{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T05:47:47Z","timestamp":1785822467850,"version":"3.56.0"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pharmacol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sepsis-associated cardiac dysfunction is a major contributor to morbidity and mortality and is driven by dysregulated inflammation and impaired cellular bioenergetics. Therapeutic strategies that target both processes remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This study evaluated the cardioprotective effects of Xiangdan Injection in murine sepsis models induced by Gram-positive\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                      and Gram-negative\n                      <jats:italic>Escherichia coli<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sepsis caused reduced survival, myocardial structural damage, increased circulating inflammatory mediators, elevated cardiac injury biomarkers, and mitochondrial ultrastructural disruption. Xiangdan Injection improved survival in a dose-dependent manner (p &amp;lt; 0.05), reduced serum IL-6, TNF-\u03b1, IL-1\u03b2, and HMGB1 levels (all p &amp;lt; 0.05), and decreased BNP, CK-MB, and cardiac troponin I levels (all p &amp;lt; 0.05). Transmission electron microscopy showed preservation of mitochondrial ultrastructure, reflected by reduced mitochondrial damage scores (p &amp;lt; 0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings indicate that Xiangdan Injection attenuates sepsis-induced myocardial injury by suppressing systemic inflammation and preserving mitochondrial structure. Comparable effects were observed in both bacterial models, supporting further investigation of Xiangdan Injection as a potential adjunctive intervention for sepsis-associated myocardial injury.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fphar.2026.1860982","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T05:39:19Z","timestamp":1785821959000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Xiangdan Injection attenuates experimental sepsis-induced myocardial injury by suppressing inflammation and preserving mitochondrial ultrastructure"],"prefix":"10.3389","volume":"17","author":[{"given":"Yan","family":"Qian","sequence":"first","affiliation":[{"name":"Department of Emergency Intensive Care Unit, Wuhu Hospital, East China Normal University","place":["Wuhu, Anhui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenmin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of PICU, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University","place":["Guangzhou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunmin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of PICU, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University","place":["Guangzhou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinda","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of PICU, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University","place":["Guangzhou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyi","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Zhujiang Hospital, Southern Medical University","place":["Guangzhou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Outpatient Clinic, The Affiliated Chuzhou Hospital of Anhui Medical University (The First People\u2019s Hospital of Chuzhou)","place":["Chuzhou, Anhui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1038\/s41522-025-00782-y","article-title":"Immune dysfunction during Staphylococcus aureus biofilm-associated implant infections: opportunities for novel therapeutic strategies","volume":"11","author":"Brandquist","year":"2025","journal-title":"Npj Biofilms Microbiomes"},{"key":"B2","first-page":"629","article-title":"Organ dysfunction in sepsis: an ominous trajectory from infection to death","volume":"92","author":"Caraballo","year":"2019","journal-title":"Yale J. 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