{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T06:03:29Z","timestamp":1780985009649,"version":"3.54.1"},"reference-count":64,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>\n                    Rheum tanguticum (\n                    <jats:italic>R. tanguticum<\/jats:italic>\n                    ) originates from high-altitude regions such as Qinghai and Gansu in China. It serves as both a precious traditional medicinal botanical drug and a potential functional food, and its extensive pharmacological activities have stimulated global demand. However, existing research predominantly focuses on optimizing individual drying techniques or single bioactive metabolites, failing to integrate multi-omics technologies to elucidate the chemical and physical alterations induced by drying. To this end, we evaluated five drying methods by integrating an approach that links physical indicators with chemical composition, revealing that, for the preservation of physical indicators, especially color and rehydration properties, vacuum freeze drying (LD) is optimal; for the retention of the key pharmaceutical metabolite free anthraquinones, microwave drying (WB) is the most effective. Whereas in the comprehensive evaluation of multi-dimensional quality, SG is optimal. Metabolomic analysis confirmed that LD and YG were most effective in preserving key metabolites. Flavonoids, phenolic acids, and amino acids collectively form the core metabolites of differential metabolites in dried\n                    <jats:italic>R. tanguticum<\/jats:italic>\n                    , primarily enriched in pathways such as purine metabolism. Collectively, this work systematically elucidates the impact of drying on\n                    <jats:italic>R. tanguticum<\/jats:italic>\n                    \u2019s metabolite profile and physicochemical traits, offering both a theoretical basis for its precision processing and a transferable framework for optimizing drying techniques in related medicinal edible plants.\n                  <\/jats:p>","DOI":"10.3389\/fphar.2026.1854690","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T05:43:42Z","timestamp":1780983822000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Drying methods for Rheum tanguticum: a comprehensive study of quality traits and metabolite dynamics"],"prefix":"10.3389","volume":"17","author":[{"given":"Zengrong","family":"Ye","sequence":"first","affiliation":[{"name":"School of Ecological and Environmental Engineering, Qinghai University","place":["Xining, Qinghai, China"]},{"name":"Sichuan Zoige Alpine Wetland Ecosystem National Observation and Research Station, Southwest Minzu University","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Huaibei Normal University","place":["Huaibei, Anhui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Zhao","sequence":"additional","affiliation":[{"name":"Northwest Institute of Plateau Biology, Chinese Academy of Sciences","place":["Xining, Qinghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianan","family":"Li","sequence":"additional","affiliation":[{"name":"Northwest Institute of Plateau Biology, Chinese Academy of Sciences","place":["Xining, Qinghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Jin","sequence":"additional","affiliation":[{"name":"School of Ecological and Environmental Engineering, Qinghai University","place":["Xining, Qinghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[{"name":"Northwest Institute of Plateau Biology, Chinese Academy of Sciences","place":["Xining, Qinghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoying","family":"Zhou","sequence":"additional","affiliation":[{"name":"Sichuan Zoige Alpine Wetland Ecosystem National Observation and Research Station, Southwest Minzu University","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.lwt.2012.01.026","article-title":"Moisture sorption isotherms and isosteric heat of sorption of leaves and stems of lemon balm (Melissa officinalis L.) established by dynamic vapor sorption","volume":"47","author":"Argyropoulos","year":"2012","journal-title":"LWT"},{"key":"B2","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1186\/s12870-025-06110-y","article-title":"Effect of drying methods on phenolic compounds and antioxidant activity of Capparis spinosa L. fruits","volume":"25","author":"Babaei Rad","year":"2025","journal-title":"BMC Plant Biol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"9580","DOI":"10.1080\/10408398.2022.2067121","article-title":"Kaempferol: a flavonoid with wider biological activities and its applications","volume":"63","author":"Bangar","year":"2023","journal-title":"Crit. Rev. in Food Science and Nutrition"},{"key":"B4","doi-asserted-by":"publisher","first-page":"3964","DOI":"10.1016\/j.apsb.2024.05.027","article-title":"Aloe emodin promotes mucosal healing by modifying the differentiation fate of enteroendocrine cells via regulating cellular free fatty acid sensitivity","volume":"14","author":"Bao","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"key":"B5","doi-asserted-by":"publisher","first-page":"143511","DOI":"10.1016\/j.foodres.2025.115924","article-title":"Structural integrity, bioactive components, and physico-chemical characteristics of Kashmiri saffron (Crocus Sativus L.) as affected by different drying techniques","volume":"476","author":"Bashir","year":"2025","journal-title":"Food Chem."