{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:14:08Z","timestamp":1786115648557,"version":"build-2736575974"},"reference-count":132,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:p>Cardiovascular diseases continue to be a predominant cause of global mortality, driven by pathological molecular transport networks. Exosomes, which encapsulate diverse molecular cargo reflective of their cellular origins and associated pathological states, serve as valuable resources for identifying diagnostic and prognostic biomarkers. An increasing number of studies conducted in recent years have shown that exosomal circular RNA (circRNA) is important for a variety of cardiovascular diseases (CVDs), such as coronary heart disease, atherosclerosis, senescence, myocardial infarction, and myocardial damage. Recent research has highlighted the critical functions of circRNAs, which operate through various mechanisms, including the regulation of gene expression by serving as microRNA (miRNA) sponges, operating a dual synergistic mechanism that simultaneously promotes cytokinesis and cell cycle restoration, which enhances myocardial repair, and directly combines RNA-binding proteins and ligases to promote the recognition and degradation of proteins. Exploring the mechanisms underlying CVDs from the perspective of exosomal circRNA is of great significance. It has far-reaching value for the prevention, early diagnosis, and effective treatment of cardiovascular disorders. This review summarizes the latest investigation on the hyperlink between CVDs and exosomal circRNA.<\/jats:p>","DOI":"10.3389\/fphar.2026.1860253","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T04:24:23Z","timestamp":1785990263000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Comprehensive landscape and future perspectives of exosomal circular RNAs in cardiovascular disease"],"prefix":"10.3389","volume":"17","author":[{"given":"Yuan","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Anatomy, School of Integrative Medicine, Shanghai University of Traditional Chinese Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianhui","family":"You","sequence":"additional","affiliation":[{"name":"Department of Anatomy, School of Integrative Medicine, Shanghai University of Traditional Chinese Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Shu","sequence":"additional","affiliation":[{"name":"Shenzhen Bao\u2019an Authentic TCM Therapy Hospital, Guangzhou University of Chinese Medicine","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurui","family":"Yuan","sequence":"additional","affiliation":[{"name":"Chinese PLA General Hospital, Medical School of Chinese PLA","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuoyue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anatomy, School of Integrative Medicine, Shanghai University of Traditional Chinese Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Chen","sequence":"additional","affiliation":[{"name":"Oncology Department, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine","place":["Suzhou, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baonian","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anatomy, School of Integrative Medicine, Shanghai University of Traditional Chinese Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s10875-025-01965-0","article-title":"Exosomes in autoimmunity: mediators of autoantigen presentation and targets for therapeutic intervention in autoimmune diseases","volume":"46","author":"Almohaimeed","year":"2025","journal-title":"J. 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