chinese compound formulas. Post-COVID syndrome represents a complex public health challenge. Further in-depth mechanistic research and rational application of emerging technologies are still required to develop therapeutic strategies for preventing and alleviating the onset and progression of post-COVID syndrome.<\/jats:p>","DOI":"10.3389\/fphar.2026.1852220","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T05:39:24Z","timestamp":1785908364000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The Post-COVID syndrome caused by excessive inflammation: pathogenesis, potential targets and therapeutic agents"],"prefix":"10.3389","volume":"17","author":[{"given":"Tao","family":"Zhou","sequence":"first","affiliation":[{"name":"Chinese Medicine Germplasm Resources Innovation and Effective Uses Key Laboratory of Sichuan Province, School of Pharmacy, Chengdu University of Traditional Chinese Medicine","place":["Chengdu, China"]},{"name":"School of Modern Chinese Medicine Industry, Chengdu University of Traditional Chinese Medicine","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guotao","family":"Xue","sequence":"additional","affiliation":[{"name":"Chinese Medicine Germplasm Resources Innovation and Effective Uses Key Laboratory of Sichuan Province, School of Pharmacy, Chengdu University of Traditional Chinese Medicine","place":["Chengdu, China"]},{"name":"School of Modern Chinese Medicine Industry, Chengdu University of Traditional Chinese Medicine","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Chinese Medicine Germplasm Resources Innovation and Effective Uses Key Laboratory of Sichuan Province, School of Pharmacy, Chengdu University of Traditional Chinese Medicine","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengqi","family":"Li","sequence":"additional","affiliation":[{"name":"Sichuan Nursing Vocational College","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingkun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Chinese Medicine Germplasm Resources Innovation and Effective Uses Key Laboratory of Sichuan Province, School of Pharmacy, Chengdu University of Traditional Chinese Medicine","place":["Chengdu, China"]},{"name":"Sichuan Provincial Engineering Research Center of Innovative Re-Development of Famous Classical Formulas, Tianfu TCM Innovation Harbour, Chengdu University of Traditional Chinese Medicine","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junzhi","family":"Lin","sequence":"additional","affiliation":[{"name":"TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanhong","family":"Luo","sequence":"additional","affiliation":[{"name":"Chinese Medicine Germplasm Resources Innovation and Effective Uses Key Laboratory of Sichuan Province, School of Pharmacy, Chengdu University of Traditional Chinese Medicine","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Han","sequence":"additional","affiliation":[{"name":"Chinese Medicine Germplasm Resources Innovation and Effective Uses Key Laboratory of Sichuan Province, School of Pharmacy, Chengdu University of Traditional Chinese Medicine","place":["Chengdu, China"]},{"name":"School of Modern Chinese Medicine Industry, Chengdu University of Traditional Chinese Medicine","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinna","family":"Tian","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Chengdu University of Traditional Chinese Medicine","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haozhou","family":"Huang","sequence":"additional","affiliation":[{"name":"Chinese Medicine Germplasm Resources Innovation and Effective Uses Key Laboratory of Sichuan Province, School of Pharmacy, Chengdu University of Traditional Chinese Medicine","place":["Chengdu, China"]},{"name":"School of Modern Chinese Medicine Industry, Chengdu University of Traditional Chinese Medicine","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.conb.2021.09.005","article-title":"PTEN-induced kinase 1 (PINK1) and Parkin: unlocking a mitochondrial quality control pathway linked to Parkinson\u2019s disease","volume":"72","author":"Agarwal","year":"2022","journal-title":"Curr. 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