},{"key":"B6","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1590\/S0101-20612002000100008","article-title":"Effect of polyphenol oxidase (PPO) and air treatments on total phenol and tannin content of cocoa nibs","volume":"22","author":"Brito","year":"2002","journal-title":"Food Sci. and Technol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"133849","DOI":"10.1016\/j.foodchem.2022.133849","article-title":"Influence of combined freeze-drying and far-infrared drying technologies on physicochemical properties of seed-used pumpkin","volume":"398","author":"Chao","year":"2023","journal-title":"Food Chem."},{"key":"B8","doi-asserted-by":"publisher","first-page":"140460","DOI":"10.1016\/j.foodchem.2024.140460","article-title":"Hepatoprotective potential of four fruit extracts rich in different structural flavonoids against alcohol-induced liver injury via gut microbiota-liver axis","volume":"460","author":"Chen","year":"2024","journal-title":"Food Chem."},{"key":"B9","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1007\/s11483-025-10079-4","article-title":"Dynamic regulation mechanism of metabolites and drying kinetic model construction during vacuum freeze-drying of rhubarb: a multi-dimensional study of integrated physiology, untargeted metabolomics and enzyme activity","volume":"20","author":"Cheng","year":"2025","journal-title":"Food Biophys."},{"key":"B10","first-page":"25","volume-title":"Pharmacopoeia of the People\u2019s Republic of China","year":"2025"},{"key":"B11","doi-asserted-by":"publisher","first-page":"11802","DOI":"10.1080\/10408398.2022.2096561","article-title":"Assessment of the stability of compounds belonging to neglected phenolic classes and flavonoid sub-classes using reaction kinetic modeling","volume":"63","author":"De Beer","year":"2023","journal-title":"Crit. Rev. in Food Sci. and Nutr."},{"key":"B12","doi-asserted-by":"publisher","first-page":"115824","DOI":"10.1016\/j.indcrop.2022.115824","article-title":"Metabolites changes of Eucommia ulmoides olive samaras from different regions and cultivars","volume":"189","author":"Du","year":"2022","journal-title":"Industrial Crops and Prod."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1422622","DOI":"10.1016\/j.foodchem.2024.142262","article-title":"Effects of different drying methods on the chemical components and activities of taihang chrysanthemum (Opisthopappus taihangensis)","volume":"466","author":"Fan","year":"2025","journal-title":"Food Chem."},{"key":"B14","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.jgg.2015.04.004","article-title":"Pyrimidine metabolism: dynamic and versatile pathways in pathogens and cellular development","volume":"42","author":"Garavito","year":"2015","journal-title":"J. of Genetics and Genomics"},{"key":"B15","doi-asserted-by":"publisher","first-page":"121125","DOI":"10.1016\/j.indcrop.2025.121125","article-title":"Profiling the dynamic alterations of metabolites and phytohormones in response to stress during the post-harvest processing of Pogostemon cablin leaves","volume":"230","author":"Ge","year":"2025","journal-title":"Industrial Crops and Prod."},{"key":"B16","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1055\/s-2004-818971","article-title":"Stability control of senna leaves and senna extracts","volume":"70","author":"Goppel","year":"2004","journal-title":"Planta Medica"},{"key":"B17","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/j.jare.2024.05.014","article-title":"L-lysine dietary supplementation for childhood and adolescent growth: promises and precautions","volume":"70","author":"Gunarathne","year":"2025","journal-title":"J. of Adv. Res."},{"key":"B18","doi-asserted-by":"publisher","first-page":"421","DOI":"10.3390\/molecules29020421","article-title":"Trollius chinensis Bunge: a comprehensive review of research on botany, materia medica, ethnopharmacological use, phytochemistry, pharmacology, and quality control","volume":"29","author":"He","year":"2024","journal-title":"Molecules"},{"key":"B19","doi-asserted-by":"publisher","first-page":"145126","DOI":"10.1016\/j.foodchem.2025.145126","article-title":"Metabolomic insights into pigment and bioactive metabolite alterations in Eucommia ulmoides leaves: a comparison between new variety and wild-type varieties","volume":"491","author":"Hong","year":"2025","journal-title":"Food Chem."