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MicroRNAs (miRNAs) have emerged as central regulators of these processes by coordinating gene expression, metabolic balance, and stress responses. This review summarizes current understanding of how miRNAs modulate ferroptosis, anoikis, and pyroptosis across liver, lung, gastric, breast, and other cancers. They influence ferroptosis through lipid peroxidation and antioxidant systems, regulate anoikis via integrin signaling and cytoskeletal remodeling, and tune pyroptosis through inflammasome activation and gasdermin-mediated pore formation. Emerging evidence suggests that miRNAs function as integrative nodes linking metabolic reprogramming, immune-inflammatory signaling, and adaptive survival pathways. Their stability, druggability, and cross-pathway influence highlight their promise as biomarkers and therapeutic targets, and advancing RNA-based technologies may enable more precise manipulation of cell-death programs to overcome resistance and refine cancer treatment.<\/jats:p>","DOI":"10.3389\/fphar.2026.1862213","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T06:45:55Z","timestamp":1787640355000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["MircoRNAs as regulators of regulated cell death in cancer progression: a focus on ferroptosis, anoikis and pyroptosis"],"prefix":"10.3389","volume":"17","author":[{"given":"Di","family":"Xiao","sequence":"first","affiliation":[{"name":"West China School of Pharmacy, Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanzhou","family":"Luo","sequence":"additional","affiliation":[{"name":"West China School of Pharmacy, Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyuan","family":"Liu","sequence":"additional","affiliation":[{"name":"West China School of Pharmacy, Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajie","family":"Lu","sequence":"additional","affiliation":[{"name":"West China School of Pharmacy, Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofang","family":"Xie","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Southwestern Chinese Medicine Resources, Chinese Medicine Germplasm Resources Innovation and Effective Uses Key Laboratory of Sichuan Province, Chengdu University of Traditional Chinese Medicine","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaokai","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Urology, National Clinical Research Center for Metabolic Diseases, The Second Xiangya Hospital of Central South University","place":["Changsha, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Ma","sequence":"additional","affiliation":[{"name":"West China School of Pharmacy, Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu","family":"Peng","sequence":"additional","affiliation":[{"name":"West China School of Pharmacy, Sichuan University","place":["Chengdu, China"]},{"name":"Department of Pharmacology, Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.tips.2025.10.015","article-title":"Sodium\u2019s role and therapeutic targeting in cancer","volume":"47","author":"An","year":"2026","journal-title":"Trends Pharmacol. 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