{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T05:45:58Z","timestamp":1785735958660,"version":"3.56.0"},"reference-count":51,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This systematic review and meta-analysis aimed to quantitatively evaluate the protective effects of resveratrol (RES) in animal models of chronic obstructive pulmonary disease (COPD) and systematically summarize its potential molecular regulatory mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eight databases were systematically searched for eligible animal studies from inception to February 2026. Methodological quality was assessed using the SYRCLE tool. Meta-analyses were performed using Review Manager 5.4 and Stata 18.0.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      This meta-analysis included 14 preclinical studies involving a total of 377 experimental animals (experimental group: 239; control group: 138). The results showed that RES significantly alleviated airflow limitation and improved pulmonary function in COPD models (FEV\n                      <jats:sub>0.3<\/jats:sub>\n                      \/FVC: SMD = 1.79, 95% CI [0.94, 2.63],\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.0001; lung compliance: SMD = 1.63, 95% CI [0.92, 2.33],\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.00001). Regarding inflammatory regulation, RES significantly reduced serum levels of pro-inflammatory cytokines, including TNF-\u03b1 (SMD = \u22123.18, 95% CI [-4.92, \u22121.44],\n                      <jats:italic>P<\/jats:italic>\n                      = 0.0003), IL-8 (SMD = \u22122.79, 95% CI [-4.71, \u22120.86],\n                      <jats:italic>P<\/jats:italic>\n                      = 0.005), and IL-6 (SMD = \u22121.28, 95% CI [-2.03, \u22120.53],\n                      <jats:italic>P<\/jats:italic>\n                      = 0.0008). At the pulmonary level, RES also downregulated both the protein (SMD = \u22126.57, 95% CI [-9.94, \u22123.20],\n                      <jats:italic>P<\/jats:italic>\n                      = 0.0001) and mRNA (SMD = \u22121.48, 95% CI [-2.22, \u22120.73],\n                      <jats:italic>P<\/jats:italic>\n                      = 0.0001) expression of TNF-\u03b1 in lung tissue. Furthermore, RES attenuated oxidative stress-related injury in lung tissue, as reflected by decreased malondialdehyde (MDA) levels (SMD = \u22122.64, 95% CI [-3.93, \u22121.35],\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.0001) and increased superoxide dismutase (SOD) activity (SMD = 3.52, 95% CI [1.22, 5.82],\n                      <jats:italic>P<\/jats:italic>\n                      = 0.003). Substantial heterogeneity was observed in some pooled outcomes, and Egger\u2019s test suggested potential publication bias.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Current preclinical evidence suggests that RES may improve pulmonary function and attenuate inflammatory responses and oxidative stress-related injury in COPD animal models. However, these findings should be considered preliminary, and further well-designed studies are needed to validate the translational relevance of RES in COPD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Systematic Review Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link>https:\/\/www.crd.york.ac.uk\/PROSPERO\/view\/CRD420261309405<\/jats:ext-link>\n                      , identifier CRD420261309405.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphar.2026.1854452","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T05:30:12Z","timestamp":1785735012000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Protective effects of resveratrol in animal models of chronic obstructive pulmonary disease: a preclinical systematic review and meta-analysis"],"prefix":"10.3389","volume":"17","author":[{"given":"Siping","family":"Wang","sequence":"first","affiliation":[{"name":"Changchun University of Chinese Medicine","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotong","family":"Wei","sequence":"additional","affiliation":[{"name":"Changchun University of Chinese Medicine","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[{"name":"Changchun University of Chinese Medicine","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengnan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Changchun University of Chinese Medicine","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunze","family":"Hu","sequence":"additional","affiliation":[{"name":"Changchun University of Chinese Medicine","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongpeng","family":"Yu","sequence":"additional","affiliation":[{"name":"Changchun University of Chinese Medicine","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xize","family":"Zhang","sequence":"additional","affiliation":[{"name":"Changchun University of Chinese Medicine","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Liang","sequence":"additional","affiliation":[{"name":"Changchun University of Chinese Medicine","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaodan","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Pneumology, the Affiliated Hospital to Changchun University of Chinese Medicine","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Pneumology, the Affiliated Hospital to Changchun University of Chinese Medicine","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2300239","DOI":"10.1183\/13993003.00239-2023","article-title":"Global initiative for chronic obstructive lung disease 2023 report: GOLD executive summary","volume":"61","author":"Agust\u00ed","year":"2023","journal-title":"Eur. 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