},{"key":"B20","doi-asserted-by":"publisher","first-page":"e20210407","DOI":"10.1590\/1678-4685-GMB-2021-0407","article-title":"Comparative transcriptome analysis of different tissues of Rheum tanguticum maxim. Ex. Balf. (polygonaceae) reveals putative genes involved in anthraquinone biosynthesis","volume":"45","author":"Hu","year":"2022","journal-title":"Genet. and Molecular Biology"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1069310","DOI":"10.3389\/fphar.2022.1069310","article-title":"Aquaporins: a new target for traditional Chinese medicine in the treatment of digestive system diseases","volume":"13","author":"Huang","year":"2022","journal-title":"Front. in Pharmacol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/j.cmet.2007.10.005","article-title":"Metabolomics","volume":"6","author":"Idle","year":"2007","journal-title":"Cell Metab."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1002\/jsfa.6501","article-title":"Comparison of drying characteristic and uniformity of banana cubes dried by pulse\u2010spouted microwave vacuum drying, freeze drying and microwave freeze drying","volume":"94","author":"Jiang","year":"2014","journal-title":"J. of the Sci. of Food and Agric."},{"key":"B24","doi-asserted-by":"publisher","first-page":"5147373","DOI":"10.1155\/2022\/5147373","article-title":"Hotair drying characteristics of sea cucumber (Apostichopus japonicus) and its rehydration properties","volume":"2022","author":"Jiang","year":"2022","journal-title":"J. of Food Qual."},{"key":"B25","doi-asserted-by":"publisher","first-page":"113017","DOI":"10.1016\/j.scienta.2024.113017","article-title":"Shading in fruit changes the polyphenol accumulation of pellicle by regulating activity of key enzymes and expression of their gene related polyphenol anabolism of Juglans sigillata dode","volume":"329","author":"Jiang","year":"2024","journal-title":"Sci. Hortic."},{"key":"B26","doi-asserted-by":"publisher","first-page":"102","DOI":"10.4997\/JRCPe.2017.121","article-title":"Rhubarb (rheum species): the role of Edinburgh in its cultivation and development","volume":"47","author":"Lee","year":"2017","journal-title":"J. of the R. Coll. of Physicians of Edinb."},{"key":"B27","doi-asserted-by":"publisher","first-page":"963","DOI":"10.3390\/biology14080963","article-title":"Mechanistic elucidation and establishment of drying kinetic models of differential metabolite regulation in Rheum palmatum during natural sun drying: an integrated physiology, untargeted metabolomics, and enzymology study","volume":"14","author":"Luo","year":"2025","journal-title":"Biology"},{"key":"B28","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1002\/pca.3308","article-title":"Photostability of sennosides and their aglycones in solution","volume":"35","author":"Meier","year":"2024","journal-title":"Phytochem. Anal."},{"key":"B29","doi-asserted-by":"publisher","first-page":"212","DOI":"10.48130\/fia-0024-0020","article-title":"Comparing the appearance and phytochemical characterization of dried lily (L. davidii var. unicolor) bulbs processed by different drying technologies","volume":"3","author":"Mi","year":"2024","journal-title":"Food Innovation and Adv."},{"key":"B30","doi-asserted-by":"publisher","first-page":"197","DOI":"10.22271\/phyto.2021.v10.i5c.14197","article-title":"Optimization of primary post-harvest processing techniques for Cassia angustifolia Vahl","volume":"10","author":"Nilofer","year":"2021","journal-title":"J. of Pharmacogn. and Phytochemistry"},{"key":"B31","doi-asserted-by":"publisher","first-page":"2407","DOI":"10.3390\/foods11162407","article-title":"Effect of pulsed electric field pre-treatment and the freezing methods on the kinetics of the freeze-drying process of apple and its selected physical properties","volume":"11","author":"Nowak","year":"2022","journal-title":"Foods"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.18782\/2320-7051.2597","article-title":"Review on microwave assisted extraction technique","volume":"5","author":"Nukasani","year":"2017","journal-title":"Int. J. of Pure and Appl. Biosci."},{"key":"B33","doi-asserted-by":"publisher","first-page":"853","DOI":"10.3390\/foods10040853","article-title":"Microwave and ultrasound pre-treatments for drying of the \u201cRocha\u201d pear: impact on phytochemical parameters, color changes and drying kinetics","volume":"10","author":"\u00d6nal","year":"2021","journal-title":"Foods"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.1007\/s11947-013-1199-0","article-title":"Comparison of freeze-drying and freeze-drying combined with microwave vacuum drying methods on drying kinetics and rehydration characteristics of button mushroom (Agaricus bisporus) slices","volume":"7","author":"Pei","year":"2014","journal-title":"Food and Bioprocess Technol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"2253","DOI":"10.3390\/foods13142253","article-title":"Anticancer potential of flavonoids: their role in cancer prevention and health benefits","volume":"13","author":"Pyo","year":"2024","journal-title":"Foods"},{"key":"B36","doi-asserted-by":"publisher","first-page":"102419","DOI":"10.1016\/j.fochx.2025.102419","article-title":"Changes in chemical composition, volatile compound, and bioactive compounds retention in shallots (Allium ascalonicum L.) under different drying methods","volume":"27","author":"Ratseewo","year":"2025","journal-title":"Food Chem. X"},{"key":"B37","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/S0260-8774(00)00228-4","article-title":"Hot air and freeze-drying of high-value foods: a review","volume":"49","author":"Ratti","year":"2001","journal-title":"J. of Food Engineering"},{"key":"B38","doi-asserted-by":"publisher","first-page":"e70782","DOI":"10.1002\/fsn3.70782","article-title":"Drying temperature and storage duration for the retention of bioactive compounds of selected wild edible plants from Ethiopia","volume":"13","author":"Rumicha","year":"2025","journal-title":"Food Sci. and Nutr."},{"key":"B39","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s40538-025-00745-7","article-title":"Optimizing drying time for Centella asiatica (L.) urban: metabolomic insights into dehydration effects on primary and secondary metabolites","volume":"12","author":"Ryu","year":"2025","journal-title":"Chem. and Biol. Technol. in Agric."},{"key":"B40","doi-asserted-by":"publisher","first-page":"2097","DOI":"10.1021\/es5002105","article-title":"Identifying small molecules via high resolution mass spectrometry: communicating confidence","volume":"48","author":"Schymanski","year":"2014","journal-title":"Environ. Sci. and Technol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"114021","DOI":"10.1016\/j.lwt.2022.114021","article-title":"Influence of different drying methods coupled with different process modes on physicochemical qualities and anthraquinones contents of Rheum palmatum L","volume":"170","author":"Shen","year":"2022","journal-title":"Lwt"},{"key":"B42","doi-asserted-by":"publisher","first-page":"112","DOI":"10.3390\/foods11010112","article-title":"Comparison of drying methods and their effect on the stability of Gra\u0161evina grape pomace biologically active compounds","volume":"11","author":"Soka\u010d","year":"2022","journal-title":"Foods"},{"key":"B43","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/S0031-9422(02)00708-2","article-title":"Plant metabolomics: large-scale phytochemistry in the functional genomics era","volume":"62","author":"Sumner","year":"2003","journal-title":"Phytochemistry"},{"key":"B44","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.tifs.2019.12.018","article-title":"Advances in umami taste and aroma of edible mushrooms","volume":"96","author":"Sun","year":"2020","journal-title":"Trends in Food Sci. and Technol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"115924","DOI":"10.3390\/foods13060830","article-title":"Influences on the phytochemical characteristics and multiple bioactivities of Mesona chiensis Benth polysaccharides in response to different drying methods","volume":"204","author":"Tang","year":"2025","journal-title":"Food Res. Int."},{"key":"B46","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1016\/j.semnephrol.2010.07.007","article-title":"Analytical approaches to metabolomics and applications to systems biology","volume":"30","author":"Wang","year":"2010","journal-title":"Seminars in Nephrology"},{"key":"B47","doi-asserted-by":"publisher","first-page":"e51667","DOI":"10.1371\/journal.pone.0051667","article-title":"Genetic variation in Rheum palmatum and Rheum tanguticum (Polygonaceae), two medicinally and endemic species in China using ISSR markers","volume":"7","author":"Wang","year":"2012","journal-title":"Plos One"},{"key":"B48","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1186\/s12906-022-03611-3","article-title":"Network pharmacology combined with molecular docking to explore the potential mechanisms for the antioxidant activity of Rheum tanguticum seeds","volume":"22","author":"Wang","year":"2022","journal-title":"BMC Complementary Medicine and Therapies"},{"key":"B49","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1186\/s12870-024-04933-9","article-title":"Metabolomics analysis reveals the metabolite profiles of Rheum tanguticum grown under different altitudinal gradients","volume":"24","author":"Wang","year":"2024","journal-title":"BMC Plant Biol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"144498","DOI":"10.1016\/j.foodchem.2025.144498","article-title":"Integrating widely targeted metabolomics and network pharmacology to provide insights into the mechanism of nutrition changes in walnut kernel under different drying methods","volume":"485","author":"Wang","year":"2025","journal-title":"Food Chem."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.1152\/physrev.00035.2018","article-title":"Metabolomics for investigating physiological and pathophysiological processes","volume":"99","author":"Wishart","year":"2019","journal-title":"Physiol. Reviews"},{"key":"B52","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1017\/S0007114515001476","article-title":"Asparagine attenuates hepatic injury caused by lipopolysaccharide in weaned piglets associated with modulation of Toll-like receptor 4 and nucleotide-binding oligomerisation domain protein signalling and their negative regulators","volume":"114","author":"Wu","year":"2015","journal-title":"Br. J. of Nutr."},{"key":"B53","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/s13020-022-00631-6","article-title":"Fecal fermentation characteristics of Rheum tanguticum polysaccharide and its effect on the modulation of gut microbial composition","volume":"17","author":"Wu","year":"2022","journal-title":"Chin. Med."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.3390\/foods13111639","article-title":"Effects of drying methods on morphological characteristics, metabolite content, and antioxidant capacity of Cordyceps sinensis","volume":"13","author":"Xiao","year":"2024","journal-title":"Foods"},{"key":"B55","doi-asserted-by":"publisher","first-page":"494","DOI":"10.3390\/plants14030494","article-title":"Widely targeted metabolomics analyses provide insights into the transformation of active ingredients during drying and the mechanisms of color change for forest ginseng (Panax ginseng CA Mey. cv. sativi-nemoralis)","volume":"14","author":"Xing","year":"2025","journal-title":"Plants"},{"key":"B56","doi-asserted-by":"publisher","first-page":"4321","DOI":"10.3390\/foods12234321","article-title":"Novel efficient physical technologies for enhancing freeze drying of fruits and vegetables: a review","volume":"12","author":"Yao","year":"2023","journal-title":"Foods"},{"key":"B57","doi-asserted-by":"publisher","first-page":"112090","DOI":"10.1016\/j.foodres.2022.112090","article-title":"Metabolomic analysis provides insights into the mechanism of color and taste changes in Dictyophora indusiata fruiting bodies under different drying processes","volume":"162","author":"Zeng","year":"2022","journal-title":"Food Res. Int."},{"key":"B58","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1186\/s13020-024-01013-w","article-title":"Metabolomics and proteomics analyses of Chrysanthemi Flos: a mechanism study of changes in proteins and metabolites by processing methods","volume":"19","author":"Zhang","year":"2024","journal-title":"Chin. Medicine"},{"key":"B59","doi-asserted-by":"publisher","first-page":"105463","DOI":"10.1016\/j.jfca.2023.105463","article-title":"Study on the quality characteristics and geographical origin authentication of wild Rheum tanguticum in three authentic regions","volume":"123","author":"Zhao","year":"2023","journal-title":"J. of Food Compos. and Analysis"},{"key":"B60","doi-asserted-by":"publisher","first-page":"105426","DOI":"10.1016\/j.fbio.2024.105426","article-title":"Metabolomic characteristics and anthraquinones accumulation patterns of rhubarb in different tissues and roots from different developmental stages","volume":"62","author":"Zhao","year":"2024","journal-title":"Food Biosci."},{"key":"B61","doi-asserted-by":"publisher","first-page":"144018","DOI":"10.1016\/j.foodchem.2025.144018","article-title":"Drying methods affect nutritional value, amino acids, bioactive compounds, and in vitro function of extract in mulberry leaves","volume":"481","author":"Zhao","year":"2025","journal-title":"Food Chem."},{"key":"B62","doi-asserted-by":"publisher","first-page":"118475","DOI":"10.1016\/j.jep.2024.118475","article-title":"Scorch processing of rhubarb (Rheum tanguticum maxim. Ex Balf.) pyrolyzed anthraquinone glucosides into aglycones and improved the therapeutic effects on thromboinflammation via regulating the complement and coagulation cascades pathway","volume":"333","author":"Zhong","year":"2024","journal-title":"J. of Ethnopharmacol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"115501","DOI":"10.1016\/j.lwt.2023.115501","article-title":"Widely targeted metabolomics analysis of the main bioactive compounds of Ganpu tea processing through different drying methods","volume":"189","author":"Zhou","year":"2023","journal-title":"Lwt"},{"key":"B64","doi-asserted-by":"publisher","first-page":"139584","DOI":"10.1016\/j.foodchem.2024.139584","article-title":"Comparative metabolomics profiling reveals the unique bioactive compounds and astringent taste formation of rosehips","volume":"452","author":"Zhou","year":"2024","journal-title":"Food Chem."}],"container-title":["Frontiers in Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2026.1854690\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T05:43:46Z","timestamp":1780983826000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2026.1854690\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,9]]},"references-count":64,"alternative-id":["10.3389\/fphar.2026.1854690"],"URL":"https:\/\/doi.org\/10.3389\/fphar.2026.1854690","relation":{},"ISSN":["1663-9812"],"issn-type":[{"value":"1663-9812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,9]]},"article-number":"1854690"}}